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Synthesis and in vivo evaluation of bicyclic gababutins
- Source :
- Bioorganicmedicinal chemistry letters. 20(2)
- Publication Year :
- 2009
-
Abstract
- Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (−)-(11A) and (20A) which both had an excellent level of potency against α2δ and were profiled in an in vivo model of neuropathic pain.
- Subjects :
- Gabapentin
Cyclohexanecarboxylic Acids
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
CHO Cells
Ring (chemistry)
Biochemistry
Bridged Bicyclo Compounds
Structure-Activity Relationship
Cricetulus
In vivo
Cricetinae
Drug Discovery
medicine
Potency
Animals
Amines
Amino Acids
Molecular Biology
gamma-Aminobutyric Acid
Pain Measurement
Bicyclic molecule
Chemistry
Organic Chemistry
Stereoisomerism
Rats
Blood-Brain Barrier
Neuropathic pain
Molecular Medicine
Neuralgia
medicine.drug
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 20
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....75b555ffed073e7ca0a441ec5e587197