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FDG-PET and diffusion-weighted MRI in head-and-neck cancer patients: Implications for dose painting
- Source :
- Radiotherapy and Oncology. 106:250-254
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Purpose The purpose of this study was to investigate if FDG-PET and DWI identify the same or different targets for dose escalation in the GTV of HN cancer patients. Additionally, the dose coverage of DWI-targets in an FDG-PET-based dose painting plan was analyzed. Materials and methods Eighteen HN cancer patients underwent FDG-PET and DWI exams, which were converted to standardized uptake value (SUV)- and apparent diffusion coefficient (ADC)-maps. The correspondence between the two imaging modalities was determined on a voxel-level using Spearman's correlation coefficient ( ρ ). Dose painting plans were optimized based on the 50% isocontour of the maximum SUV ( SUV 50%max ). Dose coverage was analyzed in three different SUV- and three different ADC-targets using the mean dose and the near-minimum and near-maximum doses. Results The average maximum SUV was 13.9 and the mean ADC was 1.17·10 −3 mm 2 /s. The average ρ between SUV and ADC was −0.2 (range: −0.6 to 0.4). The ADC-targets were only partly overlapping the SUV 50%max -target and the dose parameters were significantly smaller in the ADC-targets compared to the SUV 50%max -target. Conclusions FDG-PET and DWI contain different information, resulting in different targets. Further information about failure patterns and dose relations can be obtained by adding DWI to currently ongoing dose painting trials.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Standardized uptake value
Imaging modalities
Fluorodeoxyglucose F18
Dose painting
medicine
Dose escalation
Humans
Effective diffusion coefficient
Radiology, Nuclear Medicine and imaging
business.industry
Radiotherapy Planning, Computer-Assisted
Head and neck cancer
Radiotherapy Dosage
Hematology
medicine.disease
Radiation therapy
Diffusion Magnetic Resonance Imaging
Oncology
Head and Neck Neoplasms
Positron-Emission Tomography
Radiology
Radiopharmaceuticals
Nuclear medicine
business
Radiotherapy, Image-Guided
Diffusion MRI
Subjects
Details
- ISSN :
- 01678140
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- Radiotherapy and Oncology
- Accession number :
- edsair.doi.dedup.....049dead0da6b1346cb58309a48c7342c