50 results on '"David I. Kaufman"'
Search Results
2. Utilization of bioimpedance spectroscopy in the prevention of chronic breast cancer-related lymphedema
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Chirag Shah, Marisa Rizzi, Frank A. Vicini, and David I. Kaufman
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Cancer Research ,medicine.medical_specialty ,business.industry ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Lymphedema ,Breast cancer ,Oncology ,Bioimpedance spectroscopy ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,030212 general & internal medicine ,Paragraph ,business ,Breast Cancer Related Lymphedema - Abstract
In the original publication of the article, under the heading, Study limitations in the Discussion section, the second paragraph, fifth sentence was published incorrectly as “Patients with an L-Dex increase of ≥ 5.5 undergo…sleeve for 4 weeks”.
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- 2017
3. Elevations in MicroRNA Biomarkers in Serum Are Associated with Measures of Concussion, Neurocognitive Function, and Subconcussive Trauma over a Single National Collegiate Athletic Association Division I Season in Collegiate Football Players
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Julian E. Bailes, Barbara Knollmann-Ritschel, David C. Zhu, Alexa E Walter, Semyon Slobounov, David I. Kaufman, Dennis L. Molfese, Brian F. G. Johnson, Manish Bhomia, Thomas M. Talavage, Tim Bream, Stephen Bravo, Linda Papa, Peter H. Seidenberg, and Hans C. Breiter
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Male ,030506 rehabilitation ,medicine.medical_specialty ,Football ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Concussion ,Medicine ,Humans ,Prospective Studies ,RNA, Messenger ,Serum microrna ,Brain Concussion ,Football players ,biology ,business.industry ,Athletes ,Recovery of Function ,Original Articles ,medicine.disease ,biology.organism_classification ,Physical therapy ,Neurology (clinical) ,0305 other medical science ,business ,Neurocognitive ,030217 neurology & neurosurgery ,Biomarkers ,Cohort study - Abstract
This prospective controlled observational cohort study assessed the performance of a novel panel of serum microRNA (miRNA) biomarkers on indicators of concussion, subconcussive impacts, and neurocognitive function in collegiate football players over the playing season. Male collegiate student football athletes participating in a Division I Football Bowl Subdivision of the National Collegiate Athletic Association (NCAA) were enrolled. There were a total of 53 participants included in the study, 30 non-athlete control subjects and 23 male collegiate student football athletes. Neurocognitive assessments and blood samples were taken within the week before the athletic season began and within the week after the last game of the season and measured for a panel of pre-selected miRNA biomarkers. All the athletes had elevated levels of circulating miRNAs at the beginning of the season compared with control subjects (p
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- 2018
4. Ethical Considerations of Medical Photography in the Management of Breast Disease
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Nathalie Johnson, Tina J. Hieken, Lindi Vanderwalde, Terry Sarantou, Emily C. Bellavance, Paige Teller, Jennifer O’Neill, Thomas Eisenhauer, Alyssa D. Throckmorton, Caitlin R. Patten, David I. Kaufman, Toan T. Nguyen, and Sarah E. Tevis
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Best practice ,education ,Medical Records ,Digital media ,03 medical and health sciences ,Breast Diseases ,0302 clinical medicine ,Informed consent ,Photography ,Medicine ,Humans ,030212 general & internal medicine ,Practice Patterns, Physicians' ,030223 otorhinolaryngology ,Panel discussion ,Medical education ,Informed Consent ,business.industry ,Medical record ,Medical photography ,medicine.disease ,Oncology ,Surgery ,Female ,Breast disease ,business ,Confidentiality - Abstract
Medical photography has become an important component of the evaluation and management of patients across many specialties. It is increasingly utilized in contemporary practice with modern smartphones and enhanced digital media. Photography can enhance and improve treatment plans and communication between providers and patients. Additionally, photography supplements education, research, and marketing in both print and social media. Ethical and medicolegal standards for medical photography, specifically for patients with breast disease, have not been formally developed to guide medical providers. To provide guidelines for breast care physicians using medical photography, the Ethics Committee of the American Society of Breast Surgeons presents an updated review of the literature and recommendations for ethical and practical use of photography in patient care. An extensive PubMed review of articles in English was performed to identify studies and articles published prior to 2018 investigating the use of medical photography in patient care and the ethics of medical photography. After review of the literature, members of the Ethics Committee convened a panel discussion to identify best practices for the use of medical photography in the breast care setting. Results of the literature and panel discussion were then incorporated to provide the content of this article. The Ethics Committee of the American Society of Breast Surgeons acknowledges that photography of the breast has become an invaluable tool in the delivery of state-of-the-art care to our patients with breast disease, and we encourage the use of this important medium. Physicians must be well informed regarding the concerns associated with medical photography of the breast to optimize its safe and ethical use in clinical practice.
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- 2018
5. A Call to Arms: The Need to Create an Inter-Institutional Concussion Neuroimaging Consortium to Discover Clinically Relevant Diagnostic Biomarkers and Develop Evidence-Based Interventions to Facilitate Recovery
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Hans C. Breiter, Semyon Slobounov, T. Perrish, Dennis L. Molfese, Julian E. Bailes, Thomas M. Talavage, David I. Kaufman, David C. Zhu, S. Bravo, and Z. Lu
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medicine.medical_specialty ,Neuropsychology and Physiological Psychology ,Neuroimaging ,Traumatic brain injury ,Evidence based interventions ,Public health ,Concussion ,Developmental and Educational Psychology ,medicine ,Diagnostic biomarker ,medicine.disease ,Intensive care medicine ,Psychology - Abstract
Mild traumatic brain injury (mTBI/concussion) as experienced through sports, combat, and automobile-related injuries has emerged as a major public health issue. Unfortunately, only limited science ...
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- 2015
6. Current electrophysiology in ophthalmology
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Eric R. Eggenberger, David I. Kaufman, and Blair Katherine Young
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Refractive error ,Eye Diseases ,genetic structures ,medicine.diagnostic_test ,business.industry ,Photic Stimulation ,Vision Disorders ,Objective measurement ,MEDLINE ,General Medicine ,medicine.disease ,Electrophysiology ,Ophthalmology ,P100 Latency ,Electroretinography ,medicine ,Evoked Potentials, Visual ,Humans ,Optometry ,Current (fluid) ,business - Abstract
To summarize current technique, indications, and pitfalls of electrophysiologic testing used in ophthalmology.Visual evoked potentials (VEPs) may be useful as an objective measurement of refractive error in complicated patients. VEP P100 latency was found superior to color vision and visual field in early stages of hydroxychloroquine maculopathy. VEP results can be predictive of visual recovery in traumatic optic neuropathy. Multifocal electroretinogram (ERG) or VEP can provide an objective assessment of visual field defects not yet present on automated perimetry in patients with glaucomatous and nonglaucomatous optic neuropathies. In patients with intraocular lymphoma, reduced amplitudes of all ERG components can be recorded, with the b-wave amplitude being most significantly affected.Various visual electrophysiologic tests are useful to the ophthalmologist, each with different indications. The flash ERG is most useful in diffuse retinal disorders, whereas the multifocal ERG is superior in localized retinal disease. VEPs can be valuable in diagnosing optic neuropathies, nonorganic visual loss, and assessing visual function in infants or children.
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- 2012
7. Visual function at baseline and 1 month in acute optic neuritis: Predictors of visual outcome
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John Guy, Dongyuan Xing, William T. Shults, Edward G. Buckley, Robin L. Gal, John A. McCrary, Barrett Katz, Neil R. Miller, Roy W. Beck, Georgia A. Chrousos, N. Miller, David I. Kaufman, Michael C. Brodsky, James Goodwin, Craig H. Smith, Jonathan D. Trobe, M. J. Kupersmith, Peter J. Savino, James J. Corbett, and Mark J. Kupersmith
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medicine.medical_specialty ,Pediatrics ,Optic Neuritis ,Visual acuity ,genetic structures ,media_common.quotation_subject ,Eye disease ,Visual Acuity ,Contrast Sensitivity ,Predictive Value of Tests ,medicine ,Humans ,Contrast (vision) ,Optic neuritis ,media_common ,Clinical Trials as Topic ,business.industry ,medicine.disease ,eye diseases ,Surgery ,Visual field ,Clinical trial ,Treatment Outcome ,Predictive value of tests ,Acute Disease ,Optic nerve ,Neurology (clinical) ,Visual Fields ,medicine.symptom ,business ,Follow-Up Studies ,Forecasting - Abstract
To identify cutpoints for visual measures at baseline and 1 month predictive of abnormal 6-month vision that could be used as eligibility criteria in a clinical trial to test potential neuroprotection or myelin repair agents in patients with optic neuritis. To determine whether moderate-to-severe dysfunction in one or more visual measures at baseline or 1 month correlates with having major vision loss at 6 months.We used the Optic Neuritis Treatment Trial database to evaluate various cutpoints for baseline and 1-month vision levels that predicted abnormal 6-month vision. For selected cutpoints, we computed a 95% CI for positive predictive value and the required sample size if the cutpoint was to be used for clinical trial eligibility. We evaluated whether the degree of visual loss at baseline, 1 month, or change in visual function from baseline to 1 month correlated with 6-month visual acuity, contrast sensitivity, or threshold visual field.The best cutpoints for baseline and 1 month were visual acuityor= 20/50, contrast sensitivity1.0 log units, and visual field mean deviationor= -15 dB. The same levels of visual dysfunction at 1 month, but not at baseline, correlated with having 6-month moderate-to-severe loss for each of these measures (p = 0.01). A trial could require as few as 100 subjects for an outcome variable of one or more abnormal measures. Cutpoints at 1 month were highly predictive of abnormal 6-month vision, but the proportion of patients who would be eligible for a trial would be small.Provided data can be used either for the clinician to counsel patients on expected visual outcome or for designing studies to test therapies that might reduce the amount of permanent optic nerve damage due to optic neuritis in high-risk patients.
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- 2007
8. Effect of the Glycine Antagonist Gavestinel on Cerebral Infarcts in Acute Stroke Patients, a Randomized Placebo-Controlled Trial: The GAIN MRI Substudy
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David I. Kaufman, Ralph L. Sacco, Marc Fisher, Steven Warach, Markku Kaste, Thomas Devlin, David Chiu, Marie Luby, Ajaz Rashid, Linda M. Clayton, and Kennedy R. Lees
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Indoles ,endocrine system diseases ,Placebo-controlled study ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Double-Blind Method ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Stroke ,medicine.diagnostic_test ,Cerebral infarction ,business.industry ,Gavestinel ,Antagonist ,nutritional and metabolic diseases ,Glycine Agents ,Magnetic resonance imaging ,Cerebral Infarction ,medicine.disease ,Magnetic Resonance Imaging ,Treatment Outcome ,Neurology ,chemistry ,Anesthesia ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,hormones, hormone substitutes, and hormone antagonists ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Background and Purpose: Gavestinel, GV150526, is a selective antagonist at the glycine site of the N-methyl-D-aspartate receptor. The safety and efficacy of GV150526 were studied in two phase III randomized placebo-controlled clinical trials of acute ischemic stroke patients within 6 h from onset [The Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas Trials]. A planned MRI substudy within these trials investigated the effect of gavestinel on infarct volume. Methods: Patients enrolled in the GAIN trials at designated MRI substudy sites were eligible if they had a pretreatment acute cortical lesion on diffusion-weighted MRI of at least 1.5 cm diameter or 5 cm3. Final lesion assessment was performed on T2-weighted MRI at month 3. Blinded image analysis was performed centrally. The primary hypothesis was that gavestinel would attenuate lesion growth from baseline relative to placebo. Results: A total of 106 patients were eligible, 75 (34 gavestinel, 41 placebo) of whom had month 3 scans (primary analysis population). No effects of gavestinel on infarct volume were observed in the primary or other analyses. However, significant associations of lesion volume to clinical severity and outcomes were observed. Ischemic lesion volume decrease was predictive of substantial clinical improvement. Conclusion: Consistent with the clinical outcomes in the GAIN trials, no effects of gavestinel on ischemic infarction was observed. Concordance of results of the clinical outcome trials with those of this infarct volume substudy as well the associations of infarct volume to clinical outcomes further support the potential role of infarct volume as a marker of outcome in dose finding and proof of principle acute stroke trials.
