Neuro-Ophthalmology Manifestations of Systemic Disease

This issue of Ophthalmology Clinics of North America was developed to help the reader understand how the neuro-visual system can be used by a careful clinician to assist with the diagnosis and treatment strategies for a wide spectrum of brain and systemic diseases. A meticulous clinician can diagnosis a number of diseases such as multiple sclerosis, myasthenia gravis, and degenerative diseases at the bedside by understanding how these abnormalities affect vision. We are indebted to the senior contributing authors and their associates for sharing their knowledge and expertise, rendering our task as editors a pleasure. Steven Galetta and his unit at the University of Pennsylvania review how multiple sclerosis can not only be diagnosed, but accurate treatment strategy and prognosis can be documented through a precise bedside examination and MRI scanning. David Weinberg’s team at the University of Vermont review some of the basic background information available on myasthenia gravis and provide excellent illustrations on how to make this diagnosis through ocular motility examinations. They also review bedside diagnostic techniques such as the brest testQ to avoid the need for Tensilon in most patients being evaluated for myasthenia. There is also a nice discussion on treatment strategy for not only symptoms but for the immunology of this muscle disease as well. Victoria Pelak reviews neuro-degenerative diseases and their