Back to Search
Start Over
Lipoprotein(a), Interleukin-10, C-Reactive Protein, and 8-Year Outcome After Percutaneous Coronary Intervention
- Source :
- Clinical Cardiology, 35(8), 482-489. Wiley-Blackwell
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Background: This prospective study investigated the association between preprocedural biomarker levels and incident major adverse cardiac events (MACE) in complex patients undergoing percutaneous coronary intervention (PCI) with sirolimus-eluting stenting. Hypothesis: Lipoprotein(a) (Lp[a]), interleukin-10 (IL-10), and high-sensitivity C-reactive protein (CRP) have long-term prognostic value in patients undergoing PCI. Methods: Between April 2002 and February 2003, 161 patients were included in the study. Blood was drawn before the procedure, and biomarkers were measured. Patients were followed-up for MACE (death, nonfatal myocardial infarction, and repeat revascularization). Cox proportional hazard models were used to determine risk of MACE for tertiles of biomarkers. Both 1-year and long-term follow-up (median, 6 years; maximum, 8 years) were evaluated. Results: Mean age was 59 years, and 68% were men. During long-term follow-up, 72 MACE occurred (overall crude cumulative incidence: 45% [95% confidence interval (CI): 37%-52%]). Lp(a) was associated with a higher 1-year risk of MACE, with an adjusted hazard ratio (HR) of 3.1 (95% CI: 1.1-8.6) for the highest vs the lowest tertile. This association weakened and lost significance with long-term follow-up. IL-10 showed a tendency toward an association with MACE. The 1-year HR was 2.1 (95% CI: 0.92-5.0). Long-term follow-up rendered a similar result. The association of CRP with MACE did not reach statistical significance at 1-year follow-up. However, CRP was associated with long-term risk of MACE, with an HR of 1.9 (95% CI: 1.0-3.5). Conclusions: In this prospective study, preprocedural Lp(a) level was associated with short-term prognosis after PCI. The preprocedural CRP level was associated with long-term prognosis after PCI. Clin. Cardiol. 2012 DOI: 10.1002/clc.21988 The authors have no funding, financial relationships, or conflicts of interest to disclose.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Clinical Investigations
Coronary Artery Disease
Risk Assessment
Coronary artery disease
Surveys and Questionnaires
Internal medicine
Confidence Intervals
medicine
Health Status Indicators
Humans
Prospective Studies
cardiovascular diseases
Myocardial infarction
Angioplasty, Balloon, Coronary
Prospective cohort study
biology
business.industry
Hazard ratio
Percutaneous coronary intervention
Drug-Eluting Stents
General Medicine
Lipoprotein(a)
Middle Aged
Prognosis
medicine.disease
Interleukin-10
Surgery
C-Reactive Protein
Conventional PCI
biology.protein
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Mace
Subjects
Details
- ISSN :
- 01609289
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Clinical Cardiology
- Accession number :
- edsair.doi.dedup.....59f4f61faf3bb17a73ec6c08f7c61020