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Villous trophoblast cell turnover in placentas from preterm pregnancy and pregnancy complicated by intrauterine growth restriction (IUGR)
- Source :
- Folia biologica. 58(1-2)
- Publication Year :
- 2010
-
Abstract
- Disturbed trophoblast turnover, a key process in placental physiology, may lead to a number of pregnancy-associated pathologies. This study examines PCNA expression and describes and quantifies morphological changes during trophoblast turnover in preterm placentas and term placentas complicated by IUGR. The number ofCTF cells increased two-fold in preterm and IUGR placentas. A concurrent and slightly reduced proliferation rate of these cells was also found. The number of STF nuclei of terminal villi was lower by 21% in IUGR and by 18% in preterm placentas (P > 0.05). A statistically significant reduction of the number of syncytial knots by 50% as compared to the control placentas was observed. Correlations between PCNA-reactive CTF nuclei and syncytial knots, PCNA-reactive CTF nuclei and CCO activity, and CCO activity and syncytial knots were found. Moreover, a strong inverse relation was observed between syncytial knots and CTF cells, and CCO activity and CTF cells.
- Subjects :
- medicine.medical_specialty
proliferation
Placenta
Intrauterine growth restriction
Biology
trophoblast turnover
General Biochemistry, Genetics and Molecular Biology
Preterm pregnancy
Andrology
IUGR placenta
Pregnancy
Cell turnover
medicine
Birth Weight
Humans
reproductive and urinary physiology
Fetal Growth Retardation
Obstetrics
preterm placenta
Infant, Newborn
Trophoblast
General Medicine
medicine.disease
Villous trophoblast
Trophoblasts
Pregnancy Complications
medicine.anatomical_structure
Syncytial knots
embryonic structures
Premature Birth
Female
Chorionic Villi
morphometry
Subjects
Details
- ISSN :
- 00155497
- Volume :
- 58
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Folia biologica
- Accession number :
- edsair.doi.dedup.....dc1c44ef154042d92d62841bff4ac8eb