51 results on '"Patrick Kay"'
Search Results
2. Lipoprotein(a), Interleukin-10, C-Reactive Protein, and 8-Year Outcome After Percutaneous Coronary Intervention
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Sally P.A. McCormick, Ron T. van Domburg, Eric Boersma, I. Patrick Kay, Isabella Kardys, Joost Daemen, Patrick W. Serruys, Gregory T. Jones, Robert-Jan van Geuns, Rohit M. Oemrawsingh, Epidemiology, Cardiology, and Radiology & Nuclear Medicine
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Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Clinical Investigations ,Coronary Artery Disease ,Risk Assessment ,Coronary artery disease ,Surveys and Questionnaires ,Internal medicine ,Confidence Intervals ,medicine ,Health Status Indicators ,Humans ,Prospective Studies ,cardiovascular diseases ,Myocardial infarction ,Angioplasty, Balloon, Coronary ,Prospective cohort study ,biology ,business.industry ,Hazard ratio ,Percutaneous coronary intervention ,Drug-Eluting Stents ,General Medicine ,Lipoprotein(a) ,Middle Aged ,Prognosis ,medicine.disease ,Interleukin-10 ,Surgery ,C-Reactive Protein ,Conventional PCI ,biology.protein ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Mace - Abstract
Background: This prospective study investigated the association between preprocedural biomarker levels and incident major adverse cardiac events (MACE) in complex patients undergoing percutaneous coronary intervention (PCI) with sirolimus-eluting stenting. Hypothesis: Lipoprotein(a) (Lp[a]), interleukin-10 (IL-10), and high-sensitivity C-reactive protein (CRP) have long-term prognostic value in patients undergoing PCI. Methods: Between April 2002 and February 2003, 161 patients were included in the study. Blood was drawn before the procedure, and biomarkers were measured. Patients were followed-up for MACE (death, nonfatal myocardial infarction, and repeat revascularization). Cox proportional hazard models were used to determine risk of MACE for tertiles of biomarkers. Both 1-year and long-term follow-up (median, 6 years; maximum, 8 years) were evaluated. Results: Mean age was 59 years, and 68% were men. During long-term follow-up, 72 MACE occurred (overall crude cumulative incidence: 45% [95% confidence interval (CI): 37%-52%]). Lp(a) was associated with a higher 1-year risk of MACE, with an adjusted hazard ratio (HR) of 3.1 (95% CI: 1.1-8.6) for the highest vs the lowest tertile. This association weakened and lost significance with long-term follow-up. IL-10 showed a tendency toward an association with MACE. The 1-year HR was 2.1 (95% CI: 0.92-5.0). Long-term follow-up rendered a similar result. The association of CRP with MACE did not reach statistical significance at 1-year follow-up. However, CRP was associated with long-term risk of MACE, with an HR of 1.9 (95% CI: 1.0-3.5). Conclusions: In this prospective study, preprocedural Lp(a) level was associated with short-term prognosis after PCI. The preprocedural CRP level was associated with long-term prognosis after PCI. Clin. Cardiol. 2012 DOI: 10.1002/clc.21988 The authors have no funding, financial relationships, or conflicts of interest to disclose.
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- 2012
3. Abstract 13272: Efficacy and Safety of Non-invasive Renal Denervation Study Using Externally Delivered Focused Ultrasound in Severe Resistant Hypertension
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Roland E. Schmieder, Omar Dawood, John A. Ormiston, Zdenek Starek, Petr Neuzil, William B. White, Michael Gertner, Patrick Kay, and Thomas L. Anderson
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Denervation ,Catheter ,medicine.medical_specialty ,business.industry ,Physiology (medical) ,Ultrasound ,Non invasive ,Resistant hypertension ,medicine ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Focused ultrasound - Abstract
Background: Invasive catheter based techniques for renal denervation have been extensively examined in treating patients with resistant hypertension, with mixed results and some periprocedural complications. New evidence suggested that not all renal nerves are in the range of invasive procedures limited to a distance 4 to 6 mm from the lumen. Aims: To evaluate the safety and efficacy of an entirely non-invasive approach to renal denervation using externally delivered focused ultrasound to the peri-renal artery tissue with real time Doppler-based image guidance. Methods and results: Twenty-seven patients with severe, treatment resistant hypertension, defined as persistent systolic blood pressure (BP) > 160 mmHg despite 3 or more antihypertensive medications, were treated non-invasively with the Kona Medical Surround Sound System™. Focused ultrasound energy was delivered to the renal arteries bilaterally and surrounding tissue using Doppler-based imaging and continuous tracking with automatic correction for kidney motion throughout treatment. Patients received conscious sedation during the treatment period. At this time, all patients have completed 24 weeks and 23 patients 52 weeks of follow up. Post-denervation, the mean changes from baseline BP (175/92 mmHg) were -16.8/-8.6 mmHg at 3 weeks, -23.2/-10.8 mmHg at 6 weeks, -29.7/-13.1 mmHg at 12 weeks, -21.6/-8.7 mmHg at 24 weeks and -25.6/-10.1 mmHg at 52 weeks . No serious device-related events have been reported to date. Forty-one percent of subjects (11/27) reported mild back pain immediately following the denervation treatment. The majority of cases (7/11) completely resolved within three days post treatment without any significant intervention and no case was associated with any motor, sensory deficits. Conclusions: This is the first study in humans using a non-invasive renal denervation system in severe resistant hypertension. Results showed clinically meaningful reductions from baseline in office BP through 52 weeks post-denervation. The procedure was well-tolerated with no serious adverse events. This technology should enable patients to benefit from renal denervation therapy without the invasive risks associated with catheter based techniques.
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- 2015
4. Two Causes of Ventricular Tachycardia in a 26 Year-old Male
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Patrick Kay, Niels van Pelt, Ruvin Gabriel, and Janarthanan Sathananthan
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Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Cardiomegaly ,Coronary Angiography ,Ventricular tachycardia ,Sudden cardiac death ,Cardiac magnetic resonance imaging ,Internal medicine ,medicine.artery ,medicine ,Humans ,cardiovascular diseases ,Coronary sinus ,medicine.diagnostic_test ,business.industry ,Hypertrophic cardiomyopathy ,Implantable cardioverter-defibrillator ,medicine.disease ,Echocardiography ,Right coronary artery ,Tachycardia, Ventricular ,cardiovascular system ,Cardiology ,Radiology ,Transthoracic echocardiogram ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business - Abstract
We present the case of a 26 year-old man who presented to hospital with monomorphic ventricular tachycardia (VT) at a rate of 170bpm after exercising on a treadmill. Multimodality imaging with transthoracic echocardiogram (TTE), cardiac magnetic resonance imaging (CMRI) and computed tomography coronary angiogram (CTCA) demonstrated two causes for ventricular tachycardia; hypertrophic cardiomyopathy (HCM) and an anomalous right coronary artery (RCA) arising from the left coronary sinus, with a potentially malignant interarterial course. Both conditions can be associated with sudden cardiac death (SCD). We discuss the management dilemmas in this unique patient.
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- 2014
5. Long-Term Outcome of Patients from the Auckland Region with Spontaneous Coronary Artery Dissection
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Peter Ruygrok, Jim Stewart, Ali Khan, Tim Glenie, Frederic Devroey, Patrick Kay, John A. Ormiston, Timothy J. N. Watson, Guy Armstrong, Douglas Scott, Mark Webster, Wil Harrison, Jithendra B. Somaratne, Ammar Alsamarrai, and Seif El Jack
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Artery dissection ,Outcome (game theory) ,Surgery ,Term (time) - Published
- 2018
6. Feasibility, Safety, and Efficacy of a Novel Polymeric Pimecrolimus-Eluting Stent
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Peter Ruygrok, Mark Webster, Robert S. Schwartz, Patrick Gladding, I. Patrick Kay, John A. Ormiston, James T. Stewart, and Robert Hatrick
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Neointimal hyperplasia ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Stent ,medicine.disease ,Surgery ,Restenosis ,Drug-eluting stent ,Angioplasty ,Cardiovascular agent ,Intravascular ultrasound ,medicine ,Clinical endpoint ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives The aim of this study was to determine the safety and efficacy of a novel pimecrolimus-eluting stent in a porcine coronary model and in a phase I clinical trial. Background Rapamycin- and paclitaxel-eluting stents reduce the need for repeat intervention by limiting neointimal hyperplasia but might cause delayed healing, pre-disposing patients to late stent thrombosis. Because inflammation plays a key role in restenosis, pimecrolimus, an anti-inflammatory drug, might reduce restenosis without adversely affecting re-endothelialization. Methods We evaluated a novel polymeric pimecrolimus-eluting stent covered with a thin parylene C diffusion barrier in a porcine coronary model and in a phase I human clinical trial. The clinical study was a prospective, nonrandomized, first-in-human hypothesis-generating study that enrolled 15 patients who had a single de novo native coronary stenosis. Results At 28 days and 3 months in the porcine model, histopathologic indicators predicted safety and biocompatibility when stents coated with polymer only, drug only, and 2 drug-polymer formulations were compared with bare-metal stents (BMS). In the phase I clinical trial, 15 patients had successful implantation of pimecrolimus-eluting stents. By 6 months, no patient suffered death, myocardial infarction, or stent thrombosis. However, the angiographic restenosis (61%), mean late loss (1.44 mm), and repeat target lesion revascularization (53%) were significantly higher than historical BMS controls. Whereas the primary end point was percent volume obstruction, restenosis was so severe that operators performed intravascular ultrasound examination in only 6 patients. Conclusions Pimecrolimus-eluting stents induced an exaggerated neointimal hyperplasia at 6 months in comparison with historical controls.
