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Synthesis and in vivo evaluation of bicyclic gababutins

Authors :
Justin Stephen Bryans
David C. Blakemore
Simon A. Osborne
Andrew N. Warren
Pauline Carnell
Natasha Kinsella
Sophie Caroline Williams
Nicola E.A. Chessum
Christopher L. Carr
Mark J. Field
Source :
Bioorganicmedicinal chemistry letters. 20(2)
Publication Year :
2009

Abstract

Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (−)-(11A) and (20A) which both had an excellent level of potency against α2δ and were profiled in an in vivo model of neuropathic pain.

Details

ISSN :
14643405
Volume :
20
Issue :
2
Database :
OpenAIRE
Journal :
Bioorganicmedicinal chemistry letters
Accession number :
edsair.doi.dedup.....75b555ffed073e7ca0a441ec5e587197