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Objective: The aim was to evaluate the possible effects of anti-angiogenic factors including soluble endoglin (sEng), placental growth factor (Pgf), and soluble fms-like tyrosine kinase 1 (sFlt-1) in both normotensive pregnant patients and preeclampsia (PE) patients. Material and Methods: The study was carried out at the Departments of Gynecology and Obstetrics and Biochemistry of Yozgat Bozok University Training and Research Hospital. Eighteen women with PE who were pregnant for at least 20 weeks comprised the study group. The control group consisted of 33 pregnant women with no complications and with similar demographic features. In the study, laboratory parameters, demographic characteristics, sEng, sFlt-1, and Pgf levels, delivery type, APGAR scores of the infants, and birthweight were determined and a comparison was made between the groups. Results: It was found that the sEng level was significantly lower in the PE group compared to the control group (p

BACKGROUND/AIM Necrotizing enterocolitis (NEC) is one of the most important causes of morbidity and mortality in premature infants. Although there are no specific diagnostic tools, the main factors affecting prognosis are clinical and laboratory findings, and early diagnosis and treatment. In this study, we demonstrate the importance of dual-energy computed tomography (DECT) in confirming intestinal ischemia in neonates with NEC. MATERIALS AND METHODS Patients diagnosed with NEC in a neonatal intensive care unit were staged according to modified Bell?s classification, and DECT was performed on patients with NEC stages 2-A, 2-B and 3-A. According to their DECT reports, these patients were then separated into two groups: those with intestinal ischemia and those without intestinal ischemia. The patients with intestinal ischemia were evaluated using surgical reports, and the other patients were evaluated using clinical findings. RESULTS DECT was performed in 21 patients with NEC stages 2-A, 2-B and 3-A. Twelve patients (57.1%) without ischemia were followed up without surgery. Nine patients (42.9%) with ischemia on DECT were operated on, and resection and anastomosis or ileostomy and colostomy were performed. CONCLUSIONS In patients with NEC, DECT significantly increases overall diagnostic confidence in assessing intestinal necrosis when compared with traditional diagnostic methods.

Prenatal subdural hematoma is a rare condition and causes death or neurological impairment in newborns. The etiology of subdural hematoma is still controversial, but trauma is seen most important reason. In this disease, a multidisciplinary study is required, which includes gynecology, neurosurgery, neonatology, and radiology. We presented a newborn with prenatal subdural hematoma who we operated a treated in a multidisciplinary way.

Purpose: Preeclampsia (PE) is a pregnancy-specific syndrome characterized by placentation disorder that increases maternal and fetal morbidity and mortality. Overproduction of anti-angiogenic factors such as soluble fms-like tyrosine kinase receptor 1 (sFlt-1) and soluble endoglin (sEng) and low production of placental growth factor (Pgf) from angiogenic factors contribute to preeclampsia pathogenesis. In this study, factors involved in angiogenesis including sEng, Pgf and sFlt1 were investigated for pre-recognition of preeclampsia. Methods: A total of 54 pregnant women were included in the study and the patients were divided into normotensive (n = 25) and preeclampsia groups (n = 29). Both groups demographic characteristics, laboratory parameters, sEng, sFlt1 and placental growth factor levels were compared. Results: While AST, uric acid, LDH mean values were significantly higher in the study group compared to the control group (p

AIM Ovarian torsion is a gynecopathology that requires emergency surgery in women. However, ischemia reperfusion injury (IRI) occurs after treatment with detorsion. This study aimed to evaluate the effects of monoacylglycerol lipase inhibitor JZL184 on ovarian IRI and ovarian reserve. METHODS Forty-eight female Wistar albino rats were divided into six groups. Group 1: Sham, Group 2: Ischemia, Group 3: ischemia/reperfusion (IR), Group 4: IR + JZL184 4 mg/kg, Group 5: IR + JZL184 16 mg/kg, Group 6: IR + vehicle (dimethyl sulfoxide). Three hours of ischemia followed by 3 h of reperfusion. Two different doses of JZL184 (4 and 16 mg/kg) were administered intraperitoneally in Group 4 and 5, 30 min before reperfusion. Ovarian IRI and ovarian reserve were evaluated in serum and tissue by using histopathological and biochemical parameters. RESULTS Treatment with JZL184 was associated with a significant increase in ovarian 2-arachidonoylglycerol and improved serum anti-Mullerian hormone, Inhibin B, primordial follicle count, and ovarian histopathological damage score (p

Amaç: Patoloji sonucu uterin leiomyom olarak sonuçlanan vakaların, yapılan cerrahi işlem, myom özellikleri ve eşlik eden patolojiler açısından değerlendirilmesi hedeflenmiştir. Ayrıca; myom sayısı, büyüklüğü ve lokalizasyonuna göre inflamatuar belirteçlerin de değerlendirilmesi amaçlanmıştır.Gereç ve Yöntemler: Cerrahi sonrası patoloji sonucu uterin leiomyom olarak değerlendirilen 102 hastanın verileri retrospektif olarak değerlendirildi. Olguların yaş, gravida, parite, preoperatif ve postoperatif hemogram sonuçlarına hasta dosyalarından ulaşıldı. Myoma eşlik eden diğer jineko-patolojiler, myom boyutu, sayısı ve yerleşimi bilgilerine patoloji raporlarından ulaşıldı.Bulgular: Myom yerleşimi incelendiğinde olguların %44.1’inin intramural yerleşim gösterdiği, myom sayısına bakıldığında ise hastaların %61’ inde en az iki adet myom olduğu saptandı. Hastalara yapılan cerrahi işlemler retrospektif değerlendirildiğinde olguların %46’sına total abdominal histerektomi yapıldığı görüldü. İnflamatuar parametrelerle myom büyüklüğü arasındaki ilişki incelendiğinde; ≤5 cm ile ˃5 cm myomu olan olgular karşılaştırıldığında nötrofil/lenfosit oranı ve lenfosit/monosit oranı değerleri istatistiksel olarak anlamlı farklı bulundu (sırasıyla, p=0.023; 0.038), ancak platelet/lenfosit oranı değerleri istatistiksel olarak anlamsız bulundu (p˃0.05). Hem myom boyutu hem de sayısı açısından incelenen olguların preoperatif ve postoperatif hemoglobin değerleri arasında istatistiksel olarak bir farklılık saptanmadı (p˃0.05).Sonuç: Artmış myom sayısı ile lenfosit/monosit oranında azalma gözlenirken, myom boyutu artışıyla nötrofil/lenfosit oranında artış ve lenfosit/monosit oranında da azalma olmaktadır.

