Search

Your search keyword '"Natasha Kinsella"' showing total 4 results
Start Over Author "Natasha Kinsella" Topic medicine.drug
4 results on '"Natasha Kinsella"'

1. ChemInform Abstract: Synthesis and in vivo Evaluation of 3-Substituted Gababutins

Author

Simon A. Osborne, Sophie Caroline Williams, Nicola E.A. Chessum, Mark J. Field, Natasha Kinsella, Pauline Carnell, Jack K. Kinsora, David C. Blakemore, and Justin Stephen Bryans

Subjects
Gabapentin, In vivo, Chemistry, Stereochemistry, Calcium channel, Protein subunit, medicine, chemistry.chemical_element, Potency, General Medicine, Calcium, medicine.drug
Abstract

A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the α2δ calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo models of pain and anxiety.

Published
2010
Full Text
View/download PDF

2. ChemInform Abstract: Synthesis and in vivo Evaluation of 3,4-Disubstituted Gababutins

Author

Jack K. Kinsora, Lisa R. Thompson, Pauline Carnell, Mark J. Field, Natasha Kinsella, Justin Stephen Bryans, Sophie Caroline Williams, Simon A. Osborne, David C. Blakemore, and Leonard T. Meltzer

Subjects
Gabapentin, In vivo, Stereochemistry, Chemistry, medicine, Alpha (ethology), Potency, General Medicine, Ring (chemistry), medicine.drug
Abstract

A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against alpha(2)delta and was profiled in in vivo models of pain and anxiety.

Published
2010
Full Text
View/download PDF

3. Synthesis and in vivo evaluation of bicyclic gababutins

Author

Justin Stephen Bryans, David C. Blakemore, Simon A. Osborne, Andrew N. Warren, Pauline Carnell, Natasha Kinsella, Sophie Caroline Williams, Nicola E.A. Chessum, Christopher L. Carr, and Mark J. Field

Subjects
Gabapentin, Cyclohexanecarboxylic Acids, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Ring (chemistry), Biochemistry, Bridged Bicyclo Compounds, Structure-Activity Relationship, Cricetulus, In vivo, Cricetinae, Drug Discovery, medicine, Potency, Animals, Amines, Amino Acids, Molecular Biology, gamma-Aminobutyric Acid, Pain Measurement, Bicyclic molecule, Chemistry, Organic Chemistry, Stereoisomerism, Rats, Blood-Brain Barrier, Neuropathic pain, Molecular Medicine, Neuralgia, medicine.drug
Abstract

Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (−)-(11A) and (20A) which both had an excellent level of potency against α2δ and were profiled in an in vivo model of neuropathic pain.

Published
2009

4. Synthesis and in vivo evaluation of 3-substituted gababutins

Author

Pauline Carnell, David C. Blakemore, Natasha Kinsella, Mark J. Field, Jack K. Kinsora, Simon A. Osborne, Sophie Caroline Williams, Nicola E.A. Chessum, and Justin Stephen Bryans

Subjects
Cyclohexanecarboxylic Acids, Stereochemistry, Clinical Biochemistry, Analgesic, Pregabalin, Pharmaceutical Science, chemistry.chemical_element, Cyclopentanes, Calcium, Carrageenan, Biochemistry, Chemical synthesis, In vivo, Drug Discovery, medicine, Potency, Animals, Amines, Amino Acids, Molecular Biology, gamma-Aminobutyric Acid, Calcium channel, Organic Chemistry, Stereoisomerism, Rats, chemistry, Anti-Anxiety Agents, Hyperalgesia, Molecular Medicine, Calcium Channels, medicine.symptom, Gabapentin, medicine.drug
Abstract

A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the alpha2delta calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo models of pain and anxiety.

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results