1. A Case of Tacrolimus-Induced Posterior Reversible Encephalopathy Syndrome Initially Presenting as a Bilateral Optic Neuropathy
- Author
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Upneet Bains, Sumana S Kommana, Jeffrey D Henderer, and Vivian Fasula
- Subjects
medicine.medical_specialty ,Weakness ,genetic structures ,medicine.medical_treatment ,Case Report ,Optic neuropathy ,Tacrolimus ,lcsh:Ophthalmology ,medicine ,Posterior reversible encephalitis syndrome ,Kidney transplantation ,Subclinical infection ,business.industry ,Medication toxicity ,Posterior reversible encephalopathy syndrome ,Immunosuppression ,Ischemic optic neuropathy ,medicine.disease ,eye diseases ,Surgery ,Ophthalmology ,surgical procedures, operative ,lcsh:RE1-994 ,sense organs ,medicine.symptom ,business - Abstract
Purpose: To report a case of asymmetric bilateral optic neuropathy in a patient receiving tacrolimus for immunosuppression after kidney transplantation with subsequent stroke-like symptoms of posterior reversible encephalopathy syndrome (PRES). Method: Case report. In a 54-year-old Hispanic male receiving tacrolimus after orthotropic kidney transplantation, serial ophthalmologic examinations, laboratory studies, and imaging were performed. Results: The patient had deterioration of vision in the left eye with subclinical optic neuropathy in the right eye, with clinical features resembling ischemic optic neuropathy. Additionally, he developed a change in mental state with weakness of extremities. After the cessation of tacrolimus, the visual loss remained but the other neurologic symptoms resolved. Conclusion: Tacrolimus may be associated with optic neuropathy and PRES at the initial presentation to an ophthalmologist.
- Published
- 2019
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