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- 2009
7. The Pharmacogenetics and Pharmacodynamics of Clopidogrel Response
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Mark Webster, Irene Zeng, Patrick Gladding, Seif El-Jack, Marja-Liisa Dahl, James T. Stewart, Peter Ruygrok, Guy Armstrong, Helen Farrell, Douglas Scott, John A. Ormiston, Arzu Gunes, and Patrick Kay
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medicine.medical_specialty ,Maintenance dose ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,CYP2C19 ,Clopidogrel ,Gastroenterology ,Loading dose ,P2Y12 ,Anesthesia ,Pharmacodynamics ,Internal medicine ,medicine ,business ,Cardiology and Cardiovascular Medicine ,Pharmacogenetics ,medicine.drug - Abstract
Objectives This study assessed the effect of pharmacogenetics on the antiplatelet effect of clopidogrel. Background Variability in clopidogrel response might be influenced by polymorphisms in genes coding for drug metabolism enzymes (cytochrome P450 [CYP] family), transport proteins (P-glycoprotein) and/or target proteins for the drug (adenosine diphosphate–receptor P2Y12). Methods Sixty patients undergoing elective percutaneous coronary intervention in the randomized PRINC (Plavix Response in Coronary Intervention) trial had platelet function measured using the VerifyNow P2Y12 analyzer after a 600-mg or split 1,200-mg loading dose and after a 75- or 150-mg daily maintenance dosage. Polymerase chain reaction–based genotyping evaluated polymorphisms in the CYP2C19, CYP2C9, CYP3A4, CYP3A5, ABCB1, P2Y12, and CES genes. Results CYP2C19*1*1 carriers had greater platelet inhibition 2 h after a 600-mg dose (median: 23%, range: 0% to 66%), compared with platelet inhibition in CYP2C19*2 or *4 carriers (10%, 0% to 56%, p = 0.029) and CYP2C19*17 carriers (9%, 0% to 98%, p = 0.026). CYP2C19*2 or *4 carriers had greater platelet inhibition with the higher loading dose than with the lower dose at 4 h (37%, 8% to 87% vs. 14%, 0% to 22%, p = 0.002) and responded better with the higher maintenance dose regimen (51%, 15% to 86% vs. 14%, 0% to 67%, p = 0.042). Conclusions Carriers of the CYP2C19*2 and *4 alleles showed reduced platelet inhibition after a clopidogrel 600-mg loading dose but responded to higher loading and maintenance dose regimens. Genotyping for the relevant gene polymorphisms may help to individualize and optimize clopidogrel treatment. (Australia New Zealand Clinical Trials Registry; ACTRN12606000129583)
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- 2008
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8. Four-Year Clinical Follow-Up After Implantation of the Endeavor Zotarolimus-Eluting Stent: ENDEAVOR I, the First-in-Human Study
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Ian T. Meredith, John A. Ormiston, I. Patrick Kay, Donald E. Cutlip, Peter J. Fitzgerald, Robert Whitbourn, David W.M. Muller, and Jeffrey J. Popma
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Male ,Target lesion ,medicine.medical_specialty ,medicine.medical_treatment ,Coronary Disease ,Angioplasty ,medicine ,Humans ,Zotarolimus ,Myocardial infarction ,Angioplasty, Balloon, Coronary ,Coronary Artery Bypass ,Sirolimus ,business.industry ,Stent ,Drug-Eluting Stents ,Middle Aged ,medicine.disease ,Anti-Bacterial Agents ,Cardiac surgery ,Surgery ,Treatment Outcome ,Drug-eluting stent ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Mace ,Follow-Up Studies ,medicine.drug - Abstract
The Endeavor zotarolimus-eluting stent (ZES; Medtronic Vascular, Santa Rosa, CA) has been found to provide event-free clinical outcomes to 2 years for the treatment of symptomatic CAD by suppressing neointimal proliferation of the target lesion. The clinical outcomes of patients treated with the Endeavor ZES were evaluated at 4 years after implantation. One hundred consecutive patients with symptomatic ischemic heart disease due to de novo stenotic lesions of native coronary arteries were treated with the Endeavor ZES at 8 centers according to a standardized procedure. At 4 years, 3 patients were lost to follow-up analysis. The incidence of major adverse cardiac events (MACE; defined as death, myocardial infarction, emergent cardiac surgery, or repeat revascularization of the target lesion) was 2% at 4 months, 2% at 1 year, 3% at 2 years, 6.1% at 3 years, and 7.2% at 4 years. The difference in these rates was due to 4 deaths caused by cancer (metastatic melanoma, metastatic adenocarcinoma, small-cell cancer of the bladder, and lung carcinoma). From 2-4 years, there was an additional reported case of target lesion revascularization (TLR). A single case of stent thrombosis occurred at 10 days after the index procedure but no cases occurred thereafter. The treatment of patients with symptomatic CAD due to de novo lesions in native coronary arteries with the Endeavor ZES has sustained clinical benefits to 4 years, with very low rates of MACE and TLR.
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- 2007
9. TCT-87 Non-invasive Renal Denervation Study Using Externally Delivered Focused Ultrasound in Severe Resistant Hypertension: 1 Year Follow up Results
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Petr Neuzil, Zdenek Starek, Michael Gertner, Roland E. Schmieder, John A. Ormiston, Omar Dawood, Thomas Anderson, Patrick Kay, and William B. White
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Denervation ,medicine.medical_specialty ,business.industry ,Non invasive ,Resistant hypertension ,1 year follow up ,urologic and male genital diseases ,Focused ultrasound ,Surgery ,medicine.artery ,Medicine ,Renal artery ,business ,Image guidance ,Cardiology and Cardiovascular Medicine - Abstract
The Kona Medical Surround Sound™ System is a non-invasive device for renal denervation that delivers externally focused ultrasound to the renal nerves using Doppler-based image guidance to track and correct for renal artery motion during the procedure. Aims: To evaluate the safety and efficacy of
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- 2015
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10. Clinical outcome of older patients with acute coronary syndrome over the last three decades
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Eng Wei Tang, Micheal J. A. Williams, Norma J. Restieaux, Peter Herbison, Cheuk-Kit Wong, Patrick Kay, and Gerard T. Wilkins
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Adult ,Male ,Aging ,medicine.medical_specialty ,Acute coronary syndrome ,Time Factors ,Coronary Disease ,Older patients ,Risk Factors ,Internal medicine ,Odds Ratio ,Humans ,Medicine ,Myocardial infarction ,Aged ,Aged, 80 and over ,Heart Failure ,business.industry ,Mortality rate ,Medical record ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Treatment Outcome ,Physical therapy ,Coronary care unit ,Female ,Geriatrics and Gerontology ,business - Abstract
OBJECTIVE To Evaluate the clinical outcome of patients with acute coronary syndrome (ACS) in the Coronary Care Unit (CCU) over three decades in Dunedin, New Zealand. DESIGN Registry study. SETTING AND PATIENTS all consecutive patients (n = 3,013) with ACS admitted to the CCU from 1979 to 1981 (n = 966) and from 1989 to 1991 (n = 1470) were included prospectively. Data on ACS patients managed in the CCU in 2001-2002 (n = 577) were obtained via medical chart review. RESULTS There was a rising proportion of older (> or = 75 years of age) patients with ACS (3.8% in 1979-1981, 15.2% in 1989-1991 and 25.6% in 2001-2002, P < 0.0005). However, we observed a progressive reduction of in-hospital mortality for ACS (10.7, 7.3 and 5.0%, P < 0.005) and for ST-elevation myocardial infarction (STEMI) (18.4, 16.1 and 6.6%, P < 0.005). The progressive fall in mortality rate was also observed amongst older patients, both for ACS (27, 19.2 and 11.5%, P = 0.011) and for STEMI (34.8, 30.9 and 15.4%, P < 0.005). Of concern, only 10% of patients presented within 1 h of symptom onset and 50% within 5 h, and this has not changed over three decades. The variables associated with < 5 h from symptom onset to presentation were men [odds ratio (OR) 1.25, 95% confidence interval (CI) 1.10-1.42, P = 0.001], a history of ischaemic heart disease (OR 1.25, 95% CI 1.09-1.43, P = 0.002) and STEMI (OR 1.41, 95% CI 1.18-1.67, P < 0.0001). Advanced age was not a predictor for late presentation. CONCLUSIONS Over the past three decades, more old patients were treated in the CCU. However, there was a decline in hospital mortality, particularly for STEMI. Further efforts are required to decrease the time to presentation.
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- 2006
11. Coronary flow velocity reserve after percutaneous interventions is predictive of periprocedural outcome
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G. Van Langenhove, Patrick Kay, M A Costa, Jan J. Piek, Mariano Albertal, Jorge Belardi, Michiel Voskuil, B. De Bruyne, T. Beijsterveldt, Eric Boersma, José Eduardo Moraes Rego Sousa, P. W. Serruys, and Cardiology
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Male ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Coronary Angiography ,Balloon ,Disease-Free Survival ,Coronary circulation ,Coronary Circulation ,Physiology (medical) ,Angioplasty ,Internal medicine ,medicine ,Humans ,Angioplasty, Balloon, Coronary ,medicine.diagnostic_test ,business.industry ,Microcirculation ,Myocardium ,Blood flow ,Middle Aged ,Echocardiography, Doppler ,Confidence interval ,Treatment Outcome ,medicine.anatomical_structure ,Multivariate Analysis ,Angiography ,Cardiology ,Female ,Stents ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Blood Flow Velocity ,Follow-Up Studies ,Forecasting ,Artery - Abstract
Background — Because heterogeneous results have been reported, we assessed coronary flow velocity changes in individuals who underwent percutaneous transluminal coronary angioplasty (PTCA) and examined their impact on clinical outcome. Methods and Results — As part of the Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) II study, 379 patients underwent Doppler flow–guided angioplasty. All patients were evaluated according to their coronary flow velocity reserve (CFVR) results (≥2.5 or P P P =0.034) and at 1 year (OR, 2.06; 95% CI, 1.16 to 3.66; P =0.014). After excluding MACE at 30 days, no difference in MACE at 1 year was observed between the patients with and without a CFVR Conclusions — A low postprocedural CFVR was associated with a worse periprocedural outcome (which was related to microcirculatory disturbances), but there was no significant difference at late follow-up.
