Author: "A. Davila" / Topic: medicine.disease - Searchworks@Jio Institute Digital Library Search Results

1,827 results on '"A. Davila"'

1. The current obstetrical and perinatal management of congenital diaphragmatic hernia

Author: Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu', Bucureşti, România, Neonatologie, Spitalul Clinic Filantropia, Bucureşti, România, Obstetrică-Ginecologie, Universitatea de Medicină şi Farmacie „Carol Davila', Bucureşti, România, Ana Maria Alexandra Stănescu, Pediatrie, Universitatea de Medicină şi Farmacie „Carol Davila', Bucureşti, România, Bianca Danciu, Obstetrică-Ginecologie, Spitalul Clinic Filantropia, Bucureşti, România, Vlad Dima, Anca A. Simionescu, and Dora Boghițoiu
Subjects: medicine.medical_specialty, business.industry, Materials Chemistry, medicine, Congenital diaphragmatic hernia, Current (fluid), medicine.disease, business, Surgery
Abstract: Congenital diaphragmatic hernia is a severe condition with an etiology and pathogenesis still been developed; also, the involvement of genetic and environmental factors in the occurrence of this malformation is under study. Morbi-mortality in these patients is high, and quality of life is diminished. Under these circumstances, careful follow-up of the pregnancy and multidisciplinary management after birth is needed to diagnose the malformation as early as possible and adapt the therapeutic plan to the particularities of each case. In conclusion, despite several research data in the literature concerning this topic, the management of newborn babies with congenital diaphragmatic hernia remains a severe challenge. The treatment of congenital diaphragmatic hernia remains the prerogative of overqualified teams.
Published: 2021
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2. What the neonatologists need to know about the Cantrell’s pentalogy

Author: Anca A. Simionescu, Dora Boghițoiu, Ana Maria Alexandra Stănescu, Obstetrică-Ginecologie, Spitalul Clinic Filantropia, Bucureşti, România, Bianca Danciu, Vlad Dima, Pediatrie, Universitatea de Medicină şi Farmacie „Carol Davila', Bucureşti, România, Obstetrică-Gynecologie, Universitatea de Medicină şi Farmacie „Carol Davila', Bucureşti, România, Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu', Bucureşti, România, and Neonatologie, Spitalul Clinic Filantropia, Bucureşti, România
Subjects: Need to know, Materials Chemistry, medicine, Medical emergency, Psychology, medicine.disease
Abstract: Cantrell’s pentalogy is a congenital syndrome that includes multiple defects which predispose the fetus to a high mortality rate. Over time, the association of malformations defining this syndrome has changed accepting incomplete forms, or forms that associate other anomalies. The therapeutic strategy in Cantrell's pentalogy is an intensely debated one as it deals with newborns having a low survival rate and multiple malformations. Once treatment is started for certain malformations it can lead to the aggravation of others. In conclusion, a conservative approach is recommended, with the initiation of surgical treatment after the stabilization of the newborn. A multidisciplinary approach is needed to achieve optimal results in these difficult cases.
Published: 2021
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3. Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): Molecular Profiling Confirms Frequent MAPK Pathway Activation

Author: Kay Minn, Jaime I. Davila, Cristiane M. Ida, Caterina Giannini, Robert B. Jenkins, Kevin C. Halling, Kar-Ming A Fung, Timothy J. Kaufmann, Jessica R. Balcom, Dong Kun Kim, Numrah Fadra, Asha Nair, Derek R. Johnson, Benjamin R. Kipp, Thomas M. Kollmeyer, Ida C.M., Johnson D.R., Nair A.A., Davila J., Kollmeyer T.M., Minn K., Fadra N.M., Balcom J.R., Fung K.-M.A., Kim D.K., Kaufmann T.J., Kipp B.R., Halling K.C., Jenkins R.B., and Giannini C.
Subjects: Adult, MAPK/ERK pathway, NTRK2, Mitogen-Activated Protein Kinase Kinase, Biology, medicine.disease_cause, BRAF, Pathology and Forensic Medicine, Polymorphous low-grade neuroepithelial tumor, Cellular and Molecular Neuroscience, Recurrence, Seizures, Chromosome instability, KIAA1549, Gene duplication, medicine, Humans, Receptor, trkB, Mitogen-Activated Protein Kinase Kinases, Mutation, Membrane Glycoproteins, Chromosome, Original Articles, General Medicine, Aneuploidy, medicine.disease, Seizure, Neoplasms, Neuroepithelial, Neuroepithelial cell, Neurology, FGFR2, Cancer research, Female, CD34, Membrane Glycoprotein, Neurology (clinical), Oligodendroglioma, Gene Fusion, Chromosomes, Human, Pair 9, V600E, Human, Transcription Factors
Abstract: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently described epileptogenic tumor characterized by oligodendroglioma-like components, aberrant CD34 expression, and frequent mitogen-activated protein kinase (MAPK) pathway activation. We molecularly profiled 13 cases with diagnostic histopathological features of PLNTY (10 female; median age, 16 years; range, 5–52). Patients frequently presented with seizures (9 of 12 with available history) and temporal lobe tumors (9 of 13). MAPK pathway activating alterations were identified in all 13 cases. Fusions were present in the 7 youngest patients: FGFR2-CTNNA3 (n = 2), FGFR2-KIAA1598 (FGFR2-SHTN1) (n = 1), FGFR2-INA (n = 1), FGFR2-MPRIP (n = 1), QKI-NTRK2 (n = 1), and KIAA1549-BRAF (n = 1). BRAF V600E mutation was present in 6 patients (17 years or older). Two fusion-positive cases additionally harbored TP53/RB1 abnormalities suggesting biallelic inactivation. Copy number changes predominantly involving whole chromosomes were observed in all 10 evaluated cases, with losses of chromosome 10q occurring with FGFR2-KIAA1598 (SHTN1)/CTNNA3 fusions. The KIAA1549-BRAF and QKI-NTRK2 fusions were associated respectively with a 7q34 deletion and 9q21 duplication. This study shows that despite its name, PLNTY also occurs in older adults, who frequently show BRAF V600E mutation. It also expands the spectrum of the MAPK pathway activating alterations associated with PLNTY and demonstrates recurrent chromosomal copy number changes consistent with chromosomal instability.
Published: 2021
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4. Preeclampsia Predicts Risk of Hospitalization for Heart Failure With Preserved Ejection Fraction

Author: Victor G. Davila-Roman, Margaret A. Olsen, Kathryn J. Lindley, Karen E. Joynt Maddox, Molly J. Stout, Dominique Williams, Joshua I. Rosenbloom, and Elena Deych
Subjects: Adult, medicine.medical_specialty, Adolescent, Risk Assessment, Ventricular Function, Left, Preeclampsia, Young Adult, Pre-Eclampsia, Pregnancy, Risk Factors, Interquartile range, Internal medicine, medicine, Humans, Risk factor, reproductive and urinary physiology, Retrospective Studies, Heart Failure, Ejection fraction, Eclampsia, business.industry, Proportional hazards model, Incidence, Stroke Volume, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, United States, female genital diseases and pregnancy complications, Hospitalization, embryonic structures, Female, Cardiology and Cardiovascular Medicine, Heart failure with preserved ejection fraction, business, Follow-Up Studies
Abstract: Background Preeclampsia is associated with increased risk of future heart failure (HF), but the relationship between preeclampsia and HF subtypes are not well-established. Objectives The objective of this analysis was to identify the risk of HF with preserved ejection fraction (HFpEF) following a delivery complicated by preeclampsia/eclampsia. Methods A retrospective cohort study using the New York and Florida state Healthcare Cost and Utilization Project State Inpatient Databases identified delivery hospitalizations between 2006 and 2014 for women with and without preeclampsia/eclampsia. The authors identified women admitted for HF after discharge from index delivery hospitalization until September 30, 2015, using International Classification of Diseases-9th Revision-Clinical Modification diagnosis codes. Patients were followed from discharge to the first instance of primary outcome (HFpEF hospitalization), death, or end of study period. Secondary outcomes included hospitalization for any HF and HF with reduced ejection fraction, separately. The association between preeclampsia/eclampsia and HFpEF was analyzed using Cox proportional hazards models. Results There were 2,532,515 women included in the study: 2,404,486 without and 128,029 with preeclampsia/eclampsia. HFpEF hospitalization was significantly more likely among women with preeclampsia/eclampsia, after adjusting for baseline hypertension and other covariates (aHR: 2.09; 95% CI: 1.80-2.44). Median time to onset of HFpEF was 32.2 months (interquartile range: 0.3-65.0 months), and median age at HFpEF onset was 34.0 years (interquartile range: 29.0-39.0 years). Both traditional (hypertension, diabetes mellitus) and sociodemographic (Black race, rurality, low income) risk factors were also associated with HFpEF and secondary outcomes. Conclusions Preeclampsia/eclampsia is an independent risk factor for future hospitalizations for HFpEF.
Published: 2021
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5. Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study

Author: Hyun Cheol Chung, Jeeyun Lee, Tracy C. Kuo, Won Seog Kim, Feng Jin, Sophia Randolph, Nehal Lakhani, Yung-Jue Bang, Rafael Santana-Davila, Philip Fanning, Wells A. Messersmith, Pierre Squifflet, Jaume Pons, Justin F. Gainor, Hong I. Wan, Keun-Wook Lee, Laura Q.M. Chow, F.S. Hodi, and Patricia LoRusso
Subjects: Male, medicine.medical_specialty, Maximum Tolerated Dose, Pembrolizumab, Neutropenia, Antibodies, Monoclonal, Humanized, Gastroenterology, Loading dose, Trastuzumab, Neoplasms, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Adverse effect, Lung cancer, Aged, business.industry, Middle Aged, Prognosis, medicine.disease, Immunoglobulin Fc Fragments, Oncology, Tolerability, Response Evaluation Criteria in Solid Tumors, Female, business, Follow-Up Studies, medicine.drug
Abstract: Summary Background Both innate and adaptive immune responses are important components of anticancer immunity. The CD47–SIRPα interaction could represent an important pathway used by tumour cells to evade immune surveillance. We aimed to evaluate the safety, pharmacokinetics, pharmacodynamics, and anticancer activity of evorpacept (also known as ALX148), a high-affinity CD47-blocking protein with an inactive IgG Fc region in patients with solid tumours. Methods We did a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study at nine hospitals and one clinic in the USA and Korea. Eligible patients for the dose-escalation and safety lead-in phases were aged 18 years or older with histological or cytological diagnosis of advanced or metastatic solid tumours with no available standard therapy, measurable or unmeasurable disease according to the Response Evaluation Criteria in Solid Tumors version 1.1, and an Eastern Cooperative Oncology Group performance status score of 0 or 1. In the dose-escalation phase, which used a 3 + 3 design, patients received intravenous evorpacept at either 0·3, 1, 3, or 10 mg/kg once per week in 21-day cycles, or 30 mg/kg once every other week in 28-day cycles. In the safety lead-in phase, patients were given the maximum tolerable dose of evorpacept from the dose-escalation phase plus either intravenous pembrolizumab (200 mg administered once every 3 weeks) or intravenous trastuzumab (8 mg/kg loading dose followed by 6 mg/kg once every 3 weeks). In the dose-expansion phase, additional patients aged 18 years or older with second-line or later-line advanced malignancies were enrolled into three parallel cohorts: those with head and neck squamous cell carcinoma (HNSCC) and those with non-small-cell lung cancer (NSCLC) were given the maximum tolerated dose of evorpacept plus intravenous pembrolizumab (200 mg administered once every 3 weeks), and patients with HER2-positive gastric or gastroesophageal junction cancer were given the maximum tolerated dose of evorpacept plus intravenous trastuzumab (8 mg/kg loading dose followed by 6 mg/kg once every 3 weeks) until disease progression, voluntary withdrawal from the study, or unacceptable toxicity. The primary endpoint was the maximum tolerated dose of evorpacept administered as a single agent and in combination with pembrolizumab or trastuzumab, measured by the occurrence of dose-limiting toxicities during the first cycle, and was assessed in all patients who had received at least one dose of evorpacept. Secondary outcomes included the safety, tolerability, and antitumour activity of evorpacept, alone or in combination with pembrolizumab or trastuzumab. The primary outcome, safety, and tolerability were assessed in all patients who had received at least one dose of evorpacept, and antitumour activity was assessed in those who recieved at least one dose of study treatment and underwent at least one post-baseline tumor assessment. This trial is registered with ClinicalTrials.gov , NCT03013218 . Findings Between March 6, 2017, and Feb 21, 2019, 110 patients received single-agent evorpacept (n=28), evorpacept plus pembrolizumab (n=52), or evorpacept plus trastuzumab (n=30), and were included in the safety analysis. Median follow-up was 29·1 months (95% CI not calculable [NC]–NC) in the single-agent cohort, 27·0 months (25·1–28·8) in the evorpacept plus pembrolizumab cohort, and 32·7 months (27·0–32·7) in the evorpacept plus trastuzumab cohort. Two (7%) dose-limiting toxicities in the first cycle were reported in patients who received single-agent evorpacept; neutropenia with an associated infection in one patient with gastroesophageal junction cancer who received 3 mg/kg once per week, and thrombocytopenia with associated bleeding in one patient with pancreatic cancer who received 30 mg/kg once every other week. No maximum tolerated dose was reached; the maximum administered doses were 10 mg/kg once per week or 30 mg/kg once every other week. The 10 mg/kg once per week dose was used in the expansion cohorts in combination with pembrolizumab or trastuzumab. The most common grade 3 or worse treatment-related adverse events were thrombocytopenia with single-agent evorpacept (two [7%] patients) and evorpacept plus pembrolizumab (two [4%]), and thrombocytopenia (two [7%]) and neutropenia (two [7%]) with evorpacept plus trastuzumab. In patients who received single-agent evorpacept, four treatment-related serious adverse events were reported. Five serious treatment-related adverse events related to evorpacept plus pembrolizumab were reported, and one serious adverse event related to evorpacept plus trastuzumab was reported. In response-evaluable patients in the dose-escalation phase (n=15) receiving single-agent evorpacept once per week, four (27%) had a best overall response of stable disease (two received 0·3 mg/kg, one received 3 mg/kg, and one received 10 mg/kg); in the 11 patients who received single-agent evorpacept at the highest dose of 30 mg/kg once every other week, two (18%) had stable disease. In the dose-expansion cohort, overall responses were recorded in four (20·0%; 95% CI 5·7–43·7) of 20 patients with HNSCC who received evorpacept plus pembrolizumab, in one (5·0%; 0·1–24·9) of 20 patients with NSCLC who received evorpacept plus pembrolizumab, and in four (21·1%; 6·1–45·6) of 19 patients with gastric or gastroesophageal junction cancer who received evorpacept plus trastuzumab. Interpretation The safety findings support the use of evorpacept in combination with pembrolizumab or trastuzumab for patients with advanced solid tumours. Preliminary antitumour activity results support future investigation of evorpacept combined with pembrolizumab or trastuzumab in patients with HNSCC, gastric or gastroesophageal junction cancer, and NSCLC. Funding ALX Oncology.
Published: 2021
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6. Conjunctival Myxoma: High-Resolution Optical Coherence Tomography Findings of a Rare Tumor

