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Your search keyword '"S.P. Gunaletchumy"' showing total 3 results
Start Over Author "S.P. Gunaletchumy" Topic medicine.disease
3 results on '"S.P. Gunaletchumy"'

1. Helicobacter pylori Genetic Diversity and Gastro-duodenal Diseases in Malaysia

Author

Jamuna Vadivelu, Indran Seevasant, Hazel M. Mitchell, Khean-Lee Goh, Mun Fai Loke, Mun Hua Tan, Laurence J. Croft, and S.P. Gunaletchumy

Subjects
medicine.medical_specialty, Peptic Ulcer, Molecular Sequence Data, Chronic gastritis, Disease, Gastroenterology, Article, Helicobacter Infections, Gastro, Stomach Neoplasms, Internal medicine, Fructose-Bisphosphate Aldolase, medicine, Humans, Amino Acid Sequence, Genetic Association Studies, Phylogeny, Multidisciplinary, biology, Helicobacter pylori, Incidence (epidemiology), Malaysia, Cancer, Genetic Variation, medicine.disease, biology.organism_classification, digestive system diseases, Duodenal Diseases, Genes, Bacterial, Gastritis, medicine.symptom, Bacterial Outer Membrane Proteins, Multilocus Sequence Typing
Abstract

Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.

Published
2014

2. Multiple Genome Sequences of Helicobacter pylori Strains of Diverse Disease and Antibiotic Resistance Backgrounds from Malaysia

Author

Nadeem O. Kaakoush, Laurence J. Croft, S.P. Gunaletchumy, Mun Fai Loke, Khean-Lee Goh, Hazel M. Mitchell, Susana Wang, Meredith Ashby, Siddarth Singh, Jamuna Vadivelu, Mun Hua Tan, Vellaya Rehvathy, Primo Baybayan, and Xinsheng Teh

Subjects
Chronic gastritis, Disease, Biology, Helicobacter pylori, medicine.disease, biology.organism_classification, Genome, digestive system diseases, Lymphoma, Microbiology, Gastric adenocarcinoma, Antibiotic resistance, Microbial risk, Genetics, medicine, Prokaryotes, Molecular Biology
Abstract

Helicobacter pylori causes human gastroduodenal diseases, including chronic gastritis and peptic ulcer disease. It is also a major microbial risk factor for the development of gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Twenty-one strains with different ethnicity, disease, and antimicrobial susceptibility backgrounds were sequenced by use of Illumina HiSeq and PacBio RS platforms.

Published
2013
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3. Draft genome sequences of Helicobacter pylori isolates from Malaysia, cultured from patients with functional dyspepsia and gastric cancer

Author

Thevakumar Kavitha, Liang Chung Tay, Halimah Alias, Stephen Rudd, Norzawani Buang M. Yassin, Nadeem O. Kaakoush, HueyTyng Lee, Eng Guan Chua, Nur Siti Khadijah Ramli, Khean-Lee Goh, Joanne Mason, Xinsheng Teh, Mun Fai Loke, Hazel M. Mitchell, Jamuna Vadivelu, S.P. Gunaletchumy, Nur Zafirah Zaidan, and Yalda Khosravi

Subjects
DNA, Bacterial, Biopsy, Population structure, Molecular Sequence Data, Microbiology, Genome, Helicobacter Infections, Stomach Neoplasms, medicine, Humans, Risk factor, Dyspepsia, Molecular Biology, Genetic diversity, biology, medicine.diagnostic_test, Helicobacter pylori, Malaysia, Cancer, Sequence Analysis, DNA, medicine.disease, biology.organism_classification, digestive system diseases, Lymphoma, Genome Announcements, Genome, Bacterial
Abstract

Helicobacter pylori is the main bacterial causative agent of gastroduodenal disorders and a risk factor for gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. The draft genomes of 10 closely related H. pylori isolates from the multiracial Malaysian population will provide an insight into the genetic diversity of isolates in Southeast Asia. These isolates were cultured from gastric biopsy samples from patients with functional dyspepsia and gastric cancer. The availability of this genomic information will provide an opportunity for examining the evolution and population structure of H. pylori isolates from Southeast Asia, where the East meets the West.

Published
2012

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