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Factors Associated With Antidepressant Dosing in Asia
- Source :
- Journal of Clinical Psychopharmacology. 36:716-719
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods. The AD doses varied by twofold among countries (highest in PR China and RO Korea, lowest in Singapore and Indonesia), and averaged 124 (120-129) mg/d imipramine-equivalents. Average daily doses increased by 12% between 2004 and 2013. Doses were significantly higher among hospitalized patients and ranked by diagnosis: major depression > anxiety disorders > bipolar disorder, but were not associated with private/public or psychiatric/general-medical settings, nor with age, sex, or cotreatment with a mood stabilizer. In multivariate modeling, AD-dose remained significantly associated with major depressive disorder and being hospitalized. Doses of ADs have increased somewhat in Asia and were higher when used for major depression or anxiety disorders than for bipolar depression and for hospitalized psychiatric patients.
- Subjects :
- medicine.medical_specialty
Asia
Bipolar Disorder
Time Factors
Cross-sectional study
medicine.drug_class
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Pharmacology (medical)
Bipolar disorder
Practice Patterns, Physicians'
Medical prescription
Psychiatry
Depression (differential diagnoses)
Depressive Disorder, Major
Dose-Response Relationship, Drug
business.industry
Pharmacoepidemiology
Mood stabilizer
medicine.disease
Anxiety Disorders
Antidepressive Agents
030227 psychiatry
Hospitalization
Psychiatry and Mental health
Cross-Sectional Studies
Multivariate Analysis
Antidepressant
Major depressive disorder
Anxiety
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1533712X and 02710749
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Psychopharmacology
- Accession number :
- edsair.doi.dedup.....38cb9fd35b6437cff5ca602c78e024d4