Author: Dolores Ríos y Valles-Valles, I. Hernández-Ayuso, Abelardo A. Rodríguez-Reyes, Jesus H. Davila-Alquisiras, Nallely Ramos-Betancourt, K.A. Vázquez-Romo, and Rosa Alvarado-Villacorta
Subjects: Pathology, medicine.medical_specialty, genetic structures, Microscopy, Acoustic, Ultrasound biomicroscopy, High resolution, Conjunctival Neoplasms, Lesion, Optical coherence tomography, medicine, Humans, medicine.diagnostic_test, business.industry, Eye Neoplasms, Myxoma, Middle Aged, medicine.disease, eye diseases, Sclera, Ophthalmology, Rare tumor, medicine.anatomical_structure, Conjunctival Cyst, Female, sense organs, medicine.symptom, business, Tomography, Optical Coherence
Abstract: Purpose The purpose of this study was to describe 2 cases of biopsy-proven conjunctival myxomas and present their optical signs on high-resolution optical coherence tomography (HR-OCT) with clinical and histopathological correlations. Methods Two middle-aged female patients with a clinical diagnosis of conjunctival cysts were referred for surgical treatment. Clinical assessment, photographs, ultrasound biomicroscopy, and HR-OCT images were obtained. Excisional biopsies were performed, and specimens were sent for histopathological and immunohistochemical analyses. Results Clinically, these patients presented with a well-circumscribed, semitranslucent, yellow-pinkish mass. Ultrasound biomicroscopy showed a dome-shaped epibulbar mass with medium-to-high internal reflectivity. No compromise of the underlying sclera was noted. HR-OCT showed a normal conjunctival epithelium, a subepithelial nonhomogeneous mass with hyperreflective and hyporeflective areas lined by a highly hyperreflective band, and mild posterior shadowing. Histopathological findings and immunoreactivity for CD34 and vimentin confirmed the diagnosis of conjunctival myxoma. Conclusions The HR-OCT optical signs found in our 2 cases strongly correlated with the microscopic findings. Disclosing the optical signs observed on HR-OCT can help clinicians diagnose and differentiate this lesion, guiding its management. However, more studies with a larger number of patients comparing conjunctival myxoma and other ocular surface tumors are needed to enlighten readers about the unique pattern observed by HR-OCT.
Published: 2021
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7. Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial

Author: Dipika Singh, Hedy L. Kindler, Valsamo Anagnostou, Thomas Purcell, Hossein Borghaei, Julie R. Brahmer, Rachel Karchin, Arkadiusz Z. Dudek, Rafael Santana-Davila, Archana Balan, Z. Sun, Sampriti Thapa, Xiaoshan M. Shao, Victor E. Velculescu, Zineb Belcaid, Drew M. Pardoll, Suresh S. Ramalingam, Noushin Niknafs, Suzanne E. Dahlberg, Peter B. Illei, Patrick M. Forde, Christopher Cherry, James R. White, Kellie N. Smith, Hok Yee Chan, Mara Lanis, and I K Ashok Sivakumar
Subjects: Adult, Male, Mesothelioma, Oncology, medicine.medical_specialty, Durvalumab, DNA Repair, medicine.medical_treatment, Cancer immunotherapy, Pemetrexed, Article, Phase II trials, General Biochemistry, Genetics and Molecular Biology, Carboplatin, Antineoplastic Agents, Immunological, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Cancer genomics, Clinical endpoint, medicine, Humans, Genetic Predisposition to Disease, Germ-Line Mutation, Aged, Nucleic Acid Synthesis Inhibitors, Aged, 80 and over, Cisplatin, Chemotherapy, business.industry, Tumor Suppressor Proteins, Mesothelioma, Malignant, Antibodies, Monoclonal, Cancer, General Medicine, Middle Aged, medicine.disease, Progression-Free Survival, Immune checkpoint, Tumour immunology, Female, business, Ubiquitin Thiolesterase, medicine.drug
Abstract: Mesothelioma is a rare and fatal cancer with limited therapeutic options until the recent approval of combination immune checkpoint blockade. Here we report the results of the phase 2 PrE0505 trial (NCT02899195) of the anti-PD-L1 antibody durvalumab plus platinum-pemetrexed chemotherapy for 55 patients with previously untreated, unresectable pleural mesothelioma. The primary endpoint was overall survival compared to historical control with cisplatin and pemetrexed chemotherapy; secondary and exploratory endpoints included safety, progression-free survival and biomarkers of response. The combination of durvalumab with chemotherapy met the pre-specified primary endpoint, reaching a median survival of 20.4 months versus 12.1 months with historical control. Treatment-emergent adverse events were consistent with known side effects of chemotherapy, and all adverse events due to immunotherapy were grade 2 or lower. Integrated genomic and immune cell repertoire analyses revealed that a higher immunogenic mutation burden coupled with a more diverse T cell repertoire was linked to favorable clinical outcome. Structural genome-wide analyses showed a higher degree of genomic instability in responding tumors of epithelioid histology. Patients with germline alterations in cancer predisposing genes, especially those involved in DNA repair, were more likely to achieve long-term survival. Our findings indicate that concurrent durvalumab with platinum-based chemotherapy has promising clinical activity and that responses are driven by the complex genomic background of malignant pleural mesothelioma., In a phase 2 trial, the combination of chemotherapy with durvalumab, an anti-PD-L1 antibody, exhibited promising clinical activity in patients with previously untreated, unresectable mesothelioma, with additional analyses providing insights into genomic and immunologic features potentially associated with response.
Published: 2021
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8. Macular Edema and Serous Macular Detachment after a Standard Dose of Intracameral Cefuroxime

Author: Jose R. Davila, Loh-Shan Leung, and Kapil Mishra
Subjects: medicine.medical_specialty, genetic structures, medicine.medical_treatment, Intraocular lens, Vitrectomy, Macular Edema, Lens Implantation, Intraocular, Ophthalmology, medicine, Humans, Macular edema, Cefuroxime, Retina, Phacoemulsification, business.industry, Serous macular detachment, Retinal Detachment, Cataract surgery, medicine.disease, eye diseases, Anti-Bacterial Agents, medicine.anatomical_structure, sense organs, Subretinal fluid, business, medicine.drug
Abstract: Intracameral cefuroxime has been associated with postoperative macular edema and sub-retinal fluid. To date, nearly all published cases are attributed to errors in antibiotic dilution, leading to administration of supratherapeutic doses. We report three cases of postoperative macular edema and subretinal fluid following a standard dose of 1 mg/0.1 mL of cefuroxime at the end of cataract surgery. Distinguishing features of these cases were intraoperative zonular instability and history of vitrectomy. We hypothesize that certain factors may increase the risk of cefuroxime-associated retinal toxicity, including history of vitrectomy, zonular compromise, posterior capsular break, surgery for a secondary intraocular lens, and unicameral state. [ Ophthalmic Surg Lasers Imaging Retina . 2021;52:615–618.]
Published: 2021
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9. Female Sexual Dysfunction as Measured by Low Sexual Frequency is Associated with Lower Socioeconomic Status: An Analysis of the National Health and Nutrition Examination Survey (NHANES), 2007-2016

Author: Nitya Abraham, Joseph I. Kim, Jonathan Davila, Justin Lee, Denzel Zhu, Barbara M. Chubak, and Michal L. Melamed
Subjects: Biopsychosocial model, National Health and Nutrition Examination Survey, business.industry, Urology, Endocrinology, Diabetes and Metabolism, Female sexual dysfunction, Family income, medicine.disease, Psychiatry and Mental health, Endocrinology, Reproductive Medicine, Medicine, Marital status, Social determinants of health, business, Socioeconomic status, Reproductive health, Demography
Abstract: Background Female sexual dysfunction (FSD) is a complex disorder of biopsychosocial etiology, and FSD symptoms affect more than 40% of adult women worldwide. Aim In this cross-sectional study, we sought to investigate the association between FSD and socioeconomic status (SES) in a nationally representative female adult population. Methods Economic and sexual data for women aged 20–59 from the 2007–2016 National Health and Nutrition Examination Survey, a United States nationwide representative database, was analyzed. Poverty income ratio (PIR), a ratio of family income to poverty threshold, was used as a measure of SES, and low sexual frequency was used as a measure of FSD. The association between FSD and SES was analyzed using survey-weighted logistic regression after adjusting for relevant social and gynecologic covariates, such as marital status and history of pregnancy, as well as significant medical comorbidities. Outcomes We found that FSD, as measured by low sexual frequency, was associated with lower SES. Results Among the 7,348 women of mean age 38.4 (IQR 29–47) included in the final analysis, 26.3% of participants reported sexual frequency of 0–11 times/year and 73.7% participants reported sexual frequency >11 times/year. Participants of PIR Clinical Implications The evaluation and treatment of FSD may benefit from a comprehensive approach that takes SES into account. Strengths & Limitations This study is limited by its cross-sectional design, but it is strengthened by a large, nationally representative sample with extensive, standardized data ascertainment. Conclusion Lower SES and lower sexual frequency are directly correlated among female adults in the United States; future studies should focus on social determinants of health as risk factors for FSD.
Published: 2021
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10. Outpatient surgery for the inpatient: an introduction to postacute care

Author: Victor Davila
Subjects: Rehabilitation, endocrine system diseases, business.industry, medicine.medical_treatment, Surgical care, education, Outpatient surgery, food and beverages, Perioperative, Postacute Care, medicine.disease, humanities, Anesthesiology and Pain Medicine, health services administration, Intervention (counseling), medicine, In patient, Medical emergency, business, Inpatient rehabilitation
Abstract: PURPOSE OF REVIEW This article considers how postacute care (PAC) facilities such as skilled nursing facilities, inpatient rehabilitation facilities and long-term care hospitals could represent an opportunity for outpatient surgical facilities to improve patient care. In order to understand how these facilities interact with outpatient surgical services, it is first necessary to understand the types of facilities that provide PAC. RECENT FINDINGS The significant costs associated with PAC have led to some proposed regulatory changes. Evidence examining postacute costs following total joint replacement has indicated that these costs may be decreased with cooperative efforts between perioperative physicians and PAC facilities. However, the lack of currently published data on the interaction between outpatient surgery and inpatient PAC facilities creates a need to explore how greater cooperation between these types of facilities could lead to improvements in patient care. SUMMARY PAC facilities are inpatient facilities focused on the rehabilitation of patients recovering from an acute illness or surgical intervention. This article seeks to provide ambulatory practitioners a fundamental understanding of PAC as a starting point for future collaborative efforts with PAC facilities; improving care for patients referred to and from PAC facilities for outpatient surgical care.
Published: 2021
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11. Impact of Testicular Germ Cell Tumor Laterality on Recurrence-Free Survival in the Mexican Population

Author: Thalia de los Milagros Alcantara Velarde, Daniel Motola Kuba, Rita Dorantes Heredia, Erika Adriana Martinez Castaneda, Jose Manuel Ruiz Morales, and David Davila Dupont
Subjects: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Laterality, Left, Non-seminoma, Testicular Germ Cell Tumor, Histology, Seminoma, medicine.disease, Mexican population, Right, Recurrence, Internal medicine, Statistical significance, Cohort, medicine, Original Article, Germ cell tumors, business
Abstract: Background: To date, the prognostic value of laterality for testicular germ cell tumors remains unknown. Herein, we describe this prognostic factor in the Mexican population. Methods: A retrospective single-center study that included 37 patients with primary testicular germ cell tumors was conducted. Primary outcome was recurrence-free survival (RFS) at 2 years. Secondary outcomes were RFS by histology, progression-free survival by laterality, and 2-year overall survival. Results: Thirty-seven patients were included, of which five showed relapses. By laterality, the 2-year RFS rate was 100% for left tumors and 77.3% for right tumors, with a trend toward statistical significance (P = 0.058). By histology, the RFS rate was higher for seminomas than non-seminomas (89% vs. 83%, respectively) without this difference being statistically significant. Progression-free survival was higher for right tumors than left tumors (91% vs. 80%, respectively) but without reaching statistical significance. The overall survival rate for the entire cohort was 94.5%. Conclusions: Our study shows that patients with primary germ cell tumors of the right testicle have a higher risk of recurrence than those with primary germ cell tumors of the left testicle, with a trend toward statistical significance. World J Oncol. 2021;12(5):173-177 doi: https://doi.org/10.14740/wjon1404
Published: 2021
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12. Whole genome sequencing identifies pathogenic <scp> RNU4ATAC </scp> variants in a child with recurrent encephalitis, microcephaly, and normal stature

Author: Kym M. Boycott, Kristin D. Kernohan, Matt Osmond, Pranesh Chakraborty, Hugh J. McMillan, David A. Dyment, and Jorge Davila
Subjects: Microcephaly, Spondyloepimetaphyseal dysplasia, Pediatrics, medicine.medical_specialty, business.industry, Mitochondrial disease, Disease, medicine.disease, Genetics, medicine, Decompensation, Primordial dwarfism, business, Exome, Genetics (clinical), Encephalitis
Abstract: Biallelic pathogenic variants in RNU4ATAC have been linked to microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1). Although children with MOPD1 have been reported to show profound, life-limiting clinical decompensation at the time of a febrile illness, these episodes including magnetic resonance imaging (MRI) findings have not been well characterized. We present acute MRI brain findings for a 10-year-old girl with homozygous variants in RNU4ATAC (NR_023343.1) n.55G>A, who presented with two episodes of clinical decompensation associated with a febrile illness in early childhood. The pathogenic variants were identified by whole genome sequencing as RNU4ATAC is not captured in most exome products. Her MRI of the brain revealed symmetric, diffusion restriction of the deep gray nuclei that initially pointed to a mitochondrial disease or acute necrotizing encephalopathy. Her phenotype included microcephaly and profound cognitive impairment that can be seen with MOPD1. However, she did not demonstrate clinical or radiographic evidence of a spondyloepimetaphyseal dysplasia or "primordial dwarfism" that is characteristic of this disease. As such, the predominant neurological presentation of this child represents an atypical variant of RNU4ATAC-associated disease and should be a diagnostic consideration for geneticists and neurologists caring for children, particularly in the event of an acute clinical decline.
Published: 2021
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13. Outcomes of upfront autologous hematopoietic cell transplantation in patients with multiple myeloma who are 75 years old or older

Author: Omar Davila, Muzaffar H. Qazilbash, Parameswaran Hari, Nina Shah, Pashna N. Munshi, Shaji Kumar, David H. Vesole, Andrew St. Martin, and Anita D'Souza
Subjects: Male, Melphalan, Cancer Research, medicine.medical_specialty, Transplantation Conditioning, medicine.medical_treatment, Oncology and Carcinogenesis, Population, utilization, Hematopoietic stem cell transplantation, Regenerative Medicine, elderly, Transplantation, Autologous, Clinical Research, Internal medicine, medicine, Humans, Oncology & Carcinogenesis, education, hematopoietic, Multiple myeloma, Aged, Transplantation, education.field_of_study, Proportional hazards model, business.industry, Incidence (epidemiology), Hematopoietic Stem Cell Transplantation, Hematology, medicine.disease, United States, Confidence interval, Neoplasm Recurrence, myeloma, Good Health and Well Being, Treatment Outcome, Local, Oncology, Public Health and Health Services, Female, Neoplasm Recurrence, Local, Multiple Myeloma, business, Autologous, medicine.drug
Abstract: BACKGROUND Consolidative autologous hematopoietic stem cell transplantation (AHCT) is commonly used for patients with multiple myeloma (MM). We studied AHCT use and outcomes in patients with MM ≥75 years old. METHODS Patients with MM ≥75 years old receiving AHCT between 2013 and 2017 in the United States were identified using the Center for International Blood and Marrow Transplant Research database. Relapse and/or progression (REL), progression-free survival (PFS), and overall survival (OS) were modeled using Cox proportional hazards models. Covariates used were age, sex, Karnofsky performance score (KPS), HCT-comorbidity index (HCT-CI), International Staging System and/or Durie-Salmon stage, high-risk cytogenetics, melphalan dose, and disease status at and 1 year after transplant. AHCT utilization rate using the Surveillance, Epidemiology, and End Results database was used to estimate specific incidence among ≥75 years old by race and gender. RESULTS Of 360 patients, 63% were male, 84% were White, 56% had KPS
Published: 2021
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14. Management of symptomatic uncomplicated diverticular colon disease: A systematic review of diagnosis and treatment