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- 2002
12. A review of a regional primary percutaneous coronary intervention service, with a focus on door to reperfusion times: the 2012 Auckland/Northland experience
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Greg D. Gamble, Seif El-Jack, Mark Webster, G. Armstrong, Wil Harrison, John A. Ormiston, A. Lin, Chris Ellis, Alastair McGeorge, D. Scott, Peter Ruygrok, T. Oh, Mohammed Alawami, Ali Khan, James T. Stewart, Patrick Kay, and Andrew Kerr
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Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,Acute coronary syndrome ,Databases, Factual ,medicine.medical_treatment ,Coronary artery disease ,Percutaneous Coronary Intervention ,medicine ,ST segment ,Humans ,Myocardial infarction ,Hospital Mortality ,Aged ,Retrospective Studies ,business.industry ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,Optimal management ,Catheter ,Emergency medicine ,Conventional PCI ,Female ,Medical emergency ,Cardiology and Cardiovascular Medicine ,business ,New Zealand - Abstract
Aims Primary percutaneous coronary intervention (PCI) is the optimal management for ST segment elevation myocardial infarction (STEMI) patients. We reviewed the largest primary PCI regional service in New Zealand: the Auckland/Northland service based at Auckland City Hospital, to assess patient management, in particular the door to reperfusion times (DTRTs), and predictors of death in hospital. Methods We obtained patient details from a comprehensive prospective database of all primary PCI patients admitted with STEMI from 1/1/12 to 31/12/12 to the Auckland City Hospital cardiac catheterisation laboratory. Of four District Health Boards (DHBs) within the region, two accessed this regional service at all times, and two accessed the Auckland City Hospital cardiac catheterisation laboratory ‘after hours’: all times except for 08:00 to 16:00 hours on Monday to Friday. Results A total of 401 adult patients underwent a primary PCI at the Auckland City Hospital Regional centre for a STEMI presentation, over the 12 months period. The median patient age was 61 years, 77% were male. Overall 183 (46%) (95% CI 41, 51) patients achieved a DTRT of 90 mins, and 266 (66%) (95% CI 61, 71) a DTRT of 120mins, with a clear geographical influence to these times. Of 27 patients with direct transfer to the catheter laboratory from the community, the DTRT was 120 mins in 24 (92%) (95% CI 72, 96) patients. In-hospital mortality was 24 (6%) patients (95% CI 4, 9). Conclusions The 2012 Auckland/Northland primary PCI service delivers good outcomes consistent with current Australasian standards. Although geographical isolation complicates door to reperfusion times, these may potentially be improved by more focus on direct transfer to the cardiac catheterisation laboratory, especially directly from the community.
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- 2014
13. Radioactive Stents Delay but Do Not Prevent In-Stent Neointimal Hyperplasia
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A. H. Marco Knook, Alexander J Wardeh, George Sianos, Patrick W. Serruys, Ken Kozuma, I. Patrick Kay, Peter C. Levendag, Willem J. van der Giessen, Attila Thury, and David P. Foley
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Brachytherapy ,Coronary Disease ,Coronary Angiography ,Radiation Dosage ,Endosonography ,Restenosis ,Physiology (medical) ,Intravascular ultrasound ,medicine ,Humans ,Treatment Failure ,cardiovascular diseases ,Myocardial infarction ,Aged ,Neointimal hyperplasia ,medicine.diagnostic_test ,business.industry ,Graft Occlusion, Vascular ,Stent ,Middle Aged ,Hyperplasia ,equipment and supplies ,medicine.disease ,Stenosis ,Treatment Outcome ,Angiography ,Female ,Stents ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Phosphorus Radioisotopes ,Follow-Up Studies - Abstract
Background —Restenosis after conventional stenting is almost exclusively caused by neointimal hyperplasia. β-Particle–emitting radioactive stents decrease in-stent neointimal hyperplasia at 6-month follow-up. The purpose of this study was to evaluate the 1-year outcome of 32 P radioactive stents with an initial activity of 6 to 12 μCi using serial quantitative coronary angiography and volumetric ECG-gated 3D intravascular ultrasound (IVUS). Methods and Results —Of 40 patients undergoing initial stent implantation, 26 were event-free after the 6-month follow-up period and 22 underwent repeat catheterization and IVUS at 1 year; they comprised half of the study population. Significant luminal deterioration was observed within the stents between 6 months and 1 year, as evidenced by a decrease in the angiographic minimum lumen diameter (−0.43±0.56 mm; P =0.028) and in the mean lumen diameter in the stent (−0.55±0.63 mm; P =0.001); a significant increase in in-stent neointimal hyperplasia by IVUS (18.16±12.59 mm 3 at 6 months to 27.75±11.99 mm 3 at 1 year; P =0.001) was also observed. Target vessel revascularization was performed in 5 patients (23%). No patient experienced late occlusion, myocardial infarction, or death. By 1 year, 21 of the initial 40 patients (65%) remained event-free. Conclusions —Neointimal proliferation is delayed rather than prevented by radioactive stent implantation. Clinical outcome 1 year after the implantation of stents with an initial activity of 6 to 12 μCi is not favorable when compared with conventional stenting.
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- 2001
14. Evaluation of left ventricular volumes and ejection fraction with a nonfluoroscopic endoventricular three-dimensional mapping technique
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Glenn Van Langenhove, Mariano Albertal, Emile Onderwater, Jaap N. Hamburger, I. Patrick Kay, Peter Smits, Patrick W. Serruys, and Cardiology
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Male ,Cardiac Catheterization ,medicine.medical_specialty ,Cardiac Volume ,Heart Ventricles ,Hemodynamics ,Ventricule gauche ,Internal medicine ,Humans ,Ventricular Function ,Medicine ,Observer Variation ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Body Surface Potential Mapping ,Angiography ,Stroke Volume ,Left ventriculogram ,Stroke volume ,Middle Aged ,medicine.anatomical_structure ,Ventricle ,Cardiology ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,business ,Algorithms - Abstract
Background Recently, a novel nonfluoroscopic 3-dimensional electromechanical mapping technique was introduced in the clinical arena. Although initial in vitro and in vivo studies suggested the reliability of the system in volumetric and hemodynamic evaluation of the left ventricle, no validation in human beings has been performed. Methods A nonfluoroscopic electromechanical mapping (NOGA, Biosense-Webster) procedure was performed in 44 patients. All patients received a contrast left ventriculogram during the same session. Volumetric (end-diastolic [EDV] and end-systolic volumes [ESV]) and hemodynamic (left ventricular ejection fraction [LVEF] and stroke volume) parameters of both systems were compared. Results Two uncomplicated pericardial effusions occurred with the first-generation mapping catheters. No procedural complications were noted with the new-generation mapping catheters. Significant correlations were found between mapping-derived and ventriculography-based measurements for both ESV (r = 0.67, P < .001) and LVEF (r = 0.78, P < .001). Absolute volumes, however, were only comparable for ESV (46.6 ± 25.3 mL vs 48.8 ± 37.0 mL, respectively; P = .13) but differed greatly for LVEF (35% ± 13% vs 65% ± 19%, respectively; P < .001), EDV (69.1 ± 28.6 mL vs 125.9 ± 53.4 mL, respectively; P < .001) and stroke volume (22.4 ± 9.9 mL vs 77.1 ± 33.7 respirations; P < .001). Moreover, Bland-Altman analysis showed the clinical noninterchangeability between these techniques for the measurement of hemodynamic parameters. Conclusion Measurement of hemodynamic parameters with nonfluoroscopic mapping of the left ventricle is feasible and safe. The system provides data that strongly correlate but that are in clinical disagreement with angiographic data. Therefore the interchangeability of these techniques may be questioned. (Am Heart J 2000;140:596-602.)
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- 2000
15. I Like the Candy, I Hate the Wrapper
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I. Patrick Kay and Patrick W. Serruys
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Neointimal hyperplasia ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Late Lumen Loss ,Stent ,equipment and supplies ,medicine.disease ,Balloon ,Surgery ,Restenosis ,Physiology (medical) ,Angioplasty ,Medicine ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Animal species ,Efficacy Study - Abstract
United States patent 5059166, issued October 22, 1991, to Robert and Tim Fischell, described an “intraarterial stent with the capability to inhibit intimal hyperplasia.”1 The proponents of this patent went on to say in their proposal: “Since radiation from a radioisotope source is capable of selectively inhibiting the growth of hyperproliferating cells as compared with normal cells, a radioisotope material which forms part of the stent can be used to decrease the rate of arterial reclosure. The radioisotope could be placed inside the stent, alloyed into the metal from which the stent is made, or preferably, it can be coated onto the stent’s exterior surface.” So began the story of the radioactive stent. Eight years and several animal species later, we are becoming aware of the bright and dark sides of this treatment modality in the human model. The safety and efficacy study by Albiero and colleagues2 describes the dose-related decrease noted at 6-month follow-up of intrastent neointimal hyperplasia after implantation of 32P radioactive stents at activities of 0.75 to 12 μCi. Whereas in-stent restenosis was all but obliterated at higher doses of radiation, intralesion restenosis was high because of late lumen loss at the stent edges. Aptly, the authors coined the term “candy wrapper” to describe this new restenotic pattern. It is possible that the animal workers who implanted the first radioactive stents observed this phenomenon. Unfortunately, the significance of this finding may not have been immediately apparent. The study by Albiero and colleagues reflects the courage of the investigators who, despite indifferent and at times contradictory results from animal work, persisted in their endeavor to discover whether radioactive stent implantation would be effective in humans. Previously, Hehrlein et al,3 4 using the rabbit iliac model, polyisotopic 55Co (elements 55Co, 56Co, 57 …
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- 2000
16. Methodological and clinical implications of the relocation of the minimal luminal diameter after intracoronary radiation therapy
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Ken Kozuma, I. Patrick Kay, William Wijns, Marco A. Costa, Connie J van der Wiel, Manel Sabaté, Patrick W. Serruys, Vitali E. Verin, and Cardiology
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medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,medicine.medical_treatment ,Brachytherapy ,Balloon ,medicine.disease ,Clinical trial ,Restenosis ,Angioplasty ,medicine ,Population study ,Radiology ,Cardiology and Cardiovascular Medicine ,Complication ,business - Abstract
OBJECTIVESThe aims of the study were to determine the incidence of relocation of the minimal luminal diameter (MLD) after beta-radiation therapy following balloon angioplasty (BA) and to describe a new methodological approach to define the effect of brachytherapy on treated coronary stenoses.BACKGROUNDLuminal diameter of coronary lesions may increase over time following angioplasty and irradiatation. As a result, the MLD at follow-up may be relocated from its location preintervention, which may induce misleading results when a restricted definition of the target segment by quantitative coronary angiography (QCA) is performed.METHODSPatients treated with BA followed by intracoronary brachytherapy according to the Dose-Finding Study constituted the study population. A historical cohort of patients treated with BA was used as control group. To be included in the analysis, an accurate angiographic documentation of all instrumentations during the procedure was mandatory. In the irradiated patients, four regions were defined by QCA: vessel segment (VS), target segment (TS), injured segment (INS), and irradiated segment (IRS).RESULTSSixty-five patients from the Dose-Finding Study and 179 control patients were included. At follow-up, MLD was relocated more often in the radiation group (78.5% vs. 26.3%; p < 0.0001). The rate of >50% diameter stenosis differed among the four predefined regions: 3.1% in the TS; 7.7% in the INS; 9.2% in the IRS and 13.8% in the VS.CONCLUSIONSRelocation of the MLD is commonly demonstrated after BA and brachytherapy, and it should be taken into account during the analysis of the results of radiation clinical trials.