Aim:To evaluate subclinical inflammatory markers in hyperemesis gravidarum (HEG) cases and to determine the relationship of these markers with the gestational age at delivery and birth weight in pregnant women with HEG.Methods:Fifty-two patients who presented to our hospital between 1 May 2017 and 1 September 2019 with HEG and 60 pregnant women as the control group were included in this retrospectively designed study. The relationship of subclinical inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the lymphocyte-to-monocyte ratio (LMR) with HEG, and their relationship with birth week and birth weight in HEG cases were examined.Results:In HEG cases, NLR and PLR values were higher (p=0.006 and p=0.004, respectively), whereas LMR values were lower (p

The objective of this study is to assess the levels of heavy metals (cadmium, lead, antimony, mercury, and arsenic), which are also called endocrine-disrupting chemicals, and trace elements (chromium-III, chromium-VI, zinc, copper, and selenium) vs. monocyte to HDL ratio among pregnant women with gestational diabetes mellitus (GDM). A total of 112 pregnant women (60 with GDM and 52 healthy women) were included in this case-control study. Analysis of heavy metals and trace elements were performed in inductively coupled plasma mass spectrometer. Heavy metals (cadmium, lead, antimony, mercury, and arsenic), trace elements (chromium-III, chromium-VI, zinc, copper, and selenium), and metabolic parameters were assessed in both groups. It was determined that the levels of cadmium, lead, antimony, and copper were higher (p 0.05) and levels of chromium-III, zinc, and selenium were lower (p 0.05) among the GDM group compared to the control group, whereas there was a statistically insignificant difference between the two groups, regarding the levels of copper, mercury, and arsenic (p 0.05). Moreover, the monocyte to HDL ratio was higher in the GDM group (p 0.05), and the insulin resistance was significantly higher as well (p 0.05). The results of our study demonstrated that environmental factors could be effective in the etiology of GDM. Toxic heavy metals, through inducing Cu, OS, and chronic inflammation, and other trace elements, either directly by impacting insulin secretion or through weakening the body's antioxidant defense system, could play a role in the occurrence of GDM.

Purpose To compare the rates obtained from hematological parameters in cases of late-onset idiopathic fetal growth restriction (FGR) with healthy pregnancies and to evaluate the effect on neonatal outcomes. Methods The study group consisted of 63 pregnant women with late-onset idiopathic FGR and the control group consisted of 91 healthy pregnant women. The determined rates were calculated from the control hemograms of patients at 28 weeks. Both groups were compared for neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and other parameters. Results NLR, leukocyte and neutrophil levels were significantly higher in the FGR group (p0.05). To predict FGR, the best cut-off value of NLR was determined to be 4.11 with 56% sensitivity and 88% specificity values. Conclusion Neutrophil, lymphocyte and platelet interactions have an important role in FGR development. Inflammation can be involved in the etiopathogenesis in late-onset FGR.

Screening critical congenital heart disease in neonates with 24-48 h of age could be made by oxygen saturation determination. Perfusion index may be used as an adjunct to pulse oximetry screening to detect non-cyanotic critical congenital heart disease cases such as a left heart outflow obstruction. We evaluate the results of combined screening for oxygen saturation and peripheral perfusion index at high altitudes. The study included 501 neonates older than gestational week 35. The mean oxygen saturation was lower than at sea level, and the screening test was positive in a total of 21 (4.2%) babies. Critical congenital heart diseases were not detected in any patient. A total of 10 (2%) babies were detected with PDA, nine (1.8%) of whom recorded a positive screening test. The prevalence of PDA was significantly higher in the positive screening test group when compared with those who underwent echocardiography due to clinical findings.Conclusion: The median peripheral perfusion index at high altitude was not lower than at sea level, while the mean oxygen saturation, in contrast, was lower than at sea level. The low partial oxygen pressure found at high altitudes leads to a variation in postnatal adaptation and an increased prevalence of PDA. Accordingly, oxygen saturation screening may serve to identify babies with PDA at high altitudes. What is Known: • Oxygen saturation is known to be low at high altitudes, and thus the rates of false positivity are high when screening for critical congenital heart disease. • High altitudes are also associated with an increased prevalence of simple congenital heart disease. What is New: • The peripheral perfusion index at high altitude is not lower than at sea level. • The prevalence of PDA is significantly higher in those with false positive screening results.

Objective This study was planned to evaluate obstetricians' practices of umbilical cord clamping, milking, and skin-to-skin contact applications and to determine the related variables. Material and methods A total of 522 obstetricians participated in the study. Participants were reached via the internet and a 15-item questionnaire was applied about umbilical cord clamping, cord milking, and skin-to-skin contact. Mann-Whitney U test and Student's t-test were used for continuous data and Chi-square test or Fisher's exact test for categorical data in determining the difference between groups. For the multivariate analysis, the possible factors identified with univariate analyses were entered into the logistic regression analysis to determine further independent predictors of delayed clamping. Statistical analysis was performed using the SPSS software (version 20, IBM Corp, Armonk, USA). Results It was determined that 234 (44.8%) of the participants clamped the umbilical cord early whereas 288 (55.2%) clamped it late. It was found that the delayed clamping rates of physicians working in public hospitals were significantly lower than those working in private (p

Introduction:There is no regional study presenting the pediatric intoxication cases followed in pediatric intensive care units (PICUs). As they show regional features, we aimed to present the pediatric intoxication cases followed in our PICU, and indicate our self-constituted protocol about the PICU admission rules in these patients.Methods:Demographic, clinical and laboratory data of patients who admitted with intoxication and followed in PICU between October 2015 and October 2017 were noted. PICU admission indications were evaluated.Results:Twenty-four (14%) of the 171 intoxication cases formed the study group. Fourteen (58.3%) were female. Ten cases (41.7%) were under 5 years old, 6 (20.8%) were 5-12 years and 8 (37.5%) were over 12 years. In first group, all intoxications were by accident. In second, intoxications were due to accident (n=3), during drug use in treatment dose (n=2) and as a result of child abuse (n=1). In last group, it was by accident in 2, but as a result of suicide in 6 cases. Active ingredients were; central nervous system drugs (n=9), plant (atropa belladona) (n=3), decongestant drugs (n=3), multiple drugs (n=4), intoxication by inhalation (n=1) and other drugs (n=4). Fifteen patients (62.5%) had clinical indications for PICU admission. In five (20.8%) the poison control center advised PICU admission. In four patients (16.7%) we decided PICU admission because of the fatal nature of the ingested drugs.Conclusion:Our results suggest that every clinic, by taking their availabilities into account, should form its own protocols for PICU admission for pediatric intoxication cases.

Numerous studies have been carried out on depression and sexual dysfunction concomitant with polycystic ovary syndrome (PCOS). Increasing evidence has revealed the importance of inflammation in the etiology of PCOS. In addition, it has been known that some neuromodulators affect depression and sexual function. However, their effects on PCOS are not known. This study aimed to evaluate the relationship of depression and sexual function with cytokines and neuromodulators in PCOS patients. The present study included 20 fertile and 30 infertile patients diagnosed with PCOS and 30 healthy volunteers. Metabolic and endocrine parameters, interleukin (IL)-1β, IL-6, TNFα, γ-aminobutyric acid (GABA), Glutamate, Brain-derived neurotrophic factor (BDNF) serum levels, Beck Depression Index (BDI) and Female Sexual Function Index (FSFI) scores of the patients were compared between the groups. TNFα, IL-1β, IL-6, glutamate, GABA, and BDI scores were found to be significantly higher (p < 0.05) in the PCOS group (p < 0.05). Glutamate, TNFα, IL-1β, and IL-6 values were higher whereas GABA and BDNF values were lower in pateints with moderate and severe depression (p < 0.05). There were no statistically significant relationships between these parameters and the FSFI scores (p > 0.05). Multivariate logistic regression analysis was conducted with potential factors that may affect sexual dysfunction. The results indicated that high waist-to-hip ratio (WHR) (> 0.80) with an odds ratio of 1.81 in PCOS patients, and body mass index (BMI) with an odds ratio of 2.3 and high WHR (> 0.80) with an odds ratio of 1.97 in all patients were found to be independent risk factors affecting sexual dysfunction. The results of the present study suggested that chronic low-dose inflammation seen in PCOS may interact with some neuromodulators, leading to the development of depression. However, no relationship was found between these parameters and sexual function. © 2020 Elsevier Ltd

