1. Metabolic-associated fatty liver disease and major adverse cardiac events in patients with chronic coronary syndrome: a matched case–control study
- Author
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Ying Gao, Ye-Xuan Cao, Qian Dong, Jian-Jun Li, Rui-Xia Xu, Jing-Lu Jin, Cheng-Gang Zhu, Na-Qiong Wu, Ming-Hua Zheng, Yuan-Lin Guo, and Hui-Hui Liu
- Subjects
medicine.medical_specialty ,Hepatology ,Proportional hazards model ,business.industry ,Fatty liver ,Case-control study ,medicine.disease ,Coronary artery disease ,Non-alcoholic Fatty Liver Disease ,Case-Control Studies ,Internal medicine ,Nonalcoholic fatty liver disease ,medicine ,Humans ,cardiovascular diseases ,Risk factor ,business ,Survival rate - Abstract
A consensus of experts suggests that nonalcoholic fatty liver disease (NAFLD) does not appropriately reflect current knowledge and metabolic-associated fatty liver disease (MAFLD) is supposed to be a more suitable overarching concept. However, the association of MAFLD with cardiovascular outcomes in patients with coronary artery disease has not been examined yet. Thus, this study aimed to assess the impact of MAFLD on major adverse cardiac events (MACEs) in patients with chronic coronary syndrome (CCS). This study included 3306 patients with CCS who were diagnosed with MAFLD. Controls without MAFLD were matched (1:1) to cases by age and gender. All participants were followed up for the occurrence of MACEs. Finally, the association between MAFLD and the risk of MACEs was assessed. During an average of 55.09 ± 19.92 months follow-up, 376 and 248 MACEs were observed in MAFLD and control groups, respectively. When compared with controls, Kaplan–Meier analysis showed that patients with MAFLD had significantly lower event-free survival rate and multivariate Cox regression analysis further revealed that MAFLD group had significantly increased MACEs risk (both p
- Published
- 2021