- Published
- 2000
17. The role of intravascular ultrasound imaging in vascular brachytherapy
- Author
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Stéphane G, Carlier, Véronique LMA, Coen, Manel, Sabaté, I Patrick, Kay, Jurgen MR, Ligthart, Willem J, Van Der Giessen, Peter C, Levendag, K, Bom, and Patrick W, Serruys
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Brachytherapy ,Lumen (anatomy) ,medicine.disease ,Clinical trial ,Coronary arteries ,Vascular brachytherapy ,medicine.anatomical_structure ,Restenosis ,Intravascular ultrasound ,Angiography ,cardiovascular system ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Intracoronary brachytherapy has recently emerged as a new therapy to prevent restenosis. Initial experimental work was achieved in animal models and the results were assessed by histomorphometry. Initial clinical trials used angiography to guide dosimetry and to assess efficacy. Intravascular ultrasound (IVUS) permits tomographic examination of the vessel wall, elucidating the true morphology of the lumen and transmural components, which cannot be investigated on the lumenogram obtained by angiography. This paper reviews the use of IVUS in the clinical studies of brachytherapy conducted to date. IVUS allows clinicians to make a thorough assessment of the remodeling of the vessel and appears to have a major role to play in facilitating understanding of the underlying mechanisms of action in this emerging field. The authors propose that state-of-the-art IVUS techniques should be employed to further knowledge of the mechanisms of action of brachytherapy in atherosclerotic human coronary arteries.
- Published
- 2000
18. Application of β-irradiation through the struts of a previously deployed stent
- Author
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Georgios Sianos, Patrick W. Serruys, Alexander J Wardeh, I. Patrick Kay, Peter C. Levendag, Jurgen Mr Lighart, V.L.M.A. Coen, and Stephane Carlier
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Stent ,Target vessel ,equipment and supplies ,medicine.disease ,Coronary arteries ,Catheter ,surgical procedures, operative ,medicine.anatomical_structure ,Restenosis ,medicine ,Radiology, Nuclear Medicine and imaging ,Beta irradiation ,cardiovascular diseases ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
The application of g -radiation in coronary arteries is a promising new technique for the treatment of in-stent restenosis. This is the first case in which the 5 F. delivery catheter of the Beta-Cath™ system was advanced through the struts of a stent, previously deployed in an adjacent branch, so as to deliver radiation to the target vessel. (Int J Cardiovasc Intervent 2000; 3: 121-125)
- Published
- 2000
19. Preserved Endothelium-Dependent Vasodilation in Coronary Segments Previously Treated With Balloon Angioplasty and Intracoronary Irradiation
- Author
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V.L.M.A. Coen, Patrick W. Serruys, Alexander J Wardeh, Willem J. van der Giessen, I. Patrick Kay, Stephane Carlier, Joan Antoni Gómez-Hospital, Angel Cequier, Manel Sabaté, Peter C. Levendag, Johannes P. A. Marijnissen, and Jurgen Ligthart
- Subjects
Male ,Cardiac Catheterization ,medicine.medical_specialty ,Endothelium ,medicine.medical_treatment ,Brachytherapy ,Coronary Disease ,Vasomotion ,Coronary Angiography ,Nitric Oxide ,Balloon ,Restenosis ,Physiology (medical) ,Angioplasty ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Angioplasty, Balloon, Coronary ,Endothelial dysfunction ,Aged ,business.industry ,Radiotherapy Dosage ,Middle Aged ,medicine.disease ,Coronary Vessels ,Acetylcholine ,Beta Particles ,Vasodilation ,Vasomotor System ,medicine.anatomical_structure ,Heart catheterization ,Cardiology ,Feasibility Studies ,Female ,Radiotherapy, Adjuvant ,Endothelium, Vascular ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Vasoconstriction ,Follow-Up Studies - Abstract
Background —Abnormal endothelium-dependent coronary vasomotion has been reported after balloon angioplasty (BA), as well as after intracoronary radiation. However, the long-term effect on coronary vasomotion is not known. The aim of this study was to evaluate the long-term vasomotion of coronary segments treated with BA and brachytherapy. Methods and Results —Patients with single de novo lesions treated either with BA followed by intracoronary β-irradiation (according to the Beta Energy Restenosis Trial-1.5) or with BA alone were eligible. Of these groups, those patients in stable condition who returned for 6-month angiographic follow-up formed the study population (n=19, irradiated group and n=11, control group). Endothelium-dependent coronary vasomotion was assessed by selective infusion of serial doses of acetylcholine (ACh) proximally to the treated area. Mean luminal diameter was calculated by quantitative coronary angiography both in the treated area and in distal segments. Endothelial dysfunction was defined as a vasoconstriction after the maximal dose of ACh (10 −6 mol/L). Seventeen irradiated segments (89.5%) demonstrated normal endothelial function. In contrast, 10 distal nonirradiated segments (53%) and 5 control segments (45%) demonstrated endothelium-dependent vasoconstriction (−19±17% and −9.0±5%, respectively). Mean percentage of change in mean luminal diameter after ACh was significantly higher in irradiated segments ( P =0.01). Conclusions —Endothelium-dependent vasomotion of coronary segments treated with BA followed by β-radiation is restored in the majority of stable patients at 6-month follow-up. This functional response appeared to be better than those documented both in the distal segments and in segments treated with BA alone.
- Published
- 1999
20. Quantitative measurements of in-stent restenosis: A comparison between quantitative coronary ultrasound and quantitative coronary angiography
- Author
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I. Patrick Kay, Clemens Disco, Micheal J.B. Kutryk, Jurgen Ligthart, Jos R.T.C. Roelandt, Manel Sabaté, Pim J. de Feyter, Nico Bruining, and Patrick W. Serruys
- Subjects
Coronary angiography ,medicine.medical_specialty ,medicine.diagnostic_test ,Luminal diameter ,business.industry ,medicine.medical_treatment ,Ultrasound ,Stent ,General Medicine ,medicine.disease ,Coronary artery disease ,Internal medicine ,Intravascular ultrasound ,medicine ,Cardiology ,Stent implantation ,Radiology, Nuclear Medicine and imaging ,In stent restenosis ,Cardiology and Cardiovascular Medicine ,business - Abstract
While quantitative coronary angiography (QCA) remains the standard used to assess new interventional therapies, intracoronary ultrasound (ICUS) is gaining interest. The aim of the study was to determine the relationship between QCA and quantitative coronary ultrasound (QCU) measurements after stenting. Sixty-two consecutive patients with both QCA and QCU analysis after stent implantation were included in the study. The mean luminal diameter (QCU vs. QCA) were 2.74 +/- 0.46 mm and 2.41 +/- 0.49 mm (P < 0.0001), the minimal luminal diameter (MLD) 2.08 +/- 0.44 mm and 1.62 +/- 0.42 mm (P < 0. 0001), and the projected QCU MLD 1.90 +/- 0.42 mm (P < 0.0001 with respect to QCA). Percentage obstruction diameter (QCU vs. QCA) were 41.53% +/- 10.78% and 43.15% +/- 12.72% (P = NS). The stent diameter (QCU vs. QCA) were 3.54 +/- 0.65 mm and 3.80 +/- 0.37 mm (P = 0. 0004). Stent length measured by QCU were longer at 31.11 +/- 13.54 mm against 28.63 +/- 12.75 mm, P < 0.0001 with respect to QCA. In conclusion, while QCA and QCU appear to be comparable tools for measuring corrected stent diameters and stent lengths, smaller luminal diameters were found using QCA. This is of particular relevance to quantitative studies addressing absolute changes in vascular or luminal diameters. Cathet. Cardiovasc. Intervent. 48:133-142, 1999.
- Published
- 1999
21. Periprocedural quantitative coronary angiography after Palmaz-Schatz stent implantation predicts the restenosis rate at six months
- Author
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I. Patrick Kay, Pim J. de Feyter, Patrick W. Serruys, Clemens Disco, Niteen V Deshpande, and Music Study Groups
- Subjects
Univariate analysis ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Stent ,medicine.disease ,Balloon ,Coronary arteries ,Stenosis ,medicine.anatomical_structure ,Restenosis ,Angioplasty ,Coronary stent ,medicine ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES We aimed to identify periprocedural quantitative coronary angiographic (QCA) variables that have predictive value on long-term angiographic results and to construct multivariate models using these variables for postprocedural prognosis. BACKGROUND Coronary stent implantation has reduced the restenosis rate significantly as compared with balloon angioplasty in short de novo lesions in coronary arteries >3 mm in size. Although the postprocedural minimal luminal diameter (MLD) is known to have significant bearing on long-term angiographic results, no practically useful model exists for prediction of angiographic outcome based on the periprocedural QCA variables. METHODS The QCA data from patients who underwent Palmaz-Schatz stent implantation for short ( 3 mm and completed six months of angiographic follow-up in the four prospective clinical trials (BENESTENT I, BENESTENT II pilot, BENESTENT II and MUSIC) were pooled. Multiple models were constructed using multivariate analysis. The Hosmer-Lemeshow goodness-of-fit test was used to identify the model of best fit, and this model was used to construct a reference chart for prediction of angiographic outcome on the basis of periprocedural QCA variables. RESULTS Univariate analysis performed using QCA variables revealed that vessel size, MLD before and after the procedure, reference area before and after the procedure, minimal luminal cross-sectional area before and after the procedure, diameter stenosis after the procedure, area of plaque after the procedure and area stenosis after the procedure were significant predictors of angiographic outcome. Using multivariate analysis, the Hosmer-Lemeshow goodness-of-fit test showed that the model containing percent diameter stenosis after the procedure and vessel size best fit the data. A reference chart was then developed to calculate the expected restenosis rate. CONCLUSIONS Restenosis rate after stent implantation for short lesions can be predicted using the variables percent diameter stenosis after the procedure and vessel size. This meta-analysis indicates that the concept of “the bigger the better” holds true for coronary stent implantation. Applicability of the model beyond short lesions should be tested.