Objective: Preeclampsia (PE) is a dangerous complication of pregnancy and still a major cause of maternal-fetal morbidity and mortality. Its etiology remains largely unknown, but researchers have suggested oxidative stress-mediated inflammation for the same. The purpose of this study is to investigate the relationship between oxidative stress and PE as well as the usability of oxidative stress indicators such as serum ischemia-modified albumin (IMA) levels and thiol/disulfide balance in the prediction of PE. Materials and Methods: The study included 47 pregnant women with PE and 57 healthy pregnant women. We measured their serum IMA, native thiol, total thiol, and disulfide levels. Additionally, we determined the optimal cutoff values via the receiver operating characteristic curve analysis. Results: There were no differences between the two groups with respect to the maternal age, body mass index, gravida, and parity. The native and total thiol levels were found to be low when the disulfide and IMA levels were high in the patients with PE (p

This study aimed to determine the relationship between the metabolic and endocrinological pathologies in polycystic ovary syndrome (PCOS) and the levels of arsenic, chromium, cadmium, lead, mercury, antimony, zinc, and copper to evaluate the relationship of these toxic metals with inflammatory/oxidative parameters. This study included a total of 154 patients (84 with PCOS, 70 healthy volunteers). Metabolic and endocrine parameters and arsenic, chromium, cadmium, lead, mercury, antimony, zinc, and copper serum levels of the patients were compared between the groups. Considering the action mechanism of toxic metals, serum malondialdehyde (MDA), superoxide dismutase (SOD), serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), tumor necrosis factor-alpha (TNFα), and high-sensitivity C-reactive protein (HsCRP) levels were determined. Serum TAS (p = 0.002), OSI (p = 0.006), SOD (p = 0.006), zinc (p = 0.010), and copper (p = 0.030) values were statistically lower whereas TOS (p = 0.008), MDA (p < 0.001), HsCRP (p < 0.001), TNFα (p < 0.001), antimony (p < 0.001), cadmium (p < 0.001), lead (p < 0.001), and mercury (p < 0.001) levels were significantly higher in the PCOS group than those determined in the control group. Antimony was positively correlated with fasting glucose (FG) and HOMA-IR while cadmium, in addition to FG and HOMA-IR, positively correlated with insulin and lead had a positive correlation only with FG (p < 0.05). Also, these three heavy metals correlated positively with some oxidative system and inflammatory parameters and negatively with the antioxidant system parameters (p < 0.05). In conclusion, heavy metal exposures in PCOS may be related to insulin resistance and hirsutism through oxidative and inflammatory mechanisms. This approach can be used to identify the risky patient group and to develop new treatment modalities. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Purpose: ACE 2 RNA expression has been detected in organs of the female reproductive tract, suggesting that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could potentially infect female reproductive organs. In this study, we investigated the presence of SARS-CoV-2 virus in the cervicovaginal fluid.Materials and Methods: Our study included 31 female patients aged 18–65 years. The presence of SARS-COV-2 RNA was investigated by RT-PCR in two separate cervicovaginal swab samples collected from patients 14 days apart. Viral RNA was extracted using viral nucleic acid buffer (vNAT) solution, and SARS-COV-2 RNA was analyzed using Bio-speedy SARS-CoV-2 RT-qPCR kits in Bio-Rad CFX96 TouchTM device.Results: The first and second cervical swab samples were collected from 22 of 31 patients 14 days apart. The first cervical swab sample was collected from 9 patients; however, the second swab sample could not be collected after 14 days. SARS-COV-2 RNA result was negative in 100% of a total of 53 cervicovaginal swab samples collected. Moreover, the SARS-COV-2 RNA result was negative in the nasopharyngeal swab of babies after delivery in three pregnant women.Conclusion: Negative SARS-COV-2 RNA results in cervicovaginal swab samples suggest that there is no sexual transmission of COVID-19 and no vertical transmission during pregnancy. However, the number of studies conducted on this subject and the sample size examined are still insufficient.

Objectives Gonadotropin-releasing hormone agonist (GnRHa) could influence the levels of sex hormones and thyroid hormones. The aim of this study was to investigate the effect of GnRHa on thyroid function. Materials and methods The data of the patients were collected from the registrations of July 2014–October 2014. A total of 41 women who underwent one-time IVF cyclus were evaluated in this cross-sectional study. The patients were categorized into two groups according to the serum T3, T4, and TSH levels before and 2 weeks’ after the administration of GnRHa. Results Mean basal TSH and mean TSH levels on hCG day were 1.98 ± 0.77 and 1.75 ± 0.70, respectively. The difference between the two groups was statistically significant (p 3 and T4 levels. Conclusions In conclusion, our results demonstrate that GnRHa led to a decrease on serum TSH level. Serum-free T3 and T4 levels were remained unchanged and this might be due to early measurement of the hormone levels (just 2 weeks later from GnRHa administration).

