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Objective: To discuss the correlation on TCM syndromes of congestive heart failure, cardiac function and brain natriuretic peptide. Methods: 423 congestive heart failure cases from several hospitals (from December, 2010 to September, 2012) have been collected, with statistical analyzing by SPSS18.0. The correlations on CHF syndromes, cardiac functional grading and brain natriuretic peptide have got studied. Results: With the going up of brain natriuretic peptide, syndromes are in order of heart blood stasis, qi-yin deficiency, phlegm blocking heart vessels, yang-deficiency-water-flooding, phlegm-stagnation, qi-deficiency-blood-stasis, Qi-stagnation-blood-stasis, etc. Syndromes of phlegm blocking heart vessels, heart blood stasis, qi-yin deficiency are mostly manifested in patients of cardiac function level 1 or 2. Syndromes of qi-deficiency-blood-stasis, heart-qi-deficiency, and phlegm-stagnation are often in cardiac function level 3. And y ang-deficiency-water-flooding syndrome is closely related to the ones of cardiac function level 4. The level of brain natriuretic peptide goes up with the increase of cardiac function grading. Conclusion: The levels of cardiac function and brain natriuretic peptide increase in patients with congestive heart failure. TCM syndromes aggravate with the going up of both of them. The two indexes are expected to provide reference for the diagnostic criteria establishment of common syndromes of congestive heart failure.

Objective To investigate the effect of Xinfukang Oral Liquid on the expression of ND4 mRNA and Protein of myocardial mitochondria in pressure overload-induced left ventricular hypertrophy rats. Methods Totally, 240 SD rats were randomly divided into three groups, sham operation group (SH) (n=80), coarctation of abdominal aorta model group (CAA) (n=80) and model and Xinfukang liquid treatment group (XFK) (n=80). Congestive Heart Failure rat models were made by partly coarctating the abdominal aorta of rats. Expression of ND4 mRNA and protein were observed at the fourth, eighth and 12th week after the treatment, respectively by RT-PCR and Western Blotting. Results In CAA group at the eighth week after operation, the content of ND4 mRNA and ND4 protein were both decreased compared with SH group (p Conclusion XFK oral liquid can upregulate expression of ND4 mRNA and ND4 protein in myocardial mitochondria of pressure overload rats and improve Myocardial energy metabolism.

Objectives Exercise is a special kind of stressor. Moderate exercise will be helpful to improve cardiovascular function and enhance cardiac contractility. In contrast, exhaustive exercise (the intensity or duration of the exercise is beyond the physical endurance of human-beings) will lead to the exercise-induced myocardial. In the course of exhaustive exercise, there will be a general acceleration of the body metabolism and dramatic increase of blood and oxygen requirements. Consequently, the heart rate and blood output per pulse become higher and higher. Finally, this would have overshoot the endurance and the buffering mechanism of the myocardial, and then resulted in myocardial injury. Therefore, to explore the effective medicine that can protect the cardiac function or reduce the damage of myocardium is a essential topic in the field of the Sports Medicine. In the present study, the protective effect of Sal. against ischaemia/reperfusion of repeated exhaustive swimming injury in the rats and the underlying mechanism was investigated by using the Langendorff isolated heart perfusion technique. Methods Male Sprague-Dawley rats were randomly divided into four groups: control group, salidroside group (Sal), salidroside-repeated exhaustive swimming group (Sal-RES), repeated exhaustive swimming group (RES). The rats in control group and RES group were given 0.9%NaCl (3ml·kg -1 ·d) by lumbar injection two weeks. The rats in Sal- RES group and Sal group were given salidroside (30mg·kg -1 ·d) by lumbar injection two weeks. After two weeks, the rats in control group and Sal group were not to do any exercise. And the rats in Sal- RES group and RES group done repeated exhaustive exercise by swimming one week. The rats hearts of each group were taken after the last swimming day. In isolated rat heart, Langendorff technique was used to observe the effect of salidroside on left ventricular function before and after 30min ischaemia/60min reperfusion, respectively. Results 1. In basic state, LVDP, + LVdp/dtmax,- LVdp/dtmax of the control group and Sal group have no significant difference among each other ( P >0.05); compared with the Control group, LVDP, +LVdp / dtmax,- LVdp / dtmax of the Sal-RES group and the RES group decreased significantly ( P P P > 0.05), compared to the Control group, Sal-RES group and the RES group decreased significantly (P P Conclusions In this study, it is found that salidroside showed good benefits on the heart protection through suppressing the change of blood dynamics and the damage of cardiac caused by ischaemia/reperfusion. Such protection function of salidroside is probably related to its capability to enhance the cardiac anti-oxidant capacity.

Objectives To investigate the effect and safety of esmolol in treating ventricular arrhythmias Methods We gave intravenous injection of esmolol either alone or along with electrical defibrillation, electrical cardioversion, to 48 ventricular arrhythmias cases (including ventricular premature contractions, paroxysmal ventricular tachycardia, sustained ventricular tachycardia, ventricular fibrillation) during hospitalisation in Department of Cardiology of PLA 252 Hospital since January 1st, 2011. Then we investigated the restoration of sinus rhythm and control of ventricular rate, recorded the changes in blood pressure and heart rate before and after treatment Results Among the 48 cases, 16 cases converted to sinus rhythm by usage of esmolol and electrical defibrillation, 4 cases converted to sinus rhythm by usage of esmolol and electrical cardioversion; among the rest, 7 cases of premature ventricular contractions were treated with esmolol for prevention, 21 cases of ventricular tachycardia (including paroxysmal ventricular tachycardia)converted to sinus rhythm by usage of esmolol alone. The total efficiency rate was up to 91.6%. 4 patients died. Conclusions Esmolol as the ultrashort sblockers has good efficacy, less adverse reactions, and is worthy of further research in treatment of rapid ventricular arrhythmia

To evaluate the effect of PCI in the patients who get the anterior myocardial infarction with ventricular aneurysm and the change of N-terminal B-type natriuretic peptide (BNP), serum high-sensitivity C-reactive protein (hs-CRP) in perioperative period of PCI, and whether these factors could be