- Published
- 1999
22. Late Coronary Occlusion After Intracoronary Brachytherapy
- Author
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Peter C. Levendag, P. Serrano, Pavel Cervinka, Marco A. Costa, Patrick W. Serruys, Manel Sabaté, Wim J. van der Giessen, V.L.M.A. Coen, I. Patrick Kay, and Jurgen Ligthart
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Interventional cardiology ,business.industry ,medicine.medical_treatment ,Stent ,Balloon ,medicine.disease ,Thrombosis ,Restenosis ,Coronary occlusion ,Physiology (medical) ,Internal medicine ,Angioplasty ,Angiography ,medicine ,Cardiology ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background —Intracoronary brachytherapy appears to be a promising technology to prevent restenosis. Presently, limited data are available regarding the late safety of this therapeutic modality. The aim of the study was to determine the incidence of late (>1 month) thrombosis after PTCA and radiotherapy. Methods and Results —From April 1997 to March 1999, we successfully treated 108 patients with PTCA followed by intracoronary β-radiation. Ninety-one patients have completed at least 2 months of clinical follow-up. Of these patients, 6.6% (6 patients) presented with sudden thrombotic events confirmed by angiography 2 to 15 months after intervention (2 balloon angioplasty and 4 stent). Some factors (overlapping stents, unhealed dissection) may have triggered the thrombosis process, but the timing of the event is extremely unusual. Therefore, the effect of radiation on delaying the healing process and maintaining a thrombogenic coronary surface is proposed as the most plausible mechanism to explain such late events. Conclusions —Late and sudden thrombosis after PTCA followed by intracoronary radiotherapy is a new phenomenon in interventional cardiology.
- Published
- 1999
23. Remodeling of atherosclerotic coronary arteries varies in relation to location and composition of plaque
- Author
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Niteen V Deshpande, Pim J. de Feyter, Patrick W. Serruys, Ron T. van Domburg, Alexander J Wardeh, Eric Boersma, Manel Sabaté, I. Patrick Kay, A. L. Gijzel, Jurgen Ligthart, and Cardiology
- Subjects
Male ,Target lesion ,medicine.medical_specialty ,Lumen (anatomy) ,Coronary Artery Disease ,Group A ,Internal medicine ,Intravascular ultrasound ,medicine ,Humans ,Ultrasonography, Interventional ,Analysis of Variance ,medicine.diagnostic_test ,Vascular disease ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,Coronary Vessels ,Confidence interval ,Coronary arteries ,medicine.anatomical_structure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
The aim of this study was to determine the contribution of morphologic characteristics and location of plaque in remodeling of atherosclerotic coronary arteries. Consecutive intravascular ultrasound studies performed in native coronary arteries before an intervention were included in the study. Total vessel, lumen and plaque + media areas were measured at target lesion, and distal and proximal references. Remodeling index was calculated as target total vessel area/proximal reference total vessel area, and categorized into 3 groups based on relative total vessel-area ratio: (1) >1.1 (group A, adequate remodeling); (2) 0.9 to 1.1 (group B, failure of compensatory enlargement); and (3)
- Published
- 1999
24. PREDICTORS OF BLOOD PRESSURE RESPONSE IN THE NON-INVASIVE RENAL DENERVATION STUDY USING EXTERNALLY DELIVERED FOCUSED ULTRASOUND IN SEVERE RESISTANT HYPERTENSION
- Author
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Petr Neuzil, Michael Gertner, John A. Ormiston, Roland E. Schmieder, Patrick Kay, Omar Dawood, Thomas Anderson, and Zdenek Starek
- Subjects
Denervation ,medicine.medical_specialty ,Blood pressure ,business.industry ,Internal medicine ,Non invasive ,Resistant hypertension ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Focused ultrasound ,Surgery - Published
- 2016
25. Characteristics, outcomes, and complications during the first year of coronary rotational atherectomy at Middlemore Hospital
- Author
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S. Graham, A. Escondo, Patrick Kay, R. McIntosh, C. Flynn, and Wil Harrison
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Medicine ,Rotational atherectomy ,Cardiology and Cardiovascular Medicine ,business ,Surgery - Published
- 2014
26. Five-year clinical follow-up after implantation of the Endeavor zotarolimus-eluting stent: ENDEAVOR I, first-in-human study
- Author
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I. Patrick Kay, Donald E. Cutlip, Ian T Meredith, Robert Whitbourn, David W.M. Muller, and John A. Ormiston
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Myocardial Infarction ,Coronary Angiography ,Prosthesis Design ,Severity of Illness Index ,Coronary artery disease ,Angioplasty ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Zotarolimus ,cardiovascular diseases ,Myocardial infarction ,Prospective Studies ,Angioplasty, Balloon, Coronary ,Aged ,Sirolimus ,business.industry ,Australia ,Coronary Stenosis ,Stent ,Cardiovascular Agents ,Drug-Eluting Stents ,Thrombosis ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Stenosis ,Treatment Outcome ,Massachusetts ,Cardiovascular agent ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Mace ,medicine.drug ,New Zealand - Abstract
Objective: To evaluate the 5-year clinical outcomes of patients treated with the Endeavor zotarolimus-eluting stent (ZES) in the ENDEAVOR I first-in-human study. Background: ENDEAVOR I was a prospective, nonrandomized, multicenter study of the Endeavor ZES in 100 consecutive patients with symptomatic coronary artery disease (CAD) due to de novo, stenotic lesions in native coronary arteries. Methods: Patients with single or multivessel CAD were eligible to participate, but only one lesion per patient was treated. The lesion had to have ≥50% stenosis, be ≤15 mm in length, and located in a vessel with a reference diameter of 3.0–3.5 mm. Major adverse cardiac events (MACE), target lesion revascularization (TLR), target vessel failure (TVF), and stent thrombosis were evaluated 5 years after stent implantation. Results: The cumulative incidence of MACE was 2.0% at 1 year, 3.0% at 2 years, 6.1% at 3 years, 7.2% at 4 years, and 7.2% at 5 years. At 5 years, there were seven patients who had eight events; four noncardiac (cancer) deaths, three cases of TLR, of which one presented as a non-Q-wave MI because of a stent thrombosis at 10 days after the index procedure. There were no late or very late stent thromboses by any definition. TVF at 5 years was 5.2%. Conclusions: Use of the Endeavor ZES to treat symptomatic CAD due to de novo lesions in native coronary arteries resulted in sustained clinical benefits to 5 years, with low rates of MACE, TLR, TVF, and stent thrombosis. © 2009 Wiley-Liss, Inc.
- Published
- 2009
27. A novel paclitaxel-eluting dedicated bifurcation stent: a case report from the first human use Taxus Petal trial
- Author
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Thomas W. Johnson, I. Patrick Kay, and John A. Ormiston
- Subjects
Male ,medicine.medical_specialty ,Percutaneous ,Paclitaxel ,medicine.medical_treatment ,Lumen (anatomy) ,Coronary Artery Disease ,Coronary Angiography ,Prosthesis Design ,Severity of Illness Index ,Intravascular ultrasound ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Angioplasty, Balloon, Coronary ,Bifurcation ,Ultrasonography, Interventional ,Clinical Trials as Topic ,medicine.diagnostic_test ,business.industry ,Stent ,Percutaneous coronary intervention ,Cardiovascular Agents ,Drug-Eluting Stents ,General Medicine ,Middle Aged ,equipment and supplies ,Surgery ,Ostium ,surgical procedures, operative ,Treatment Outcome ,Angiography ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
A dedicated bifurcation stent has the potential to simplify and improve the outcomes of percutaneous coronary bifurcation intervention. We report a patient from the first human use trial of a novel paclitaxel-eluting dedicated bifurcation stent. By 6 months, there were no adverse events and the stent lumen and, in particular, the side-branch ostium were widely patent on angiography and intravascular ultrasound. This device may offer superior results without the limitations of conventional stent techniques in the treatment of coronary bifurcation disease. © 2008 Wiley-Liss, Inc.
- Published
- 2009
28. Late drug-eluting stent thrombosis and erythropoietin: cause and effect?
- Author
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Patrick Gladding, Patrick Kay, and M.W.I. Webster
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Coated Materials, Biocompatible ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Myocardial infarction ,Stent thrombosis ,Angioplasty, Balloon, Coronary ,Erythropoietin ,Sirolimus ,Dose-Response Relationship, Drug ,business.industry ,Coronary Thrombosis ,Stent ,Cardiovascular Agents ,equipment and supplies ,medicine.disease ,Thrombosis ,Surgery ,surgical procedures, operative ,Drug-eluting stent ,Cardiology ,Stents ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
A case of late thrombosis of a sirolimus-eluting stent, 16 months after implantation, is described. Two weeks prior to presentation with stent thrombosis the patient had a 50% dose increase of longterm erythropoietin. The prothrombotic effect of erythropoietin may have precipitated the thrombotic event.
- Published
- 2006
29. Initial experience with a new femoral artery closure device following percutaneous coronary intervention with glycoprotein IIb/IIIa inhibition
- Author
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Peter Ruygrok, Stephanie Simpson-Plaumann, I. Patrick Kay, Tony M. Chou, Seif El Jack, Mark Webster, James T. Stewart, and John A. Ormiston
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Pilot Projects ,Femoral artery ,Platelet Glycoprotein GPIIb-IIIa Complex ,Punctures ,Statistics, Nonparametric ,Angioplasty ,medicine.artery ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Angioplasty, Balloon, Coronary ,Aged ,Ultrasonography ,Chi-Square Distribution ,Aspirin ,Unstable angina ,business.industry ,Heparin ,Percutaneous coronary intervention ,General Medicine ,Tirofiban ,Equipment Design ,Middle Aged ,Clopidogrel ,medicine.disease ,Hemostasis, Surgical ,Surgery ,Femoral Artery ,Treatment Outcome ,Eptifibatide ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,Glycoprotein IIb/IIIa ,business ,Platelet Aggregation Inhibitors ,medicine.drug - Abstract
The aim of the study was to determine the safety and efficacy of a novel femoral artery closure device (StarClose, Abbott Vascular Devices, Redwood City, CA) following percutaneous coronary intervention employing aspirin, heparin, and glycoprotein (GP) IIb/IIIa inhibition. A prospective nonrandomized single-center pilot study of the StarClose device included a subset of patients undergoing percutaneous coronary intervention utilizing GP IIb/IIIa inhibitors. Those that fulfilled the inclusion criteria (age < 80, no periprocedural haematoma, puncture above the superficial femoral and profunda femoralis artery bifurcation, no significant femoral artery disease) underwent closure of the femoral artery puncture site with a StarClose device immediately on completion of the procedure. Time to hemostasis (TTH), bleeding, mobilization, and short-term clinical follow-up data were collected, and an ultrasound scan of the femoral artery was performed 2 weeks later. Twenty-five patients were recruited, of whom 23 underwent percutaneous coronary intervention (PCI). Their mean age was 58 ± 12 years, 84% were male, and 63% had unstable angina. All were on aspirin 100–150 mg daily and all PCI patients received i.v. heparin 4–10,000 units at commencement of the procedure and clopidogrel 600 mg on completion. Two patients were on a tirofiban infusion and 23 received a double bolus of eptifibatide, each 0.18 mg/kg, separated by 10 min. The procedural success was 100% and device success 23/25 (92%), with 1 failure due to technical error. The median device delivery time was 36 sec (range, 11–178) and median TTH 37 sec (range, 10–509 sec). There were no major adverse events. In 10 patients, a moderate amount of tract ooze required a short period of adjunctive manual compression. Follow-up ultrasound femoral artery scans revealed no compromise of the vessel lumen. Femoral artery closure with the device following coronary angiography and intervention using glycoprotein IIb/IIIa receptor inhibitors is safe and effective. A randomized trial of a larger number of patients is warranted. © 2005 Wiley-Liss, Inc.