Amaç Preterm bebekleryenidoğan yoğun bakım ünitelerinde (YYBÜ) uzun süre takip edilirler ve bunedenle uzun süreli damar yolu ihtiyaçları olur. Uzun süreli damar yolusağlamak amacıyla umbilikal ven kateterleri, santral venöz kateterler veperiferik olarak yerleştirilmiş santral kateterler (PYSK) kullanılır. Buçalışmada PYSK uygulanan yeni doğan bebeklerin klinik özelliklerinideğerlendirmeyi amaçladık.Gereç ve YöntemlerHaziran 2016 - Haziran 2019 tarihleri arasında YYBÜ’de PYSK yerleştirilenyenidoğan bebeklerin tıbbi kayıtları retrospektif olarak incelendi. Hastalarındemografik özellikleri, PYSK yerleştirilme nedenleri, bebeklerin PYSKyerleştirme sırasındaki klinik özellikleri ve uygulama komplikasyonlarıkaydedildi.Bulgular 129 yenidoğan bebekteyerleştirilen 151 PYSK’ya ait veriler toplandı. PYSK takılan 134 (% 88,7)hastada enfeksiyon nedeniyle antibiyotik tedavisi gerekti. Sepsis bu vakaların72'sinde (% 47.6) PYSK yerleştirilmeden önce, 17'sinde (% 11.2) ise PYSK yerleştirildikten sonra tespit edildi. PYSKyerleştirilen hastalarda vücudun üst bölge damarları, alt bölge damarları vesağ taraf damarları ve sol taraf damarları arasında tıkanma, sızıntı ve / veyatromboflebit sıklığı açısından istatistiksel bir fark bulunmadı (p> 0.05).Sonuç Sonuçlarımız PYSKuygulamasının yenidoğan bebeklerde periferik damar yolu girişim sayısını önemliölçüde azalttığını, uzun süreli TPN ve antibiyotik uygulamasının mümkünolduğunu, ayrıca üst veya alt ekstremite venlerinden ve sağ veya sol taraftakivenlerden PYSK uygulanmasının komplikasyon sıklığını etkilemediğinigöstermektedir., Objective Preterm babies are followed in neonatal intensivecare units (NICU) for long times, sothey need long-term vascular access. For long-term vascular access umbilicalvein catheters, central venous catheters and peripherally inserted centralcatheters (PICC) are used. In present study we aimed to evaluate the clinicalfeatures of newborn infants in whom PICC was inserted.Materialsand Methods The medicalrecords of the newborn infants in whom PICC had been inserted from June 2016 toJune 2019 are evaluated retrospectively. Demographic features of the patients,reasons for PICC insertion, clinical features of the infants during PICCinsertion, and complications of the application are recorded.Results The data of 151 PICC that were inserted in 129newborn infants were collected. Antibiotic treatment was needed because ofinfections in 134 (88.7%) PICCs. In 72 (47.6%) of them sepsis was presentbefore PICC insertion, and in 17 (11.2%) after PICC insertion. No statistical difference was found in termsof the frequency of occlusion, leak and/or thrombophlebitis between patients inwhom PICCs were inserted via the upper body veins and lower body veins, andright veins and left veins (p>0.05).Conclusion Our results indicate thatthe PICC application significantly decreases the number of peripheral vascularaccess attempts in newborn infants, long-term total parenteral nutrition (TPN) and antibiotic administration becomes possible and insertion fromupper or lower extremity veins and right or left side veins does not affect thefrequency of complications.

The most common cause of subarachnoid hemorrhage at the period of pregnancy and during puerperium is rupture of an intracranial aneurysm. It is five times more common in pregnant women than in non-pregnant women. This pathology is more common in primiparous women and in the third trimester of pregnancy. A 37-year-old woman who was admitted to the emergency department with sudden-onset headache and loss of consciousness was diagnosed with intracranial hemorrhage due to middle cerebral artery aneurysm rupture. The patient, who gave birth with emergency cesarean delivery, underwent surgery for subarachnoid hemorrhage. The case is presented here because of its rarity.

Patent ductus arteriosus is an important problem in preterms. We aimed to investigate the relation of patent ductus arteriosus with shunt index.The preterm infants with a birth weight of ≤1500 g and/or gestational age of30 weeks and an indication for umbilical artery and venous catheterization formed the study group. Between the postnatal 24-48 hours, the first arterial and venous blood samples were obtained and the patients were evaluated by echocardiography. In patients with hemodynamically significant patent ductus arteriosus (patient group), during the first 24 hours after the competition of the first course of medical treatment, the second blood samples were obtained and echocardiography repeated. In patients without patent ductus arteriosus (control group), second blood samples were taken after the postnatal 72 hours. Also, echocardiography was performed.A total of 60 infants, (female = 29, male = 31), were included in the study. We did not find a statistically significant relation between shunt index and the presence of patent ductus arteriosus (p .05). A statistically significant positive correlation between the fraction of inspired oxygen and shunt index was found. As the postnatal ages progressed, the shunt index values tended to decrease significantly.Our results suggest that shunt index cannot be used as an indicator of hemodynamically significant patent ductus arteriosus in preterm infants. The postnatal age and fraction of inspired oxygen have a significant effect on shunt index in these patients. It was thought that the other possible factors that affect the shunt index should be investigated in preterms between certain postnatal ages.

The aim of the study was to investigate knee cartilage thickness in polycystic ovary syndrome (PCOS) patients using ultrasonography and to assess the effects of sex steroids on osteoarthritis development. A total of 90 female patients were enrolled in the study, including 47 patients diagnosed with PCOS as study group and 43 patients admitted to our hospital for any other complaints as control group. Ultrasonographic evaluation of both knees was performed in all patients. The knee cartilage thickness was measured at lateral condyle, intercondylar area and medial condyle. The measurements were averaged for each region. The mean femoral cartilage thickness was greater in the study group compared with control group in all regions, with a statistically significant difference (p, Cilj istraživanja bio je ultrazvučno procijeniti debljinu hrskavice koljena u bolesnica sa sindromom policističnih jajnika (SPCJ) i učinak spolnih hormona na razvoj osteoartritisa. U istraživanje je bilo uključeno ukupno 90 žena, tj. 47 bolesnica s dijagnozom SPCJ kao ispitna skupina i 43 bolesnice primljene na odjel zbog drugih tegoba kao kontrolna skupina. Ultrazvučna procjena obaju koljena učinjena je u svih bolesnica. Debljina hrskavice koljena mjerena je u lateralnom kondilu, interkondilarnom području i medijalnom kondilu te je izračunat prosjek mjerenja za svaku regiju. Srednja debljina koljenske hrskavice bila je veća u ispitnoj skupini u usporedbi s kontrolnom skupinom u svim regijama, a razlika je bila statistički značajna (p

Objective Telomere length is used as an indicator of biological aging. It is well known that one of the most remarkable risk factors of recurrent pregnancy losses is advanced maternal age. The objective of this study was to investigate the correlation between idiopathic recurrent pregnancy loss and telomere length. Method The study group included 40 women, while the control group consisted of 41 healthy women whose age and body mass index were matched. A venous blood sample was taken from all participants into EDTA tubes in the early follicular phase, and telomere length was measured through the qPCR technique. Results When the mean TL of the groups was compared, it was determined that TL was significantly shorter among the iRPL group (7763.89±924.58 base pair) compared to the control group (8398.84±1102.95 base pair) (p Conclusion Shortened telomere length might play a role in the etiology of iRPL. We are of the opinion that patients with RPL should be screened for the presence of cardiovascular diseases and other chronic diseases, as is the case for POF.

Objective To evaluate the relationship between the maternal pulmonary function test (PFT) and the Apgar score of the newborn, umbilical cord blood (UCB) gas values and the duration of delivery. Material and Methods The present study included 41 volunteer nulliparous pregnant women who presented to our obstetrics clinic and PFTs were performed by using spirometry. Results A significant positive correlation was observed between 5th-minute Apgar scores and maternal FEV1 (forced expiratory volume in the first second) (lt), FEV1%, FVC (lt), FVC% (r=0.509, p=0.003; r=0.47, p=0.007; r=0.434, p=0.013; r=0.417, p=0.017; respectively). A significant positive correlation was observed between UCB pH value and maternal FEV1 (lt), FVC (lt) (r=0.515, p=0.003; r=0.351, p=0.049; respectively). Conclusion Our results showed that FEV1 and FVC values, which indicate maternal respiratory functions, may affect Apgar scores of the newborn and UCB gas values.