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- 2006
9. Inhibition of Brain GTP Cyclohydrolase I and Tetrahydrobiopterin Attenuates Cerebral Infarction via Reducing Inducible NO Synthase and Peroxynitrite in Ischemic Stroke
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David I. Kaufman, Hua Hong, Alex F. Chen, Arshad Majid, and Grant A. Kidd
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Male ,GTP cyclohydrolase I ,Ischemia ,Biopterin ,Pharmacology ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Superoxides ,Peroxynitrous Acid ,medicine ,Animals ,GTP Cyclohydrolase ,Advanced and Specialized Nursing ,biology ,business.industry ,Cerebral infarction ,Brain ,Cerebral Infarction ,Tetrahydrobiopterin ,medicine.disease ,Rats ,Nitric oxide synthase ,Peroxynitrous acid ,chemistry ,Hypoxanthines ,Anesthesia ,biology.protein ,Neurology (clinical) ,Nitric Oxide Synthase ,Cardiology and Cardiovascular Medicine ,business ,Peroxynitrite ,medicine.drug - Abstract
Background— Inducible NO synthase (NOS)–derived peroxynitrite (ONOO − ) during ischemia/reperfusion contributes to ischemic brain injury. However, inducible NOS (iNOS) regulation in ischemic stroke remains unknown. Tetrahydrobiopterin (BH 4 ) is an essential cofactor for NOS activity. The present study tested the hypothesis that inhibition of endogenous BH 4 rate-limiting enzyme GTP cyclohydrolase I (GTPCH I), and thus BH 4 synthesis, reduces cerebral infarction via inhibiting iNOS and ONOO − in transient focal ischemia. Methods— Focal ischemia (2 hours) was created in adult male Sprague-Dawley rats (250 to 300 g) by middle cerebral artery occlusion (MCAO). Rats were treated 12 hours before MCAO with vehicle or diamino-6-hydroxypyrimidine (DAHP; 0.5 g/kg IP), a selective GTPCH I inhibitor. Brains were harvested 24 hours after reperfusion for assays of infarct volume, blood–brain barrier (BBB) permeability, GTPCH I activity, BH 4 levels, GTPCH I and NOS mRNA, protein expression, and superoxide anion (O 2 · − ) and ONOO − levels. Results— Endogenous GTPCH I activity, BH 4 levels, iNOS activity, and (O 2 · − and ONOO − levels were all augmented after ischemia/reperfusion. DAHP treatment significantly reduced GTPCH I activity, resulting in decreased BH 4 levels, iNOS activity, and ONOO − levels. Consequently, DAHP treatment significantly reduced the infarct size compared with the nontreated group (22.3±5.6 versus 38.3±7.4%; n=6; P P Conclusion— These results demonstrate that blockade of endogenous brain BH 4 synthesis attenuates cerebral infarction via inhibiting iNOS and ONOO − , which may provide a mechanistic basis of novel therapeutic strategies for ischemic stroke.
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- 2005
10. Neurologic Impairment 10 Years After Optic Neuritis
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Xing D, Roy W. Beck, Jonathan D. Trobe, Bhatti Mt, Michael C. Brodsky, Pamela S. Moke, Edward G. Buckley, David I. Kaufman, Neil R. Miller, Georgia A. Chrousos, Silvia Orengo-Nania, Robin L. Gal, Peter J. Savino, Eric R. Eggenberger, James J. Corbett, John L. Keltner, Sarkis M. Nazarian, James Goodwin, Craig H. Smith, William T. Shults, Michael Wall, Barrett Katz, and Mark J. Kupersmith
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Multiple Sclerosis ,Optic Neuritis ,Radiography ,Relatively benign course ,Disability Evaluation ,Arts and Humanities (miscellaneous) ,medicine ,Humans ,Optic neuritis ,Clinical Trials as Topic ,Expanded Disability Status Scale ,medicine.diagnostic_test ,business.industry ,Multiple sclerosis ,Brain ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Functional system ,Clinical trial ,Female ,Neurology (clinical) ,business ,Follow-Up Studies - Abstract
Background Participants enrolled in the Optic Neuritis Treatment Trial have been observed for more than a decade to assess the relationship between optic neuritis and the development of clinically definite multiple sclerosis. Objective To assess neurologic disability 10 to 12 years after an initial episode of optic neuritis. Design Longitudinal follow-up of a clinical trial. Setting Fourteen Optic Neuritis Treatment Trial clinical centers performed standardized neurologic examinations, including an assessment of neurologic disability. Participants One hundred twenty-seven patients who had developed clinically definite multiple sclerosis. Main outcome measures Functional Systems Scale and Expanded Disability Status Scale. Results The disability of most patients was mild, with 65% of patients having an Expanded Disability Status Scale score lower than 3.0. The degree of disability appeared to be unrelated to whether the baseline magnetic resonance imaging scan was lesion-free or showed lesions (P =.51). Among patients with baseline lesions, the degree of disability was unrelated to the number of lesions that were present on the scan (P =.14). Two patients died owing to severe multiple sclerosis, one of whom had no lesions revealed on the baseline scan. Conclusion Most patients who develop clinically definite multiple sclerosis following an initial episode of optic neuritis will have a relatively benign course for at least 10 years.
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- 2004
11. Baseline MRI characteristics of patients at high risk for multiple sclerosis: results from the CHAMPS trial
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D. Barlett, L. Vining, J. Friedman, F. Munschauer, T. Anderson, J. Wolinsky, J. Lynn, G. Liu, R. Arnoutelis, T. Bental, J. Rose, David I. Kaufman, J. Astruc, E. Cerretta, M. Petrie, A. Goodman, R. P. Kinkel, J. Herbert, M. Kaufman, D. Snider, J. Guarnaccia, M. Freedman, D. Pfohl, K. Costello, P. Mandalfind, E. Eggenberger, D. Court, D. Stefoski, J. McGee, L. Cappolino, R. Dubois, C. Bever, W. Morrison, S. Galetta, G. Rice, T. Grabowski, D. Patry, H. Rabinowicz, J. Richert, C. Tornatore, E. Carter, J. Kline, S. Putnam, R. Lesser, L. Scheller, E. Holzemer, J. Cohen, L. Pappert, C. Miller, Michael Wall, C. Smith, K. Rammohan, J. Burns, L. M. Metz, W. Stuart, M. Reiss, P. O'Connor, A. Blumenfeld, T. Gray, S. Hamilton, L. Durcan, W. Fenton, D. Arnold, L. Rolak, T. Murray, J. Selhourst, D. Stuart, G. Bernier, David L. Jacobson, A. Wallin, A. Stiffort, J. Rosenberg, L. Jacobs, J. Brillman, J. Oger, M. Kupersmith, David Mattson, F. Bhan, J. Goldstein, B. Apatoff, K. Karlin, J. O'Bannon, U. Webb, G. Glista, K. Arapello, S. Hashimoto, D. Bolibrush, S. Thurston, T. Scott, H. Panitch, P. Duquette, D. McHugh, A. Davis, M. Butler, Jack H. Simon, P. Fleming, D. Kuder, P. Weldon, and Staley A. Brod
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medicine.medical_specialty ,Physical medicine and rehabilitation ,Neurology ,business.industry ,Multiple sclerosis ,medicine ,Brain mri ,Optic neuritis ,Neurology (clinical) ,medicine.disease ,Baseline (configuration management) ,business - Published
- 2002
12. Internuclear Ophthalmoplegia After Coronary Artery Catheterization and Percutaneous Transluminal Coronary Balloon Angioplasty
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David I. Kaufman, Eric R. Eggenberger, Nayan P. Desai, and Misha Pless
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Male ,Cardiac Catheterization ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Internuclear ophthalmoplegia ,Coronary Disease ,Balloon ,Angioplasty ,Humans ,Medicine ,Angioplasty, Balloon, Coronary ,Aged ,Retrospective Studies ,Cardiac catheterization ,Diplopia ,Ophthalmoplegia ,business.industry ,Brain ,Perioperative ,Middle Aged ,medicine.disease ,Coronary Vessels ,Magnetic Resonance Imaging ,eye diseases ,Diagnostic catheterization ,Surgery ,Ophthalmology ,Female ,Neurology (clinical) ,medicine.symptom ,Tomography, X-Ray Computed ,business - Abstract
A retrospective chart review was performed for identification of patients with isolated internuclear ophthalmoplegia (INO) postcardiac catheterization from two neuro-ophthalmology units. Of the 110 patients with a diagnosis of INO who were evaluated during the observation period, five patients (4.5%) demonstrated relatively isolated INO occurring in the perioperative period of a cardiac endovascular procedure. These five patients underwent diagnostic catheterization alone (three patients), balloon angioplasty (one patient), or stent placement (one patient). All patients improved, with resolution of diplopia in primary position after a mean period of 82 days. The occurrence of INO in the postcardiac catheterization setting is not uncommon, and it appears to be related to dorsal pontine ischemia. The pontomesencephalic medial longitudinal fasciculus is supplied by small-caliber perforating end-arteries from the basilar trunk, which increases selective vulnerability of this area. Cardiac catheterization may precipitate microemboli involving these vessels, leading to internuclear ophthalmoplegia.
- Published
- 2000
13. Acute optic neuritis
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David I. Kaufman
- Subjects
medicine.medical_specialty ,Neurology ,medicine.diagnostic_test ,Lumbar puncture ,business.industry ,Multiple sclerosis ,Magnetic resonance imaging ,medicine.disease ,3. Good health ,Surgery ,Optic neuropathy ,03 medical and health sciences ,0302 clinical medicine ,Prednisone ,Diabetes mellitus ,030221 ophthalmology & optometry ,medicine ,Optic neuritis ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
In acute monosymptomatic optic neuritis, treatment with oral prednisone alone should be avoided. Therapy with intravenous methylprednisolone (1 g/day for 3 days) followed by 11 days of oral prednisone (1 mg/kg with a short taper) should be considered instead. This is particularly true if a patient considers accelerated visual recovery to be particularly urgent or if magnetic resonance imaging (MRI) demonstrates three or more signal abnormalities consistent with demyelination. In patients without a diagnosis of clinically definite multiple sclerosis (CDMS), an MRI should be considered to assess the prognosis for developing multiple sclerosis (MS) and to eliminate other causes of optic neuropathy. Foregoing an MRI or steroid treatment is an acceptable option. Chest x-ray, blood tests, and lumbar puncture are not necessary in evaluating patients with typical clinical features of optic neuritis. These tests may be appropriate, however, for patients who are about to undergo corticosteroid therapy, which could complicate or mask an unrecognized condition.