- Published
- 2005
30. Drug-eluting stents for coronary bifurcations: insights into the crush technique
- Author
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Monique J. Panther, Richard C. Padgett, J T Stewart, John A. Ormiston, Mark W.I. Webster, P. Ruygrok, Erin Currie, and Patrick Kay
- Subjects
medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Balloon ,Prosthesis Design ,Main branch ,Coronary Restenosis ,Restenosis ,Side branch ,Angioplasty ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Angioplasty, Balloon, Coronary ,business.industry ,Stent ,General Medicine ,equipment and supplies ,medicine.disease ,Surgery ,Ostium ,surgical procedures, operative ,Stents ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Sirolimus-eluting stents appear to reduce substantially restenosis following percutaneous coronary bifurcation intervention. The crush technique was devised to reduce restenosis further by improving stent and drug application to the side-branch ostium. We aimed to investigate the performance of drug-eluting stent (DES) platforms with the crush technique, to identify deployment pitfalls, and to clarify the best deployment strategies. Each stage of the crush technique was photographed in a bifurcation phantom. Simultaneous side- and main-branch dilatation (kissing balloons) fully expanded the stent in the side-branch ostium, widened the gaps between stent struts covering the side branch, and eliminated main-branch distortion. With side branches angled at > 70 degrees , sequential (side- then main-branch) inflations may be needed to achieve best results. Postdilatation of the main branch with a balloon of narrower diameter than the deploying balloon caused main-branch stent distortion. These principles applied to all the bifurcation strategies and stent designs tested.
- Published
- 2004
31. Physiological assessment of coronary circulation using pressure and Doppler guidewires
- Author
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Manel Sabaté, Patrick Kay, and M A Costa
- Subjects
medicine.medical_specialty ,symbols.namesake ,Coronary circulation ,medicine.anatomical_structure ,business.industry ,Internal medicine ,medicine ,symbols ,Cardiology ,business ,Doppler effect - Published
- 2004
32. Spontaneous coronary artery dissection: long stenting in a patient with polycythemia vera
- Author
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I. Patrick Kay and Michael J.A. Williams
- Subjects
medicine.medical_specialty ,Myocardial ischemia ,Unstable angina ,business.industry ,medicine.medical_treatment ,medicine.disease ,Sudden cardiac death ,Polycythemia vera ,hemic and lymphatic diseases ,Angioplasty ,Internal medicine ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,Artery dissection ,business ,Coronary dissection - Abstract
Spontaneous coronary artery dissection is a rare cause of myocardial ischemia or sudden cardiac death. We describe a patient with polycythemia vera and a chronic spontaneous coronary artery dissection who was treated with successful angioplasty and long stenting.
- Published
- 2003
33. PT189 Short Term Outcome of Bioresorbable Vascular Scaffold Use in Patients with ST Elevation Myocardial Infarction – The Auckland Regional Experience
- Author
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John A. Ormiston, William Harrison, Patrick Kay, Jonathon M. White, D. Scott, P Ding, and Ali Khan
- Subjects
Community and Home Care ,medicine.medical_specialty ,Epidemiology ,business.industry ,St elevation myocardial infarction ,medicine ,In patient ,Cardiology and Cardiovascular Medicine ,business ,Surgery ,Bioresorbable vascular scaffold - Published
- 2014
34. Percutaneous coronary intervention rates and outcomes of coronary angiography in patients with prior CABG - an ANZACS-QI single centre study
- Author
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G. Sathananthan, D. Scott, Wil Harrison, C. Flynn, Patrick Kay, and Andrew Kerr
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Rehabilitation ,Referral ,business.industry ,medicine.medical_treatment ,Psychological intervention ,Percutaneous coronary intervention ,Type 2 diabetes ,medicine.disease ,Health psychology ,Intervention (counseling) ,Internal medicine ,Emergency medicine ,Community health ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background:Home based cardiac rehabilitation (CR) is an evidenced based intervention that provides further choice of CR interventions for patients after a cardiac event. Te Hononga O Tamaki Me Hoturoa is a kaupapa Maori non-government organisation that has been delivering home based CR for the past six years. Methods: Patients are referred from the Middlemore Hospital CR team following ACS, coronary intervention or valvular surgery and the nurse led team provide a structured level of home based CR based on the Heart Guide Aotearoa program within a whanau ora/holistic model. This includes access to experienced cardiac nurses, community health worker support and health psychologists review. Data is collected in a local data base and in the Anzac-QI system. Results: Between 1/1/13 and 1/1/14, 206 patients were referred, and 182 patients had full referral data available for analysis. The majority were male (53%), median age 66 years (IQR 57-76) and ethnicity was non-European/others 44%, Maori 25%, Pacific 19%, Indian 10%, and Asian 2%. 38% had type 2 diabetes, median HbA1c 7.5 (IQR 6.5-8.9), median BMI was 28.1 (IQR 25-32.7). and 19% were current smokers, 156 (83%)were able to be contacted and participated in the program. There was no statistical demographic difference between engaged and non-engaged patients. Conclusion: The program continues to provide a viable alternative for patients wanting a structured and in home approach to secondary prevention following a cardiac event. More work is needed to increase referrals, simplify data collection and to add a focus on outcome measures.
- Published
- 2014
35. Statistical methods to improve the precision of the treadmill exercise test
- Author
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I. Patrick Kay, Ralph A.H Stewart, and John Kittelson
- Subjects
medicine.medical_specialty ,Vasodilator Agents ,Myocardial Ischemia ,Administration, Oral ,Isosorbide Dinitrate ,Placebo ,Severity of Illness Index ,Diagnosis, Differential ,Electrocardiography ,Double-Blind Method ,Internal medicine ,Regression toward the mean ,Linear regression ,medicine ,ST segment ,Humans ,Aged ,ST depression ,Cross-Over Studies ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Middle Aged ,Crossover study ,Sample size determination ,Data Interpretation, Statistical ,Cardiology ,Physical therapy ,Exercise Test ,medicine.symptom ,business ,Cardiology and Cardiovascular Medicine - Abstract
OBJECTIVES The study systematically compared different measures of ST segment depression from the treadmill exercise test. BACKGROUND The value of the treadmill exercise test for objectively measuring treatment effects is limited by random error in the measurement of ST depression and may be biased by regression to the mean or by the decision to terminate the test. METHODS Treadmill exercise was performed in 21 subjects with ischemic heart disease 1 h after isosorbide dinitrate 10 mg or placebo in a double-blind randomized crossover study. A 12-lead electrocardiogram (ECG) was recorded every 30 s during and at peak exercise. The relative sample size needed to detect the nitrate effect was compared for different summary measures of ST depression. RESULTS The ST depression measured from a single unmatched lead at longest equivalent sub-maximal exercise needed the lowest sample size to detect the nitrate effect in paired comparisons (p = 0.000006). Averaging over multiple leads or times did not improve detection of the nitrate effect. The rate of increase in ST depression (in mm/min) calculated by linear regression needed a similar sample size (×1.32, 95% CI 0.62 to 2.58). A larger sample size was needed for ST depression at peak exercise (×2.9, CI 1.3, 11.1) and exercise duration (×4.5, CI 1.5, 38). Time to 1-mm ST depression was the least efficient measurement (relative sample size ×15.5, CI 1.6, >1000). Comparison of matched leads resulted in >2-fold differences in estimates of the nitrate effect because of bias from regression to the mean. CONCLUSIONS Maximal ST depression at longest equivalent sub-maximal exercise and the maximal rate of increase in ST depression had less bias and random variation than did other commonly used measures. The rate of increase in ST depression is preferred because it can be calculated in either paired or unpaired studies.
- Published
- 2000
36. Three-dimensional intravascular ultrasound assessment of noninjured edges of β-irradiated coronary segments
- Author
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Ken Kozuma, M A Costa, I. Patrick Kay, Patrick W. Serruys, Jurgen Ligthart, P. Serrano, Peter C. Levendag, Manel Sabaté, V.L.M.A. Coen, Johannes P. A. Marijnissen, Cardiology, and Radiotherapy
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Brachytherapy ,Balloon ,Placebo ,Coronary Angiography ,Placebo group ,Restenosis ,Physiology (medical) ,Angioplasty ,Intravascular ultrasound ,medicine ,Humans ,Irradiation ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Dose-Response Relationship, Radiation ,medicine.disease ,Coronary Vessels ,Beta Particles ,Radiology ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Angioplasty, Balloon - Abstract
Background —The “edge effect,” late lumen loss at the margins of the treated segment, has become an important issue in the field of coronary brachytherapy. The aim of the present study was to assess the edge effect in noninjured margins adjacent to the irradiated segments after catheter-based intracoronary β-irradiation. Methods and Results —Fifty-three vessels were assessed by means of 3-dimensional intravascular ultrasound after the procedure and at 6- to 8-month follow-up. Fourteen vessels (placebo group) did not receive radiation (sham source), whereas 39 vessels were irradiated. In the irradiated group, 48 edges (5 mm in length) were identified as noninjured, whereas 18 noninjured edges were selected in the placebo group. We compared the volumetric intravascular ultrasound measurements of the noninjured edges of the irradiated vessels with the fully irradiated nonstented segments (IRS, n=27) (26-mm segments received the prescribed 100% isodose) and the noninjured edges of the vessels of the placebo patients. The lumen decreased (6 mm 3 ) in the noninjured edges of the irradiated vessels at follow-up ( P =0.001). We observed a similar increase in plaque volume in all segments: noninjured edges of the irradiated group (19.6%), noninjured edges of the placebo group (21.5%), and IRS (21.0%). The total vessel volume increased in the IRS in the 3 groups. No edge segment was subject to repeat revascularization. Conclusions —The edge effect occurs in the noninjured margins of radiation source train in both irradiated and placebo patients. Thus, low-dose radiation may not play an important role in this phenomenon, whereas nonmeasurable device injury may be considered a plausible alternative explanation.