Objective The aim of this study was to assess the diagnostic values of new biochemical markers that may be an alternative to the oral glucose tolerance test (OGTT) and determine the differences in these markers among three groups of women with varying degrees of glucose homeostasis dysregulation. Material and Methods This was a prospective study. All women were screened with 50 gram (g) oral glucose and a 100 g OGTT for gestational diabetes mellitus (GDM). The patients were divided into three groups depending on the result of the tests: no evidence of glucose metabolism abnormality (controls); impaired glucose tolerance (IGT); and GDM. All three groups were evaluated for serum human advanced glycation end-products (AGEs) concentrations, carboxymethyl lysine (CML) concentration and receptor for advanced glycation end-product concentrations (RAGE/AGER), body mass index (BMI), age, fasting glucose levels, obstetrical parameters and gestational age. Results The study included 180 women divided into 59 (32.8%) GDM, 50 (27.8%) IGT and 71 (39.4%) controls. Age was similar among the three groups. Whereas fasting glucose levels and BMI in the three groups was significantly different, AGEs, CML, RAGE/AGER levels were found as significantly different between the groups (p

Life-long anticoagulation therapy is mandatory in patients with mechanical heart valve to prevent the valve thrombosis. It may cause teratogenic effects and hemorrhage complications in the pregnant woman. In this report, we present a case who developed post-partum haemorrhage related to anticoagulants and subsequently developed aspiration pneumonia.

OBJECTIVE The aim of this study was to evaluate endometrial receptivity by measuring HOXA-10, HOXA-11, and LIF gene expressions in women with polycystic ovary syndrome. METHODS A total of 48 women were included in this clinical study. Thepatients were allocated to two groups: study group consisted of 28 patients with myoma uteri and control group consisted of 20 patients without myoma uteri. Endometrial sampling was performed during the proliferative phase. The biopsies obtained from the patients with myoma uteri were taken from the place where the fibroids were localized. HOXA-10, HOXA-11, and LIF expressions were measured in the endometrial sampling material. Demographic data of the patients such as age, obstetric and gynecologic history, medical conditions, medications, surgical history, last menstrual period were recorded. Also, the number, size, localization, and type of the myoma were registered. RESULTS The mean age of the patients was 42.07 and 38.17, respectively. HOXA-11 levels in the study and control groups were 0.004 ± 0.001 and 0.010 ± 0.001, respectively ( P

ObjectiveGlucagon-like peptide 1 (GLP-1), a gut-derived peptide has been reported to have insulin-like effects. Our aim is to examine GLP1 levels in hyperemesis gravidarum (HEG).Materials-methodsThe study population consisted of 2 groups: Group 1 (control subjects) consisted of 22 women with uncomplicated singleton pregnancies in the first trimester. Group 2 consisted of 22 singleton pregnancies complicated by HEG. Glucose and GLP1 levels were determined. Enzyme-linked Immunosorbent Assay Kit for Glucagon like Peptide 1 (GLP1) was used (Uscn, Life Science Inc.).ResultsNo significant differences in maternal age, gestational age and gravida were observed between hypermetric and control groups. Maternal serum GLP1 levels were significantly higher in HEG compared with control group (P = 0.004).ConclusionThe results of our study revealed that the presence of increased GLP1 levels in women with HEG could contribute to the pathogenesis of the disease. Our results indicated that increased GLP1 levels may be associated with hyperemesis gravidarum. The limitation of our study was the restricted number of patients. Large prospective and randomized studies are required to evaluate the effect of GLP1 levels on hyperemesis gravidarum.

OZET AMAC: Hamilelik esnasinda gecirilen asi ile onlenebilen hastaliklar sadece anne icin degil fetus icin de risklidir. Bu calismanin amaci; Turkiye’nin Yozgat ilindeki hamile kadinlarda secilmis asi ile onlenebilen hastalik etkenleri olan kizamik, kizamikcik, kabakulak, sucicegi (KKKS) ve tetanoz hastaligi antikorlarinin seroprevalansini arastirmaktir. METHOD: Kan ornekleri, hastanemiz kadin hastaliklari ve dogum poliklinigine basvuran 176 hamile kadindan alindi. KKKS virusleri ve tetanoza karsi spesifik antikor titreleri ELISA ile kantitatif olarak saptandi. Hastalik, asilama gecmisi ve demografik bilgilerinin dahil oldugu anket formu dolduruldu. SONUCLAR: Katilimcilarin yas ortalamasi 27.2±4.9 (18-45) idi. Tetanoz ,KKKS IgG seropozitifligi sirasiyla % 90.34, % 97.16, % 98.30, % 99.4, % 100 idi. Son 5 yil icerisinde tetanoz asisi olanlarda bagisiklik orani olmayanlara gore daha yuksek bulundu (93.7% ye 84.6 % , p= 0.049). Tetanoza karsi bagisik olanlarin yas ortalamasi 26.9±5, bagisik olmayanlarin yas ortalamasi 29.8±3.7 bulundu (p=0.0195). Yas ile tetanoz bagisiklik oranlari arasinda ters korelasyon tespit edildi. Yas artikca tetanoz bagisiklik oraninin azaldigi tespit edildi (p=0.002). TARTISMA: Calismamizda gebelerde yuksek oranda tetanoz ve KKKS bagisikligi bulunmustur. Ancak, hamilelik esnasinda enfeksiyonun neden oldugu riskler goz onunde bulunduruldugunda, asi ile onlenebilen hastaliklara karsi antikorlar; daha once asilanmamis ya da hastalik gecirmemis dogurganlik caginda olan kadinlarda taranmalidir ve seronegatif olanlar asilanmalidir. Anahtar kelimeler: gebelik, kizamik, kizamikcik, kabakulak, sucicegi, tetanoz, asi ile onlenebilen hastaliklar

Aim: Patent ductus arteriosus (PDA) is a frequent health problem in premature infants. Pharmacologic closure is recommended only for hemodynamically significant PDA (hsPDA) that is defined according to the clinical and echocardiographic criteria. The aim of this study was to explore the value of commonly used criteria in defining hsPDA and predicting the required number of courses of ibuprofen treatment to close PDA in premature infants. Methods: Sixty premature infants with a gestational age of ≤33 weeks were evaluated prospectively. Clinical and echocardiographic criteria [O2 requirement, ductus diameter (DD) and left atrial-to-aortic root diameter ratio (LA:Ao)] were used to define hsPDA. Clinical improvement after pharmacologic closure of PDA and association between the criteria and required number of ibuprofen courses were investigated. Results: O2 requirement decreased by PDA closure but was not different between patients with hsPDA and the others with PDA. Also, O2 requirement was not found to be associated with required number of ibuprofen courses. DD and LA:Ao were greater in patients with hsPDA. DD was found to be associated with required number of courses of ibuprofen treatment. Conclusion: Although there was an improvement in O2 requirement with PDA closure, echocardiographic criteria were found to be more valuable in defining hsPDA. DD should also be used to estimate the duration of treatment.

