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The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence
- Source :
- Neuroscience and biobehavioral reviews. 37(8)
- Publication Year :
- 2012
-
Abstract
- Nicotine dependence is common in people with mood disorders; however the operative pathways are not well understood. This paper reviews the contribution of inflammation and oxidative stress pathways to the co-association of depressive disorder and nicotine dependence, including increased levels of pro-inflammatory cytokines, increased acute phase proteins, decreased levels of antioxidants and increased oxidative stress. These could be some of the potential pathophysiological mechanisms involved in neuroprogression. The shared inflammatory and oxidative stress pathways by which smoking may increase the risk for development of depressive disorders are in part mediated by increased levels of pro-inflammatory cytokines, diverse neurotransmitter systems, activation the hypothalamic-pituitary-adrenal (HPA) axis, microglial activation, increased production of oxidative stress and decreased levels of antioxidants. Depressive disorder and nicotine dependence are additionally linked imbalance between neuroprotective and neurodegenerative metabolites in the kynurenine pathway that contribute to neuroprogression. These pathways provide a mechanistic framework for understanding the interaction between nicotine dependence and depressive disorder.
- Subjects :
- medicine.medical_specialty
Kynurenine pathway
Cognitive Neuroscience
Inflammation
medicine.disease_cause
Neuroprotection
Nicotine
Behavioral Neuroscience
Internal medicine
medicine
Humans
Psychiatry
Depressive Disorder, Major
business.industry
Acute-phase protein
Brain
Tobacco Use Disorder
medicine.disease
Oxidative Stress
Neuropsychology and Physiological Psychology
Endocrinology
Mood disorders
Major depressive disorder
medicine.symptom
business
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 18737528
- Volume :
- 37
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Neuroscience and biobehavioral reviews
- Accession number :
- edsair.doi.dedup.....0ea735866c29dbe737db63ed34d1644e