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Liver fibrosis scores and coronary atherosclerosis: novel findings in patients with stable coronary artery disease
- Source :
- Hepatology International. 15:413-423
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Although non-invasive liver fibrosis scores (LFSs) have already been considered as effective tools for estimating cardiovascular risk, their roles in predicting disease severity and cardiovascular event (CVEs) in patients with stable coronary artery disease (CAD) are not comprehensively evaluated. The aim of the present study was to investigate whether non-alcoholic fatty liver disease fibrosis score (NAFLD-FS) and fibrosis-4 (FIB-4) are associated with CVEs in a large cohort with long-term follow-up. A cohort of 5143 patients with angiography-proven stable CAD were consecutively enrolled and followed up for CVEs. The degree of coronary severity was assessed using the number of diseased vessels, Gensini, Syntax, and Jeopardy scores. The predictive values of NAFLD-FS and FIB-4 scores to coronary severity, coronary calcification (CAC), and CVEs were assessed, respectively. During a median follow-up of 7 years, 435 CVEs were recorded. Both NAFLD-FS and FIB-4 were predictors for the presence of CAC. The degree of coronary stenosis was significantly higher in high NAFLD-FS categories while FIB-4 was only positively associated with the number of diseased vessels and Gensini score. In Kaplan–Meier analysis, the patients with intermediate and high NAFLD-FS and FIB-4 had higher risk of CVEs and cardiovascular mortality. In multivariate Cox regression analysis, NAFLD-FS and FIB-4 were independently associated with CVEs [hazard ratio (95% confidence interval): 1.150 (1.063–1.244), p
- Subjects :
- Liver Cirrhosis
medicine.medical_specialty
Coronary Artery Disease
Severity of Illness Index
Cohort Studies
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Internal medicine
Humans
Medicine
Risk factor
Coronary atherosclerosis
Hepatology
business.industry
Proportional hazards model
Hazard ratio
Fatty liver
Atherosclerosis
medicine.disease
Confidence interval
030220 oncology & carcinogenesis
Cohort
Cardiology
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 19360541 and 19360533
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Hepatology International
- Accession number :
- edsair.doi.dedup.....c8ed1862f431c8a9a6de138f39a7aeba