Objective Tonsillectomy is one of the most common surgical procedures performed at ear, nose, and throat clinics. Chronic recurrent tonsillitis, obstructive tonsillitis, and halitosis are among the most common indications for surgery. Determining whether the infection is chronic and the patient's annual number of infections are important in estimating the necessity for surgery to be performed due to infectious causes. Red blood cell distribution width (RDW) is a numerical value present in normal complete blood count that provides information about erythrocytes and their dimensions. Studies in recent years have shown that RDW increases in chronic infections, hypoxia, and oxidative stress. This study investigated the changes in RDW in patients with chronic tonsillitis and the effect tonsillectomy has on this value by comparing RDW between patients scheduled for tonsillectomy and normal population and examining preoperative and postoperative changes in RDW. Materials and Methods Sixty-three patients scheduled for tonsillectomy due to recurrent tonsillitis aged 4-14 years were included in the study. The control group consisted of 60 subjects comparable in terms of age and sex. Hemoglobin level and RDW were recorded by collecting 2 mlof blood before surgery and at 4 months postoperatively from all patients. Results Preoperative RDW was significantly higher in the patient group than in the control group. Comparison of patients' preoperative and postoperative RDW revealed a significant decrease in RDW after surgery. Conclusion As a biomarker showing chronic infection in patients with tonsillitis, RDW can provide support to the clinician in deciding on surgery. However, this has to be confirmed in further studies with greater participation.

Thrombus incidence is higher among neonates, especially in preterm infants, due to the associated additional risk factors.The medical recordings of premature infants who had been diagnosed as having intracardiac thrombus between January 2016 and January 2019 were evaluated retrospectively. We use recombinant tissue plasminogen activator when the thrombus is relatively large compared to left atrium, pedunculated, mobile, or snake shaped.A total of 13 premature patients were diagnosed as having intracardiac thrombus during the 3-year period. All were diagnosed during echocardiographic studies. Low molecular weight heparin was administered in four patients. In three, recombinant tissue plasminogen activator was started with low dose (0.01 mg/kg/h) and increased gradually to 0.06 mg/kg/h. In three, recombinant tissue plasminogen activators were started with standard dose (0.5 mg/kg/h). In one recombinant tissue, plasminogen activator was started with low dose (0.01 mg/kg/h) and increased to standard dose. Two patients died before treatment, three patients died during treatment, follow-up was not available for two patients, and thrombus completely resolved in six patients.In preterm babies with risk factors, intracardiac thrombus should be kept in mind during all echocardiographic studies. In our patients, low and standard dose regimens were used, and the treatment results were similar.

Objective: The aim of this study was to assess the awareness level of women about cervical smears, human papilloma virus (HPV), and HPV vaccine in a rural city in the central part of Anatolia. Materials and Methods: A total of 553 patients were included in the study. A 16 item questionnaire developed by our group was completed by all participants. The first part of the questionnaire collected the demographic and socioeconomic information of the participants. In the second part, it was questioned whether this information had a relationship with HPV, HPV vaccine awareness, and cervical screening tests. In the third part, the participants were asked questions related to the acceptance of an HPV vaccine for themselves and their willingness to give consent to have their children vaccinated. Results: In our study, it was found that HPV awareness significantly increased with the level of education, occupational status and total monthly family income (p

Purpose: This study aimed to investigate the feasibility and diagnostic power of unenhanced 3D turbo spin echo MR angiography sequence (a technique based on subtraction of corresponding images acquired in diastole and systole, Syngo Native Space-Siemens healthcare) to identify peripheral artery disease (PAD). Materials and methods: Thirty patients (619 arterial segments in total) suspected with PAD and who were assessed with lower extremity MDCT angiography were examined starting from the level of aortic bifurcation for both lower extremities by 3D native space MR angiography. Two readers assessed the image quality of native space MR angiography and number of lesions, their degrees of stenosis and localizations. The differences and compliance between the readers in the parameters assessed were investigated. Results: Out of 619 segments; Reader 1 considered 187 segments (30.2 %) and Reader 2 considered 177 segments (28.6 %) to have poor and inadequate MR image quality. When compared to CTA, sensitivity, specificity and diagnostic accuracy of native space MR angiography were calculated as 81.0, 83.1, 82.6 %, respectively, by Reader 1, while the same parameters were calculated as 69.9, 92.6, 84.9 %, respectively, by Reader 2. When the two readers were examined together, sensitivity, specificity, diagnostic accuracy were found to be 76.3, 88.1, 83.7 %, respectively, and the positive predictive value and negative predictive value was 70.3 and 89.9 %, respectively. A significantly better image quality was acquired with the age group below 50 years (p = 0.002). Conclusion: Native space MR angiography technique can be used as the first-step imaging technique before contrast-enhanced examinations in young and middle age patients with suspected PAD and for patients with the risk of nephrogenic systemic fibrosis in chronic renal failure. © 2016, Italian Society of Medical Radiology.

This study aimed to investigate the relationship between skinfold thickness and serum leptin, ghrelin, adiponectin, and resistin levels in infants of diabetic mothers. Biochemical parameters were also similar for the two groups (infants of diabetic mothers and controls) (p > 0.05). We confirmed that there was a negative correlation between birth weight and serum ghrelin level (p < 0.05) in the two groups. When it was evaluated for control newborns, a positive correlation between abdominal circumference and serum resistin level was found in the controls (p < 0.05). Our results indicate that gestational diabetes by appropriate diet or insulin treatment may be effective in the protection of fetuses of diabetic mothers from the negative effects of gestational diabetes. Ghrelin alone was negatively correlated with birth weight. This negative correlation could be potentially advantageous to infants, because a reduction in appetite might prevent excessive food intake and postnatal weight gain.

Objective Our aim was to determine how Ramadan fasting effects serum Human NAD-dependent deacetylase sirtuin 1 (SIRT1/SIR2L1) and visfatin levels during pregnancy. Materials and methods Thirty-six patients were included in this case-control study. The patient group consisted of 18 pregnant women who were Ramadan fasting. Another healthy 18 pregnant women with matching pregnancy weeks and ages formed the control group. Blood samples were obtained from the patients for biochemical analyses and serum adipokine level measurements. Results The mean sirtuin and visfatin levels in fasting pregnant women were 2.87 ± 0.95 and 60.18 ± 19.49 ng/mL, respectively, while the mean serum sirtuin and visfatin levels in the control group was determined to be 4.28 ± 1.45 and 23.26 ± 6.18 ng/mL, respectively. A statistically significant difference was determined between the groups (p = 0.002, p = 0.0001). A correlation analysis provided a negative correlation between number of fasting days and sirtuin levels (r = 0.45, p = 0.005) and a positive correlation with visfatin levels (r = 0.73, p = 0.0001). Conclusion As a result, while the serum sirtuin 1 level of pregnant women decreased due to fasting in Ramadan, we determined that their visfatin levels increased and this increase was in correlation with the days of fasting.

We aimed to evaluate vitamin D, apelin-36, and visfatin levels in patients with polycystic ovary syndrome (PCOS).The study was completed in six months, including a total of 110 patients who were admitted to the obstetrics and gynecology polyclinic. Patients with a diagnosis of PCOS were divided into two subgroups according to their vitamin D levels. Thirty-four patients had 10 ng/ml of vitamin D deficiency and 21 patients had 10-30 ng/ml of vitamin D insufficiency, with each being defined as a subgroup.Average apelin-36 and visfatin levels in PCOS patients were 2.52 ± 0.68 nmol/L and 72.63 ± 22:31 ng/ml, in the control group they were 0.92 ± 0.33 nmol/L, 24.66 ± 6 ng/ml, respectively. The difference found in PCOS patients was statistically significant (p = 0.0001, p = 0.0001).In conclusion, the present study shows that in PCOS patients with low levels of vitamin D, insulin resistance is greater and apelin-36 serum levels were significantly higher. Although there are different opinions in the literature on this subject, we believe that when vitamin D levels are brought to an optimal level in PCOS patient, it can prevent the negative effects of adipokines in the pathogenesis of PCOS.