Author: Sonia Albertos, Jaime Sampson-Davila, Yuhamy Curbelo-Peña, Alejandro Serrano, David Saavedra-Perez, Luis Ibañez, Xavier Errando, and Xavier Perez
Subjects: medicine.medical_specialty, business.industry, Decision Trees, General Medicine, Disease, Uncomplicated diverticular disease, medicine.disease, Scientific evidence, Diverticulosis, Natural history, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Diverticulosis, Colonic, Diverticular disease, Humans, Medicine, 030211 gastroenterology & hepatology, Research questions, business, Intensive care medicine
Abstract: Symptomatic uncomplicated diverticular colon disease (SUDCD) is a highly prevalent disease in our setting, which significantly affects the quality of life of patients. Recent changes in understanding the natural history of this disease and technological and pharmacological advances have increased the available options for both diagnosis and treatment. However, consensus regarding the use of these options is scarce and sometimes lacks scientific evidence. The objective of this systematic review is to clarify the existing scientific evidence and analyse the use of the different diagnostic and therapeutic options for SUDCD, comparing their advantages and disadvantages, to finally suggest a diagnostic-therapeutic algorithm for this pathology and, at the same time, propose new research questions.
Published: 2021
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15. Characteristics of Pediatric Stroke and Association of Delayed Diagnosis with Mortality in a Mexican Tertiary Care Hospital

Author: Edgar Botello-Hernández, Elda Carolina Garza-Davila, Angel Martínez-Ponce de León, Gerardo Garza-Alatorre, Alfredo Falcon-Delgado, and Ana Luisa Carrion-Garcia
Subjects: Pediatrics, medicine.medical_specialty, Delayed Diagnosis, 030204 cardiovascular system & hematology, Delayed diagnosis, Brain Ischemia, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, medicine, Humans, Pediatric stroke, Child, Stroke, Retrospective Studies, business.industry, Incidence (epidemiology), Retrospective cohort study, General Medicine, medicine.disease, Confidence interval, Relative risk, Pediatrics, Perinatology and Child Health, Neurology (clinical), business, 030217 neurology & neurosurgery, Rare disease
Abstract: Background and objectives Pediatric cerebrovascular disease carries significant morbidity and mortality. Early recognition of a pediatric stroke as well and its most common risk factors are important, but that diagnosis is often delayed. It is believed that the incidence in our center is higher than it appears. This study aims to assess the incidence and characteristics of the pediatric stroke in our university hospital. Likewise, this study seeks to evaluate if a longer symptoms-to-diagnosis time is associated with mortality in patients with ischemic stroke. Methods A retrospective study including children with stroke admitted to the UANL University Hospital from January 2013 to December 2016. Results A total of 41 patients and 46 stroke episodes were admitted. About 45.7% had an ischemic stroke and 54.3% had a hemorrhagic stroke. A mortality of 24.4% and a morbidity of 60.9% were recorded. Regarding ischemic and hemorrhagic stroke, an increased symptoms-to-diagnosis time and a higher mortality were obtained with a relative risk of 2.667 (95% confidence interval [CI]: 1.09–6.524, p = 0.013) and 8.0 (95% CI: 2.18–29.24, p = Conclusions Pediatric stroke is a rare disease; however, its incidence shows a continuous increase. More awareness toward pediatric stroke is needed.
Published: 2021
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16. Managing Nonmedical Opioid Use Among Patients With Cancer Pain During the COVID-19 Pandemic Using the CHAT Model and Telehealth

Author: Jaya Sheela Amaram-Davila, Joseph Arthur, Eduardo Bruera, and Akhila Reddy
Subjects: medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical Neurology, Telehealth, Article, Neoplasms, Pandemic, medicine, Humans, Pandemics, General Nursing, SARS-CoV-2, business.industry, Opioid use, COVID-19, Opioid overdose, Cancer Pain, medicine.disease, Telemedicine, Analgesics, Opioid, Anesthesiology and Pain Medicine, Emergency medicine, Neurology (clinical), business, Cancer pain
Published: 2021
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17. The clinical and pathogenic spectrum of surgically-induced scleral necrosis: A review

Author: C. Stephen Foster, Raul E. Ruiz-Lozano, Lucas A Garza-Garza, Osvaldo Davila-Cavazos, and Alejandro Rodríguez-García
Subjects: Pathology, medicine.medical_specialty, Necrosis, genetic structures, Ocular surgery, Ischemia, Pterygium, Transplantation, Autologous, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Humans, Surgical repair, Autoimmune disease, Delayed wound healing, business.industry, medicine.disease, eye diseases, Sclera, Ophthalmology, medicine.anatomical_structure, 030221 ophthalmology & optometry, sense organs, medicine.symptom, business, 030217 neurology & neurosurgery, Scleritis
Abstract: The onset of scleral necrosis after ocular surgery may have catastrophic ocular and systemic consequences. The two most frequent surgeries causing surgically-induced scleral necrosis (SISN) are pterygium excision and cataract extraction. Several pathogenic mechanisms are involved in surgically induced scleral necrosis. All of them are poorly understood. Ocular trauma increasing lytic action of collagenases with subsequent collagen degradation, vascular disruption leading to local ischemia, and immune complex deposition activating the complement system represents some of the events that lead to scleral necrosis. The complex cascade of events involving different pathogenic mechanisms and the patient's abnormal immune response frequently leads to delayed wound healing that predisposes the development of scleral necrosis. The management of SISN ranges from short-term systemic anti-inflammatory drugs to aggressive immunosuppressive therapy and surgical repair. Therefore, before performing any ocular surgery involving the sclera, a thorough ophthalmic and systemic evaluation must be done to identify high-risk patients that may develop SISN.
Published: 2021
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18. Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