- Published
- 1999
14. Use of pattern electroretinography to differentiate acute optic neuritis from acute anterior ischemic optic neuropathy
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David I. Kaufman and Jeffrey Froehlich
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Adult ,medicine.medical_specialty ,Optic Neuritis ,genetic structures ,Eye disease ,Neuritis ,Diagnosis, Differential ,Optic neuropathy ,Ischemia ,Ophthalmology ,Optic Nerve Diseases ,Electroretinography ,medicine ,Humans ,Cranial nerve disease ,Optic neuritis ,Aged ,business.industry ,General Neuroscience ,Electroencephalography ,Middle Aged ,Ischemic optic neuropathy ,medicine.disease ,eye diseases ,Surgery ,Pattern Recognition, Visual ,Optic nerve ,Evoked Potentials, Visual ,Visual Field Tests ,Anterior ischemic optic neuropathy ,sense organs ,Neurology (clinical) ,medicine.symptom ,business - Abstract
The transient pattern electroretinogram (PERG) was recorded from 16 patients with acute optic neuritis and from 13 patients with acute non-arteritic anterior ischemic optic neuropathy (AION). All patients were tested within 35 days from the the onset of visual symptoms and all had significant central visual field abnormalities in their affected eyes as quantified by automated perimetry. Analysis of the PERGs showed that the amplitude of the N95 peak was abnormally reduced for each eye affected with AION while it remained normal in optic neuritis. No significant alteration in P50 amplitude was observed in either condition. The loss of N95 amplitude in AION was highly correlated with the average depth of visual field loss (in decibels) within a radius of 10 degrees of fixation. These results suggest that PERG could be used early in the course of optic neuropathy to distinguish optic neuritis from AION in those cases for which the diagnosis is still uncertain after the clinical examination.
- Published
- 1994
15. The pattern visual evoked potential
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Mitchell Brigell, David I. Kaufman, Ahmad Beydoun, and Phyllis Bobak
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Adult ,Male ,medicine.medical_specialty ,Multiple Sclerosis ,Optic Neuritis ,Adolescent ,genetic structures ,Audiology ,Stimulus (physiology) ,Sensitivity and Specificity ,Optic neuropathy ,Physiology (medical) ,Humans ,Medicine ,Cranial nerve disease ,Optic neuritis ,Evoked potential ,business.industry ,Multiple sclerosis ,Optic Nerve ,Middle Aged ,medicine.disease ,eye diseases ,Sensory Systems ,Electrophysiology ,Clinical trial ,Ophthalmology ,Pattern Recognition, Visual ,Optic nerve ,Evoked Potentials, Visual ,Feasibility Studies ,Female ,medicine.symptom ,business ,Neuroscience - Abstract
The peak latency of the pattern-reversal visual evoked potential is a sensitive measure of conduction delay in the optic nerve caused by demyelination. Despite its clinical utility, the pattern-reversal visual evoked potential has not previously been used in multicenter clinical trials, presumably because of difficulty in standardizing conditions between centers. To establish whether the pattern-reversal visual evoked potential could be adequately standardized for use as a measure in multicenter therapeutic trials for optic neuropathy or multiple sclerosis, stimulus and recording variables were equated at four centers and pattern-reversal visual evoked potentials were recorded from 64 normal subjects and 15 patients with resolved optic neuritis. Results showed equivalent latency and amplitude data from all centers, suggesting that stimulus and recording variables can be satisfactorily standardized for multicenter clinical trials. N70 and P100 peak latencies and N70-P100 interocular amplitude difference were sensitive measures of resolved optic neuritis.
- Published
- 1994
16. The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis
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David I. Kaufman, Jonathan D. Trobe, Roy W. Beck, Donald W. Paty, Patricia A. Cleary, Brown Ch, and Mark J. Kupersmith
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Chemotherapy ,medicine.medical_specialty ,business.industry ,medicine.drug_class ,Eye disease ,Multiple sclerosis ,medicine.medical_treatment ,General Medicine ,Placebo ,medicine.disease ,Surgery ,Prednisone ,Internal medicine ,medicine ,Corticosteroid ,Optic neuritis ,business ,medicine.drug ,Every Six Hours - Abstract
Background Optic neuritis is often the first clinical manifestation of multiple sclerosis, but little is known about the effect of corticosteroid treatment for optic neuritis on the subsequent risk of multiple sclerosis. Methods We conducted a multicenter study in which 389 patients with acute optic neuritis (and without known multiple sclerosis) were randomly assigned to receive intravenous methylprednisolone (250 mg every six hours) for 3 days followed by oral prednisone (1 mg per kilogram of body weight) for 11 days, oral prednisone (1 mg per kilogram) alone for 14 days, or placebo for 14 days. Neurologic status was assessed over a period of two to four years. The patients in the first group were hospitalized for three days; the others were treated as outpatients. Results Definite multiple sclerosis developed within the first two years in 7.5 percent of the intravenous-methylprednisolone group (134 patients), 14.7 percent of the oral-prednisone group (129 patients), and 16.7 percent of the placebo grou...
- Published
- 1993
17. A Randomized, Controlled Trial of Corticosteroids in the Treatment of Acute Optic Neuritis
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Malcolm M. Anderson, Michael C. Brodsky, Mark J. Kupersmith, Roy W. Beck, Constance W. Atwell, Barrett Katz, William T. Shults, Edward G. Buckley, Peter J. Savino, John L. Keltner, James J. Corbett, John A. McCrary, Patricia A. Cleary, John Guy, Georgia A. Chrousos, Neil R. Miller, David I. Kaufman, Jonathan D. Trobe, James Goodwin, Craig H. Smith, and H. Stanley Thompson
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Chemotherapy ,medicine.medical_specialty ,Visual acuity ,genetic structures ,business.industry ,medicine.drug_class ,medicine.medical_treatment ,General Medicine ,medicine.disease ,Placebo ,law.invention ,Surgery ,Randomized controlled trial ,Methylprednisolone ,law ,Prednisone ,Anesthesia ,medicine ,Corticosteroid ,Optic neuritis ,medicine.symptom ,business ,medicine.drug - Abstract
Background and Methods. The use of corticosteroids to treat optic neuritis is controversial. At 15 clinical centers, we randomly assigned 457 patients with acute optic neuritis to receive oral prednisone (1 mg per kilogram of body weight per day) for 14 days; intravenous methylprednisolone (1 g per day) for 3 days, followed by oral prednisone (1 mg per kilogram per day) for 11 days; or oral placebo for 14 days. Visual function was assessed over a six-month follow-up period. Results. Visual function recovered faster in the group receiving intravenous methylprednisolone than in the placebo group; this was particularly true for the reversal of visual-field defects (P = 0.0001). Although the differences between the groups decreased with time, at six months the group that received intravenous methylprednisolone still had slightly better visual fields (P = 0.054), contrast sensitivity (P = 0.026), and color vision (P = 0.033) but not better visual acuity (P = 0.66). The outcome in the oral-prednisone group did ...
- Published
- 1992
18. Visual impairment in hysteria
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Michael C. Barris, Dominic Barberio, and David I. Kaufman
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Adult ,Male ,medicine.medical_specialty ,Visual acuity ,Adolescent ,genetic structures ,Eye disease ,Visual impairment ,Hysteria ,Vision Disorders ,Visual Acuity ,Audiology ,Organic disease ,Developmental psychology ,Vision disorder ,Physiology (medical) ,Electroretinography ,medicine ,Humans ,Child ,Aged ,medicine.diagnostic_test ,Magnetic resonance imaging ,Middle Aged ,Prognosis ,medicine.disease ,Magnetic Resonance Imaging ,eye diseases ,Sensory Systems ,Visual field ,Ophthalmology ,Etiology ,Evoked Potentials, Visual ,Female ,Visual Fields ,medicine.symptom ,Psychology ,Follow-Up Studies - Abstract
We have reviewed the charts of 45 neuro-ophthamological patients diagnosed with 79 monocular visual field or visual acuity losses secondary to non-organic etiology. Our aim was to determine the percentage of patients that have improvement in vision. As part of the protocol, all patients had magnetic resonance images, pattern visual evoked potentials, and flash electroretinography in addition to complete neuro-ophthalmological examinations. A single physician performed both the initial and follow-up examinations of all patients. Thirty-three percent of these patients had visual field defects only, 62% had both visual field defects and visual acuity defects, and 5% had only visual acuity defects. After organic disease was ruled out, all were given a timetable for recovery and clear reassurance regarding their prognoses for visual recovery. Seventy-eight percent of these patients showed improvement or were normal, while 22% showed no improvement. Younger patients without obvious psychiatric disorder had better prognoses than older patients.
- Published
- 1992
19. Breast cancer metastatic to the Eye is a common entity
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David I. Kaufman, Nikolay V. Dimitrov, and Clinton F. Merrill
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Cancer ,Disease ,medicine.disease ,Metastatic breast cancer ,Eye neoplasm ,Metastasis ,Radiation therapy ,Breast cancer ,Internal medicine ,medicine ,Metamorphopsia ,Radiology ,medicine.symptom ,business - Abstract
Breast cancer metastatic to the eye is a common entity occurring in up to 30% of women with metastatic disease. The prevalence of this lesion is not appreciated because of the dominant clinical picture of metastases occurring in other organs. The diagnosis should be suspected in any women with a history of breast cancer and any visual symptoms, particularly metamorphopsia and scotomata. A thorough ophthalmologic evaluation, aided by ultrasonography, computed tomography, or magnetic resonance scanning, usually confirms the diagnosis. Early treatment with radiation therapy can alleviate symptoms and control local disease. The recognition and treatment of this disorder is important in maximizing the quality of life in patients with metastatic breast cancer, especially because newer treatment regimens prolong survival and thereby increase the chances for ocular metastasis.
- Published
- 1991
20. Aseptic meningitis with retinal ischemia due to trimethoprim-sulfamethoxazole
- Author
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David I. Kaufman and Lori B. Birndorf
- Subjects
Drug ,medicine.medical_specialty ,Retinal vasculitis ,business.industry ,media_common.quotation_subject ,Sulfamethoxazole ,Sulfonamide (medicine) ,Ischemia ,Aseptic meningitis ,medicine.disease ,Trimethoprim ,Surgery ,Ophthalmology ,Anesthesia ,medicine ,Ingestion ,Neurology (clinical) ,business ,media_common ,medicine.drug - Abstract
The authors present the first case report of an aseptic meningitis associated with a uniquely documented retinal ischemia due to trimethoprim-sulfamethoxazole.A 20-year-old woman suffered an aseptic meningitis with retinal ischemia OU, due to ingestion of Bactrim. This case highlights the potential for neuro-ophthalmic side effects of the preparation. Review of the literature and their experience suggest that prompt recognition of the syndrome and withdrawal of the drug is necessary to prevent serious neurologic complications and visual loss.