Although the in vitro fertilization-intra-cytoplasmic sperm injection (IVF-ICSI) has been utilized widely, the management in patients with an autoimmune disease is still a challenge. The aim of this study was to demonstrate IVF-ICSI outcomes in infertile women with familial Mediterranean fever (FMF). Patient data were collected from the cases registered from January 2006 until January 2014. A total of 6152 assisted reproductive technology (ART) cycles were analyzed retrospectively in the Ankara Zekai Tahir Burak Women’s Health Education and Research Hospital. Ten infertile women with FMF were included in the study. Baseline clinical and laboratory characteristics were collected and perinatal outcomes evaluated. T e mean age (years), duration of infertility (years) and body mass index (kg/m2) were 29.9±5.3, 5.7±5.3 and 27.9±5.7, respectively. The mean baseline follicle-stimulating hormone (FSH; IU/L), estradiol (E2; pg/mL) and antral follicle count were 7.0±2.4, 48.1±15.8 and 7.9±2.9, respectively. The distribution of ovarian response was heterogeneous. Fourteen cycles in ten patients were evaluated. Embryo transfer could be achieved in only ten cycles. Three out of ten patients became pregnant. No adverse perinatal outcome was observed. Our findings indicate that FMF might have no impact on ART cycles.

Tracheobronchial amyloidosis is a localised form of amyloidosis characterised by the accumulation of amyloid deposit in the trachea, main bronchi and segmentary bronchi. Although diffuse tracheobronchial amyloidosis is the most frequently seen form of primary pulmonary amyloidosis, this is a rare disease. It is demonstrated with symptoms such as progressive dyspnea, cough and haemoptysis. It may cause airway obstruction, atelectasis and recurrent bronchopulmonary infections. Although the proximal section of the tracheobronchial tree can be visualised with chest radiography and fluoroscopy, the basis for examination is computed tomography (CT). The tracheobronchial tree can be effectively evaluated with high resolution images provided by multidetector CT (MDCT) and the post-processing images of them (multiplanar reformations [MPR], minimum intensity projections [MinIP], 3D volume-rendered images (3D VR), virtual bronchoscopic images) (4). The clinical and radiological findings are here presented of a rarely encountered case of tracheal amyloidosis initially diagnosed with MDCT.

Background: 128-Multi-detector computerized tomography (128-MDCT) technologies make the detection of inferior phrenic arteries (IPAs) originations and traces possible. Knowing their originating and variations is very important for planning interventional and surgical procedures.

Objectives The aim of the study was to compare bone mineral density (BMD) in healthy postmenopausal women to BMD in type 2 diabetic hypertensive postmenopausal women with hyperlipidemia. Methods Fifty type 2 diabetic and hypertensive postmenopausal women with hyperlipidemia and 51 age and body mass index (BMI) matched healthy postmenopausal women were included. Lumbar spine and femoral neck BMD were noted in both groups. BMD was measured using dual energy X-ray absorptiometry (DXA). Serum alkaline phosphatase (ALP), calcium and phosphorous were also measured. Pearson correlation coefficients were used to establish the relationship between various clinical characteristics. Results There were no significant differences between two groups in respect to lumbar and vertebral BMD values, age, BMI, gravidity, parity. Serum cholesterol and fasting glucose levels were significantly different between each groups (P = 0.0001, P = 0.002). Conclusion We found that, accompanying chronic diseases such as diabetes, hypertension and hyperlipidemia don't affect the BMD measurements at postmenopausal period. So these postmenopausal women don't have excess risk regarding osteoporosis.

Background To investigate the transthoracic computed tomography (CT)-guided lung nodule biopsy complications and risk factors associated with the development of these complications. Methods We retrospectively evaluated a total of 41 CT-guided transthoracic biopsy complications. Data was analyzed by chi-square and independent sample t-tests. Results Twenty-seven patients (28.7%) developed pneumothorax and eight patients (8.5%) developed parenchymal hemorrhage, and four patients (4.3%) hemothorax and two (2.1%) patients developed subcutaneous emphysema. A significant correlation was obtained between the development of pneumothorax and lesion size (P = 0.040), and the distance that traversed the parenchyma (P = 0.001). There was a statistically significant difference between the parenchymal hemorrhage and lesion size and the distance from passed parenchyma (P values were 0.021 and 0.008, respectively). An increased incidence of parenchymal hemorrhage and pneumothorax was observed at small size and deep-seated lesions. Conclusion Lesion size and the distance that traversed the parenchyma on the biopsy tract are the most important factors that influence the development of complications in CT-guided transthoracic biopsy.

With continuing developments in the field of neonatology, survival rates of low birth weight and small for gestational age infants have increased, which in turn has brought important prematurity-related problems. The aim of this study was to evaluate retrospectively the prematurity problems that are the significant causes of morbidity and mortality.613 premature infants hospitalized in the neonatal intensive care unit of Ataturk University Medical Faculty Hospital between January 2010 and January 2012 were included in this study. Infants were divided into groups according to their birth weight and gestational age.323 infants were male (52.6%) and 290 were female (47.4%). 63.9% of infants weighed ≥1500 grams, and 58.5% had a gestational age of ≥33 weeks. Respiratory distress syndrome (RDS) was detected in 249 (40.6%), bronchopulmonary dysplasia (BPD) in 124 (20.2%), necrotizing enterocolitis (NEC) in 41 (6.6%), retinopathy of prematurity (ROP) in 202 (32.9%), and intracranial hemorrhage (ICH) in 15 (2.4%). RDS, BPD, NEC, ROP, and ICH rates were inversely proportional to decreases in gestational age and birth weight, and were found to be statistically significant.Mortality and morbidity rates were similar to the other data published from our country, but the rates were above those reported in developed countries. We believe that our morbidity and mortality rates can reach levels comparable to those of developed countries with improved antenatal care, regular follow-up of pregnancy and increased numbers of physicians and health care personnel per patient.Neonatoloji alanındaki gelişmelerle birlikte çok düşük doğum ağırlıklı prematüre bebeklerin yaşatılabilme oranlarındaki artış prematüreliğe bağlı önemli problemlerin çoğalmasına neden olmuştur. Bu çalışmada geriye dönük olarak prematüreliğe bağlı morbidite ve mortalite nedenlerinin değerlendirilmesi amaçlanmıştır.Bu çalışmaya Atatürk Üniversitesi Tıp Fakültesi Hastanesi, Yenidoğan Servisi’ne Ocak 2010 ile Ocak 2012 arasında yatan 613 prematüre bebek dahil edildi. Bebekler doğum ağırlığına ve gebelik yaşlarına göre gruplara ayrıldı.Bebeklerin 323’ü (%52,6) erkek, 290’ı kız (%47,4) idi. Bebeklerin %63,9’u 1500 gr ve üzerinde, %58,’i 33 hafta ve üzerindeydi. Bebeklerin 249’unda (%40,6) respiratuar distres sendromu (RDS), 202’sinde (%32,9) prematüre retinopatisi (PR), 137’sinde (%22,3) patent ductus arteriosus (PDA), 124’ünde (%20,2) bronkopulmoner displazi (BPD), 41’inde (%6,6) nekrotizan enterokolit (NEK), 15’inde (%2,4) intrakraniyal kanama (İKK) tespit edildi. RDS, BPD, PDA, NEK, PR, İKK oranlarının gebelik yaşı ve doğum ağırlığı düştükçe ters orantılı olarak arttığı saptandı ve istatistiksel olarak anlamlı bulundu.Mortalite ve morbidite oranlarımızın ülkemizden yayınlanan verilerle benzerlik göstermesine karşın, gelişmiş ülkelerin oranlarının üzerinde olduğu görülmüştür. Antenatal bakımın iyileştirilmesi, gebelik takiplerinin düzenli yapılması ve hasta başına düşen doktor ve yardımcı sağlık personeli sayımızın artmasıyla birlikte morbidite ve mortalite oranlarımızın gelişmiş ülkeler seviyesine ulaşacağını düşünmekteyiz.