Author: Stephen R Knight, Catherine A Shaw, Riinu Pius, Thomas M Drake, Lisa Norman, Adesoji O Ademuyiwa, Adewale O Adisa, Maria Lorena Aguilera, Sara W Al-Saqqa, Ibrahim Al-Slaibi, Aneel Bhangu, Bruce M Biccard, Peter Brocklehurst, Ainhoa Costas-Chavarri, Kathryn Chu, Anna Dare, Muhammed Elhadi, Cameron J Fairfield, J Edward Fitzgerald, Dhruv Ghosh, James Glasbey, Mark I. van Berge Henegouwen, J.C. Allen Ingabire, T Peter Kingham, Marie Carmela Lapitan, Ismaïl Lawani, Bettina Lieske, Richard Lilford, Janet Martin, Kenneth A McLean, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Thomas Pinkney, Ahmad Uzair Qureshi, Antonio Ramos-De la Medina, Aya Riad, Hosni Khairy Salem, Joana Simões, Richard Spence, Neil Smart, Stephen Tabiri, Hannah Thomas, Thomas G Weiser, Malcolm West, John Whitaker, Ewen M Harrison, Arben Gjata, Maria Marta Modolo, Sebastian King, Erick Chan, Sayeda Nazmun Nahar, Ade Waterman, Dominique Vervoort, Alemayehu Ginbo Bedada, Bernardo De Azevedo, Ana Gabriela Figueiredo, Manol Sokolov, Venerand Barendegere, Gerald Ekwen, Arnav Agarwal, Qinyang Liu, Juan Camilo Correa, Kalisya Luc Malemo, Jacques Bake, Jakov Mihanovic, Kamila Kuncarová, Julius Orhalmi, Hosni Salem, Jyri Teras, Aristotelis Kechagias, Alexis P Arnaud, Judith Lindert, Vasileios Kalles, Maria-Lorena Aguilera-Arevalo, Gustavo Recinos, Zsolt Baranyai, Basant Kumar, Harish Neelamraju Lakshmi, Sanoop Koshy Zachariah, Philip Alexander, Sunil Kumar Venkatappa, C Pramesh, Radhian Amandito, Christina Fleming, Luca Ansaloni, Gianluca Pellino, Ahmed M. Altibi, Ibrahim Nour, Intisar Hamdun, Ali M. Ghellai, Donatas Venskutonis, Tomas Poskus, Justas Zilinskas, Precious Malemia, Yong Yong Tew, Elaine Borg, Sarah Ellul, fatima Zahraa Wafqui, David W Borowski, Anne Sophie van Dalen, Cameron Wells, Harissou Adamou, Adesoji Ademuyiwa, Adewale Adisa, Kjetil Søreide, Sara Al Saqqa, Osaid Alser, Haya Tahboub, Helmut Alfredo Segovia Lohse, Sebastian Shu Yip, Piotr Major, António Sampaio Soares, Matei Razvan Bratu, Andrey Litvin, Armen Vardanyan, JC Allen Ingabire, Ahmad Gudal, Naif Albati, Jovan Juloski, Miran Rems, Sarah Rayne, Stephanie Van Straten, Yoshan Moodley, Irene Ortega Vázquez, Jaime Ruiz-Tovar, Kithsiri Janakantha Senanayake, Sujeewa Priyantha Bandara Thalgaspitiya, Omer Abdelbagi Omer, Anmar Homeida, Yucel Cengiz, Daniel Clerc, Muhammad Alshaar, Hanen Bouaziz, Yuksel Altinel, Matthew Doe, Maryna Freigofer, Ella Teasdale, Rakan Kabariti, Joshua Michael Clements, Stephen Richard Knight, Ahsan Ashfaq, Ijeoma Azodo, Gabriela Wagner, Ivan Trostchansky, Mayaba Maimbo, David Linyama, Helidon Nina, Amanda Zeko, Claudio Gabriel Fermani, Santiago Villalobos, Federico Carballo, Pablo Farina, Sebastian Guckenheimer, Marilla Dickfos, Ankit Ajmera, Chester Chong, Ralph Gourlay, Sikandar Hussaini, Yi Jia Lee, Adeeb Majid, Peter Martin, Rebecca Miles, Owen James Morris, Jamie Phua, William Ridley, Tarunpreet Saluja, Ryan Renxin Tan, Jen Teh, Anna Wells, Bharti Arora, Qaasim Dollie, Debbie Ho, Yanru Ma, Omattage Mahasha Perera, Anthony Truong, Amanda Caroline Dawson, Bryan Lim, Upuli Pahalawatta, Jacqueline Phan, Xiao-Ming Sarah Woon-Shoo-Tong, Andrea Yeoh, Lillian Charman, Andrew Drane, Sharon Laura, Charmaine Chu Wen Lo, Amy Mozes, Rita Poon, Hao Han Tan, Ellen Wall, Prakshi Chopra, Jasmine De Giovanni, Bal Dhital, Brian Draganic, Alexander Duller, Jonathan Gani, Yao Kuan Goh, Jun Young Jeong, Brendan McManus, Prakash Nagappan, Peter Pockney, Anya Rugendyke, Mahsa Sarrami, Stephen Smith, Vanessa Wills, Hsu Ven Wong, Geoffrey Ye, Geoffrey Zhang, Ethan Brooker, Daniel Feng, Bonnie Lau, Carlin Ngai, Sarah Birks, David Gyorki, Jaime Otero de Pablos, Ali Abbosh, Chris Gillespie, Ahmed Mahmoud, Bianca Kwan, Joshua Lawson, Andrea Warwick, Janne Bingham, Andrew J Cockbain, Nagendra Naidu Dudi-Venkata, Jordan Ellaby-Hall, Ben Finlay, Emily Humphries, Jade Pisaniello, Monique Pisaniello, Salma Salih, Tarik Sammour, Haidar Hadri Abd Wahab, April De Silva, Nicola Hayward, Kartik Iyer, Guy Maddern, Gian Andrea Prevost, Naga Annapureddy, Krishna Pranathi Settipalli, Jeremy Yeo, Lucy Hempenstall, Lily Pham, Shaun Purcell, Cherry Talavera, Ashish I Vaska, Gurpreet Chaggar, Phillip Chrapko, Annelise Cocco, Sarah Michelle Crystal Jade Coulter-Nile, Grahame Ctercteko, James French, Houchen Gong, Martijn Gosselink, Thuvarahan Jegathees, Ivan Jin, Michelle Kalachov, Kathryn Kiefhaber, Katherine Lee, Jason Luong, Steven Phan, Henry Pleass, Kelly Veale, Zhi Zeng, Angela Au, Ashe DeBiasio, Idy Deng, Jananee Myooran, Amrita Nair, Peter Stewart, Anton Stift, Lukas Walter Unger, Kerstin Wimmer, Nabila Ahmed, Syed Hasan, Saber Rahman, Margaret O'Shea, Greg Padmore, Adrian Peters, Pietro Perduca, Guenda Pulcina, Nicolas Tinton, Frederic Buxant, Elsa Dabin, Giulia Garofalo, Francis Dossou, Freddy Houehanou Rodrigue Gnangnon, Yacoubou Imorou Souaibou, Pako Motlaleselelo, Omphile Tlhomelang, Igor Lima Buarque, Gustavo Mendonça Ataíde Gomes, Aldo Vieira Barros, Ilia Batashki, Nikolai Damianov, Vladislav Stoyanov, Dragomir Dardanov, Svilen Maslyankov, Plamen Petkov, George Todorov, Evgeni Zhivkov, Aygulya Akisheva, Miguel Angel Castilla Moreno, Geno Genov, Ivelina Ilieva, Tsvetomir Ivanov, Martin Karamanliev, Azhar Khan, Emil Mitkov, Tsanko Yotsov, Boyko Atanasov, Nikolay Belev, Mihail Slavchev, Carlos Nsengiyumva, Elgan Jones, Simon Stock, Steve Kyota, James Brown, Tresor Mabanza K., Lemery Nigo Samuel, Chidi Otuneme, Ngwang Prosper, Franklin Umenze, Marylise Boutros, Natasha Caminsky, Sinziana Dumitra, Richard Garfinkle, Dominique Morency, Ebram Salama, Alexander Banks, Lorenzo Ferri, Haitian He, Amit Katz, Alexander Sender Liberman, Sarkis Meterissian, Allison Pang, Elena Parvez, Usmaan Hameed, Fahima Osman, Sangita Sequeira, Natalie Coburn, Alisha Jaffer, Paul Karanicolas, Matthew Mosseler, Reilly Musselman, Xinyuan Liu, Ching Wan Yip, Juan Sebastian Garces-Otero, Carolina Guzman, Sebastian Sierra, Andres Uribe Valencia, Paulo Andrés Cabrera Rivera, Saul Camelo, Andrea Gonzalez, Alejandro González-Orozco, Manuel Santiago Mosquera Paz, Carlos J- Perez Rivera, Felipe Gonzalez, Andres Isaza-Restrepo, Laura Nino- Torres, Natalia Arias Madrid, Maria Clara Mendoza Arango, Justin Tsandiraki, Damir Jemendžic, Branislav Kocman, Oliver Šuman, Renata Canic, Darko Jurišic, Ivana Karakas, Ana Krizanovic Rupcic, Vlatka Pitlovic, Josip Samardžic, Mario Kopljar, Ivan Bacic, Edgar Domini, Robert Karlo, Danijela Miljanic, Andrea Simic, Mariam Ahmed, Majdi Al Nassrallah, Rabiya Altaf, Talal Amjad, Ruba Eltoum, Heba Haidar, Alhassan Hassan, Omar Khalil, Marwan Qasem, Rommel Ramesh, Gautham Sajith, Maham Wisal, Jan Žatecký, Michele Bujda, Katerina Jirankova, Ales Paclik, Aya Abdallah, Mariam Abdulgawad Almogy, Esraa Ayman El-sawy, Ahmed Moustafa ElFayoumy, Nourhan Elghareeb, Nourhan Ahmed Esmat, Ahmed Fadel, Abdullah Habater, Heba Hamdy, Amr Hefni, Marwa Kamal, Norhan Mohamed Abobakr, Ahmed Sayed, Nancy Shaker, Ehab Taha, Hoda Tharwat, Omar Zakaria, Ibrahem Abdelmotaleb, Ali Al-Dhufri, Hamza S. Al-Himyari, Enas El sheikh, Asmaa Eldmaty, Aya Elkhalawy, Ahmed M.Elkhashen, Kithara Magdy, Safa Mostafa, Habib Doutoum Sadia, Mohamed mahmoud Saleh, Dina Samir, Mohamed Yahia Mohamed Ali, Mahmoud A. Nassar, Samar Abdelhady, Aly Abdelrazek, Israa Abdelsalam, Aya El-Sawy, Eman Essam, Mohamed Gadelkarim, Khaled Ghaly, Mohamed Hassabalnaby, Rana Masarani, Nourhan Mohamed Shaaban, Ahmed Sabry, Menatalla Salem, Nourhan Akram Soliman, Diaaaldin Zahran, Moustafa Ramadan Abou El.soud, Esraa Tarek Badr, Hala Borham, Nehal Elmeslemany, Mohammad Elsayed, Fawzia Elsherif, Sara Eslam, Gehad Gaber, Sondos Ibrahim, Yara Kamh, Abdelrahman Mahmoud, Shimaa gamal Mohamed, Eman Morshedy, Cinderella Omar, Fatima Salem Soliman, Shaza Abdelkawy, Naglaa Abdelmohsen, Mahmoud Abdelshakour, Ahmed Dahy, Norhan Gamal, Mohammed Gamal, Ahmad Hasan, Helal Hetta, Nehad Mousa, Mohamed Omar, Somia Rabie, Mahmoud Saad, Bakeer Saleh, Marwa Sayed Mohamed, Muhammad Shawqi, Heba Abdelhady Mousa, Mostafa Alnoury, Mohamed Elbealawy, Ahmed Elshafey, Muhammad Essam Ibrahim El Desouki Muhammad Ahmed, Mennatullah Ghonaim, Fawzy Hgag, Mohamed Ibrahim, Mahmoud Morsy, Mohamed Reda Loaloa, Ahmed Refaat, Hadeer Samir, Fatma Shahien, Mohamed Sobhy, Fathy Sroor, Esraa Abdellatif, Marina Adel, Amr Abdelghani Afifi, Eman Afifi, Marco Antaky, Amr Dawoud, Naira El Zoghby, Amira El-remaily, Ali Abdelazez Elzanfaly, Ahmed Gadallah, Fatma Alzahraa Gamal, Omar Hashem, Shrouk Medhat Youssef, Aliaa Muhammad Attyah, Malak Munir, Omar Shazly, Esraa Taha, Karim Wilson, Sawsan Adel, Asmaa Ali, Esraa Eid, Esraa Elhelow, Marwa Elmahdy, Bassant Elshatby, Amany Hossam el-din Zakaria, Ahmad Hossny, Eman Ibrahim, Ahmed M.Yonis, Maram Metwalli, Basant Yousry, Esraa Zid, Mina A Yacoub, Ahmed Abdelhakim, Nervana Abouelsoad, Mo'min Alkhatib, Ahmed Ashraf, Alaa Ashraf, Yasmin Elazab, Mahmoud Elfanty, Osama Elkabir, Mai Elsayed, Ahmed Elshimy, Hager Elsobky, John Eskander, Ahmed Gad, Ward Hamsho, Noura Khaled Abdelwahed, Menna Magdy, Dalia Moharam, Abeer Osama, Shereen Ramadan, Radwa Roum, Taqwa Sayed, Tarneem Shehada, Ahmed Mohy Zidan, Khalid Abbas, Amr Ali, Mohamed Attia, Mohamed Balata, Ayman El Nakeeb, Mohamed Ibrahim Elsayed Elewaily, Ahmed Elfallal, Hossam Elfeki, Ahmed Elkhadragy, Sameh Emile, Helmy Ezzat, Hasnaa Hosni, Islam Mansour, Waleed Omar, Gehad Othman, Kareem Sadek, Mostafa Shalaby, Noura Shehab-Eldeen, Rawda Anas khalifa, Helmy Badr, Mostafa Eldeep, Ahmed Eldeep, Amany Eldoseuky mohammed, Salwa Khallaf, Eman Magdy Hegazy, Rokia Mahmoud, Pola Mikhail, Mahmoud Morsi, Sara Mowafy, Dina Raafat, Amina Safy, Marwa Sera, Ahmed shible Sera, Mostafa Salim Mohamed AbdAllah, Muhammad Abdelkader, Abdulrahman Osama Abdou, Ahmedgaber Ahmed, Shireen Gaafar, Fatma Ibrahim negm, Mina Lapic, Ahmed Maher, Hagar Mahmoud, Ahmed Mostafa, Mohamed Samir, Fatma Samy, Nourhan Semeda, Hind I. Shalaby, Alaa El-taweel, Ahmed Galal Elnagar, Ahmed Gamal Hemidan, Mohamed Hussein, Ahmed.A. Kandil, Mf Moawad, Ayat Allah Nasser Hamamah, Mostafa Soliman, Mohamed Abdelkhalek, Noura Abdelmaksoud Tawakel, Ahmed Mohamed Abdelwahed, Alrawy Abdou, Khalid Atallah, Mohammed Yasser Elsherbeny, Eman Emara, Mohamed Hamdy, Omar Hamdy, Amira Haron, Salma Ismail, Islam Hany Metwally, Nihal Mohamed Hamed Elgaml, Ahmed Nassar, Basel Refky, Mirna Sadek, Mahmoud Saleh, Asmaa Yunes, Mai Zakaria, Mohammed Zuhdy, Notila Fayed, Mohammed Mustafa Hassan Mohammed, Sander Kütner, Priit Melnik, Indrek Seire, Toomas Ümarik, Eppu Ainoa, Verner Eerola, Hanna Koppatz, Laura Koskenvuo, Ville Sallinen, Sini Takala, Jevgeni Katunin, Arto Turunen, Niki Christou, Muriel Mathonnet, Vincent Lavoue, Krystel Nyangoh Timoh, Lucie Soulabaille, Romain Lesourd, Aude Merdrignac, Laurent Sulpice, Benoît André, Elodie Chantalat, Charlotte Vaysse, Bertrand Dousset, Sebastien Gaujoux, Gregory Martin, Octavian Clonda, Domantas Juodis, Klaus Kienle, Andras Mravik, Samuel Palmer, Gabor Szabadhegyi, Anita Eseenam Agbeko, Solomon Gyabaah, Frank Enoch Gyamfi, Nuhu Naabo, Atta Owusu senior, Joseph Yorke, Frank Owusu, Francis Abantanga, Theophilus Teddy Kojo Anyomih, Abdul-Jalilu Mohammed Muntaka, Emmanuel Owusu Abem, Mohammed Sheriff, Paul M. Wondoh, Dimitrios Balalis, Dimitrios Korkolis, Georgios Gkiokas, Eirini Pantiora, Theodosios Theodosopoulos, Argyrios Ioannidis, Konstantinos Konstantinidis, Sofia Konstantinidou, Nikolaos Machairas, Anna Paspala, Anastasia Prodromidou, Christos Chouliaras, Konstantinos Papadopoulos, Ioannis Baloyiannis, Ioannis Mamaloudis, George Tzovaras, Ioanna Akrida, Maria-Ioanna Argentou, Stylianos Germanos, Evangelos Iliopoulos, Ioannis Maroulis, George Skroubis, George Theofanis, Christos Chatzakis, Orestis Ioannidis, Lydia Loutzidou, Panagiotis Karathanasis, Nikolaos Michalopoulos, Charalampos Theodoropoulos, Dimitrios Theodorou, Tania Triantafyllou, Zoe Garoufalia, Natasha Hasemaki, Michalis Kontos, Gregory Kouraklis, Stylianos Kykalos, Theodore Liakakos, Eustratia Mpaili, Alexandros Papalampros, Dimitrios Schizas, Athanasios Syllaios, Ekaterini Christina Tampaki, Antonios Tsimpoukelis, Maria Ioanna Antonopoulou, Eirini Deskou, Dimitrios K. Manatakis, Dimitrios Papageorgiou, Menelaos Zoulamoglou, Christos Anthoulakis, Michalis Margaritis, Nikolaos Nikoloudis, Veronica Campo, André Ceballos, Mario-Andrés Flores, Waleska Giron, Donghyun Ko, Gabriel Martinez, Verónica Rivera Lara, Nataly Rueda, Andres Sanchez, Jorge Carlos Guillermo Tejeda Garrido, Alvaro Eduardo Alvarez Rivera, Elvis Benjamin Bamaca Ixcajoc, Lilian Elizabeth Barreda