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Serial 5-Year Evaluation of Side Branches Jailed by Bioresorbable Vascular Scaffolds Using 3-Dimensional Optical Coherence Tomography: Insights From the ABSORB Cohort B Trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions)
- Source :
- Circulation-Cardiovascular Interventions, 10, 9, pp. e004393, Circulation-Cardiovascular Interventions, 10, e004393, Circulation-cardiovascular interventions, 10(9):e004393. Lippincott Williams & Wilkins, Onuma, Y, Grundeken, M J, Nakatani, S, Asano, T, Sotomi, Y, Foin, N, Ng, J, Okamura, T, Wykrzykowska, J J, De Winter, R J, Van Geuns, R J, Koolen, J, Christiansen, E, Whitbourn, R, McClean, D, Smits, P, Windecker, S, Ormiston, J A & Serruys, P W 2017, ' Serial 5-year evaluation of side branches jailed by bioresorbable vascular scaffolds using 3-dimensional optical coherence tomography insights from the ABSORB cohort b trial (a clinical evaluation of the bioabsorbable everolimus eluting coronary stent system in the treatment of patients with de novo native coronary artery lesions) ', Circulation: Cardiovascular Interventions, vol. 10, no. 9, e004393 . https://doi.org/10.1161/CIRCINTERVENTIONS.116.004393, Circulation. Cardiovascular interventions, 10(9):e004393. Lippincott Williams and Wilkins
- Publication Year :
- 2016
-
Abstract
- Background— The long-term fate of Absorb bioresorbable vascular scaffold (Abbott Vascular, Santa Clara, CA) struts jailing side branch ostia has not been clarified. We therefore evaluate serially (post-procedure and at 6 months, 1, 2, 3, and 5 years) the appearance and fate of jailed Absorb bioresorbable vascular scaffold struts. Methods and Results— We performed 3-dimensional optical coherence tomographic analysis of the ABSORB Cohort B trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) up to 5 years using a novel, validated cut-plane analysis method. We included 29 patients with a total of 85 side branch ostia. From the 12 ostia which could be assessed in true serial fashion, 7 showed a pattern of initial decrease in the ostial area free from struts, followed by an increase in strut-free ostial area toward the end of the 5 years of follow-up. In a repeated-measures analysis with time as fixed variable and ostial area free from struts as dependent variable, we showed a numeric decrease in the estimated ostial area free from struts from 0.75 mm 2 (baseline) to 0.68 mm 2 (first follow-up visit at 6 months or 1 year) and 0.63 mm 2 (second follow-up visit at 2 or 3 years). However, from the second visit to the 5-year follow-up visit, there was a statistically significant increase from 0.63 to 0.89 mm 2 ( P =0.001). Struts overlying an ostium divided the ostium into compartments, and the number of these compartments decreased over time. Conclusions— This study showed that in most cases, the side branch ostial area free from struts initially decreased. However, with full scaffold bioresorption, the ostial area free from scaffold increased between 2 to 3 years and 5 years in the vast majority of patients. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00856856.
- Subjects :
- medicine.medical_specialty
Time Factors
medicine.medical_treatment
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Coronary Artery Disease
030204 cardiovascular system & hematology
Prosthesis Design
Percutaneous coronary intervention
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Optical coherence tomography
Predictive Value of Tests
Coronary stent
Absorbable Implants
medicine
Humans
030212 general & internal medicine
Everolimus
Bifurcation Lesion
610 Medicine & health
absorbable implants
medicine.diagnostic_test
business.industry
Reproducibility of Results
Cardiovascular Agents
Drug-Eluting Stents
medicine.disease
Coronary Vessels
Surgery
Ostium
medicine.anatomical_structure
Treatment Outcome
Cohort
cardiovascular system
Cardiology and Cardiovascular Medicine
business
Tomography, Optical Coherence
Artery
medicine.drug
Subjects
Details
- ISSN :
- 19417632 and 19417640
- Volume :
- 10
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Circulation. Cardiovascular interventions
- Accession number :
- edsair.doi.dedup.....19e48e3a51b06a89990a1fc324711295