- Published
- 2000
37. Positive geometric vascular remodeling is seen after catheter-based radiation followed by conventional stent implantation but not after radioactive stent implantation
- Author
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Alexander J Wardeh, Patrick W. Serruys, Mariano Albertal, Willem J. van der Giessen, Marco A. Costa, Jurgen Ligthart, Veronique M. A. Coen, Peter C. Levendag, I. Patrick Kay, Manel Sabaté, and Ken Kozuma
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Coronary Disease ,Recurrence ,Physiology (medical) ,Angioplasty ,Intravascular ultrasound ,medicine ,Stent implantation ,Humans ,cardiovascular diseases ,Aged ,Retrospective Studies ,Neointimal hyperplasia ,Intracoronary radiation ,Hyperplasia ,medicine.diagnostic_test ,business.industry ,Follow up studies ,Stent ,Radiotherapy Dosage ,Middle Aged ,equipment and supplies ,medicine.disease ,Catheter ,surgical procedures, operative ,Female ,Stents ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Tunica Intima ,Follow-Up Studies - Abstract
Background —Recent reports demonstrate that intracoronary radiation affects not only neointimal formation but also vascular remodeling. Radioactive stents and catheter-based techniques deliver radiation in different ways, suggesting that different patterns of remodeling after each technique may be expected. Methods and Results —We analyzed remodeling in 18 patients after conventional stent implantation, 16 patients after low-activity radioactive stent implantation, 16 patients after higher activity radioactive stent implantation, and, finally, 17 patients who underwent catheter-based radiation followed by conventional stent implantation. Intravascular ultrasound with 3D reconstruction was used after stent implantation and at the 6-month follow-up to assess remodeling within the stent margins and at its edges. Preprocedural characteristics were similar between groups. In-stent neointimal hyperplasia (NIH) was inhibited by high-activity radioactive stent implantation (NIH 9.0 mm 3 ) and by catheter-based radiation followed by conventional stent implantation (NIH 6.9 mm 3 ) compared with low-activity radioactive stent implantation (NIH 21.2 mm 3 ) and conventional stent implantation (NIH 20.8 mm 3 ) ( P =0.008). No difference in plaque or total vessel volume was seen behind the stent in the conventional, low-activity, or high-activity stent implantation groups. However, significant increases in plaque behind the stent (15%) and in total vessel volume (8%) were seen in the group that underwent catheter-based radiation followed by conventional stent implantation. All 4 groups demonstrated significant late lumen loss at the stent edges; however, edge restenosis was seen only in the group subjected to high-activity stent implantation and appeared to be due to an increase in plaque and, to a lesser degree, to negative remodeling. Conclusions —Distinct differences in the patterns of remodeling exist between conventional, radioactive, and catheter-based radiotherapy with stenting.
- Published
- 2000
38. Residual plaque burden, delivered dose, and tissue composition predict 6-month outcome after balloon angioplasty and beta-radiation therapy
- Author
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V.L.M.A. Coen, I. Patrick Kay, Jurgen Ligthart, Stephane Carlier, Manel Sabaté, Peter C. Levendag, Willem J. van der Giessen, Johannes P. A. Marijnissen, Patrick W. Serruys, Eric Boersma, Marco A. Costa, Cardiology, and Radiotherapy
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Brachytherapy ,Coronary Disease ,Dose distribution ,Dissection (medical) ,Balloon ,Restenosis ,Physiology (medical) ,Angioplasty ,Medicine ,Humans ,Angioplasty, Balloon, Coronary ,Ultrasonography, Interventional ,business.industry ,Dose-Response Relationship, Radiation ,Radiotherapy Dosage ,medicine.disease ,Combined Modality Therapy ,Beta Particles ,Dose–response relationship ,Treatment Outcome ,Regression Analysis ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Tissue composition ,β radiation - Abstract
Background —Inhomogeneity of dose distribution and anatomic aspects of the atherosclerotic plaque may influence the outcome of irradiated lesions after balloon angioplasty (BA). We evaluated the influence of delivered dose and morphological characteristics of coronary stenoses treated with β-radiation after BA. Methods and Results —Eighteen consecutive patients treated according to the Beta Energy Restenosis Trial 1.5 were included in the study. The site of angioplasty was irradiated with the use of a β-emitting 90 Sr/ 90 Y source. With the side branches used as anatomic landmarks, the irradiated area was identified and volumetric assessment was performed by 3D intracoronary ultrasound imaging after treatment and at 6 months. The type of tissue, the presence of dissection, and the vessel volumes were assessed every 2 mm within the irradiated area. The minimal dose absorbed by 90% of the adventitial volume (D v90 Adv) was calculated in each 2-mm segment. Diffuse calcified subsegments and those containing side branches were excluded. Two hundred six coronary subsegments were studied. Of those, 55 were defined as soft, 129 as hard, and 22 as normal/intimal thickening. Plaque volume showed less increase in hard segments as compared with soft and normal/intimal thickening segments ( P v90 Adv was associated with plaque volume at follow-up after a polynomial equation with linear and nonlinear components ( r =0.71; P =0.0001). The multivariate regression analysis identified the independent predictors of the plaque volume at follow-up: plaque volume after treatment, D v90 Adv, and type of plaque. Conclusions —Residual plaque burden, delivered dose, and tissue composition play a fundamental role in the volumetric outcome at 6-month follow-up after β-radiation therapy and BA.
- Published
- 2000
39. Three-dimensional intravascular ultrasonic volumetric quantification of stent recoil and neointimal formation of two new generation tubular stents
- Author
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Ken Kozuma, David P. Foley, Patrick W. Serruys, Mariano Albertal, Marco A. Costa, I. Patrick Kay, P. Serrano, Vincent de Valk, Pim J. de Feyter, Manel Sabaté, Jurgen Ligthart, Clemens Disco, and Cardiology
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Food and drug administration ,Recoil ,Internal medicine ,Intravascular ultrasound ,medicine ,Humans ,cardiovascular diseases ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Stent ,Equipment Design ,Middle Aged ,equipment and supplies ,medicine.disease ,Proliferative response ,Coronary arteries ,Stenosis ,surgical procedures, operative ,medicine.anatomical_structure ,Cardiology ,Ultrasonic sensor ,Female ,Stents ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Tunica Intima ,Cell Division - Abstract
Currently, several different designs of coronary stents are available. However, only a few of the new generation stents have been investigated in large randomized trials. Mechanical behavior of first-generation stents (Palmaz-Schatz, Gianturco-Roubin) may not be applied to the new designs. We investigated the chronic mechanical behavior (recoil) of 2 stents recently approved by the Food and Drug Administration (MULTILINK and NIR). Forty-eight patients with single-stent implantation (23 MULTILINK and 25 NIR) were assessed by means of volumetric 3-dimensional intravascular ultrasound analysis after the procedure and at 6-month follow-up. In addition, volumetric assessment of neointimal formation was performed. No significant chronic stent recoil was detected in both groups (delta MULTILINK stent volume: +5.6+/-41 mm3 [p = NS] and delta NIR stent volume + 2.1+/-26 mm3 [p = NS]). A similar degree of neointimal formation at 6 months was observed between the 2 stents (MULTILINK 46+/-31.9 mm3 vs NIR 39.9+/-27.6 mm3, p = NS). In conclusion, these 2 second-generation tubular stents did not show chronic recoil and appeared to promote similar proliferative response after implantation in human coronary arteries.
- Published
- 2000
40. Geometric vascular remodeling after balloon angioplasty and beta-radiation therapy: A three-dimensional intravascular ultrasound study
- Author
-
Ad den Boer, V.L.M.A. Coen, Peter C. Levendag, Manel Sabaté, Patrick W. Serruys, Willem J. van der Giessen, I. Patrick Kay, Alexander J Wardeh, A. L. Gijzel, Jurgen Ligthart, Cardiology, and Radiotherapy
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Brachytherapy ,Lumen (anatomy) ,Balloon ,Coronary Angiography ,Endosonography ,Restenosis ,Physiology (medical) ,Angioplasty ,Intravascular ultrasound ,medicine ,Humans ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Coronary Vessels ,Beta Particles ,Radiation therapy ,Coronary vessel ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Angioplasty, Balloon ,Follow-Up Studies - Abstract
Background —Endovascular radiation appears to inhibit intimal thickening after overstretching balloon injury in animal models. The effect of brachytherapy on vascular remodeling is unknown. The aim of the study was to determine the evolution of coronary vessel dimensions after intracoronary irradiation after successful balloon angioplasty in humans. Methods and Results —Twenty-one consecutive patients treated with balloon angioplasty and β-radiation according to the Beta Energy Restenosis Trial-1.5 were included in the study. Volumetric assessment of the irradiated segment and both edges was performed after brachytherapy and at 6-month follow-up. Intravascular ultrasound images were acquired by means of ECG-triggered pullback, and 3-D reconstruction was performed by automated edge detection, allowing the calculation of lumen, plaque, and external elastic membrane (EEM) volumes. In the irradiated segments, mean EEM and plaque volumes increased significantly (451±128 to 490.9±159 mm 3 and 201.2±59 to 241.7±74 mm 3 ; P =0.01 and P =0.001, respectively), whereas luminal volume remained unchanged (250.8±91 to 249.2±102 mm 3 ; P =NS). The edges demonstrated an increase in mean plaque volume (26.8±12 to 32.6±10 mm 3 , P =0.0001) and no net change in mean EEM volume (71.4±24 to 70.9±24 mm 3 , P =NS), resulting in a decrease in mean luminal volume (44.6±16 to 38.3±16 mm 3 , P =0.01). Conclusions —A different pattern of remodeling is observed in coronary segments treated with β-radiation after successful balloon angioplasty. In the irradiated segments, the adaptive increase of EEM volume appears to be the major contributor to the luminal volume at follow-up. Conversely, both edges showed an increase in plaque volume without a net change in EEM volume.
