Back to Search
Start Over
Pro-Dopamine Regulator – (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome (RDS)
- Source :
- Journal of reward deficiency syndrome and addiction science
- Publication Year :
- 2017
-
Abstract
- We are faced with a worldwide opiate/opioid epidemic that is devastating. According to the Centers for Disease Control and Prevention (CDC), at least 127 people, young and old, are dying every day in America due to narcotic overdose. The Food and Drug Administration (FDA) has approved Medication-Assisted Treatments (MATs) for opiate/opioids as well as alcohol and nicotine. The mechanism of action of most MATS favors either blocking of dopaminergic function or a form of Opiate Substitution Therapy (OST). These treatment options are adequate for short-term treatment of the symptoms of addiction and harm reduction but fail long-term to deal with the cause or lead to recovery. There is a need to continue to seek better treatment options. This mini-review is the history of the development of one such treatment; a glutaminergic-dopaminergic optimization complex called KB220. Growing evidence indicates that brain reward circuitry controls drug addiction, in conjunction with "anti-reward systems" as the "anti-reward systems" can be affected by both glutaminergic and dopaminergic transmission. KB220 may likely alter the function of these regions and provide for the possible eventual balancing the brain reward system and the induction of "dopamine homeostasis." Many of these concepts have been reported elsewhere and have become an integral part of the addiction science literature. However, the concise review may encourage readership to reconsider these facts and stimulate further research focused on the impact that the induction of "dopamine homeostasis" may have on recovery and relapse prevention.
- Subjects :
- medicine.medical_specialty
media_common.quotation_subject
Relapse prevention
Article
03 medical and health sciences
Reward system
Opioid epidemic
0302 clinical medicine
Dopamine
medicine
Psychiatry
Reward cascade
media_common
Harm reduction
business.industry
Addiction
Dopaminergic
Metenkephalin
3. Good health
030227 psychiatry
Neurotransmitter signaling
Brain stimulation reward
Opiate
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 24751405
- Volume :
- 3
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of reward deficiency syndrome and addiction science
- Accession number :
- edsair.doi.dedup.....698e6563ed5b59cbe51215fa6d00b932