GW24-e0344 The prospective study of esmolol in the treatment of rapid ventricular arrhythmia

Objectives To investigate the effect and safety of esmolol in treating ventricular arrhythmias Methods We gave intravenous injection of esmolol either alone or along with electrical defibrillation, electrical cardioversion, to 48 ventricular arrhythmias cases (including ventricular premature contractions, paroxysmal ventricular tachycardia, sustained ventricular tachycardia, ventricular fibrillation) during hospitalisation in Department of Cardiology of PLA 252 Hospital since January 1st, 2011. Then we investigated the restoration of sinus rhythm and control of ventricular rate, recorded the changes in blood pressure and heart rate before and after treatment Results Among the 48 cases, 16 cases converted to sinus rhythm by usage of esmolol and electrical defibrillation, 4 cases converted to sinus rhythm by usage of esmolol and electrical cardioversion; among the rest, 7 cases of premature ventricular contractions were treated with esmolol for prevention, 21 cases of ventricular tachycardia (including paroxysmal ventricular tachycardia)converted to sinus rhythm by usage of esmolol alone. The total efficiency rate was up to 91.6%. 4 patients died. Conclusions Esmolol as the ultrashort sblockers has good efficacy, less adverse reactions, and is worthy of further research in treatment of rapid ventricular arrhythmia