1. COVID‐19‐associated mucormycosis: An updated systematic review of literature
- Author
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Neemu Hage, Ashok Kumar, Mainak Banerjee, Rimesh Pal, Sanjay Kumar Bhadada, Birgurman Singh, and Ranjitpal Singh Bhogal
- Subjects
0301 basic medicine ,Poor prognosis ,Pediatrics ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,030106 microbiology ,Review Article ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,COVID-19 Testing ,0302 clinical medicine ,COVID‐19 ,Diabetes mellitus ,Mucormycosis ,Humans ,Medicine ,In patient ,Pulmonary mucormycosis ,Review Articles ,Glucocorticoids ,Pandemics ,business.industry ,COVID‐19‐associated mucormycosis ,Mortality rate ,COVID-19 ,General Medicine ,medicine.disease ,Comorbidity ,Infectious Diseases ,business - Abstract
In its wake, the COVID‐19 pandemic has ushered in a surge in the number of cases of mucormycosis. Most cases are temporally linked to COVID‐19; hence, the entity is described as COVID‐19‐associated mucormycosis (CAM). The present systematic review was undertaken to provide an up‐to‐date summary of the hitherto available literature on CAM. PubMed, Scopus and Google Scholar databases were systematically searched using appropriate keywords till 14 May 2021, to identify case reports/case series pertaining to mucormycosis in patients with COVID‐19. Relevant data extracted included demographic characteristics, comorbidity profile, clinical category of mucormycosis, glucocorticoid use, treatment offered and patient outcome. We identified 30 case reports/case series, pooling data retrieved from 99 patients with CAM. Most cases were reported from India (72%). The majority of the patients was male (78%) and had diabetes mellitus (85%). A prior history of COVID‐19 was present in 37% patients with mucormycosis developing after an initial recovery. The median time interval between COVID‐19 diagnosis and the first evidence of mucormycosis infection or CAM diagnosis was 15 days. Glucocorticoid use was reported in 85% of cases. Rhino‐orbital mucormycosis was most common (42%), followed by rhino‐orbito‐cerebral mucormycosis (24%). Pulmonary mucormycosis was observed in 10 patients (10%). The mortality rate was 34%; the use of adjunct surgery, which was undertaken in 81% of patients, was associated with better clinical outcomes (p
- Published
- 2021