PURPOSE We aimed to investigate the effectiveness and complications of transthoracic CT-guided biopsy techniques. METHODS A total of 94 CT-guided percutaneous transthoracic biopsy procedures performed in 85 patients were retrospectively evaluated. Core biopsy technique was used in 87 procedures and transthoracic fine-needle aspiration biopsy was used in seven procedures. RESULTS Diagnostic results were achieved in 79 of 94 biopsy procedures. Pathology results were malignant in 54 patients, suspicious for malignancy in three patients, benign in five patients, and benign nonspecific in 17 patients. Specific diagnoses were obtained in 59 patients (62.8%) using core biopsy, but no specific diagnosis could be reached with transthoracic fine-needle aspiration biopsy. Complications included pneumothorax in 27 patients (28.7%) and parenchymal hemorrhage during and after the procedure in eight patients (8.5%). CONCLUSIONS CT-guided percutaneous transthoracic needle biopsy is a highly accurate procedure for histopathological diagnosis of thoracic masses. In addition, percutaneous transthoracic biopsy has an acceptably low complication rate and it reduces the need for more invasive surgical procedures.

BACKGROUND Urinary incontinence is a significant medico-social problem and its incidence increases up to 70% in the postmenopausal period. OBJECTIVES We aimed to compare the efficacy and safety of transobturator adjustable tape (TOT) and mini sling in female urinary incontinence. MATERIAL AND METHODS A total of 69 patients were included in the study. Single surgeon applied TOT (n=56 with ISD) or 13 mini sling (n=13 with ISD). Patients were considered to have ISD identified by a Valsalva leak point pressure (VLPP) measurement

Aim: High definition(HD) Computed Tomography(CT) was presented as an improvement in CT technology which is known to have increased in sharpness of the edges of the vessels and stents in vitro. The purpose of the study was to take the effectivity of this technology clinically by evaluating the diameter and wall thickness of carotid vessels in stroke patients. Material and Method: CT Angiography(CTA) of carotid arteries; 19 with HDCT and 21 with standard definition(SD) CT, totally 40 stroke patients were examined in different University hospitals with the same imaging protocols. The vessel wall inner and outer diameters and thickness of common, internal and external carotid arteries (CCA, ICA and ECA) were assessed by two blinded radiologists. Comparison was made between the scanners for image quality, motion artefacts and image noise. Results: HD and SD CT angiography achieved comparable. The agreement of the radiologists and Cronbach Alpha value was higher in HDCT showing that vessel contours are sharper in HDCT images and measurements are more reliable. Discussion: Due to new gemstone technology image quality was improved in HDCT angiography, is found much more effective than SDCT to show the edges of the vessel wall so qualifies the establishment of the plaques and extent of osteal stenosis.

WOS: 000376566800003 Aim: Peripheral Arterial Disease(PAD) and abdominal aorta aneurysm(AAA) are frequent problems in geriatric population. In DSA, CTA or MRA techniques contrast agents has to be used for diagnosis that can be nephrotoxic for elderly patients. Magnetic resonans imaging (MRI) is the most powerful, non-ionising radiological diagnostic tool that has the highest soft tissue contrast resolution. The aim of our study was to investigate the effectivity of MRI by the means of detecting the AAA and PAD in comparison with DSA. Material and Method: After getting ethical commitee approvel and informed consent, we have performed Balanced turbo field echo(B-TFE) MRI technique without contrast agent in 1.5 Tesla MRI device before DSA examination. The luminal diameters of renal arteries, infrarenal abdominal aorta, iliac and femoral arteries was measured by using Philips DICOM Viewer R2.2 application. The intraclass corelation coefficient and reliability used to check if the techniques could be used for each other and the t-test was used to measure the differences between them. Results: There has been a high relationship between B-TFE and DSA in detecting the pathologies of larger arteries like aorta. In the case of small arterial pathologies, there is relatively lower relationship between BTFE and DSA. Discussion: For the diagnosis of AAA and PAD, DSA is the gold standart technique but it is invasive and patients have radiation exposure. In the follow up of geriatric patients with larger arterial pathologies B-TFE can be used instead of contrast enhanced MRA and invasive DSA.

WOS: 000393204400005, PubMed: 27503115, Purpose: To compare unenhanced three-dimensional (3D) NATIVE (R) true fast imaging with steady-state precession (TrueFISP) magnetic resonance (MR) angiography with the more conventional MR angiography technique obtained after intravenous administration of a gadolinium chelate in the evaluation of renal arteries and their branches in patients with suspected renal artery stenosis. Materials and methods: A total of 39 patients (25 men, 14 women) with a mean age of 51.4 +/- 17.5 years (SD) (range: 10-82 years) were included in the study. All patients with suspected renal artery stenosis underwent unenhanced 3D NATIVE (R) TrueFISP MR angiography and contrast- enhanced MR angiography. The two MR angiography methods were compared by two independent readers for image quality using a four-point scale, diagnostic performance and grading of renal artery stenosis on a total of 78 renal arteries. Results: For both readers image quality of unenhanced 3D NATIVE (R) TrueFISP MR angiography(3.12 to 3.63) was greater than that of contrast-enhanced MR angiography (1.94 to 2.71) for renal artery ostium-trunk and the left renal artery segmental branches. The sensitivity of 3D NATIVE (R) TrueFISP MR angiography for the diagnosis of renal artery stenosis was 100% for both readers for the right renal artery and 66% and 80% for the left renal artery for reader 1 and reader 2, respectively. Agreement between 3D NATIVE (R) TrueFISP MR angiography and CE-MR angiography was 95% (74/78) for reader 1 and 92% (72/78) for reader 2. Conclusion: Unenhanced NATIVE (R) TrueFISP magnetic resonance angiography can play an additional role in the evaluation of renal arteries in patients with hypertension, especially in subjects at risk of nephrogenic systemic fibrosis. (C) 2016 Editions francaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.