- Published
- 1991
21. Multiple Sclerosis Risk after Optic Neuritis: Final Optic Neuritis Treatment Trial Follow-Up
- Author
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Roy W. Beck, Michael C. Brodsky, Craig Kollman, Melvin Greer, William T. Shults, Silvia Orengo-Nania, Peter J. Savino, Mark J. Kupersmith, Robin L. Gal, John L. Keltner, Eric R. Eggenberger, Leslie McAllister, George J. Hutton, M. Tariq Bhatti, Neil R. Miller, Jonathan D. Trobe, Michael Wall, Mariya Dontchev, James Goodwin, Craig H. Smith, Wayne T. Cornblath, Thomas Leist, E. Wayne Massey, David I. Kaufman, Edward G. Buckley, Steve Hamilton, Sarkis Nazarian, and David N. Irani
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multiple Sclerosis ,Optic Neuritis ,business.industry ,Multiple sclerosis ,medicine.disease ,Magnetic Resonance Imaging ,Article ,Arts and Humanities (miscellaneous) ,Treatment trial ,Risk Factors ,Ophthalmology ,medicine ,Humans ,Optic neuritis ,Female ,Neurology (clinical) ,Prospective Studies ,business ,Follow-Up Studies - Abstract
To assess the risk of developing multiple sclerosis (MS) after optic neuritis and the factors predictive of high and low risk.Subjects in the Optic Neuritis Treatment Trial, who were enrolled between July 1, 1988, and June 30, 1991, were followed up prospectively for 15 years, with the final examination in 2006.Neurologic and ophthalmologic examinations at 13 clinical sites.Three hundred eighty-nine subjects with acute optic neuritis.Development of MS and neurologic disability assessment.The cumulative probability of developing MS by 15 years after onset of optic neuritis was 50% (95% confidence interval, 44%-56%) and strongly related to presence of lesions on a baseline non-contrast-enhanced magnetic resonance imaging (MRI) of the brain. Twenty-five percent of patients with no lesions on baseline brain MRI developed MS during follow-up compared with 72% of patients with 1 or more lesions. After 10 years, the risk of developing MS was very low for patients without baseline lesions but remained substantial for those with lesions. Among patients without lesions on MRI, baseline factors associated with a substantially lower risk for MS included male sex, optic disc swelling, and certain atypical features of optic neuritis.The presence of brain MRI abnormalities at the time of an optic neuritis attack is a strong predictor of the 15-year risk of MS. In the absence of MRI-detected lesions, male sex, optic disc swelling, and atypical clinical features of optic neuritis are associated with a low likelihood of developing MS. This natural history information is important when considering prophylactic treatment for MS at the time of a first acute onset of optic neuritis.
- Published
- 2008
22. The predictive value of CSF oligoclonal banding for MS 5 years after optic neuritis
- Author
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Stephen R. Cole, Roy W. Beck, Pamela S. Moke, Wallace W. Tourtellotte, and David I. Kaufman
- Subjects
Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Multiple sclerosis ,Magnetic resonance imaging ,medicine.disease ,eye diseases ,Central nervous system disease ,Cerebrospinal fluid ,Predictive value of tests ,medicine ,Optic nerve ,Cranial nerve disease ,Optic neuritis ,Neurology (clinical) ,medicine.symptom ,business - Abstract
The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS(p = 0.02). However, the results suggest that CSF analysis is only useful in the risk assessment of optic neuritis patients when brain MRI is normal and is not of predictive value when brain MRI lesions are present at the time of optic neuritis.
- Published
- 1998
23. Development and validation of a computerized expert system for evaluation of automated visual fields from the Ischemic Optic Neuropathy Decompression Trial
- Author
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Paul Langer, Laureen Spioch, Judith E. A. Warner, Brian R. Younge, Robert McCarter, Nahid Sadaati, Wendy Gilroy Clements, Rani Kalsi, Donald Everett, Mark Malton, Brian Ellis, Anna Bruchis, Z. Suzanne Zam, Dawn M. Govreau, Sara Casey, Kay Dickersin, Judy Beck, Qi Zhu, Rosa A. Tang, Tammy Anderson, Jacqueline Ladsten, Stuart R. Seiff, Judy Urban, Phil Aitken, Barbara Eickhoff, Carolyn Harrell, Kakarla V. Chalam, Cheryl Hiner, M.B. Hanson, Kathleen Lebarron, Melissa Hamlin, Gregory S. Kosmorsky, James A. Garrity, Charlotte Frank, Lou Anne Aber, Mark Waring, Barbara Michael, Jie Zhu, Joanne Katz, Jewel Curtis, Marian Fisher, Thomas M. Link, James Scott, Andrea LaCroix, Allen M. Putterman, Sandra Staker, Toni Scoggins, Gaye Baker, Barry Skarf, Sandra Osborn, Janet Buckley, Suzanne Bickert, Jonathan C. Horton, Howard R. Krauss, Roy W. Beck, Virginia Regan, John B. Holds, Nancy J. Newman, Patricia Streasick, Paula Morris, Frank J. Hooper, Simmons Lessell, James Goodwin, Joann Starr, Sandra Holliday, Tami Fecko, Robert Granadier, Reverend Kenneth MacLean, Roberta W. Scherer, Kerry Zimmerman, Deborah Ross, Patricia Manatrey, Richard C. E. Anderson, John B. Selhorst, George Sanborn, Sara Riedel, Amy Rogers, John V. Linberg, David I. Kaufman, Olga Lurye, Mark Croswell, Jolyn Erickson, Deborah I. Friedman, Patricia Jones, Lucy Howard, Lillian Tyler, Jacqueline A. Leavitt, Jay A. Rostvold, Michelle Sotos, Wayne T. Cornblath, David Roehr, Lori Levin, John S. Kennerdell, Charlene Campbell, Christine Evans, Timothy Saunders, Sharon Turner, Thomas A. Bersani, Donna Loupe, Karen Weber, Robert Baker, Patricia Langenberg, Robert Stalling, Ted H. Wojno, Karen King, Helen Overstreet, Edward M. Cohn, P. David Wilson, Shirley Hackett, Barbara Crawley, Portia Tello, Lenworth N. Johnson, Thomas Moore, Bhupendra C. Patel, Steven E. Feldon, Kathy Friedberg, Terrell Blackburn, Eric R. Eggenberger, Kirk Mack, Lynn K. Gordon, Anthony C. Arnold, Gordon Mcgregor, Robert J. Goldberg, Rebecca Nielsen, Maeve Chang, George Ponka, Steven A. Newman, Janet Masiero, Shalom E. Kelman, John Guy, Michael J. Elman, Revonda Burke, Sophia M. Chung, Coy Cobb, Kathleen B. Digre, Warren L. Felton, and Kristi Cummings
- Subjects
030213 general clinical medicine ,Visual acuity ,genetic structures ,Decompression ,Expert Systems ,Ophthalmologic Surgical Procedures ,Severity of Illness Index ,Optic neuropathy ,Automation ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,Foveal ,Severity of illness ,medicine ,Humans ,Multicenter Studies as Topic ,Optic Neuropathy, Ischemic ,Diagnosis, Computer-Assisted ,Randomized Controlled Trials as Topic ,business.industry ,General Medicine ,Ischemic optic neuropathy ,Decompression, Surgical ,medicine.disease ,eye diseases ,Visual field ,Ophthalmology ,lcsh:RE1-994 ,Disease Progression ,030221 ophthalmology & optometry ,Visual Field Tests ,Anterior ischemic optic neuropathy ,Optometry ,Visual Fields ,medicine.symptom ,business ,Research Article - Abstract
Background The objective of this report is to describe the methods used to develop and validate a computerized system to analyze Humphrey visual fields obtained from patients with non-arteritic anterior ischemic optic neuropathy (NAION) and enrolled in the Ischemic Optic Neuropathy Decompression Trial (IONDT). The IONDT was a multicenter study that included randomized and non-randomized patients with newly diagnosed NAION in the study eye. At baseline, randomized eyes had visual acuity of 20/64 or worse and non-randomized eyes had visual acuity of better than 20/64 or were associated with patients refusing randomization. Visual fields were measured before treatment using the Humphrey Field Analyzer with the 24-2 program, foveal threshold, and size III stimulus. Methods We used visual fields from 189 non-IONDT eyes with NAION to develop the computerized classification system. Six neuro-ophthalmologists ("expert panel") described definitions for visual field patterns defects using 19 visual fields representing a range of pattern defect types. The expert panel then used 120 visual fields, classified using these definitions, to refine the rules, generating revised definitions for 13 visual field pattern defects and 3 levels of severity. These definitions were incorporated into a rule-based computerized classification system run on Excel® software. The computerized classification system was used to categorize visual field defects for an additional 95 NAION visual fields, and the expert panel was asked to independently classify the new fields and subsequently whether they agreed with the computer classification. To account for test variability over time, we derived an adjustment factor from the pooled short term fluctuation. We examined change in defects with and without adjustment in visual fields of study participants who demonstrated a visual acuity decrease within 30 days of NAION onset (progressive NAION). Results Despite an agreed upon set of rules, there was not good agreement among the expert panel when their independent visual classifications were compared. A majority did concur with the computer classification for 91 of 95 visual fields. Remaining classification discrepancies could not be resolved without modifying existing definitions. Without using the adjustment factor, visual fields of 63.6% (14/22) patients with progressive NAION and no central defect, and all (7/7) patients with a paracentral defect, worsened within 30 days of NAION onset. After applying the adjustment factor, the visual fields of the same patients with no initial central defect and 5/7 of the patients with a paracentral defect were seen to worsen. Conclusion The IONDT developed a rule-based computerized system that consistently defines pattern and severity of visual fields of NAION patients for use in a research setting.