- Published
- 1999
41. Intracoronary Ultrasound Longitudinal Reconstruction of a Postangioplasty Coronary Artery Dissection
- Author
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Patrick W. Serruys, Pim J. de Feyter, Manel Sabaté, I. Patrick Kay, Jurgen Ligthart, Willem J. van der Giessen, and Cardiology
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Coronary Disease ,Dissection (medical) ,Coronary Angiography ,Physiology (medical) ,Internal medicine ,medicine.artery ,Angioplasty ,medicine ,Humans ,cardiovascular diseases ,Angioplasty, Balloon, Coronary ,Artery dissection ,Ultrasonography, Interventional ,medicine.diagnostic_test ,Unstable angina ,business.industry ,Stent ,Middle Aged ,medicine.disease ,Coronary Vessels ,Right coronary artery ,Angiography ,Cardiology ,Female ,Stents ,Intracoronary ultrasound ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
A62-year-old woman presented with unstable angina. Angiography demonstrated a severe stenosis in the distal right coronary artery (RCA), and angioplasty with stent implantation was undertaken. This was complicated by a coronary artery dissection distal to the stent that was detected by angiography and intracoronary ultrasound (ICUS). Figure 1. Coronary angiogram (left anterior oblique projection) demonstrates a longitudinal dissection proximal to bifurcation of right coronary artery into posterior descending and posterolateral arteries. Inset, …
- Published
- 1999
42. Resting Systolic Anterior Motion of Mitral Valve Apparatus
- Author
-
Andrew Kerr, Patrick Kay, A Khan, and Andrew To
- Subjects
Male ,medicine.medical_specialty ,Heart Diseases ,Systole ,Coronary angiogram ,Chest pain ,Electrocardiography ,Basal (phylogenetics) ,Internal medicine ,Mitral valve ,medicine ,Humans ,Aged ,business.industry ,ST elevation ,Apical Ballooning Syndrome ,medicine.anatomical_structure ,Echocardiography ,Cardiology ,Mitral Valve ,Female ,Presentation (obstetrics) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Sudden onset - Abstract
Two patients, a 67-year-old man (patient 1) and a 72-year-old woman (patient 2), presented with sudden onset chest pain after significant emotional stress. Patient 2 also had acute pulmonary edema on presentation. An ECG showed ST elevation in the precordial leads, and the patient’s cardiac enzymes were elevated. A coronary angiogram showed no flow-limiting lesions. A left ventriculogram demonstrated the typical pattern of apical ballooning syndrome with basal hypercontractility and apical akinesis (Figure, A, …
- Published
- 2008
43. Primary Percutaneous Coronary Intervention (PPCI) for ST Segment Elevation Myocardial Infarction (STEMI) Patients: The 2012 Auckland/Northland Experience
- Author
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Wil Harrison, T. Oh, Ali Khan, G. Armstrong, Chris Ellis, D. Scott, A. Lin, John A. Ormiston, James T. Stewart, K.L. Chow, JL Looi, Khang-Li Looi, S. El-Jack, M.W.I. Webster, Gregory D. Gamble, Patrick Kay, Mohammed Alawami, and Peter Ruygrok
- Subjects
Pulmonary and Respiratory Medicine ,Acute coronary syndrome ,education.field_of_study ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Population ,Psychological intervention ,Percutaneous coronary intervention ,medicine.disease ,Pill ,Cohort ,Emergency medicine ,medicine ,Physical therapy ,Myocardial infarction ,Medical prescription ,Cardiology and Cardiovascular Medicine ,education ,business - Abstract
Background:Medicationand lifestyleadherence following an acute coronary syndrome (ACS) can significantly improve outcomes but is influenced by patient, system and environmental factors. The EARLY PREVENT study is investigating using electronic linkage to pharmaceutical dispensing records as the electronic core of a personalised program to support appropriate medication and lifestyle adherence. The aim of this sub-study was to better understand our ACS population and the potential barriers to adherence as background to the development of a postdischarge adherence intervention program. Methods: We identified all NZ residents (1/8/07 to 18/5/09),who resided inCountiesManukaudistrictHealth Board at the time of their ACS admission. The cohort was divided into four groups by ethnicity and then patients were randomlyselected toapproach for interview toassess predictors of medication adherence. Results: 188 patients consented to be interviewed (Maori 27%, Pacific 20%, Indian 26%,& Euro/other 27%). Compared to other ethnicities, Europeans are approximately 10 years older (p< 0.0001),more likely retired (p< 0.0001), less likely to have diabetes (p 0.006) or experience barriers around access to a telephone (p< 0.0001), internet (p= 0.05), transport (p= 0.0003), funding prescriptions (p= 0.004), taking pills as prescribed (p= 0.03), reporting cultural fit with GP (p= 0.0004), and understanding need for lifelong statins (p= 0.005). Conclusion:Culturally and language appropriate interventions to assess for barriers to adherence and to develop solutions should be a feature of proactive ACS discharge planning and would be relatively simple to instigate.
- Published
- 2013
44. Acute Predict Cardiac Catheter Lab (CCL)—An Electronic Real-Time Audit, Quality Improvement Process in Middlemore Hospital CCL
- Author
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C. Flynn, Andy McLachlan, Andrew Kerr, J. White, Patrick Kay, S. Graham, and D. Scott
- Subjects
Pulmonary and Respiratory Medicine ,Catheter ,Quality audit ,medicine.medical_specialty ,business.industry ,Emergency medicine ,medicine ,Medical emergency ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2011
45. Surgeons and Anaesthetists Require Education about the Appropriate Timing of Elective Surgery and the Perioperative Management of Antiplatelet Therapy in Patients with Drug Eluting Stents
- Author
-
Scott A. Harding, J. Swampillai, Helen Tanner, Wil Harrison, A. Ranchord, Manuprabha Ratnayeke, Susan Plunkett, and Patrick Kay
- Subjects
Pulmonary and Respiratory Medicine ,Drug ,medicine.medical_specialty ,biology ,business.industry ,media_common.quotation_subject ,medicine.medical_treatment ,Stent ,medicine.disease ,Troponin ,Surgery ,Anesthesia ,Diabetes mellitus ,Conventional PCI ,biology.protein ,Medicine ,In patient ,Elective surgery ,Cardiology and Cardiovascular Medicine ,business ,Mace ,media_common - Abstract
Results: There were 115 interventional procedures performed on SVG with a mean follow up 27± 18 months. The use of DP was strongly associated with a reduction in post-procedure troponin rise (15.9± 5.6 versus 47.8± 5.0%, p< 0.01). High extent score, use of covered stents and long stent length were all associated with increased troponin levels post procedure. MACE Event free survival p-Value Extent score 55.7% 25.6% 0.02 Diabetes 34.6% 10.0%
- Published
- 2008
46. Coronary Artery Anatomy in Apical Ballooning Syndrome
- Author
-
Patrick Kay, Andrew Kerr, A Khan, and Andrew To
- Subjects
Pulmonary and Respiratory Medicine ,Coronary artery anatomy ,medicine.medical_specialty ,business.industry ,Internal medicine ,Apical Ballooning Syndrome ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business - Published
- 2008
47. Elevated Plasma Active Matrix Metalloproteinase-9 Level Is Associated With Coronary Artery In-Stent Restenosis
- Author
-
Gerard T. Wilkins, Gregory T. Jones, L.V. Phillips, A.M. van Rij, Maree P. McCormick, I. Patrick Kay, Michael J.A. Williams, and J. Chu
- Subjects
Bare-metal stent ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Coronary Angiography ,Severity of Illness Index ,Lesion ,Coronary Restenosis ,Restenosis ,Internal medicine ,Severity of illness ,Medicine ,Humans ,Risk factor ,Aged ,Retrospective Studies ,Tissue Inhibitor of Metalloproteinase-1 ,business.industry ,Cholesterol, HDL ,Stent ,Odds ratio ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Matrix Metalloproteinase 9 ,Cardiology ,Female ,Stents ,medicine.symptom ,business ,Cardiology and Cardiovascular Medicine ,Artery - Abstract
Objective— This study aimed to determine whether the plasma levels of matrix metalloproteinase-9 (MMP-9) or tissue inhibitor of metalloproteinases-1 (TIMP-1) were altered in patients with a history of symptomatic in-stent restenosis (ISR). Methods and Results— A group of 158 patients with a history of ISR were compared with 128 symptom-free patients. Plasma samples and a detailed risk factor history were collected. Plasma samples were analyzed for pro–MMP-9 and latent MMP-9 and active MMP-9, latent MMP-3, and TIMP-1. Several variables were associated with ISR, including index coronary disease extent and severity (number of diseased vessels and American College of Cardiology/American Heart Association lesion classification), number, diameter, and total length of stent(s) inserted, and plasma high-density lipoprotein cholesterol. Plasma active MMP-9 (odds ratio, 1.96; 95% CI, 1.43 to 2.69) showed independent risk association with ISR. Patients with multiple sites of ISR had significantly higher levels of active MMP-9 compared with patients with only a single ISR lesion or no ISR. Conclusion— Plasma active MMP-9 levels may be a useful independent predictor of bare metal stent ISR.
- Published
- 2006
48. 1024-53 Drug-eluting stents for coronary bifurcations: Bench-top insights into the 'crush' technique
- Author
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Mark Webster, John A. Ormiston, Peter Ruygrok, Erin Currie, Patrick Kay, Monique J. Panther, and J T Stewart
- Subjects
Drug ,medicine.medical_specialty ,integumentary system ,business.industry ,musculoskeletal, neural, and ocular physiology ,media_common.quotation_subject ,equipment and supplies ,surgical procedures, operative ,nervous system ,Internal medicine ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,media_common - Published
- 2004
49. Stent and stent-edge remodeling after conventional and radioactive stent implantation
- Author
-
Manel Sabaté, I. Patrick Kay, Ken Kozuma, V.L.M.A. Coen, Jurgen Ligthart, Willem G. van der Giessen, Peter C. Levendag, Mariano Albertal, Marco A. Costa, and Patrick W. Serruys
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,medicine ,Stent implantation ,Stent ,Radiology ,Edge (geometry) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2000
50. Coronary artery remodeling after balloon angioplasty and β-radiation followed by conventional stenting
- Author
-
Willem J. van der Giessen, Manel Sabaté, Peter C. Levendag, Ken Kozuma, Patrick W. Serruys, V.L.M.A. Coen, I. Patrick Kay, Mariano Albertal, Marco A. Costa, and Jurgen Ligthart
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Balloon ,medicine.anatomical_structure ,Internal medicine ,Angioplasty ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,β radiation ,Artery - Published
- 2000
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