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Cost and yield considerations when expanding recruitment for genetic studies: the primary open-angle African American glaucoma genetics study
- Source :
- BMC Medical Research Methodology, BMC Medical Research Methodology, Vol 17, Iss 1, Pp 1-7 (2017)
- Publication Year :
- 2017
-
Abstract
- Background African Americans have been historically under-represented in genetic studies. More research is needed on effective recruitment strategies for this population, especially on approaches that supplement traditional clinic enrollment. This study evaluates the cost and efficacy of four supplemental recruitment methods employed by the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. Methods After enrolling 2304 patients from University of Pennsylvania ophthalmology clinics, the POAAGG study implemented four new recruitment methods to supplement clinic enrollment. These methods included: 1) outreach in the local community, 2) in-house screening of community members (“in-reach”), 3) expansion to two external sites, and 4) sampling of the Penn Medicine Biobank. The cost per subject was calculated for each method and enrollment among cases, controls, and suspects was reported. Results The biobank offered the lowest cost ($5/subject) and highest enrollment yield (n = 2073) of the four methods, but provided very few glaucoma cases (n = 31). External sites provided 88% of cases recruited from the four methods (n = 388; $85/subject), but case enrollment at these sites declined over the next 9 months as the pool of eligible subjects was depleted. Outreach and in-reach screenings of community members were very high cost for low return on enrollment ($569/subject for 102 subjects and $606/subject for 45 subjects, respectively). Conclusions The biobank offered the most cost-effective method for control enrollment, while expansion to external sites was necessary to recruit richly phenotyped cases. These recruitment methods helped the POAAGG study to exceed enrollment of the discovery cohort (n = 5500) 6 months in advance of the predicated deadline and could be adopted by other large genetic studies seeking to supplement clinic enrollment.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Outreach
Epidemiology
Cost-Benefit Analysis
Population
Alternative medicine
Glaucoma
Health Informatics
030105 genetics & heredity
External sites
03 medical and health sciences
0302 clinical medicine
Enrollment
Medicine
Humans
Genetic Testing
Recruitment methods
education
Genetic studies
Aged
African american
Genetics
Philadelphia
African Americans
lcsh:R5-920
education.field_of_study
business.industry
Patient Selection
African American recruitment
Reproducibility of Results
Middle Aged
medicine.disease
Biobank
3. Good health
Black or African American
Biobanks
African American enrollment
Cohort
030221 ophthalmology & optometry
Recruitment
lcsh:Medicine (General)
business
Glaucoma, Open-Angle
Research Article
Subjects
Details
- ISSN :
- 14712288
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC medical research methodology
- Accession number :
- edsair.doi.dedup.....d61bb5f387cbb6ccb5e75a956611b842