1. Implications for comorbidities, maternal smoking during pregnancy, and inflammation in current smokers
- Author
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Sandra Odebrecht Vargas Nunes, Mauro Porcu, Heber Odebrecht Vargas, Mariana Ragassi Urbano, Waldiceu A. Verri, Ana C. Rossaneis, Robson Zazula, Regina Célia Bueno Rezende Machado, Adna de Moura Fereli Reis, and Décio Sabattini Barbosa
- Subjects
medicine.medical_specialty ,Maternal smoking ,Population ,Lipid peroxidation ,Inflammation ,Tobacco use disorder ,Childhood adverse experiences ,Internal medicine ,medicine ,education ,RZ400-408 ,Pregnancy ,education.field_of_study ,Lipid Hydroperoxide ,medicine.diagnostic_test ,business.industry ,Depression ,Leptin ,medicine.disease ,Lipid profile ,behavior and behavior mechanisms ,Major depressive disorder ,medicine.symptom ,business ,Mental healing - Abstract
Background: Evaluate comorbidities, childhood abuse, and inflammation in current heavy-smokers compared to light-smokers and never-smokers. Methods: Current-Smokers (n = 129) and never-smokers (n = 85) were screened for the use of alcohol, tobacco, and other substances, and assessed for nicotine dependence and childhood trauma. Tumor necrosis factor alpha (TNF-α) and its receptors (sTNFR1 and sTNFR2), leptin, lipid hydroperoxide, and lipid profile biomarkers were measured after overnight fasting. Results: Current-smokers presented higher prevalence of major depressive disorder (PR = 1.79, CI 95% [1.36–2.37], p
- Published
- 2021