- Published
- 2006
24. Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke
- Author
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Jin Sheng Zeng, Alex F. Chen, David I. Kaufman, Hua Hong, and David L. Kreulen
- Subjects
Male ,Time Factors ,Physiology ,Atorvastatin ,Nitric Oxide Synthase Type II ,Pharmacology ,medicine.disease_cause ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Superoxides ,Physiology (medical) ,Medicine ,Animals ,Pyrroles ,cardiovascular diseases ,chemistry.chemical_classification ,Reactive oxygen species ,NADPH oxidase ,biology ,business.industry ,Superoxide ,Cerebral infarction ,NADPH Oxidases ,Cerebral Infarction ,medicine.disease ,Rats ,Disease Models, Animal ,Neuroprotective Agents ,chemistry ,Biochemistry ,Heptanoic Acids ,Ischemic stroke ,biology.protein ,Cardiology and Cardiovascular Medicine ,business ,Early phase ,Oxidative stress ,medicine.drug - Abstract
Statins have recently been shown to exert neuronal protection in ischemic stroke. Reactive oxygen species, specifically superoxide formed during the early phase of reperfusion, augment neuronal injury. NADPH oxidase is a key enzyme for superoxide production. The present study tested the hypothesis that atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in transient focal ischemia. Transient focal ischemia was created in halothane-anesthetized adult male Sprague-Dawley rats (250–300 g) by middle cerebral artery occlusion (MCAO). Atorvastatin (Lipitor, 10 mg/kg sc) was administered three times before MCAO. Infarct volume was measured by triphenyltetrazolium chloride staining. NADPH oxidase enzymatic activity and superoxide levels were quantified in the ischemic core and penumbral regions by lucigenin (5 μM)-enhanced chemiluminescence. Expression of NADPH oxidase membrane subunit gp91phox and membrane-translocated subunit p47phox and small GTPase Rac-1 was analyzed by Western blot. NADPH oxidase activity and superoxide levels increased after reperfusion and peaked within 2 h of reperfusion in the penumbra, but not in the ischemic core, in MCAO rats. Atorvastatin pretreatment prevented these increases, blunted expression of membrane subunit gp91phox, and prevented translocation of cytoplasmic subunit p47phox to the membrane in the penumbra 2 h after reperfusion. Consequently, cerebral infarct volume was significantly reduced in atorvastatin-treated compared with nontreated MCAO rats 24 h after reperfusion. These results indicate that atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in transient focal ischemia.
- Published
- 2006
25. Monocular temporal hemianopia associated with optic nerve hypoplasia
- Author
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David I. Kaufman, Eric R. Eggenberger, and Albert Smolyar
- Subjects
medicine.medical_specialty ,Optic nerve hypoplasia ,Monocular ,Adolescent ,business.industry ,Optic Nerve ,Audiology ,medicine.disease ,Nervous System Malformations ,Hypoplasia ,Ophthalmology ,Vision, Monocular ,medicine ,Optic nerve ,Hemianopsia ,Humans ,Visual Field Tests ,Female ,Visual Fields ,business - Published
- 2005
26. Chapter 19 Optic neuropathies and disorders of optic chiasma
- Author
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Eric R. Eggenberger and David I. Kaufman
- Subjects
Retina ,Visual acuity ,genetic structures ,Multiple sclerosis ,medicine.disease ,eye diseases ,medicine.anatomical_structure ,Optic chiasma ,medicine ,Optic nerve ,Pupillography ,Anterior ischemic optic neuropathy ,Optic neuritis ,sense organs ,medicine.symptom ,Psychology ,Neuroscience - Abstract
Publisher Summary The eye, optic nerve, and chiasm are an accessible, easily quantifiable, sensory system within the brain. The retina is a highly specialized part of the brain's gray matter, while the optic nerve is a simplified central nervous system (CNS) white matter tract. Visual loss and recovery because of the optic nerve pathophysiology can be quantified by a number of modalities including visual acuity, color vision testing, pupillography, perimetry, fundoscopy, imaging, electrophysiology, and psychophysical techniques. The study of optic neuropathies has become an important tool for understanding the neurobiology, prognosis, and treatment strategies for many central nervous system diseases—for example, optic neuritis may well be a forme fruste of multiple sclerosis while anterior ischemic optic neuropathy (AION) is related to small vessel cerebral vascular disease. Advancing the understanding of optic neuropathies may well gain insight into therapeutic issues surrounding brain diseases such as multiple sclerosis and stroke.
- Published
- 2005
27. Delayed gene therapy of glial cell line-derived neurotrophic factor is efficacious in a rat model of Parkinson's disease
- Author
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Ling Ling Tang, Ren Ya Zhan, John L. Goudreau, Yong Qing Zhou, David I. Kaufman, Jie Sheng Zheng, Shu-Sen Zheng, and Alex F. Chen
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,Time Factors ,Tyrosine 3-Monooxygenase ,Dopamine ,Genetic Vectors ,Nigrostriatal pathway ,Gene Expression ,Substantia nigra ,Cell Count ,Striatum ,Motor Activity ,Adenoviridae ,Rats, Sprague-Dawley ,Cellular and Molecular Neuroscience ,Adrenergic Agents ,Neurotrophic factors ,Internal medicine ,Glial cell line-derived neurotrophic factor ,medicine ,Animals ,Glial Cell Line-Derived Neurotrophic Factor ,Nerve Growth Factors ,Oxidopamine ,Molecular Biology ,Analysis of Variance ,biology ,Tyrosine hydroxylase ,Behavior, Animal ,Parkinson Disease ,Genetic Therapy ,medicine.disease ,Immunohistochemistry ,Corpus Striatum ,Rats ,Disease Models, Animal ,Endocrinology ,medicine.anatomical_structure ,nervous system ,Gene Expression Regulation ,Rotarod Performance Test ,biology.protein ,medicine.drug - Abstract
Gene transfer of glial cell line-derived neurotrophic factor (GDNF) in rodent models of Parkinson's disease (PD) has been shown to protect against neurodegeneration either prior to or immediately after neurotoxin-induced lesions; however, the nigrostriatal pathway was largely intact when gene delivery was completed in these models, which may not accurately reflect the clinical situation encountered with Parkinson's patients. In this study, replication-incompetent adenoviral vectors encoding the rat GDNF gene were administered into the striatum 4 weeks following 6-hydroxydopamine (6-OHDA) injection in the unilateral striatum, more closely resembling fully developed PD. Apomorphine-induced rotational behavior testing was performed every week following 6-OHDA injection. At the 10th week after gene transfer, the striatal dopamine concentrations were measured by HPLC with an electrochemical detector and the number of tyrosine hydroxylase (TH)-positive dopamine neurons in the substantia nigra (SN) was determined by immunohistochemistry. Injection of 6-OHDA into the striatum produced stable increases in rotation, which reached a plateau between 4 and 5 weeks post-injection. The number of TH-positive neuron in the SN and dopamine levels in the striatum was significantly lower in the 6-OHDA group compared to the normal group. Gene transfer of GDNF, but not beta-galactosidase, significantly increased the number of TH-positive neurons and dopamine levels, with a subsequent behavioral recovery between 5 and 10 weeks following GDNF transduction. These findings demonstrate that adenovirus-mediated gene transfer of GDNF is efficacious even in the late stages of 6-OHDA-induced PD rats. They also provide further evidence on the effectiveness of GDNF-based gene therapy for experimental Parkinson's disease.
- Published
- 2004
28. Acute Monosymptomatic Optic Neuritis: Potential Clues to Early Therapy in Multiple Sclerosis
- Author
-
David I. Kaufman
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Multiple sclerosis ,Central nervous system ,Sensory system ,Early Therapy ,medicine.disease ,White matter ,Optic neuropathy ,medicine.anatomical_structure ,medicine ,Optic nerve ,Optic neuritis ,business - Abstract
The optic nerve is a 50 mm by 4.5 mm white matter tract of the central nervous system (CNS). Its physiology and response to therapy can be precisely quantified by a number of common, easily available, neuro-ophthalmological techniques. Detection of an early, subtle, optic neuropathy is relatively easy compared with many of the difficult-to-document sensory or even motor complaints in early multiple sclerosis (MS).
- Published
- 2004
29. Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial
- Author
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Mark J. Kupersmith, William T. Shults, David I. Kaufman, John L. Keltner, Silvia Orengo-Nania, Eric R. Eggenberger, Sarkis M. Nazarian, Peter J. Savino, Roy W. Beck, James J. Corbett, Barrett Katz, Michael C. Brodsky, Jonathan D. Trobe, M. Tariq Bhatti, Pamela S. Moke, Neil R. Miller, James Goodwin, Craig H. Smith, Michael Wall, Dongyuan Xing, Edward G. Buckley, Robin L. Gal, and Georgia A. Chrousos
- Subjects
Adult ,Male ,medicine.medical_specialty ,Visual acuity ,Multiple Sclerosis ,Optic Neuritis ,genetic structures ,Adolescent ,media_common.quotation_subject ,Visual Acuity ,law.invention ,Contrast Sensitivity ,Randomized controlled trial ,law ,Recurrence ,Ophthalmology ,Surveys and Questionnaires ,medicine ,Contrast (vision) ,Health Status Indicators ,Humans ,Optic neuritis ,Vision test ,Glucocorticoids ,media_common ,business.industry ,Multiple sclerosis ,Vision Tests ,Middle Aged ,medicine.disease ,eye diseases ,United States ,Visual field ,Clinical trial ,National Institutes of Health (U.S.) ,Quality of Life ,Female ,sense organs ,medicine.symptom ,Visual Fields ,business ,Follow-Up Studies - Abstract
PURPOSE To assess visual function more than 10 years after an episode of optic neuritis in patients enrolled in the Optic Neuritis Treatment Trial. DESIGN Longitudinal follow-up of a randomized clinical trial. METHODS Vision testing included measures of visual acuity, contrast sensitivity, and visual field. Quality of life was assessed with the National Eye Institute Visual Function Questionnaire. RESULTS Examinations were completed on 319 patients. In most patients, visual function test results in the eyes that experienced optic neuritis at study entry ("affected eyes") were normal or only slightly abnormal after 9.9 to 13.7 years. Visual acuity in the affected eyes was >or=20/20 in 74%, 20/25 to 20/40 in 18%
- Published
- 2004
30. Visual distortion provoked by a stimulus in migraine associated with hyperneuronal activity
- Author
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Yue Cao, Thomas G. Cooper, David I. Kaufman, Banu Satana, and Jie Huang
- Subjects
