1. Breast-shape changes during radiation therapy after breast-conserving surgery
- Author
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Anja Betgen, Corine van Vliet-Vroegindeweij, Tanja Alderliesten, Wilma D. Heemsbergen, Peter Remeijer, Paula H.M. Elkhuizen, Rajko Topolnjak, Radiotherapy, CCA - Imaging and biomarkers, and CCA - Cancer Treatment and Quality of Life
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,Cone beam computed tomography ,medicine.medical_treatment ,lcsh:R895-920 ,lcsh:RC254-282 ,Standard deviation ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Breast-conserving surgery ,medicine ,Radiology, Nuclear Medicine and imaging ,Original Research Article ,Shape variability ,skin and connective tissue diseases ,Radiation ,business.industry ,Cone-beam computed tomography ,Partial Breast Irradiation ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Breast shape ,Radiation therapy ,Axilla ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Nuclear medicine ,business - Abstract
Background & purpose: With the introduction of more conformal techniques for breast cancer radiation therapy (RT), motion management is becoming increasingly important. We studied the breast-shape variability during RT after breast-conserving surgery (BCS). Materials & Methods: Planning computed tomography (CT) and follow-up cone-beam CT (CBCT) scans were available for 71 fractions of 17 patients undergoing RT after BCS. First, the CT and the CBCT scans were registered on bones. Subsequently, breast-contour data were generated. The CBCT contours were analyzed in 3D in terms of deviations (mean and standard deviation) relative to the contour of the CT scan for the upper medial, lower medial, upper lateral, and lower lateral breast quadrants, and the axilla. Results: Regional systematic and random standard deviations of the breast quadrants varied between 1.5 and 2.1 mm and 1.0–1.6 mm, respectively, and were larger for the axilla (3.0 mm). An absolute average shape change of ≥4.0 mm in at least one region was present in 21/71 fractions (30%), predominantly in breast volumes > 800 cc (p =
- Published
- 2018