1. The influence of vitamin D on neurodegeneration and neurological disorders: a rationale for its physio-pathological actions
- Author
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Rossella Zenobi, Francois Feron, Pascal Millet, Delphine Stephan, Maria Morello, Massimo Pieri, Alessandra Talamo, Véréna Landel, Institut de neurophysiopathologie (INP), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
amyotrophic lateral sclerosis ,Parkinson's disease ,Multiple Sclerosis ,medicine.medical_treatment ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,Disease ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Drug Discovery ,[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] ,Vitamin D and neurology ,Medicine ,Humans ,Amyotrophic lateral sclerosis ,Vitamin D ,[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,Pharmacology ,0303 health sciences ,business.industry ,Multiple sclerosis ,Settore BIO/12 ,Neurodegeneration ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,Vitamins ,Alzheimer's disease ,medicine.disease ,3. Good health ,neurodegenerative diseases ,Steroid hormone ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,business ,Neuroscience ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,030217 neurology & neurosurgery ,Hormone - Abstract
Vitamin D is a steroid hormone implicated in the regulation of neuronal integrity and many brain functions. Its influence, as a nutrient and a hormone, on the physiopathology of the most common neurodegenerative diseases is continuously emphasized by new studies. This review addresses what is currently known about the action of vitamin D on the nervous system and neurodegenerative diseases such as Multiple Sclerosis, Alzheimer’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis. Further vitamin D research is necessary to understand how the action of this “neuroactive” steroid can help to optimize the prevention and treatment of several neurological diseases.
- Published
- 2020