1. Meal-Induced Symptoms in Children with Dyspepsia–Relationships to Sex and the Presence of Gastroparesis
- Author
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Robert J. Shulman, Liz Febo-Rodriguez, Andrew C. Sher, Salma Musaad, and Bruno P. Chumpitazi
- Subjects
Male ,medicine.medical_specialty ,Gastroparesis ,Adolescent ,Nausea ,Severity of Illness Index ,Gastroenterology ,Article ,Eating ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Bloating ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,Ingestion ,Prospective Studies ,030212 general & internal medicine ,Dyspepsia ,Child ,Radionuclide Imaging ,Meals ,Meal ,Gastric emptying ,business.industry ,digestive, oral, and skin physiology ,Symptom severity ,medicine.disease ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Cohort ,Female ,medicine.symptom ,business - Abstract
OBJECTIVES: To test the hypothesis that in dyspeptic children, prospective symptom severity following ingestion of a meal would correlate with percent gastric retention, and those ultimately diagnosed with gastroparesis would report worse symptoms. STUDY DESIGN: Prospective, single center study with 104 children with dyspepsia completing a prospective dyspepsia symptom questionnaire before and after eating a standardized Tougas meal during gastric emptying scintigraphy (GES). Main outcomes included correlation between gastric retention and symptoms and comparison of symptom severity between those with and without gastroparesis. RESULTS: 52 children (50%) had gastroparesis (gastroparesis: 12.5 ± 2.9 years, 65% female; non-gastroparesis: 13.0 ± 2.9 years, 60% female; all P>0.05). Bloating was the only symptom significantly worse in youth with gastroparesis. For the entire cohort, bloating and fullness correlated with percent retention. However, in those with gastroparesis, only nausea correlated with retention (4 hr.; r(s)=0.275, P< .05). Girls with gastroparesis had significantly worse symptoms (except satiety) when compared with boys with gastroparesis (P
- Published
- 2021