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Primary hyperparathyroidism in pregnancy: observations from the Indian PHPT registry
- Source :
- Journal of Endocrinological Investigation. 44:1425-1435
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- To present the data on primary hyperparathyroidism (PHPT) in pregnancy from India obtained from a large database maintained over 15 years. We retrieved data of all women with gestational PHPT from the Indian PHPT registry between July 2005 and January 2020, and compared their clinical, biochemical, and other characteristics with age-matched non-pregnant women with PHPT. Out of 386 women, eight had gestational PHPT (2.1%). The common presenting manifestations were acute pancreatitis (50%) and renal stone disease (50%); two were asymptomatic. Five women (62.5%) had a history of prior miscarriages. Seven patients (88%) had preeclampsia during the present gestation. Serum calcium and intact parathyroid hormone (iPTH) were not statistically different from the age-matched non-pregnant PHPT group. Six patients with mild-to-moderate hypercalcemia were medically managed with hydration with/without cinacalcet while one patient underwent percutaneous ethanol ablation of the parathyroid adenoma; none underwent surgery during pregnancy. Mean serum calcium maintained from treatment initiation till delivery was 10.5 ± 0.4 mg/dl. One patient had spontaneous preterm delivery at 36 weeks; the remaining patients had normal vaginal delivery at term. None had severe preeclampsia/eclampsia. Fetal outcomes included low birth weight in three newborns (37.5%); two of them had hypocalcemic seizures. The prevalence of gestational PHPT was 2.1% in this largest Indian PHPT cohort, which is higher than that reported from the West (
- Subjects :
- Pediatrics
medicine.medical_specialty
Pregnancy
Cinacalcet
Eclampsia
endocrine system diseases
business.industry
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
medicine.disease
Asymptomatic
Preeclampsia
Miscarriage
03 medical and health sciences
Low birth weight
0302 clinical medicine
Endocrinology
030220 oncology & carcinogenesis
Medicine
medicine.symptom
business
Primary hyperparathyroidism
medicine.drug
Subjects
Details
- ISSN :
- 17208386
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinological Investigation
- Accession number :
- edsair.doi...........e0e13f6658e51282a12a16c2c02b4471