1. Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer
- Author
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Tayyaba Hasan, Rowland Illing, B. W. Pogue, M. T. Huggett, Marco Novelli, A. Gillams, SP Pereira, S. Mosse, Michael Jermyn, E. Kent, and Sg Bown
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Porphyrins ,medicine.medical_treatment ,Photodynamic therapy ,Adenocarcinoma ,Necrosis ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Pancreatic cancer ,pancreatic adenocarcinoma ,medicine ,Humans ,Aged ,030304 developmental biology ,0303 health sciences ,verteporfin ,Photosensitizing Agents ,business.industry ,Skin photosensitivity ,Irreversible electroporation ,Middle Aged ,medicine.disease ,Verteporfin ,3. Good health ,Surgery ,Pancreatic Neoplasms ,Radiation therapy ,photodynamic therapy ,Photochemotherapy ,Oncology ,030220 oncology & carcinogenesis ,Clinical Study ,Disease Progression ,Feasibility Studies ,Female ,Radiology ,Skin cancer ,business ,medicine.drug - Abstract
Background: Patients with pancreatic cancer have a poor prognosis apart from the few suitable for surgery. Photodynamic therapy (PDT) produces localised tissue necrosis but previous studies using the photosensitiser meso-tetrahydroxyphenylchlorin (mTHPC) caused prolonged skin photosensitivity. This study assessed a shorter acting photosensitiser, verteporfin. Methods: Fifteen inoperable patients with locally advanced cancers were sensitised with 0.4 mg kg−1 verteporfin. After 60–90 min, laser light (690 nm) was delivered via single (13 patients) or multiple (2 patients) fibres positioned percutaneously under computed tomography (CT) guidance, the light dose escalating (initially 5 J, doubling after each three patients) until 12 mm of necrosis was achieved consistently. Results: In all, 12 mm lesions were seen consistently at 40 J, but with considerable variation in necrosis volume (mean volume 3.5 cm3 at 40 J). Minor, self-limiting extrapancreatic effects were seen in multifibre patients. No adverse interactions were seen in patients given chemotherapy or radiotherapy before or after PDT. After PDT, one patient underwent an R0 Whipple's pancreaticoduodenectomy. Conclusions: Verteporfin PDT-induced tumour necrosis in locally advanced pancreatic cancer is feasible and safe. It can be delivered with a much shorter drug light interval and with less photosensitivity than with older compounds.
- Published
- 2014