Adult ,Male ,genetic structures ,Aura ,media_common.quotation_subject ,Migraine with Aura ,Illusion ,Vision Disorders ,Pilot Projects ,Stimulus (physiology) ,medicine ,Humans ,Vision test ,media_common ,Visual Cortex ,Vision Tests ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,eye diseases ,Migraine with aura ,Visual cortex ,medicine.anatomical_structure ,Neurology ,Migraine ,Female ,Neurology (clinical) ,Spatial frequency ,medicine.symptom ,Visual Fields ,Psychology ,Neuroscience - Abstract
Background.—Migraineurs with visual aura are highly susceptible to illusions and visual distortion and areparticularly sensitive to a pattern of regularly spaced parallel lines or stripes.Purpose.—To determine whether the high degree of susceptibility to illusions and visual distortion in mi-graineurs with aura is associated with hyperneurological activity of the occipital cortex.Methods.—In order to investigate any relationships among neuronal activity, spatial frequency of square-wave gratings, and self-described visual distortion, we investigated the neuronal and psychophysical responses tosquare-wave gratings in migraineurs with visual aura and in nonheadache controls.Results.—Square-wave gratings provoked various types of visual distortion and illusions and induced a hyper-neuronal response in the visual cortex of migraineurs with visual aura, a response that strongly depended upon thestimulus spatial frequency.Conclusion.—The hyperneuronal activity of the occipital cortex is consistent with general cortical hyperexcit-ability in migraine.Key words: migraine, visual distortion, visual activation, functional MRIAbbreviations: SF spatial frequency, NHCs nonheadache controls, MWA migraine with aura, cpd cycles perdegree, BOLD blood oxygenation level dependent
- Published
- 2003
31. Predictors of short-term disease activity following a first clinical demyelinating event: analysis of the CHAMPS placebo group
- Author
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Joanne Lynn, T. Murray, S. Bansil, Robert P. Lisak, H. S. Panitch, M. Lajaunie, Michael Wall, K. Lloyd, N. Simonian, E. Carter, D. Patry, D. Bolibrush, Paul O'Connor, S. Cooper Hanel, A. Gulati, Stanley A. Hashimoto, Dennis Bourdette, J. Brillman, Lloyd H. Kasper, Trevor A. Gray, M. Kupersmith, Dusan Stefoski, Claudia F. Lucchinetti, R. P. Kinkel, A. Walker, C. Miller, K. White, R. J. Whaley, C. Gustafson, James L. Bernat, Christopher T. Bever, J. O'Bannon, Jeffrey A. Cohen, L. Cappolino, H. Park, A. Wallin, W. Tyor, S. Peters, K. Ryan, J. Javerbaum, Staley A. Brod, M. Shepard, G. Glista, A. Cajade-Law, P. Fleming, T. Bental, J. Ware, Jonathan Goldstein, C. Brownscheidle, Melvin Greer, H. Rabinowicz, D. Pfohl, J. Lehrich, C. Coon, G. Donneief, Gilles P Bernier, Michele Mass, V. Bhan, M. Yeung, J. Kline, U. Webb, B. Richardson, D. Kuder, S. Horowitz, D. Singel, P. Weldon, Pierre Duquette, W. Sibley, John Guy, C. Yardley, Steven Galetta, M. Meyer, Luanne M. Metz, W. Morrison, E. Holzemer, Lawrence W. Myers, T. Anderson, D. L. Chandler, Alexandros Tselis, D. Stuart, R. Burger, Carlo Tornatore, B. Muntz, M. Camasso, T. Scott, L. Durcan, Jack H. Simon, Jerry S. Wolinsky, B. Apatoff, T. Johnson, S. E. Jackson, Frederick Munschauer, Timothy Vollmer, S. Wray, J. Astruc, Douglas L. Arnold, L. Kerson, D. Court, R. Arnoutelis, W. Brown, W. Stuart, K. Karlin, S. Thurston, K. Costello, L. Scheller, Lawrence Jacobs, E. Bastings, G. Birnbaum, T. Hedges, Stephen C. Reingold, T. Grabowski, Warren L. Felton, P. Mandalfino, M. Butler, A. Blumenfeld, John W. Rose, C. Kung, Douglas Jeffery, Richard J. Caselli, Stuart D. Cook, N. Blanchard, R. Leek, B. Ehrenberg, P. Slasor, F. Votruba, E. Cerretta, J. Buckner, Kottil Rammohan, G. Liu, A. Siffort, Andrew D. Goodman, B. Quandt, L. Pappert, Joseph Guarnaccia, J. McGee, A. Bonnett, D. McHugh, D. Jacobson, John B. Selhorst, G. Rice, T. Tran, Eric R. Eggenberger, S. Hamilton, Jonathan L. Carter, Stephen R. Cole, Michael Kaufman, R. Burde, L. Vining, Roy W. Beck, J. Cooper, D. Mattson, P. Pennell, C. Griffin, J. Warner, S. Putnam, A. Jotkowitz, J. Gilmore, J. Friedman, P. Sexton, D. E. Miller, M. Reiss, John H. Noseworthy, J. Herbert, J. Burns, D. Snider, J. Rosenberg, Nancy J. Newman, M. Botten, M. Petrie, Joel Oger, John R. Richert, M. Wilson, E. Escott, R. Dubois, Loren A. Rolak, A. Sandrock, James Goodwin, J. Antel, B. Coombs, Mark S. Freedman, Craig H. Smith, G. Hayat, D. Bartlett, David I. Kaufman, J. Brown, A. Miller, C. E. Maxner, and C. Orapello
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multiple Sclerosis ,Time Factors ,Placebo group ,Disease activity ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Brain mri ,Medicine ,Humans ,Multicenter Studies as Topic ,030212 general & internal medicine ,business.industry ,Multiple sclerosis ,Brain ,medicine.disease ,Prognosis ,Magnetic Resonance Imaging ,Term (time) ,Neurology ,Physical therapy ,Female ,Neurology (clinical) ,Controlled Clinical Trials as Topic ,business ,Event analysis ,030217 neurology & neurosurgery ,Demyelinating Diseases - Abstract
We evaluated 190 patients in the placebo group of the CHAMPS trial in order to assess factors associated with short-term clinical and brain magnetic resonance imaging (MRI) outcomes in patients with a first clinical demyelinating event involving the optic nerve, spinal cord, or brainstem/cerebellum, and subclinical demyelination on brain MRI. The two study outcomes were 1) development of clinically definite multiple sclerosis (CDMS) and 2) development of CDMS or two or more new or enlarging brain MRI T2 lesions. The presence of gadolinium (Gd)- enhancing lesions on the baseline scan was the only MRI characteristic associated with a higher risk of both the clinical and combined outcomes (p=0.003 and
- Published
- 2002
32. The fellow eye in NAION: report from the ischemic optic neuropathy decompression trial follow-up study
- Author
-
Roberta Scherer, David I. Kaufman, Steven E. Feldon, Shalom E. Kelman, Kay Dickersin, Patricia Langenberg, and Nancy J. Newman
- Subjects
Male ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Vision Disorders ,Visual Acuity ,law.invention ,Optic neuropathy ,Diabetes Complications ,Randomized controlled trial ,law ,Risk Factors ,Ophthalmology ,medicine ,Prevalence ,Humans ,Optic Neuropathy, Ischemic ,Prospective Studies ,Prospective cohort study ,Aged ,Aged, 80 and over ,business.industry ,Incidence ,Optic Nerve ,Ischemic optic neuropathy ,Middle Aged ,medicine.disease ,Decompression, Surgical ,eye diseases ,Arteritic anterior ischemic optic neuropathy ,Cohort ,Acute Disease ,Anterior ischemic optic neuropathy ,Female ,sense organs ,medicine.symptom ,business ,Follow-Up Studies - Abstract
PURPOSE: To examine the prevalence and incidence of second eye nonarteritic anterior ischemic optic neuropathy (NAION) and associated patient characteristics in patients enrolled in the Ischemic Optic Neuropathy Decompression Trial (IONDT) Follow-up Study. DESIGN: Randomized clinical trial with observational cohort. METHODS: Patients randomized to optic nerve sheath decompression surgery or careful follow-up had a diagnosis of acute unilateral NAION, visual acuity between 20/64 and light perception, and were aged 50 years or older. Eligible patients who declined randomization or whose visual acuity was better than 20/64 were not randomized but followed as part of an observational cohort. Follow-up examinations took place at 3, 6, 12, 18, and 24 months and annually thereafter. RESULTS: Four hundred eighteen patients were enrolled; 258 randomized and 160 observed. Previous NAION or other optic neuropathy was present in the fellow eye of 21.1% (88/418) of patients at baseline. Four patients developed optic neuropathy in the fellow eye at follow up that could not be conclusively diagnosed as NAION. New NAION in the fellow eye occurred in 14.7% (48/326) of patients at risk during a median follow up of 5.1 years. Randomized patients experienced a higher incidence (35/201; 17.4%) than nonrandomized patients (13/125; 10.4%). A history of diabetes and baseline visual acuity of 20/200 or worse in the study eye, but not age, sex, aspirin use, or smoking were significantly associated with new NAION in the fellow eye. Final fellow eye visual acuity was significantly worse in those patients with new fellow eye NAION whose baseline study eye visual acuity was 20/200 or worse. CONCLUSIONS: Follow-up data from the IONDT cohort provide evidence that the incidence of fellow eye NAION is lower than expected: new NAION was diagnosed in 14.7% of IONDT patients over approximately 5 years. Increased incidence is associated with poor baseline visual acuity in the study eye and diabetes, but not age, sex, smoking history, or aspirin use.
- Published
- 2002
33. Prognosis of ischemic internuclear ophthalmoplegia
- Author
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Andrew G. Lee, Analyn Suntay, Charles Stevens, Michael Vaphlades, Eric R. Eggenberger, Banu Satana, Michael Wall, Karl C. Golnik, Ronel Santos, David I. Kaufman, and Randy H. Kardon
- Subjects
medicine.medical_specialty ,Ataxia ,Time Factors ,Internuclear ophthalmoplegia ,Remission, Spontaneous ,Infarction ,Asymptomatic ,Brain Ischemia ,Ocular Motility Disorders ,Vertigo ,medicine ,Diplopia ,Humans ,Aged ,Retrospective Studies ,Palsy ,medicine.diagnostic_test ,biology ,business.industry ,Magnetic resonance imaging ,Cerebral Infarction ,Middle Aged ,medicine.disease ,biology.organism_classification ,Prognosis ,Magnetic Resonance Imaging ,eye diseases ,Surgery ,Ophthalmology ,Radiology ,medicine.symptom ,business - Abstract
Objectives To determine the prognosis of internuclear ophthalmoplegia (INO) caused by infarction. Design Multicenter, retrospective observational case series. Participants Thirty three patients with ischemic-related INO. Methods Chart review of clinical details. Main outcome measure Resolution of diplopia in primary position. Results Of the group, 78.8% demonstrated resolution of diplopia in primary position with an average time to resolution of 2.25 months. The presence of associated neurologic symptoms (vertigo, ataxia, dysarthria, facial palsy, pyramidal tract signs) correlated with a worse prognosis for resolution of diplopia. When performed magnetic resonance imaging (MRI) demonstrated the causative infarct in only 52% of cases; the presence of an MRI-demonstrable lesion was not significantly associated with prognosis for resolution. Conclusions Similar to ischemic ocular motor palsies, most ischemic-based INO become asymptomatic in primary position over 2 to 3 months. The presence of associated features correlated with persistent diplopia. MRI has limited yield in demonstrating the causative infarct.
