1. Antioxidants activities and concentration of selenium, zinc and copper in preterm and IUGR human placentas
- Author
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Renata Wietecha-Posłuszny, Halina Mrowiec, Stanisław Walas, Antoni Marcinek, Monika Zadrożna, Małgorzata Gawlik, Barbara Nowak, and Paweł Zagrodzki
- Subjects
Adult ,medicine.medical_specialty ,Placenta ,chemistry.chemical_element ,Intrauterine growth restriction ,Dehydrogenase ,Biochemistry ,Antioxidants ,Inorganic Chemistry ,Superoxide dismutase ,Selenium ,chemistry.chemical_compound ,Pregnancy ,Internal medicine ,medicine ,Humans ,Cytochrome c oxidase ,reproductive and urinary physiology ,chemistry.chemical_classification ,Fetal Growth Retardation ,biology ,Glutathione peroxidase ,Glutathione ,medicine.disease ,Trace Elements ,Zinc ,Endocrinology ,medicine.anatomical_structure ,chemistry ,embryonic structures ,biology.protein ,Molecular Medicine ,Female ,Copper - Abstract
The aim of this study was to examine changes in activities of cytochrome c oxidase (CCO), glucose-6-phosphate dehydrogenase (G6PDH), Cu-Zn superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px), glutathione (GSH) levels and copper (Cu), zinc (Zn) and selenium (Se) concentrations, and to assess the possible differences between preterm placentas, placentas from term pregnancies complicated by intrauterine growth restriction (IUGR) and full-term control placentas. The enzyme activities and the level of GSH decreased in IUGR and preterm placentas in comparison with the control group. CCO activity and GSH level in preterm placentas were markedly lower compared with the IUGR (P0.01; P0.05) and control (P0.01; P0.05) placentas, respectively. In IUGR placentas the level of Cu was reduced by 23% (P0.05) and Zn by 37%. In preterm placentas the level of Cu was reduced by 19% and Zn by 42%. Se level in IUGR and preterm placentas was higher (P0.05) by 28% and 32% than in control group, respectively. The strong relation was observed between birth weight and CCO activity, birth weight and Cu-Zn SOD activity, and a low level of Zn and Cu influenced the birth weight especially in IUGR cases. Moreover, the strong inverse correlation between Se level and birth weight, Se level and placental weight and Se level and CCO activity are new findings.
- Published
- 2009