Zelaya, Patricia Chacòn-Herrera, Ligia Margarita Corea Ruiz, Guillermo Echeverria-Davila, Mario Garcia, Danilo García, Edgar Fernando Gutiérrez Mayen, Noriega José, Nery Mazariegos, Diego Méndez, Michael Paniagua Espinoza, David Bardos, Marton Benke, Kristof Illes, Balint András Kokas, Réka Szabó, Akhila Appukuttan, Anjitha Asok, Vijaykumar D.k, Kapil Malik, Praveen Ravishankaran, Ritesh Tapkire, Guru Moorthy, Joyner Abraham, Ramesh Muthuvel, John Alapatt, Abhay Kattepur, Nizamudheen Pareekutty, Mebanshanbor Garod, Caleb Harris, Cliff Wanniang, Ashish Gupta, Deepak Nehra, Sanjeev Parshad, Rajgopal Acharya, Rajendra Badwe, Manish Bhandare, Urvashi Jain, Karishma Kirti, Nita Nair, Shailesh Shrikhande, Purvi Thakkar, Premkumar Anandan, Archana C S, Arun Holenarasipur Narasannaiah, Tejaswi Jagarlamudi, Rashmi M R, Mallikarjuna Manangi, Abhishek Raghavendra, K. Seshagiri Rao, Vinay S, Vinay Sajjan, Aneesh Shenoy, Santhosh Shivashankar Chikkanayakanahalli, Kavya Tharanath, Sushmita V, Peter Adidharma, Raksheeth Agarwal, Phebe Anggita Gultom, Ghafur Rasyid Arifin, Matthew Billy, Zatira Elfizri, Alessa Fahira, Devi Felicia, Triana Hardianti Gunardi, Nadya Johanna, Nadia Rahmadiani Nugrahadi, Sonar Soni Panigoro, Siti Rahmayanti, Retta Catherina Sihotang, Santi Yuanita Brata, Hadi Winoto, Nastaran Barati, Manoochehr Karami, Hamidreza Khorshidi, Homa Naderifar, Mazin A. Abdulla, Maggie Coleman, Ronan J Doherty, Rob Hannon, Brenda Murphy, Aine Stakelum, Des Winter, Lylas Aljohmani, Richard Farnan, Yeshey Seldon, Tanna Tan, Shriya Varghese, Mohammad Alherz, Muaaz Ather, Mohammad Bajilan, Vivien Graziadei, Isobel Pilkington, Omar Quidwai, Paul Ridgway, Haaris Shiwani, Abd al-Rahman Tahir, Eimear Blunnie, Daniel Burke, Niall Kennedy, Kate Macdonagh, Maeve O'Neill, Siobhan Rooney, Giuseppe Falco, Guglielmo Ferrari, Simone Mele, Gabriela Elisa Nita, Lara Ugoletti, Maurizio Zizzo, Gianmaria Confalonieri, Giovanni Pesenti, Fulvio Tagliabue, Gianluca Baronio, Deborah Ongaro, Giacomo Pata, Bruno Compagnoni, Renato Salvadori, Lucio Taglietti, Nicola D'Alessandro, Pierpaolo Di Lascio, Giovanni Pascale, Luca Bortolasi, Tommaso Campagnaro, Massimo Carlini, Giorgio Lisi, Davide Lombardi, Corrado Pedrazzani, Domenico Spoletini, Giulia Turri, Paola Violi, Donato Francesco Altomare, Fabrizio Aquilino, Nicola Musa, Vincenzo Papagni, Arcangelo Picciariello, Leonardo Vincenti, Dario Andreotti, Savino Occhionorelli, Matteo Tondo, Stefano Maria Massimiliano. Basso, Riccardo Cirelli, Marco Enrico Mario Maino, Guglielmo Niccolò Piozzi, Emanuele Picone, Rosa Scaramuzzo, Giovanni Sinibaldi, Alfonso Amendola, Lorenzo Anastasio, Luigi Bucci, Emanuele Caruso, Antonio Castaldi, Sara Di Maso, Vincenza Paola Dinuzzi, Giovanni Esposito, Maria Gaudiello, Mariano Cesare Giglio, Paola Antonella Greco, Gaetano Luglio, Andrea Manfreda, Ester Marra, Federica Mastella, Gianluca Pagano, Roberto Peltrini, Vincenzo Pepe, Michele Sacco, Viviana Sollazzo, Giovanni Spiezio, Ettore Cianchetti, Nunzia Menduni, Michele Maria Carvello, Francesca Di Candido, Antonino Spinelli, Fabio Corsi, Luca Sorrentino, Fabio Marino, Emanuele Luigi Giuseppe Asti, Luigi Bonavina, Emanuele Rausa, Martina Asta, Andrea Belli, Francesco Bianco, Carmela Cervone, Paolo Delrio, Armando Falato, Andrea Fares Bucci, Rita Guarino, Ugo Pace, Daniela Rega, Emilia De Luca, Gaetano Gallo, Giuseppe Sammarco, Giuseppe Sena, Giuseppina Vescio, Letizia Santandrea, Giampaolo Ugolini, Davide Zattoni, Nicola Chetta, Gaetano Logrieco, Serafino Vanella, Gianluca Garulli, Nicola Zanini, Andrea Bondurri, Francesco Cammarata, Francesco Colombo, Diego Foschi, Giulia Maria Beatrice Lamperti, Anna Maffioli, Gianluca Matteo Sampietro, Al'ona Yakushkina, Gloria Zaffaroni, Enrico Cicuttin, Maria Grazia Sibilla, Harmony Impellizzeri, Marco Inama, Gianluigi Moretto, Sylvie Mochet, Elisa Ponte, Antonella Usai, Stefano Mancini, Andrea Sagnotta, Luigi Solinas, Elisa Bolzonaro, Nicolò Tamini, Gianluca Curletti, Raffaele Galleano, Michele Malerba, Sofia Campanella, Gianfranco Cocorullo, Francesco Colli, Paolino De Marco, Nicolò Falco, Tommaso Fontana, Leonel jospin Kamdem Mambou, Antonella La Brocca, Leo Licari, Brenda Randisi, Giovanna Rizzo, Giulia Rotolo, Giuseppe Salamone, Roberta Tutino, Paolina Venturelli, Stefano Malabarba, Alessandro Sgrò, Ivan Vella, Bruno Cirillo, Daniele Crocetti, Giorgio De Toma, Pierfrancesco Lapolla, Andrea Mingoli, Paolo Sapienza, Angela Belvedere, Stefania Bianchini, Margherita Binetti, Arianna Birindelli, Valeria Tonini, Mauro Podda, Fabio Pulighe, Michele De Rosa, Lorenzo Bono, Felice Borghi, Paolo Geretto, Maria Carmela Giuffrida, Corrado Lauro, Alessandra Marano, Luca Pellegrino, Paola Salusso, Diego Sasia, Michela Campanelli, Alberto Realis Luc, Mario Trompetto, Roberto Cardia, Nicola Cillara, Antonio Nicola Giordano, Antonio Costanzo, Mario Alessandro Giovilli, Luca Turati, Silvestro Canonico, Guido Sciaudone, Francesco Selvaggi, Lucio Selvaggi, Nader Albsoul, Ahmad AlBsoul, Ala'a Aldeen Alkhatib, Osama Alsallaq, Justin Z. Amarin, Rami Ayoub, Isam Bsisu, M S El Muhtaseb, Mohammad Jabaiti, Jamal Melhem, Yasmeen Z. Qwaider, Mohammad Hasan Salameh, Ahmad Suleihat, Haya H. Suradi, Mohammad Alammarin, Almoutuz Aljaafreh, Mohammad Bani hani, Zeina Bani hani, Farah Bani Hani, Toqa Fahmawee, Shadi Hamouri, Cyrine Katanani, Ra'fat Tawalbeh, Tamara Tawalbeh, Hassan Zawahrah, Mohamad K. Abou Chaar, Lana Abusalem, Mahmoud Al-Masri, Hani Al-Najjar, Lutfi Barghuthi, Zahra Ahmed, Adnan Maulana, Omar Ngotho, Charbel Kamau, Aruyaru Stanley Mwenda, Fridah Bosire, Elizabeth Mwachiro, Robert Parker, Ian Simel, Kimutai Sylvester, Abdulmunem Ahmed Mustafa Althini, Sofian Elbarouni, Aya Elseed Elbeshina, Ahmed Gwea, Ans Malek, Wedad Albashir Masoud Farag, Abdulwahab Abdalei, Abu Baker Abdel Malik, Areej Abo-khammash, Ma'aly Abuhlaiga, Nour Adnan, Marwa Albaggar, Asma Alfitory, Asma Aljanfi, Fakhruddin Almuzghi, Zohoor Altumei, Fatima Alzabti, Hana Ashoushan, Mohamed Assalhi, Joma Azzubia, Sondos Bnhameida, Malik Delhen, Houssein Elshafei, Hana Elteir, Fatima Esbaga, Abdel Aziz Gobbi, Fatma Hamouda, Hamdan Hilan, Rania Ismail, Fieruz Jebran, Muataz Kasbour, Galia Maderi, Saja Mohammad, Burooj Mohammed, Habib Murtadi, Hamassat Mustafa, Mohamed Rajab, Sarah Trenba, Mariam Wafaa, Eman Al Sagheir, Alabas Almigheerbi, Ahmed Alzahaf, Sumayyah Ghayth Bahroun, Najah Ben Dallah, Mahmoud Elshaibani, Haitem Eswaye, Maha Karar, Samah Omar, Eman Younes, Maha Younes, Dafer Zreeg, Saleh Abujamra, Firas Ashour, Mala Elgammudi, Wesal Omar F. Aljadidi, Enas Saddouh, Randa Sharif, Aya Alabuzidi, AbdulMawlay Alwerfally, Sarra Aribi, Fatma Bibas, Taha Elfaituri, Yasmine Elhajjaji, Ala Khaled, Wegdan Khalil, Tesneem Layas, Enas Soula, Ahmed Tarek, Muad fathi khalleefah Abu hallalah, Hazem Abdelkarem Ahmed, Tagwa Alsharef, Abdulsalam Ali Ben Saoud, Tasnim El Gharmoul, Ahmed Elhadi, Safa Elrais, Abdulhalim Shebani, Heba Zarti, Asaid Zeiton, Marijus Ambrazevicius, Nerijus Kaselis, Migle Stakyte, Oleg Aliosin, Agne Cizauskaite, Sarunas Dailidenas, Vitalijus Eismontas, Migle Kybransiene, Vitalija Nutautiene, Narimantas Samalavicius, Dainius Simcikas, Algirdas Slepavicius, Albinas Tamosiunas, Nerijus Ubartas, Paulius Zeromskas, Saulius Bradulskis, Edvinas Dainius, Juozas Juocas, Egle Kubiliute, Juozas Kutkevicius, Aurimas Opolskis, Audrius Parseliunas, Andrejus Subocius, Egle Virbickaite, Diana Zuikyte, Algirdas Bogusevicius, Kristina Buzaite, Daiva Cepuliene, Ieva Cesleviciene, Vaidotas Cesna, Jolanta Gribauskaite, Povilas Ignatavicius, Mantas Jokubauskas, Monika Liugailaite, Ernest Margelis, Ruta Mazelyte, Lina Pankratjevaite, Matas Pažusis, Agne Rackeviciute, Justina Saladyte, Monika Škimelyte, Vygintas Šlenfuktas, Monika Sudeikyte, Algimantas Tamelis, Tomas Vanagas, Žygimantas Žumbakys, Aivaras Atkociunas, Audrius Dulskas, Justas Kuliavas, Justas Birutis, Sigitas Paškevicius, Mindaugas Šatkauskas, Donatas Danys, Matas Jakubauskas, Lina Jakubauskiene, Marius Kryzauskas, Vytautas Lipnickas, Gabija Makunaite, Fanjandrainy Rasoaherinomenjanahary, Herizo Rasolofonarivo, Luc Hervé Samison, Bitiel Banda, Vanessa Msosa, Ahmad Imran Ahmad Izzuddin, Andre Das, Ying Yee Gan, Tan Shong Sheng, Jia yng Siaw, Mohd Fadliyazid Ab Rahim, Dyg Zahratul Hamrak Abang Jamari, Nurfariza Che Husin, Muhd Yusairi Kamarulzaman, Yi Ping Lim, Nil Amri Mohamed Kamil, Mohd Razeen Mohd Hassan, Saidah Mohd Sahid, Johari Mustafa, Elaine Hui Been Ng, Wan Khamizar Wan Khazim, Ng Chang Ern, P.g. Lingeshan, Syariz Ezuan Sulaiman, Sue Ean Ang, Muhammad Navid Bin Mohamad Sithik, Yih Jeng Cheong, Mahadevan Deva Tata, Law Jia Xian, Aravinthan Kadravello, I-Ern Koh, Li-Yen Ng, Yuki Julius Ng We Yong, Kandasami Palayan, Chi Xuan Sam, Phuah Siow Jin, Jeremy Tan Ern Hwei, Yita Tang, Alvin Zubin Ter, Michael Pak-Kai Wong, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Fitjerald Henry, Thyivya Kalaiselvan, Muhammad Fairuz Shah Abd Karim, Mohamed Rezal Abdul Aziz, Nora Abdul Aziz, Tak Loon Khong, Peng Choong Lau, Hiong Chin Lim, April Camilla Roslani, Jonathan Chen Ken Seak, Sui-Weng Wong, Lai Fen Wong, Leow Yeen Chin, Mercy Chinemerem Anyanwu, Zachary Busuttil, Thomas Calleja, Kurt Lee Chircop, Ruth Cutajar, Andrew Michael Dimech, Joseph Galea, Kiara Gascon Perai, Ruth Gatt, Lisa Kelman, Elizabeth Micallef, Favour Nwolu, Kim Sammut, Joanna Thompson, Sean Warwicker, Matthew Zammit, Fernando Cordera, Efraín Cruz González, Jorge Sánchez-García, Francisco José Barbosa Camacho, Francisco Javier Barrera López, Carlos Jose Zuloaga Fernandez del Valle, Eric Acosta, Iván Romarico González Espinoza, Perla Moreno, Ana Olivia Cortes-Flores, Clotilde Fuentes Orozco, Alejandro Gonzalez Ojeda, Samantha Corro Díaz González, Laura Martinez, Bonifacio Mosqueda Amador, Armando Novoa, Dennet Arturo Olazo Espejo, Alejandro Jimenez, Federico Lopez Rosales, Elva Gabriela Vanoye, Luis Alberto Garcia Gonzalez, Roberto Carlos Miranda-Ackerman, Manuel Solano-Genesta, Alethia Alvarez-Cano, Hector Hugo Romero-Garza, Heriberto Medina-Franco, Lorelí Mejía-Fernández, Noel Salgado-Nesme, Omar Vergara-Fernandez, Guadalupe Montserrat Gutiérrez-Mota, Francisco Xavier Hernandez Vera, Anabella Llantada Lopez, Gilberto Morgan Villela, Felipe de Jesus Ramirez Padilla, Walezka Tapia Marin, Mónica Martínez Maldonado, Ramses Sánchez Suárez, José Manuel Troche, Chaymae Benyaiche, Oumaima Outani, Souadka Amine, Amine Benkabbou, Anass Mohammed Majbar, Raouf Mohsine, Ali Rafik, Thida Oung, Moe Moe Tin, Philipp Plarre, Anna Alberga, Nina Sluiter, Jurriaan Tuynman, Robin Blok, Didem Cömert, Roel Hompes, Marianne Kalff, Merel Elisabeth Stellingwerf, Pieter Tanis, Mark van Berge Henegouwen, Elise Maria van Praag, Daan Wisselink, Michael Gerhards, Josephine Lopes Cardozo, Emma Westerduin, Joske de Jonge, Aaw van Geloven, Kaz van Schilt, Frank den Boer, Simone Stoots, Stijn Vlek, Jamie Adams, Ibrahim S. Al-Busaidi, Gabrielle Budd, Seung il Choi, Michael Jen Jie Chu, Anurag Ganugapati, Lucy McKinstry, Rebecca Pascoe, Simon Richards, Kenrick Rosser, Annie Stevenson, Rebecca White, Shebani Farik, Jin Kwun, Ahmed Murad, Sarah Cowan, Timothy Hall, Michael Hayton, Laminou Malam Sani, Souleymane Oumarou Garba, Ibrahim Amadou Magagi, Oumarou Habou, Halima Aliyu, Muhammad Daniyan, Tunde T. Sholadoye, Lawal Abdullahi, Lofty-John Anyanwu, Aminu Mohammad Mohammad, Abubakar Bala Muhammad, Abdurrahman Abba Sheshe, Ibrahim Suleiman, Alaba Adesina, Ajibola Awolowo, Clement Onuoha, Omotayo Salami, Ogechukwu Taiwo, Agboola Taiwo, Stephen Kache, Jerry Godfrey Makama, Danjuma Sale, Olajide Abiola, Akinlabi Ajao, Anthony Ajiboye, Amarachukwu Etonyeaku, Julius Olaogun, Ademola Adebanjo, Opeoluwa Adesanya, Michael Olatunji Afolayan, Olanrewaju Balogun, Ayomide Makanjuola, Samuel Nwokocha, Rufus Wale Ojewola, Thomas Olagboyega Olajide, Adewale Aderounmu, Abdul-Rashid Adesunkanmi, Augustine Agbakwuru, Adeleke Akeem Aderogba, Olusegun Isaac Alatise, Olukayode Arowolo, Oladejo Lawal, Tajudeen Mohammed, Chinedu Ndegbu, Olalekan Olasehinde, Funmilola Wuraola, Akinbolaji Akinkuolie, Arinzechukwu Mosanya, Omobolaji Ayandipo, Peter Elemile, Taiwo Akeem Lawal, Samuel Ali SANI, Stephen Garba, Rebecca Hauwa SANI, Samson Olori, Henry Onyebuashi, Ifeanyi Umoke, Adedire Adenuga, Ademola Adeyeye, Olufemi Habeeb, Bashir Lawal, Abdulrasheed Nasir, Eirik Kjus Aahlin, Didrik Kjønås, Elisabeth Myrseth, Jibran Abbasy, Abdul Alvi, Omair Saleem, Asma Afzal, Anam Nazir, Muhammad Farooq, Ayesha Liaqat, Syed Asghar Naqi, Ali Raza, Muzna Sarfraz, Muhammad Sarwar, Muntaha