- Published
- 2002
34. Practice parameter: the role of corticosteroids in the management of acute monosymptomatic optic neuritis. Report of the Quality Standards Subcommittee of the American Academy of Neurology
- Author
-
Eric Eggenberger, David I. Kaufman, Jonathan D. Trobe, and J. N. Whitaker
- Subjects
medicine.medical_specialty ,Pediatrics ,Visual acuity ,Neurology ,Optic Neuritis ,genetic structures ,Population ,Anti-Inflammatory Agents ,Fundus (eye) ,Methylprednisolone ,Optic neuropathy ,Adrenal Cortex Hormones ,Ophthalmology ,medicine ,Humans ,Optic neuritis ,education ,education.field_of_study ,business.industry ,Academies and Institutes ,medicine.disease ,eye diseases ,Optic nerve ,Prednisone ,Neurology (clinical) ,medicine.symptom ,Differential diagnosis ,business - Abstract
Optic neuritis (ON) is an inflammatory disorder of the optic nerve. Most cases are idiopathic or associated with MS. ON can be associated with a variety of systemic or ocular disorders and is the most common acute optic neuropathy in adults younger than 46 years. Among high-risk populations for MS, the incidence of ON is about 3 per 100,000 population per year, whereas in other areas the incidence is about 1 per 100,000 population per year.1-13 Acute ON often presents as an isolated clinical event without contributory systemic abnormalities (monosymptomatic ON). Clinical features include periocular pain, abnormal visual acuity and fields, reduced color vision, a relative afferent pupillary defect, and abnormal visual evoked potentials. The fundus may appear normal or demonstrate edema of the optic nerve head (papillitis).12-18 MRI white matter abnormalities identical to those seen in MS are found in 50 to 70% of monosymptomatic ON cases.19-22 The visual deficit of ON may worsen over 1 to 2 weeks and usually begins improving over the next month. Lack of improvement in visual function by 30 days is unusual.23 However, most patients have some residual visual function deficit, even if visual acuity improves to 20/20.1-18 Differential diagnosis includes compressive, ischemic, hereditary, toxic, or other inflammatory optic neuropathies (e.g., sarcoid). These conditions usually do not exhibit the same clinical pattern (table 1) or rate of recovery as monosymptomatic ON.1-13 View this table: Table 1. Features of acute demyelinating monosymptomatic optic neuritis Treatment of monosymptomatic ON has included oral, retrobulbar, and IV steroids, immunoglobulin, and acupuncture.23-77 Monosymptomatic acute ON is not rare and because the usefulness of oral prednisone in this disorder has recently been questioned,23,78-82 this practice parameter was developed to provide …
- Published
- 2000
35. Late onset Leber's Hereditary Optic Neuropathy
- Author
-
David I. Kaufman, Roya Vakili, Alexander A. Demidenko, and Eric R. Eggenberger
- Subjects
Pediatrics ,medicine.medical_specialty ,genetic structures ,business.industry ,Genetic disorder ,Leber's hereditary optic neuropathy ,Late onset ,Audiology ,medicine.disease ,eye diseases ,Optic neuropathy ,Ophthalmology ,medicine ,Neurology (clinical) ,business - Abstract
Leber's Hereditary Optic Neuropathy is a mitochondrial genetic disorder that causes acute to subacute bilateral central loss of vision. It typically presents in young men in their second or third decade of life and onset later in life is rare. We describe a case of a 58-year-old man with late onset of LHON and discuss the importance of suspecting the diagnosis in appropriate cases.
- Published
- 2008
36. Neuro-Ophthalmology Manifestations of Systemic Disease
- Author
-
David I. Kaufman and Eric R. Eggenberger
- Subjects
Background information ,medicine.medical_specialty ,Systemic disease ,business.industry ,Ocular motility ,Multiple sclerosis ,Nice ,medicine.disease ,Myasthenia gravis ,Neuro-ophthalmology ,Ophthalmology ,Muscle disease ,Medicine ,business ,Intensive care medicine ,computer ,computer.programming_language - Abstract
This issue of Ophthalmology Clinics of North America was developed to help the reader understand how the neuro-visual system can be used by a careful clinician to assist with the diagnosis and treatment strategies for a wide spectrum of brain and systemic diseases. A meticulous clinician can diagnosis a number of diseases such as multiple sclerosis, myasthenia gravis, and degenerative diseases at the bedside by understanding how these abnormalities affect vision. We are indebted to the senior contributing authors and their associates for sharing their knowledge and expertise, rendering our task as editors a pleasure. Steven Galetta and his unit at the University of Pennsylvania review how multiple sclerosis can not only be diagnosed, but accurate treatment strategy and prognosis can be documented through a precise bedside examination and MRI scanning. David Weinberg’s team at the University of Vermont review some of the basic background information available on myasthenia gravis and provide excellent illustrations on how to make this diagnosis through ocular motility examinations. They also review bedside diagnostic techniques such as the brest testQ to avoid the need for Tensilon in most patients being evaluated for myasthenia. There is also a nice discussion on treatment strategy for not only symptoms but for the immunology of this muscle disease as well. Victoria Pelak reviews neuro-degenerative diseases and their
- Published
- 2004
37. Brain magnetic resonance imaging in acute optic neuritis. Experience of the Optic Neuritis Study Group
- Author
-
F. Reed Murtagh, John A. Arrington, Roy W. Beck, Patricia A. Cleary, and David I. Kaufman
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multiple Sclerosis ,Optic Neuritis ,Eye disease ,Arts and Humanities (miscellaneous) ,medicine ,Humans ,Brain magnetic resonance imaging ,In patient ,Optic neuritis ,medicine.diagnostic_test ,business.industry ,Multiple sclerosis ,Brain ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Clinical trial ,Acute Disease ,Optic nerve ,Female ,Neurology (clinical) ,Radiology ,business - Abstract
• Objective. —Changes in the brain on magnetic resonance images are common in patients with optic neuritis even when there is no other clinical evidence of multiple sclerosis. The current study was designed to determine systematically the prevalence of brain abnormalities on magnetic resonance images in the patients entered into the Optic Neuritis Treatment Trial. Design. —Prospective multicenter clinical trial. Setting. —Referral centers. Patients and Methods. —Brain magnetic resonance images from 418 patients with acute optic neuritis (77% women; mean age, 32.0 years) were evaluated at a central reading center with the use of a standardized classification system (ranging from 0 for normal to IV for most extensive changes). Results. —Of the scans, 40.9% were classified as grade 0, 10.8% as grade I, 9.1% as grade II, 6.7% as grade III, and 32.5% as grade IV. For patients with isolated (monosymptomatic) optic neuritis, 26.7% had two or more lesions. Conclusions. —We found a lower prevalence of brain magnetic resonance imaging abnormalities in isolated optic neuritis than previous studies have reported. This likely is due to our study having a higher degree of standardization of patient inclusion criteria, which limited patient selection bias.
- Published
- 1993
38. The pattern electroretinogram: N95 amplitudes in normal subjects and optic neuritis patients
- Author
-
David I. Kaufman and Jeffrey Froehlich
- Subjects
Adult ,Male ,medicine.medical_specialty ,Optic Neuritis ,genetic structures ,Adolescent ,Eye disease ,media_common.quotation_subject ,Population ,Vision Disorders ,Visual Acuity ,Pupil ,Retina ,Contrast Sensitivity ,Atrophy ,Vision, Monocular ,Ophthalmology ,medicine ,Electroretinography ,Reaction Time ,Contrast (vision) ,Humans ,Optic neuritis ,education ,Scotoma ,media_common ,education.field_of_study ,business.industry ,General Neuroscience ,Signal Processing, Computer-Assisted ,Anatomy ,Middle Aged ,medicine.disease ,eye diseases ,Optic Atrophy ,medicine.anatomical_structure ,Retinal ganglion cell ,Pattern Recognition, Visual ,Optic nerve ,Evoked Potentials, Visual ,Female ,sense organs ,Neurology (clinical) ,business - Abstract
Recent work has suggested that the N95 peak of the transient pattern electroretinogram (PERG) may be a more sensitve indicator of the late stages of retinal function prior to optic nerve activation than the P50 peak. In the report, we show that a new measure of N95 amplitude, based on digital filtering methods to identify a non-linear baseline measurement, greatly reduced the amplitude variation in a population of 50 normal subjects when compared with two other plausible measures. We then used that new measure to follow the time course of N95 amplitudes in 12 optic neuritis patients. It was found that mintenance of a normal N95 amplitude at 6 months after onset of optic neuritis was always associated with excellent clinical recovery as measured by visual fields, acuity, presence or absence of an afferent pupil and optic atrophy, and contrast sensitivity (CS). Loss of N95 amplitude to below laboratory limits of normal was associated with abnormalities in these indicators of visual function. This study supports the idea that the N95 peak represents retinal ganglion cell function.
- Published
- 1993
39. Optic neuritis: a prospective study
- Author
-
R. Lorance, D. Kokinakis, B. Lizano, Gastone G. Celesia, Sandra Cone Toleikis, Mitchell Brigell, and David I. Kaufman
- Subjects
Adult ,Male ,medicine.medical_specialty ,Visual acuity ,Optic Neuritis ,genetic structures ,Eye disease ,media_common.quotation_subject ,Visual impairment ,Vision Disorders ,Visual Acuity ,Vision, Monocular ,Ophthalmology ,medicine ,Contrast (vision) ,Humans ,Optic neuritis ,Vision test ,Prospective Studies ,media_common ,Vision Tests ,Middle Aged ,medicine.disease ,Prognosis ,eye diseases ,Visual field ,Surgery ,Optic nerve ,Evoked Potentials, Visual ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology - Abstract
We studied 20 patients with acute optic neuritis prospectively for 12 months. Visual fields, color vision, and VEPs to 15' checks were initially abnormal in all patients. Visual acuity was abnormal in 90% and contrast sensitivity in 95% of patients. We devised a graded visual impairment scale (GVIS) to include all visual functions tested. Complete recovery of visual function occurred in 65% of cases. Recovery in the majority of patients was rapid and complete within the first 2 months. In some patients, improvement continued over 6 months. The initial classification on the GVIS was significantly correlated with the final outcome. Patients initially classified as having moderate visual impairment recovered completely or improved to near normal vision. Sixty percent of patients initially classified as total or severe blindness had permanent visual impairment. VEP latency remained prolonged in 19 patients, even when their vision had returned to normal, and is a reliable indicator of resolved optic neuritis.
- Published
- 1990
40. High- and Low-Risk Profiles for the Development of Multiple Sclerosis Within 10 Years After Optic Neuritis
- Author
-
Eric R. Eggenberger, Roy W. Beck, Silvia Orengo-Nania, Peter J. Savino, David I. Kaufman, Pamela S. Moke, John L. Keltner, James J. Corbett, Michael Wall, Sarkis M. Nazarian, Xing D, Michael C. Brodsky, Bhatti Mt, Robin L. Gal, Edward G. Buckley, Neil R. Miller, Mark J. Kupersmith, Barrett Katz, Georgia A. Chrousos, William T. Shults, Jonathan D. Trobe, James Goodwin, and Craig H. Smith
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multiple Sclerosis ,Optic Neuritis ,Adolescent ,Anti-Inflammatory Agents ,law.invention ,Cohort Studies ,Lesion ,Sex Factors ,Randomized controlled trial ,Risk Factors ,law ,Prednisone ,medicine ,Humans ,Optic neuritis ,Methylprednisolone Hemisuccinate ,Prospective Studies ,Prospective cohort study ,medicine.diagnostic_test ,business.industry ,Multiple sclerosis ,Brain ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,United States ,Ophthalmology ,Acute Disease ,Female ,Radiology ,medicine.symptom ,business ,Cohort study ,medicine.drug - Abstract
To identify factors associated with a high and low risk of developing multiple sclerosis after an initial episode of optic neuritis.Three hundred eighty-eight patients who experienced acute optic neuritis between July 1, 1988, and June 30, 1991, were followed up prospectively for the development of multiple sclerosis. Consenting patients were reassessed after 10 to 13 years.The 10-year risk of multiple sclerosis was 38% (95% confidence interval, 33%-43%). Patients (160) who had 1 or more typical lesions on the baseline magnetic resonance imaging (MRI) scan of the brain had a 56% risk; those with no lesions (191) had a 22% risk (P.001, log rank test). Among the patients who had no lesions on MRI, male gender and optic disc swelling were associated with a lower risk of multiple sclerosis, as was the presence of the following atypical features for optic neuritis: no light perception vision; absence of pain; and ophthalmoscopic findings of severe optic disc edema, peripapillary hemorrhages, or retinal exudates.The 10-year risk of multiple sclerosis following an initial episode of acute optic neuritis is significantly higher if there is a single brain MRI lesion; higher numbers of lesions do not appreciably increase that risk. However, even when brain lesions are seen on MRI, more than 40% of the patients will not develop clinical multiple sclerosis after 10 years. In the absence of MRI lesions, certain demographic and clinical features seem to predict a very low likelihood of developing multiple sclerosis. This natural history information is a critical input for estimating a patient's 10-year multiple sclerosis risk and for weighing the benefit of initiating prophylactic treatment at the time of optic neuritis or other initial demyelinating events in the central nervous system.
