1. Increased plasma brain-derived neurotrophic factor (BDNF) as a potential biomarker for and compensatory mechanism in mild cognitive impairment: a case-control study
- Author
-
Ee Heok Kua, Ted Kheng Siang Ng, Patricia C. Heyn, Rathi Mahendran, James J. Carollo, Christina M. Coughlan, and Alex Tagawa
- Subjects
Oncology ,Male ,Aging ,medicine.medical_specialty ,Disease ,mild cognitive impairment ,Neurotrophic factors ,Internal medicine ,mental disorders ,medicine ,Humans ,Cognitive Dysfunction ,Aged ,Brain-derived neurotrophic factor ,Aged, 80 and over ,cerebral palsy ,biology ,business.industry ,Brain-Derived Neurotrophic Factor ,discriminative accuracy ,Case-control study ,Cell Biology ,Middle Aged ,Peripheral ,hs-CRP ,BDNF ,Cross-Sectional Studies ,Case-Control Studies ,Cohort ,biology.protein ,Female ,business ,Neurocognitive ,Biomarkers ,Neurotrophin ,Research Paper - Abstract
Background: Previous meta-analyses examining the continuum of Alzheimer’s disease (AD) concluded significantly decreased peripheral brain-derived neurotrophic factor (BDNF) in AD. However, across different meta-analyses, there remain inconsistent findings on peripheral BDNF levels in individuals with mild cognitive impairment (MCI). This issue has been attributed to the highly heterogenous clinical and laboratory factors. Thus, BDNF’s level, discriminative accuracy for identifying all-cause MCI and its subtypes, and its associations with other biomarkers and neurocognitive domains, remain largely unknown. Methods: To address this heterogeneity, we compared a healthy control cohort (n=56, 45 female) to an MCI cohort (n=40, 28 female), to determine whether plasma BDNF, hs-CRP, and DHEA-S can differentiate healthy from MCI individuals, including two MCI subtypes (amnestic [aMCI] and non-amnestic [non-aMCI]). The associations between BDNF with other biomarkers and neurocognitive tests were examined. Adults with cerebral palsy were included as sensitivity analyses. Results: Compared to healthy controls, BDNF was significantly higher in all-cause MCI, aMCI, and non-aMCI. Furthermore, BDNF had good (AUC=0.84, 95% CI=0.74 to 0.95, p
- Published
- 2021