Banglani, Ambreen Munir, Rahmat Sehrish, Bushra Ayub, Raza Sayyed, Amna Altaf, Saima Ayub, Komal Saeed, Bilal Syed, Sana Amir Akbar, Abdul Wahid Anwer, Ruqayya Naheed Khan, Amina Iqbal Khan, Shahid Khattak, Sameen Mohtasham, Muhammad Asad Parvaiz, Aamir Ali Syed, Abdul Basit Ansari, Noman Shahzad, Tanwir Khaliq, Isbah Rashid, Shahzad Hussain Waqar, Hasan Abu Al-saleem, Amjad Abu Alqumboz, Mohammad Alqadi, Adham Amro, Rawan Assa, Eman Awesat, Rawan Ayyad, Mohammed Hammad, Ayat Haymony, Bassel Hijazi, Bara Hmeidat, Rowaa Lahaseh, Aseel Qawasmi, Alaa Rajabi, Mohammed Shehada, Sundus Shkokani, Yasmine Yaghi, Nadine Yaghi, Mohammad AlZohour, Mohammad Farid, Yousef Mahmoud Habes, Wesam Juba, Yanal Nubani, Abdelrahman Rabee, Mohammad Sa'deh, Saeed Abed, Iyad Al basos, Mohammad Alswerki, Dina Ashour, Israa Awad, Samar Diab, Alaa El Jamassi, Sahar El-Kahlout, Somaya Elhout, Ahmed N K Hajjaj, Doaa Hasanain, Baraa Nabil hajjaj, Mohammed Obaid, Eman Saikaly, Ahmed Salhi, Hiba Al-Tammam, Murad Almasri, Muath Baniowda, Doha Beshtawi, Ali Horoub, Rami Misk, Bayan Mohammad, Rami Qasrawi, Tasnim Sholi, Samar Abu-Nimeh, Abrar Abu-srour, Sadi A. Abukhalaf, Samer Adawi, Barah Alsalameh, Kholoud Ayesh, Muawiyah Elqadi, Ahmad Hammouri, Fatima Karim Mustafa, Natalie Marzouqa, Shatha Melhem, Dima Miqdad, Balqees Mohamad, Mhammed Rawhi, Ayman B. Abu Ahammala, Ahmed Abu Ataya, Israa Abu Jayyab, Samar Al-Shwaikh, Othman Alagha, Mohammed Alasttal, Haneen Awadallah, Mahmood Elblbessy, Jehad Fares, Akram Jarbou, Ibtisam Mahfouz, Moath A. Albahnasawi, Asmaa' Abo mahadi, Hasan Abuelhatal, Ayham Abuelqomboz, Abdelrahman Almoqayyad, Abdallah Alwali, Reem Balaawi, Mahmoud Hamouda, Mohammed Humeid, Abdullah Jedyan, Tasneem Mahmoud Abu hamam, Ghadeer Matar, Ali Salem, Tahani Samra, Nureddin Shaheen, Karam Shihada, Ayoob A.Nemer, Mahmoud Abu Al Amrain, Abdulwhhab Abu Alamrain, Najlaa Abu Jamie, Mohammed R. Abu-Rous, Nada Alfarra, Mohammed AlTaweel, Noor Alwhaidi, Ramadan Hamed, Bader Saqqa, Ahmad Shaheen, Dana Aljaber, Loay Aljaberi, Malak Alwaheidi, Assef Jawaada, Hani Khaldi, Rami Qahoush, Jalil Qari, Rana Saadeh, Ahlam Salim, Aseel Yacoub, Abbas Abbas, Rana Abu shua`ib, Baraa Abu Zainah, Mahmoud AbuSirrees, Basheer Babaa, Ola Barhoush, Asef Belal qadomi, Laith Daraghmeh, Reema Haji, Alaa Khatatbeh, Lana Khatib, Salsabeel Qarariah, Yara Quzmar, Khalil Safadi, Roqaya Salameh, Mohammad Hassan, Shifaa Herzallah, Loai Massad, Ahmed Nazzal, Ranin Nazzal, Dennis Escobar, Gustavo Miguel Machain V, Agustin Rodriguez Gonzalez, Jorge Emerson Chachaima Mar, Nathaly Olga Chinchihualpa Paredes, Vicente Cuba, Walter Lopez, Maria Milagros Niquen Jimenez, Nestor Alberto Sanchez Bartra, Olenka Sapallanay Ojeda, Diego Sequeiros, Andrea Toscano Pacheco, María Vergara, Sol Abarca, Rodrigo Alcorta, Giuliano Borda-Luque, Ivan Edward Eusebio Zegarra, Claudia Luján López, Mirella Marrufo, Cinthya Mogrovejo, Andrea Nomura, Yamile Rodríguez Angeles, Maitza Rosario Vidal Meza, Gabriela Zavala, José Neiser Castillo Arrascue, Jomara Caroline Hidrogo Cabrera, José Julio Mariano Larrea vera, Miguel Osorio, Edgar Alcides Ylatoma Díaz, Mark Anthony Fontanilla, Joseph Roy Fuentes, Anna Leah Salazar, Genieve Dominguez, Marc Paul Lopez, Shiela Macalindong, Mark Augustine Onglao, Arjel Ramirez, Marie Dione Sacdalan, Mayou Martin Tampo, Gemma Leonora Uy, Jeremiah Mangahas, Kenneth Yabut, Joannes Paul Cañete, Bernalynn Eris Cansana, Ernes John Castro, Maria Kaiserin Lipana, Manuel Francisco Roxas, Vlu Jean Zara, Maciej Chrol, Paula Franczak, Michal Orlowski, Piotr Budzynski, Andrzej Budzynski, Pawel Bury, Agata Czerwinska, Jadwiga Dworak, Jacek Dziedzic, Michal Kisielewski, Jan Kulawik, Anna Lasek, Piotr Malczak, Marcin Migaczewski, Michal Pedziwiatr, Magdalena Pisarska, Dorota Radkowiak, Mateusz Rubinkiewicz, Anna Rzepa, Tomasz Skoczylas, Maciej Stanek, Katarzyna Truszkiewicz, Mateusz Wierdak, Marek Winiarski, Piotr Zarzycki, Anna Zub-Pokrowiecka, Piotr Kowalewski, Rafal Roszkowski, Maciej Waledziak, Miguel Tomé, Sara Patrocinio, Ines Guerreiro, Filipe Almeida, Xavier de Sousa, Nuno Monteiro, Maria Teresa Costa Santos, Daniela de Oliveira, Marta Lopes Serra, Daniela Morgado, Christian Neves, Ana Carolina Oliveira, Alice Pimentel, Sofia Silva, Márcia Carvalho, Lúcia Carvalho, Joana Magalhães, Leonor Matos, Tânia Monteiro, Carlota Ramos, Vanessa Santos, José Barbosa, Jose Costa-Maia, Vítor Devezas, Ana Fareleira, Cristina Fernandes, Diana Gonçalves, Henrique Mora, Marina Morais, Fabiana Silva de Sousa, Sara Catarino Santos, Ana Logrado, André Tojal, Edgar Amorim, Miguel F. Cunha, Ana Fazenda, João Pedro Melo Neves, Inês Isabel Sampaio da Nóvoa Gomes Miguel, Diogo Veiga, José Azevedo, Hugo Cardoso Louro, Mariana Leite, Maria Bairos Menezes, Bárbara Gama, Diana Brito, Marta Cristina Cruz Martins, André Graça e Magalhães, Ana Catarina Longras, Rita Lourenço, Diana Matos, Luis Castro, Filipa Policarpo, Joana Romano, Cristina Monteiro, Diogo Pinto, Marina Duarte, Sónia Fortuna Martins, Mariline Oliveira, Diogo Galvão, Lisandra Martins, Anaisa Silva, Viorel Taranu, Bárbara Vieira, Jessica Neves, Simone Oliveira, Hugo Ribeiro, Margarida Cinza, Rosa Felix, Arnaldo Machado, Joana Oliveira, Joana Patrício, Rita Pedroso de Lima, Mário Pereira, Miguel Rocha Melo, Cristina Velez, Alberto Abreu da Silva, Mariana Claro, Daniel Costa Santos, Andreia Ferreira, Hugo Capote, Daniela Rosado, Filipa Taré, Oriana Nogueira, Miguel Ângelo, José Miguel Baiao, Andreia Guimarães, João Marques, Miguel Nico Albano, Marta Silva, Ana Valente da Costa, Teresa Vieira Caroço, Sara Almeida Braga, Ines Capunge, Marta Fragoso, João Guimarães, Bruno Pinto, João Ribeiro, Miguel Angel, Guilherme Fialho, Monica Guerrero, Filipa Campos Costa, Diogo Cardoso, Vasco Cardoso, Magda Alves, Inês Estalagem, Tiago Louro, Cláudia Marques, Rita Martelo, Miguel Morgado, Rita Canotilho, Ana Margarida Correia, Pedro Martins, Mariana Peyroteo, João Gomes, Rita Monteiro, Manuela Romano, Daniela Macedo Alves, Rita Peixoto, Catarina Quintela, Maria João Jervis, Débora Melo, André Pacheco, Valter Paixão, Vera Pedro, Joana Pimenta, João Pimenta de Castro, Ana Rocha, Mircea Beuran, Cezar Ciubotaru, Bogdan Diaconescu, Sorin Hostiuc, Ionut Negoi, Bogdan Stoica, NA NA, Evgeny Anokhin, Georgy Kuznetsov, Giorgi Oganezov, Fedor Paramzin, Ekaterina Romanova, Valeryan Rutkovskii, Vasilii Rutkovskii, Mikhail Shushval, Mikhail Zabiyaka, Khasan Dzhumabaev, Valerii Ivanov, Zaman Mamedli, Sergey Achkasov, Artem Balkarov, Elnur Nabiev, Marat Nagudov, Evgeny Rybakov, Karina Saifutdinova, Oleg Sushkov, Lule Joseph, Isaac Ndayishimiye, Ntirenganya Faustin, Alphonse Zeta Mutabazi, Jean Paul Mvukiyehe, Vizir J.P Nsengimana, Carine Uwakunda, Mohammad Monir Abbas, Nouf Akeel, Murad Aljiffry, Kholoud Awaji, Ali Farsi, Ghader Jamjoum, Ahmad Khoja, Ashraf Maghrabi, Nadim Malibary, Mohammed Nassif, Abdulaziz Saleem, Abdullah Sultan, Wail Tashkandi, Hanaa Tashkandi, Nora Trabulsi, Mouhamadou Bachir Ba, Adja Coumba Diallo, Abdourahmane Ndong, Vladica Cuk, Uroš Jankovic, Sharon Zhiling Koh, Frederick Koh, Kuok Chung Lee, Kai Yin Lee, Sean Lee, Wei Qi Leong, Su Ann Lui, Prajwala Prakash, Jan Grosek, Gregor Norcic, Ales Tomazic, Nicolas Fitchat, Robert Jaich, Devorah Wineberg, Modise Zacharia Koto, Daniella Baiocchi, Damian Clarke, Christina Johanna Steenkamp, Sharon Bannister, Adam Boutall, Galya Chinnery, Anna Coccia, Angela Dell, Parveen Karjiker, Christo Kloppers, Nicholas Loxton, Tumi Mabogoane, Francois Malherbe, Eugenio Panieri, Shreya Rayamajhi, Tirsa van Wyngaard, Claire Warden, T E Madiba, Nivashen Pillay, Savannah Brooks, Charlise Kruger, Lisa Hannah Van Der Merwe, Ferhana Gool, Maahir Kariem, Heather Bougard, Nazmie Kariem, Fazlin Noor, Reantha Pillay, Leandi Steynfaardt, Lucía González González, José Miguel Marín Santos, Paula Martín-Borregón, Javier Martínez Caballero, Cristina Nevado García, Pastora Rodriguez Fraga, Gonzalo De Castro Parga, Maria Pilar Fernández Veiga, Lucía Garrido López, Hugo Infante Pino, Irene Lages Cal, Marta López Otero, Manuel Nogueira Sixto, Marta Paniagua García Señorans, Laura Rodríguez Fernández, Alejandro Ruano Poblador, Erika Rufo Crespo, Raquel Sanchez-Santos, Vincenzo Vigorita, Ester Alonso Batanero, Dorisme Asnel, Isabel Cifrian Canales, Elisa Contreras Saiz, Irene De Santiago Alvarez, Tamara Díaz Vico, Sebastian Fernandez Arias, Daniel Fernández Martínez, Carmen García Bernardo, Luis Joaquín García Flórez, Carmen Garcia Gutierrez, Manuel García Munar, Carlos Alberto Márquez Zorrilla Molina, Marta Merayo, José Luis Michi Campos, Maria Moreno Gijon, Jorge L. Otero-Diez, Jose Luis Rodicio Miravalles, Lorena Solar-Garcia, Aida Suárez Sánchez, Nuria Truan, Cristina Alejandre Villalobos, Yurena Caballero Díaz, Marta Jimenez, Dacil Montesdeoca, Antonio Navarro-Sánchez, Victor Vega, Juan Beltrán de Heredia, Zahira Gómez, Carlos Jezieniecki, Ana Patricia Legido Morán, Mario Montes-Manrique, Mario Rodriguez-Lopez, María Ruiz Soriano, Jeancarlos Trujillo Díaz, Andrea Vazquez Fernandez, Nuria Argudo, Miguel Pera, Laia Torrent Jansà, Melody García Domínguez, Ignacio Goded, Marta Roldón Golet, Issa Talal El-Abur, Alejandra Utrilla Fornals, Vanesa Zambrana Campos, Maria Del Mar Aguilar Martinez, Marina Bosch, Luis García-Catalá, Luis Sánchez-Guillén, Eva Artigau, Nuria Gomez Romeu, David Julià Bergkvist, Beatriz Espina Perez, Olga Morató, Carles Olona, Beatriz Diéguez, Alexander Forero-Torres, Manuel Losada, Segundo Gomez-Abril, Paula Gonzálvez, Rosario Martinez, Sergio Navarro Martínez, Carmen Payá-Llorente, Álvaro Pérez Rubio, Sandra Santarrufina Martinez, Juan Carlos Sebastián Tomás, Ramon Trullenque Juan, Alberto Gegúndez Simón, Paloma Maté, Maria Isabel Prieto-Nieto, Ines Rubio-Perez, Aitor Urbieta, Marina Vicario Bravo, David Abelló, Matteo Frasson, Alvaro Garcia-Granero, Alfredo Abad Gurumeta, Ane Abad-Motos, Elena Lucena-de Pablo, Beatriz Nozal, Javier Ripollés-Melchor, Rut Salvachúa, Esther Ferrero, Luis Garcia-Sancho Tellez, Antonio L. Picardo, Jose Alberto Rojo López, Laura Patricia Zorrilla Matilla, Carmen Cagigas Fernandez, Sonia Castanedo Bezanilla, José Estevez Tesouro, Maria Jose Fernandez-Diaz, Juan García Cardo, Marcos Gomez Ruiz, Erik Gonzalez-Tolaretxipi, Jaime Jimeno Fraile, Cristobal Poch, Montserrat Rodriguez-Aguirre, Noemí Troche Pesqueira, Maria Soledad Trugeda-Carrera, Javier de la Torre, Ruth Blanco-Colino, Eloy Espin-Basany, Martin Espinosa-Bravo, Clara Morales Comas, Eduardo Reyes Afonso, Joaquín Rivero Déniz, Christian Siso Raber, Mireia Verdaguer Tremolosa, Pramodh Chandrasinghe, Sumudu Kumarage, Nimeshi Wijekoon Arachchilage, Ahmed Abdalla Ahmed Elkamel, Mohammed A. Adam, Nina Blomme, Anders Thorell, Fredrik Wogensen, Andreas Älgå, Dhirar Ansarei, Fuat Celebioglu, Göran Heinius, Linda Nigard, Emil Pieniowski, Sandra Ahlqvist, Ida Björklund, Andreas Frånberg, Martina Håkansson, Karin Adamo, Oskar Franklin, Malin Sund, Rebecca Wiberg, Yvette Andersson, Abbas Chabok, Maziar Nikberg, Alexander Kugelberg, Claudia Canonica, Dimitrios Christoforidis, Fabrizio Fasolini, Paolo Gaffuri, Mauro Giuliani, Francesco Meani, Sotirios Georgios Popeskou, Silvia Pozza, Wiebke Wandschneider, Lorenz Peterer, Lukas Werner Widmer, Bernd Zimmermann, Panagiotis Bakoleas, Iris Chanousi, Lydia Charalampidou, Lukasz Filip Grochola, Franziska Heid, Sotirios Ntaoulas, Michail Outos, Georgios Peros, Hanna Podolska-Skoczek, Katharina Beate Reinisch, Christian Zielasek, Nicolas Demartines, Jérôme Gilgien, Amaniel Kefleyesus, Pénélope St-Amour, Arnaud Toussaint, Maryam Alhimyar, Bayan Alsaid, Amr Alyafi, Ahmad Alkhaledi, Basel Kouz, Ahmad Omarain, Yusra Al-Sabbagh, Haya Alkhatib, Samer Sara, Ahmad Alhaj, Aghyad Danial, Lama Kadoura, Sarah Maa Albared, Yamen Monawar, Louei Nahas, Barook Abd, Ahmad Saad, Habib Wakkaf, Hatem Bouzaiene, Montassar Ghalleb, Elif Akaydin, Ata Cem Akbaba, Onur Atakul, Ege Baltaci, Sevval Besli, Gökçen Burgu, Ulukan Cenal, Cansu de Muijnck, Hasan Can Demirkaya, Alper Dogruoz, Zeynep Ipek Gezer, Yasemin Gündogdu, Merve Kara, Hasan Kürsad Korkmaz, Gökalp Kagan Kurtoglu, Volkan Ozben, Berk Baris Ozmen, Ahmet Murat Pektas, Eda Kübra Sel, Nilüfer Yenidünya, Fuat Baris Bengur, Berke Mustafa Oral, Tahir Koray Yozgatli, Seymur Abdullayev, Mehmet Emin Gunes, Nuri Alper Sahbaz, Tuba Banaz, Kübra Kargici, Omer Faruk Kuyumcu, Erkan Yanikoglu, Merve Yesilsancak, Duygu Yilmaz, Melik Kagan Aktas, Ahmet Rencuzogullari, Arda Isik, Sezai Leventoglu, Ali Yalçinkaya, Osman Yüksel, Mustafa U Kalayci, Yasin Kara, Inanc Samil Sarici, Alp Akin, Gökçe