- Published
- 2003
41. Pattern-induced visual stress and cortical activation in migraine patients
- Author
-
Yue Cao, David I. Kaufman, Jie Huang, Thomas G. Cooper, and Banu Satana
- Subjects
Stress (mechanics) ,Neurology ,Migraine ,business.industry ,Cognitive Neuroscience ,Medicine ,business ,medicine.disease ,Neuroscience - Published
- 2001
42. Practice parameter: the role of corticosteroids in the management of acute monosymptomatic optic neuritis. report of the Quality Standards Subcommittee of the American Academy of Neurology11EDITED BY THOMAS J. LIESEGANG, MD
- Author
-
David I. Kaufman, J. N. Whitaker, Eric R. Eggenberger, and Jonathan D. Trobe
- Subjects
Ophthalmology ,medicine.medical_specialty ,Neurology ,business.industry ,media_common.quotation_subject ,medicine ,Optometry ,Optic neuritis ,Quality (business) ,Audiology ,business ,medicine.disease ,media_common - Published
- 2000
43. Optic Nerve Enhancement on Magnetic Resonance Imaging in Arteritic Ischemic Optic Neuropathy
- Author
-
Eric R. Eggenberger, David I. Kaufman, Andrew G. Lee, and Carlos Manrique
- Subjects
medicine.medical_specialty ,Pathology ,genetic structures ,medicine.diagnostic_test ,business.industry ,Ischemia ,Magnetic resonance imaging ,Ischemic optic neuropathy ,medicine.disease ,eye diseases ,Optic neuropathy ,Ophthalmology ,Giant cell arteritis ,medicine ,Optic nerve ,Cranial nerve disease ,sense organs ,Neurology (clinical) ,medicine.symptom ,business ,Vasculitis - Abstract
Although optic nerve enhancement may be seen in magnetic resonance imaging of radiation-induced ischemic optic neuropathy, similar enhancement in ischemic optic neuropathy has not been previously reported in the English-language neuroophthalmologic literature. We report three cases of optic nerve enhancement in biopsy-proven arteritic ischemic optic neuropathy. Clinicians should consider giant cell arteritis in the differential diagnosis of an optic neuropathy with optic nerve enhancement on magnetic resonance imaging.
- Published
- 1999
44. Ocular Motility Review 1996
- Author
-
Eric R. Eggenberger and David I. Kaufman
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Ocular motility ,Eye disease ,Anatomy ,medicine.disease ,Ophthalmology ,Supranuclear paralysis ,Etiology ,Medicine ,Neurology (clinical) ,medicine.symptom ,business ,Myopathy - Published
- 1998
45. Intracranial Ewing??s Sarcoma
- Author
-
Val rie Biousse, James R. Patrinely, David I. Kaufman, Eric R. Eggenberger, Nancy J. Newman, and Andrew G. Lee
- Subjects
medicine.medical_specialty ,genetic structures ,Vascular disease ,business.industry ,Eye disease ,Ewing's sarcoma ,medicine.disease ,Primary tumor ,eye diseases ,Surgery ,Central nervous system disease ,Ophthalmology ,Skull ,medicine.anatomical_structure ,Migraine ,medicine ,Neurology (clinical) ,Sarcoma ,business - Abstract
Three patients with intracranial Ewing's sarcoma had neuro-ophthalmologic manifestations. In one patient, the primary tumor was in the skull and in two, it involved the long bones. Two patients complained of intermittent headache associated with bilateral, transient visual symptoms suggestive of migraine, which prompted imaging that showed occipital metastases. The third patient had an orbital syndrome.
- Published
- 1998
46. Axonal Transport and Anterior Ischemic Optic Neuropathy
- Author
-
Steven R. Heidemann and David I. Kaufman
- Subjects
Optic nerve sheath ,medicine.medical_specialty ,business.industry ,Nerve sheath ,medicine.disease ,Surgery ,Ophthalmology ,Axoplasmic transport ,Optic nerve ,Medicine ,Anterior ischemic optic neuropathy ,business ,Fenestration - Abstract
To the Editor. —We read with interest the article by Sergott et al 1 and the ensuing correspondence. 2 In view of the poor state of understanding of axonal transport, we urge that the role of axoplasmic transport, if any, be deemphasized in further discussions of the efficacy of optic nerve sheath fenestration (ONSF) in the treatment of nonarteritic anterior ischemic optic neuropathy. In our view, this important discussion asks the following four questions. Does ONSF ameliorate nonarteritic anterior ischemic optic neuropathy? If so, is this related to edema, intraoptic nerve sheath pressure, or compression of the optic nerve? Does the edematous condition inhibit axoplasmic transport that, in turn, causes an electrophysiologic deficit responsible for visual loss? The first two issues are crucial, particularly in view of the opening of a surgical "Pandora's box" eloquently outlined by Hayreh, 2 a misgiving shared by us. However, any focus on the third
- Published
- 1991
47. Simultaneous recording of pattern electroretinography and visual evoked potentials in multiple sclerosis. A method to separate demyelination from axonal damage to the optic nerve
- Author
-
Sandra Cone, David I. Kaufman, and Gastone G. Celesia
- Subjects
Retrograde Degeneration ,medicine.medical_specialty ,Multiple Sclerosis ,genetic structures ,Eye disease ,Atrophy ,Arts and Humanities (miscellaneous) ,Ophthalmology ,Optic Nerve Diseases ,medicine ,Electroretinography ,Humans ,Axon ,Scotoma ,Central scotoma ,business.industry ,Multiple sclerosis ,Optic Nerve ,Anatomy ,medicine.disease ,eye diseases ,Ganglion ,Optic Atrophy ,medicine.anatomical_structure ,Optic nerve ,Evoked Potentials, Visual ,sense organs ,Neurology (clinical) ,business - Abstract
• Pattern electroretinograms (P-ERGs) and visual evoked potentials (VEPs) were recorded in 35 patients with multiple sclerosis and in 35 age-matched normal subjects. Four patterns of abnormalities were noted in the group with multiple sclerosis. The most frequent abnormality consisted of the following: normal P-ERG, delayed P100, and prolonged interpeak interval between the b-wave of the P-ERG and P100 (retinocortical time). This pattern indicates demyelination of the optic nerve. A second pattern consisted of absent P-ERG and absent VEP. This pattern was associated with optic atrophy and/or central scotoma, indicating severe optic nerve axonopathy with retrograde degeneration of ganglion cells. A third pattern consisted of normal P-ERG and absent VEP, suggesting a total block of transmission at the optic nerve. A fourth pattern consisted of present but low-amplitude P-ERG, delayed VEP, and prolonged retinocortical time, indicating a demyelinating process with partial axonal involvement. The concomitant use of P-ERG and VEP results in a better classification of the type and severity of dysfunction affecting the optic nerve. The prognostic value of the four patterns for recovery of visual function is discussed.
- Published
- 1986
48. Megadose corticosteroids in multiple sclerosis
- Author
-
Stephen C. Reingold, Donald W. Paty, David I. Kaufman, George C. Ebers, J. N. Whitaker, Kenneth P. Johnson, Henry F. McFarland, and Mark J. Kupersmith
- Subjects
medicine.medical_specialty ,Multiple Sclerosis ,MEDLINE ,Pulsatile flow ,Methylprednisolone ,Cohort Studies ,Text mining ,Adrenal Cortex Hormones ,medicine ,Humans ,Longitudinal Studies ,Clinical Trials as Topic ,medicine.diagnostic_test ,business.industry ,Multiple sclerosis ,Brain ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Pulsatile Flow ,Injections, Intravenous ,Prednisone ,Neurology (clinical) ,Radiology ,business ,Cohort study
49. Optic Disk Drusen and Pseudotumor Cerebri
- Author
-
David I. Kaufman and David M. Reifler
- Subjects
Adult ,Hyalin ,Pseudotumor Cerebri ,medicine.medical_specialty ,Fundus Oculi ,Pseudotumor cerebri ,business.industry ,Optic Disk ,medicine.disease ,Ophthalmology ,Optic Nerve Diseases ,medicine ,Humans ,Female ,business ,Optic Disk Drusen - Published
- 1988
50. The pattern electroretinogram: A long-term study in acute optic neuropathy
- Author
-
David I. Kaufman, Monika Woods, Shirley H. Wray, and Robert W. Lorance
- Subjects
Adult ,Male ,medicine.medical_specialty ,Optic Neuritis ,Adolescent ,genetic structures ,Eye disease ,Optic neuropathy ,Atrophy ,Ophthalmology ,Optic Nerve Diseases ,Electroretinography ,medicine ,Humans ,Optic neuritis ,Aged ,medicine.diagnostic_test ,business.industry ,Nerve Compression Syndromes ,Middle Aged ,medicine.disease ,Hereditary Optic Atrophy ,eye diseases ,Nerve compression syndrome ,Surgery ,Pattern Recognition, Visual ,Optic nerve ,Evoked Potentials, Visual ,Female ,sense organs ,Neurology (clinical) ,business - Abstract
We report a 2-year prospective study of the electroretinographic response to reversal of checkerboard patterns (P-ERG) obtained in 63 eyes with acute optic nerve lesions. The aim of the study was to document the value of P-ERG regarding diagnosis and prognosis of four types of optic neuropathy: optic neuritis, compressive or hereditary optic atrophy, and traumatic optic neuropathy. We documented visual loss by neuro-ophthalmologic examination and recorded pattern-reversal visual evoked potentials (P-VEP). The initial P-ERG was normal to large- and medium-sized checks in 89% and the P-VEP abnormal in 94% of eyes with acute optic nerve lesions. Forty-six eyes were followed for up to 2 years. Two groups emerged. Group A (n = 17) gradually and permanently had significant reduction of the P-ERG to three separate check sizes. All 17 had no improvement in acuity better than 20/100, retained centrocecal scotomas, and developed optic atrophy. In group B (n = 29) the P-ERG remained within normal limits to one or more check sizes. Twenty-two of these eyes recovered acuity to 20/25 or better and had resolution of the field defect. The data showed that P-VEP was superior to P-ERG in diagnosis of acute and chronic optic nerve lesions. However, significant reduction of the b-wave of the P-ERG to three separate check sizes correlated closely with failure of visual recovery and the eventual development of severe optic atrophy, suggesting a prognostic value for P-ERG in optic neuropathy.
- Published
- 1988
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