nur Alemdag, Ekin Arslan, Bahadir Emre Baki, Muhammed Selim Bodur, Adnan Calik, Bahar Candas Altinbas, Irem Cihanyurdu, Oguz Erkul, Burak Gül, Ali Guner, Beyza Köse, Anil Semiz, Sule Sevim, Serkan Tayar, Kadir Tomas, Ozan yavuz Tüfek, Serdar Türkyilmaz, Mehmet Ulusahin, Arif Usta, Reyyan Yildirim, Sertaç Ata Güler, Ozan Can Tatar, Ecenur Varol, Busenur Kirimtay, Muhammed Uysal, Alp Yildiz, Emin Kose, Ahmet Burak Ciftci, Elif Çolak, Huseyin Eraslan, Gultekin Ozan Kucuk, Kürsat Yemez, Herman Lule, Mumbere Bienfait, Emmanuel Bua, Noella Okalany, Maksym Basarab, Oleksii Bielosludtsev, Kateryna Kolhanova, Kateryna Perepelytsia, Kateryna Romanukha, Dmytro Savenkov, Stanislav Siryi, Maksym Tereshchenko, Nezamai Viacheslav, Anton Volovetskyi, Andrey Kebkalo, Yegor Tryliskyy, Volodimir Tyselskiy, Eilidh Bruce, Bing Lun Chow, Emma Iddles, Sarah McGuckin, Nicola Newall, George Ramsay, Parivrudh Sharma, Caitlin Stewart, Jeremy Wong, Abdul Badran, Michael Bath, Fanny Belais, Eman Butt, Kaustuv Joshi, Milan Kapur, Mike Shaw, Adam Townson, Christopher Yee Khang Williams, Timothy Gray, Robert Greig, Mansoor Husain, Elspeth Murray, Ahmed Mustafa, Ashar Asif, Arya Gokul, Max Shah, Mabel Temisanren Akitikori, Alexandros Charalabopoulos, Sophie Davidson, Sinead McNally, Shamil Rupani, Fatema Juma, Sarah Catherine Mills, Laura Muirhead, Kate Sellars, Una Walsh, Oliver Warren, Alice Chambers, Richard Hunt, Stephen Boyce, Hannah Cornwall, Isabel Tol, Eleftherios Orestis Argyriou, Nicola Eardley, Meical Povey, Joanna M S Aithie, Ahmer Irfan, Mari-Claire McGuigan, Robert Starr, Craig Russell Warren, Jess Archibald, Georgia Kirby, Ivan Kisyov, Chun Kheng Khoo, Rachel Lee, Dana Photiou, Rowan Davis, Uday Prasad, P Zichu Yang, Jonathan Bird, Edmund Leung, Virginia Summerour, Chelise Currow, Jianshen Kiam, Gerald Jack Soon Tan, Anitha Muthusami, Ibifunke Pegba-Otemolu, Tomas Urbonas, Joseph Nunoo-Mensah, Edgaras Smolskas, Alex Boddy, Gianpiero Gravante, David Hunter, David Andrew, Amanda Koh, Amari Thompson, Lawrence Adams, Hollie A Clements, Kasun De Silva, Ogbonnia Ekpete, Seraj Haque, Scott Henderson, Bilal Ibrahim, Thummini Jayasinghe, Jennifer Livie, Keir Mailley, Gopikrishnan Nair, Daniel Tan, Caitlin Baggaley, Aleksander Dawidziuk, Bartosz Szyszka, Charlotte Barter, Nirav Gandhi, Karen Hassell, Samantha Hitchin, Jennett Kelsall, Eva Nagy, Ashrafun Nessa, Lisa Whisker, Fady Yanni, Mahmoud Ali, Deeksha Arora, Sunanda Hediwattege, Navam Kumarasinghe, Munir Rathore, Athula Tennakoon, Syed Mustafa Ali Ahmad, Oreoluwa Bajomo, Fahema Nadira, Valerio Celentano, Ewen Griffiths, Rama Santhosh Karri, Jason Kei Chak Mak, Michelle Pipe, Muhammad Iqbal Bhatti, Mohamed Rabie, Connor Boyle, David Hamilton, Aishath Mihuna, James Chean Khun Ng, Gary Nicholson, Agata Oliwa, Robert Pearson, Anna Rose, Shun Qi Yong, Catherine Boereboom, Michael Hanna, Catherine Walter, Thomas Samuel Greensmith, Rachel Mitchell, Eimear Monaghan, James Crawford, Susan Moug, James Blackwell, Hannah Boyd-Carson, Philip Herrod, Omar Al-Allaf, Miriam Beattie, Cameron Bullock, Shivang Burman, Gemma Clark, Nicolas Flamey, Oliver Flannery, Alexander Harding, Ben Kodiatt, Samuel Lawday, Shivani Mahapatra, Navin Mukundu Nagesh, Michael Ng, Dupinderjit Rye, Andrel Yoong, Laura Clark, Chris Deans, Monisha Edirisooriya, Emma Victoria Carrington, Tsz Lun Ernest Wong, Baasil Yusuf, Carla Chamberlain, Kathryn Duke, Elizabeth Kmiotek, Azel Botes, Natalie Condie, Timothy Schrire, Reena Shah, Iolo Thomas-Jones, Charlotte Yates, Natasha Anthony, Edward Matthews, Kapil Sahnan, James Tankel, Sally Tucker, Jasmine Winter Beatty, Paul Ziprin, William Duggan, Anastasia Kantartzi, Shruthi Sridhar, Rachel Alys Khaw, Prakhar Srivastava, Charlotte Underwood, Homero Alves do Canto Brum, Sharat Chopra, Laura Davis, Rebecca Hughes, Joshua Tulley, Justin Alberts, Thomas Athisayaraj, Mojolaoluwa Olugbemi, Kasim Ahmad, Claudia Chan, Gavin Chapman, Hannah Fleming, Benjamin Fox, Julia Grewar, Kate Hulse, Duncan Rutherford, Mackay Sinead, Scott Smith, Doug Speake, Peter G Vaughan-Shaw, Natasha Christodoulides, Simrit Kudhail, Matthew Welch, Syed Muhibullah Husaini, Simon Lambracos, Chikamuche Anyanwu, Rishi Suresh, Jimmy Scott Thomas, Elizabeth Gleeson, Rebecca Platoff, Areeba Saif, Zachary Enumah, Eric Etchill, Alodia Gabre-Kidan, Mitchell Bernstein, Francesco Maria Carrano, Joseph Connors, Patricio Lynn, Marcovalerio Melis, Elliot Newman, Deshka S Foster, Kenneth Perrone, Ashley Titan, Sarwat Ahmad, Andrea Chao M.D. Bafford, Marco Dal Molin, Nader Hanna, Syed Nabeel Zafar, Mark Hemmila, Lena Napolitano, Jane J Wong, Julia Chandler, Lauren Wood, Sherry Wren, Taylor Ottesen, Lucia You, Kristin Yu, María del pilar Arciénega Yañez, Martin Ferreira Fernandes, Daniel González, Santiago Cubas, María Catalina González, Vanessa Zubiaurre, Rodrigo Demolin, Nicolas Giroff, Pablo Sciuto, Maite Campos, Gabriela Rodríguez Cantera, Garg Deepika, Elliot Simuchimba, Anadi Bulaya, Chali Chibuye, Bright Chirengendure, Mary-Rose Kabale, Kizito Kabongo, James Munthali, Oliver Mweso, Francis Pikiti, James Otieno, Log Tung Lai, Brighid Blackman, Sophie Richards, Suren Subramaniam, Rafid Karim, Nathan Kok, Yanni Dion Lee, Shabina Ali, Aanjaneya Sinha, Robert Corrigan, Nicole Barnes, Florence Wong, Grace Dennis, Julia Jedamzik, Emil Phillips, Wivine Piette, Marie Van hentenryck, Houenoukpo Koco, Souliath Lawani, Mamo Woldu Kassa, Tainá Santos Bezerra, Petar Gribnev, Dobromir Dimitrov, Panche Krastev, Sovannarith Oum, Divine Tim Bonghaseh, Maryam Al Farsi, Nourah Alsharqawi, Veronica Acevedo, Andrea Carolina Castillo Barbosa, Felipe Giron, Jimmy Paul Leon Rodriguez, Darko Kucan, Damir Rosko, Neven Barsic, Domagoj Župan, Amgad Hegazi, Vendula Truncíková, Vladimir Fryba, Mostafa Mohamed, Ahmed Sultan, Ahmed Nagi, Abdallah Rashad Temerik, Mohamed Elemam Elshawy, Moustafa Ibrahim Mahmoud, Shrouk Omar, Mohamed Anwar, Tarek Rageh, Aya Elmokadem, Khaled Gaballa, Sandra Teppo, Antti Turunen, Pasi Pengermä, Quentin Ballouhey, Damien Bergeat, Ariane Weyl, Elisabeth Hain, Adam Gyedu, Edwin Yenli, Dorcas 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Jimenez Ley, Daniel Arizpe, Elizabeth Lagunes Lara, Elizabeth Victoria Castro López, Jose Eaazim, Marije Gordinou de Gouberville, Vivian Bastiaenen, Simone Rottier, Fouad Nahab, Maria Yeonhee Ji, Mohammed Seyoji, Callistus Nwachukwu, Okechukwu Emeghara, Sayyid Egbunu Muhammed, Ayodeji Idowu, Olamiposi Sowemimo, Olakayode Ogundoyin, Oluwatosin Akande, Alexander Lott, Maliha Nadeem, Ahsan Ali Laghari, Asif Loya, Hassan Mushtaq, Muhammad Tariq Abdullah, Baseel Abuhilal, Mohammad Atawneh, Hamdan Hamdan, Belal Alhabil, Abedelrahman Srour, Ibrahim Mousa, Luis Da Silva Medina, Katarzyna Bartosiak, Pedro Ferreira, Vítor Francisco, Ricardo Lemos, Luísa Frutuoso, Sara Fernandes, Telma Fonseca, Jorge Pereira, Juan Rachadell, Ana Torre, Filipe Madeira Martins, Ana Cristina Carvalho, Joana Rodrigues Ferreira, Bruno Ribeiro da Silva, Helena Devesa, Ana Vieira, Inês Mónica, Margarida Amaro, Diogo Sousa, Marta Reia, João Louro, Ana Martins, Joaquina Dominguez, Inês Santos, Nuno Miguel Freitas 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F., Panieri E., Rayamajhi S., van Wyngaard T., Warden C., Madiba T.E., Pillay N., Brooks S., Kruger C., Van Der Merwe L.H., Gool F., Kariem M., Bougard H., Kariem N., Noor F., Pillay R., Steynfaardt L., Gonzalez Gonzalez L., Marin Santos J.M., Martin-Borregon P., Martinez Caballero J., Nevado Garcia C., Rodriguez Fraga P., De Castro Parga G., Fernandez Veiga M.P., Garrido Lopez L., Infante Pino H., Lages Cal I., Lopez Otero M., Nogueira Sixto M., Paniagua Garcia Senorans M., Rodriguez Fernandez L., Ruano Poblador A., Rufo Crespo E., Sanchez-Santos R., Vigorita V., Alonso Batanero E., Asnel D., Cifrian Canales I., Contreras Saiz E., De Santiago Alvarez I., Diaz Vico T., Fernandez Arias S., Fernandez Martinez D., Garcia Bernardo C., Garcia Florez L.J., Garcia Gutierrez C., Garcia Munar M., Marquez Zorrilla Molina C.A., Merayo M., Michi Campos J.L., Moreno Gijon M., Otero-Diez J.L., Rodicio Miravalles J.L., Solar-Garcia L., Suarez Sanchez A., Truan N., Alejandre Villalobos C., Caballero Diaz Y., Jimenez M., Montesdeoca D., Navarro-Sanchez A., Vega V., Beltran de Heredia J., Gomez Z., Jezieniecki C., Legido Moran A.P., Montes-Manrique M., Rodriguez-Lopez M., Ruiz Soriano M., Trujillo Diaz J., Vazquez Fernandez A., Argudo N., Pera M., Torrent Jansa L., Garcia Dominguez M., Goded I., Roldon Golet M., Talal El-Abur I., Utrilla Fornals A., Zambrana Campos V., Aguilar Martinez M.D.M., Bosch M., Garcia-Catala L., Sanchez-Guillen L., Artigau E., Gomez Romeu N., Julia Bergkvist D., Espina Perez B., Morato O., Olona C., Dieguez B., Forero-Torres A., Losada M., Gomez-Abril S., Gonzalvez P., Martinez R., Navarro Martinez S., Paya-Llorente C., Perez Rubio A., Santarrufina Martinez S., Sebastian Tomas J.C., Trullenque Juan R., Gegundez Simon A., Mate P., Prieto-Nieto M.I., Rubio-Perez I., Urbieta A., Vicario Bravo M., Abello D., Frasson M., Garcia-Granero A., Abad Gurumeta A., Abad-Motos A., Lucena-de Pablo E., Nozal B., Ripolles-Melchor J., Salvachua R., Ferrero E., Garcia-Sancho Tellez L., Picardo A.L., Rojo Lopez J.A., Zorrilla Matilla L.P., Cagigas Fernandez C., Castanedo Bezanilla S., Estevez Tesouro J., Fernandez-Diaz M.J., Garcia Cardo J., Gomez Ruiz M., Gonzalez-Tolaretxipi E., Jimeno Fraile J., Poch C., Rodriguez-Aguirre M., Troche Pesqueira N., Trugeda-Carrera M.S., de la Torre J., Blanco-Colino R., Espin-Basany E., Espinosa-Bravo M., Morales Comas C., Reyes Afonso E., Rivero Deniz J., Siso Raber C., Verdaguer Tremolosa M., Chandrasinghe P., Kumarage S., Wijekoon Arachchilage N., Abdalla Ahmed Elkamel A., A. Adam M., Blomme N., Thorell A., Wogensen F., Alga A., Ansarei D., Celebioglu F., Heinius G., Nigard L., Pieniowski E., Ahlqvist S., Bjorklund I., Franberg A., Hakansson M., Adamo K., Franklin O., Sund M., Wiberg R., Andersson Y., Chabok A., Nikberg M., Kugelberg A., Canonica C., Christoforidis D., Fasolini F., Gaffuri P., Giuliani M., Meani F., Popeskou S.G., Pozza S., Wandschneider W., Peterer L., Widmer L.W., Zimmermann B., Bakoleas P., Chanousi I., Charalampidou L., Grochola L.F., Heid F., Ntaoulas S., Outos M., Peros G., Podolska-Skoczek H., Reinisch K.B., Zielasek C., Demartines N., Gilgien J., Kefleyesus A., St-Amour P., Toussaint A., Alhimyar M., Alsaid B., Alyafi A., Alkhaledi A., Kouz B., Omarain A., Al-Sabbagh Y., Alkhatib H., Sara S., Alhaj A., Danial A., Kadoura L., Maa Albared S., Monawar Y., Nahas L., Abd B., Saad A., Wakkaf H., Bouzaiene H., Ghalleb M., Akaydin E., Akbaba A.C., Atakul O., Baltaci E., Besli S., Burgu G., Cenal U., de Muijnck C., Demirkaya H.C., Dogruoz A., Gezer Z.I., Gundogdu Y., Kara M., Korkmaz H.K., Kurtoglu G.K., Ozben V., Ozmen B.B., Pektas A.M., Sel E.K., Yenidunya N., Bengur F.B., Oral B.M., Yozgatli T.K., Abdullayev S., Gunes M.E., Sahbaz N.A., Banaz T., Kargici K., Kuyumcu O.F., Yanikoglu E., Yesilsancak M., Yilmaz D., Aktas M.K., Rencuzogullari A., Isik A., Leventoglu S., Yalcinkaya A., Yuksel O., Kalayci M.U., Kara Y., Sarici I.S., Akin A., Alemdag G.N., Arslan E., Baki B.E., Bodur M.S., Calik A., Candas Altinbas B., Cihanyurdu I., Erkul O., Gul B., Guner A., Kose B., Semiz A., Sevim S., Tayar S., Tomas K., Tufek O.Y., Turkyilmaz S., Ulusahin M., Usta A., Yildirim R., Guler S.A., Tatar O.C., Varol E., Kirimtay B., Uysal M., Yildiz A., Kose E., Ciftci A.B., Colak E., Eraslan H., Kucuk G.O., Yemez K., Lule H., Bienfait M., Bua E., Okalany N., Basarab M., Bielosludtsev O., Kolhanova K., Perepelytsia K., Romanukha K., Savenkov D., Siryi S., Tereshchenko M., Viacheslav N., Volovetskyi A., Kebkalo A., Tryliskyy Y., Tyselskiy V., Bruce E., Chow B.L., Iddles E., McGuckin S., Newall N., Ramsay G., Sharma P., Stewart C., Wong J., Badran A., Bath M., Belais F., Butt E., Joshi K., Kapur M., Shaw M., Townson A., Williams C.Y.K., Gray T., Greig R., Husain M., Murray E., Mustafa A., Asif A., Gokul A., Shah M., Akitikori M.T., Charalabopoulos A., Davidson S., McNally S., Rupani S., Juma F., Mills S.C., Muirhead L., Sellars K., Walsh U., Warren O., Chambers A., Hunt R., Boyce S., Cornwall H., Tol I., Argyriou E.O., Eardley N., Povey M., Aithie J.M.S., Irfan A., McGuigan M.-C., Starr R., Warren C.R., Archibald J., Kirby G., Kisyov I., Khoo C.K., Lee R., Photiou D., Davis R., Prasad U., Yang P.Z., Bird J., Leung E., Summerour V., Currow C., Kiam J., Tan G.J.S., Muthusami A., Pegba-Otemolu I., Urbonas T., Nunoo-Mensah J., Smolskas E., Boddy A., Gravante G., Hunter D., Andrew D., Koh A., Thompson A., Adams L., Clements H.A., De Silva K., Ekpete O., Haque S., Henderson S., Ibrahim B., Jayasinghe T., Livie J., Mailley K., Nair G., Tan D., Baggaley C., Dawidziuk A., Szyszka B., Barter C., Gandhi N., Hassell K., Hitchin S., Kelsall J., Nagy E., Nessa A., Whisker L., Yanni F., Ali M., Arora D., Hediwattege S., Kumarasinghe N., Rathore M., Tennakoon A., Ali Ahmad S.M., Bajomo O., Nadira F., Celentano V., Griffiths E., Karri R.S., Mak J.K.C., Pipe M., Bhatti M.I., Rabie M., Boyle C., Hamilton D., Mihuna A., Ng J.C.K., Nicholson G., Oliwa A., Pearson R., Rose A., Yong S.Q., Boereboom C., Hanna M., Walter C., Greensmith T.S., Mitchell R., Monaghan E., Crawford J., Moug S., Blackwell J., Boyd-Carson H., Herrod P., Al-Allaf O., Beattie M., Bullock C., Burman S., Clark G., Flamey N., Flannery O., Harding A., Kodiatt B., Lawday S., Mahapatra S., Mukundu Nagesh N., Ng M., Rye D., Yoong A., Clark L., Deans C., Edirisooriya M., Carrington E.V., Wong T.L.E., Yusuf B., Chamberlain C., Duke K., Kmiotek E., Botes A., Condie N., Schrire T., Shah R., Thomas-Jones I., Yates C., Anthony N., Matthews E., Sahnan K., Tankel J., Tucker S., Winter Beatty J., Ziprin P., Duggan W., Kantartzi A., Sridhar S., Khaw R.A., Srivastava P., Underwood C., Alves do Canto Brum H., Chopra S., Davis L., Hughes R., Tulley J., Alberts J., Athisayaraj T., Olugbemi M., Ahmad K., Chan C., Chapman G., Fleming H., Fox B., Grewar J., Hulse K., Rutherford D., Sinead M., Speake D., Vaughan-Shaw P.G., Christodoulides N., Kudhail S., Welch M., Husaini S.M., Lambracos S., Anyanwu C., Suresh R., Thomas J.S., Gleeson E., Platoff R., Saif A., Enumah Z., Etchill E., Gabre-Kidan A., Bernstein M., Carrano F.M., Connors J., Lynn P., Melis M., Newman E., Foster D.S., Perrone K., Titan A., Ahmad S., Bafford A.C.M.D., Dal Molin M., Hanna N., Zafar S.N., Hemmila M., Napolitano L., Wong J.J., Chandler J., Wood L., Wren S., Ottesen T., You L., Yu K., Arcienega Yanez M.D.P., Ferreira Fernandes M., Gonzalez D., Cubas S., Gonzalez M.C., Zubiaurre V., Demolin R., Giroff N., Sciuto P., Campos M., Rodriguez Cantera G., Deepika G., Simuchimba E., Bulaya A., Chibuye C., Chirengendure B., Kabale M.-R., Kabongo K., Munthali J., Mweso O., Pikiti F., Otieno J., Lai L.T., Blackman B., Subramaniam S., Karim R., Kok N., Lee Y.D., Ali S., Sinha A., Corrigan R., Barnes N., Wong F., Dennis G., Jedamzik J., Phillips E., Piette W., Van hentenryck M., Koco H., Lawani S., Kassa M.W., Santos Bezerra T., Gribnev P., Dimitrov D., Krastev P., Oum S., Bonghaseh D.T., Al Farsi M., Alsharqawi N., Acevedo V., Castillo Barbosa A.C., Giron F., Leon Rodriguez J.P., Kucan D., Rosko D., Barsic N., Zupan D., Hegazi A., Truncikova V., Fryba V., Mohamed M., Nagi A., Rashad Temerik A., Elshawy M.E., Mahmoud M.I., Anwar M., Rageh T., Elmokadem A., Gaballa K., Teppo S., Pengerma P., Ballouhey Q., Bergeat D., Weyl A., Hain E., Gyedu A., Yenli E., Osei-Poku D., Rompou V.-A., Zoikas A., Gaitanidis A., Koukis G., Perivoliotis K., Tavlas P., Galanos-Demiris K., Zografos G., Karavokyros I., Xanthopoulou G., Iordanidou E., Ayau F., Garcia A., Damjan P., Wason D., B L A., Rangganata E., Kamath P., O'Connor D.B., Pinto M., Perrone F., Tropeano F.P., Troilo F., Bossi D., Scala D., Pulitano L., Carella M., Pietrabissa A., Gori A., Giraudo G., De Simone V., Russo A.A., Braccio B., Al-Taher R., Athamneh S., Parker A., Sawiee A., Kattia A., Tababa O., Shaeeb Z., Syminas V., Jurgaitis J., Damuleviciene G., Svagzdys S., Razafimanjato N.N.M., Chieng Loo L., Tiong I.C., Wan Muhmad W.F., Vijeyan H., Li Ying T., Grech G., Arrangoiz R., Jimenez Ley V.B., Arizpe D., Lagunes Lara E., Castro Lopez E.V., Eaazim J., Gordinou de Gouberville M., Bastiaenen V., Rottier S., Nahab F., Ji M.Y., Seyoji M., Nwachukwu C., Emeghara O., Muhammed S.E., Idowu A., Sowemimo O., Ogundoyin O., Akande O., Lott A., Nadeem M., Laghari A.A., Loya A., Mushtaq H., Abdullah M.T., Abuhilal B., Atawneh M., Hamdan H., Alhabil B., Srour A., Mousa I., Da Silva Medina L., Bartosiak K., Ferreira P., Francisco V., Lemos R., Frutuoso L., Fernandes S., Fonseca T., Pereira J., Rachadell J., Torre A., Madeira Martins F., Carvalho A.C., Rodrigues Ferreira J., Ribeiro da Silva B., Devesa H., Vieira A., Monica I., Amaro M., Sousa D., Reia M., Louro J., Martins A., Dominguez J., Santos I., Freitas Oliveira N.M., Pereira J.C., Silva-Vaz P., Freire L., Escrevente R., Negoita V.M., Shakhmatov D., Nezerwa Y., Radulovic R., Obery G., Viljoen F., Mendes T., Suarez A., Moncada E., Fernandez-Hevia M., Curtis Martinez C., Gil Garcia J.M., Gonzalez Zunzarren M., Idris T., Eklov K., Grahn O., Amin L., Blomqvist M., Ajani C., Kraus R., Seeger N., Willemin M., Rayya F., Ayash M., Msouti R., Kannas I., Abazid E., Esper A., Slim S., Kavcar A.S., Aytac E., Dural A.C., Ilker A., Eray I.C., Kurnaz E., Altiner S., Tepe M.D., Sahin C., Savli E., Innocent A., Babirye L., Diachenko A., Hordoskiy V., Curry H., Chau C.Y.C., Robertson H., Lennon H., Loi L., Kirkham E., McCann C., Watts D., Gurung B., Wilson M., Tribedi T., Garofalo E., Zahra B., MacDonald S., Daniels I., Ng N., Khosla S., Olivier J., Yue S.Y.P., Suresh G., Wellington J., Lorejo E., Mossaad M., Crutcher M., Alimi M., Baiu I., Abdou H., Conway A., Peck C., Perdomo Perez M.A., Zulu S., Nakazwe M., Knight, S. R., Shaw, C. A., Pius, R., Drake, T. M., Norman, L., Ademuyiwa, A. O., Adisa, A. O., Aguilera, M. L., Al-Saqqa, S. W., Al-Slaibi, I., Bhangu, A., Biccard, B. M., Brocklehurst, P., Costas-Chavarri, A., Chu, K., Dare, A., Elhadi, M., Fairfield, C. J., Fitzgerald, J. E., Ghosh, D., Glasbey, J., van Berge Henegouwen, M. I., Ingabire, J. C. A., Kingham, T. P., Lapitan, M. C., Lawani, I., Lieske, B., Lilford, R., Martin, J., Mclean, K. A., Moore, R., Morton, D., Nepogodiev, D., Ntirenganya, F., Pata, F., Pinkney, T., Qureshi, A. U., Ramos-De la Medina, A., Riad, A., Salem, H. K., Simoes, J., Spence, R., Smart, N., Tabiri, S., Thomas, H., Weiser, T. G., West, M., Whitaker, J., Harrison, E. M., Gjata, A., Modolo, M. M., King, S., Chan, E., Nahar, S. N., Waterman, A., Vervoort, D., Bedada, A. G., De Azevedo, B., Figueiredo, A. G., Sokolov, M., Barendegere, V., Ekwen, G., Agarwal, A., Liu, Q., Camilo Correa, J., Malemo, K. L., Bake, J., Mihanovic, J., Kuncarova, K., Orhalmi, J., Salem, H., Teras, J., Kechagias, A., Arnaud, A. P., Lindert, J., Kalles, V., Aguilera-Arevalo, M. -L., Recinos, G., Baranyai, Z., Kumar, B., Neelamraju Lakshmi, H., Zachariah, S. K., Alexander, P., Kumar Venkatappa, S., Pramesh, C., Amandito, R., Fleming, C., Ansaloni, L., Pellino, G., Altibi, A. M., Nour, I., Hamdun, I., Ghellai, A. M., Venskutonis, D., Poskus, T., Zilinskas, J., Malemia, P., Tew, Y. Y., Borg, E., Ellul, S., Wafqui, F. Z., Borowski, D. W., van Dalen, A. S., Wells, C., Adamou, H., Ademuyiwa, A., Adisa, A., Soreide, K., Al Saqqa, S., Alser, O., Tahboub, H., Segovia Lohse, H. A., Shu Yip, S., Major, P., Sampaio Soares, A., Bratu, M. R., Litvin, A., Vardanyan, A., Allen Ingabire, J. C., Gudal, A., Albati, N., Juloski, J., Rems, M., Rayne, S., Van Straten, S., Moodley, Y., Ortega Vazquez, I., Ruiz-Tovar, J., Senanayake, K. J., Thalgaspitiya, S. P. B., Omer, O. A., Homeida, A., Cengiz, Y., Clerc, D., Alshaar, M., Bouaziz, H., Altinel, Y., Doe, M., Freigofer, M., Teasdale, E., Kabariti, R., Clements, J. M., Ashfaq, A., Azodo, I., Wagner, G., Trostchansky, I., Maimbo, M., Linyama, D., Nina, H., Zeko, A., Fermani, C. G., Villalobos, S., Carballo, F., Farina, P., Guckenheimer, S., Dickfos, M., Ajmera, A., Chong, C., Gourlay, R., Hussaini, S., Lee, Y. J., Majid, A., Martin, P., Miles, R., Morris, O. J., Phua, J., Ridley, W., Saluja, T., Tan, R. R., Teh, J., Wells, A., Arora, B., Dollie, Q., Ho, D., Ma, Y., Perera, O. M., Truong, A., Dawson, A. C., Lim, B., Pahalawatta, U., Phan, J., Woon-Shoo-Tong, X. -M. S., Yeoh, A., Charman, L., Drane, A., Laura, S., Lo, C. C. W., Mozes, A., Poon, R., Tan, H. H., Wall, E., Chopra, P., De Giovanni, J., Dhital, B., Draganic, B., Duller, A., Gani, J., Goh, Y. K., Jeong, J. Y., Mcmanus, B., Nagappan, P., Pockney, P., Rugendyke, A., Sarrami, M., Smith, S., Wills, V., Wong, H. V., Ye, G., Zhang, G., Brooker, E., Feng, D., Lau, B., Ngai, C., Birks, S., Gyorki, D., Otero de Pablos, J., Abbosh, A., Gillespie, C., Mahmoud, A., Kwan, B., Lawson, J., Warwick, A., Bingham, J., Cockbain, A. J., Dudi-Venkata, N. N., Ellaby-Hall, J., Finlay, B., Humphries, E., Pisaniello, J., Pisaniello, M., Salih, S., Sammour, T., Abd Wahab, H. H., De Silva, A., Hayward, N., Iyer, K., Maddern, G., Prevost, G. A., Annapureddy, N., Settipalli, K. P., Yeo, J., Hempenstall, L., Pham, L., Purcell, S., Talavera, C., Vaska, A. I., Chaggar, G., Chrapko, P., Cocco, A., Coulter-Nile, S. M. C. J., Ctercteko, G., French, J., Gong, H., Gosselink, M., Jegathees, T., Jin, I., Kalachov, M., Kiefhaber, K., Lee, K., Luong, J., Phan, S., Pleass, H., Veale, K., Zeng, Z., Au, A., Debiasio, A., Deng, I., Myooran, J., Nair, A., Stewart, P., Stift, A., Unger, L. W., Wimmer, K., Ahmed, N., Hasan, S., Rahman, S., O'Shea, M., Padmore, G., Peters, A., Perduca, P., Pulcina, G., Tinton, N., Buxant, F., Dabin, E., Garofalo, G., Dossou, F., Gnangnon, F. H. R., Imorou Souaibou, Y., Motlaleselelo, P., Tlhomelang, O., Lima Buarque, I., Mendonca Ataide Gomes, G., Vieira Barros, A., Batashki, I., Damianov, N., Stoyanov, V., Dardanov, D., Maslyankov, S., Petkov, P., Todorov, G., Zhivkov, E., Akisheva, A., Castilla Moreno, M. A., Genov, G., Ilieva, I., Ivanov, T., Karamanliev, M., Khan, A., Mitkov, E., Yotsov, T., Atanasov, B., Belev, N., Slavchev, M., Nsengiyumva, C., Jones, E., Stock, S., Kyota, S., Brown, J., Mabanza, K. T., Nigo Samuel, L., Otuneme, C., Prosper, N., Umenze, F., Boutros, M., Caminsky, N., Dumitra, S., Garfinkle, R., Morency, D., Salama, E., Banks, A., Ferri, L., He, H., Katz, A., Liberman, A. S., Meterissian, S., Pang, A., Parvez, E., Hameed, U., Osman, F., Sequeira, S., Coburn, N., Jaffer, A., Karanicolas, P., Mosseler, M., Musselman, R., Liu, X., Yip, C. W., Garces-Otero, J. S., Guzman, C., Sierra, S., Uribe Valencia, A., Cabrera Rivera, P. A., Camelo, S., Gonzalez, A., Gonzalez-Orozco, A., Mosquera Paz, M. S., Perez Rivera, C. J., Gonzalez, F., Isaza-Restrepo, A., Nino- Torres, L., Arias Madrid, N., Mendoza Arango, M. C., Tsandiraki, J., Jemendzic, D., Kocman, B., Suman, O., Canic, R., Jurisic, D., Karakas, I., Krizanovic Rupcic, A., Pitlovic, V., Samardzic, J., Kopljar, M., Bacic, I., Domini, E., Karlo, R., Miljanic, D., Simic, A., Ahmed, M., Al Nassrallah, M., Altaf, R., Amjad, T., Eltoum, R., Haidar, H., Hassan, A., Khalil, O., Qasem, M., Ramesh, R., Sajith, G., Wisal, M., Zatecky, J., Bujda, M., Jirankova, K., Paclik, A., Abdallah, A., Abdulgawad Almogy, M., Ayman El-sawy, E., Elfayoumy, A. M., Elghareeb, N., Esmat, N. A., Fadel, A., Habater, A., Hamdy, H., Hefni, A., Kamal, M., Mohamed Abobakr, N., Sayed, A., Shaker, N., Taha, E., Tharwat, H., Zakaria, O., Abdelmotaleb, I., Al-Dhufri, A., Al-Himyari, H. S., El sheikh, E., Eldmaty, A., Elkhalawy, A., M. Elkhashen, A., Magdy, K., Mostafa, S., Sadia, H. D., Saleh, M. M., Samir, D., Yahia Mohamed Ali, M., A. Nassar, M., Abdelhady, S., Abdelrazek, A., Abdelsalam, I., El-Sawy, A., Essam, E., Gadelkarim, M., Ghaly, K., Hassabalnaby, M., Masarani, R., Mohamed Shaaban, N., Sabry, A., Salem, M., Soliman, N. A., Zahran, D., Abou, El. soud M. R., Badr, E. T., Borham, H., Elmeslemany, N., Elsayed, M., Elsherif, F., Eslam, S., Gaber, G., Ibrahim, S., Kamh, Y., Mohamed, S. 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M., Rodriguez Gonzalez, A., Chachaima Mar, J. E., Chinchihualpa Paredes, N. O., Cuba, V., Lopez, W., Niquen Jimenez, M. M., Sanchez Bartra, N. A., Sapallanay Ojeda, O., Sequeiros, D., Toscano Pacheco, A., Vergara, M., Abarca, S., Alcorta, R., Borda-Luque, G., Eusebio Zegarra, I. E., Lujan Lopez, C., Marrufo, M., Mogrovejo, C., Nomura, A., Rodriguez Angeles, Y., Vidal Meza, M. R., Zavala, G., Castillo Arrascue, J. N., Hidrogo Cabrera, J. C., Larrea vera, J. J. M., Osorio, M., Ylatoma Diaz, E. A., Fontanilla, M. A., Fuentes, J. R., Salazar, A. L., Dominguez, G., Lopez, M. P., Macalindong, S., Onglao, M. A., Ramirez, A., Sacdalan, M. D., Tampo, M. M., Uy, G. L., Mangahas, J., Yabut, K., Canete, J. P., Cansana, B. E., Castro, E. J., Lipana, M. K., Roxas, M. F., Zara, V. J., Chrol, M., Franczak, P., Orlowski, M., Budzynski, P., Budzynski, A., Bury, P., Czerwinska, A., Dworak, J., Dziedzic, J., Kisielewski, M., Kulawik, J., Lasek, A., Malczak, P., Migaczewski, M., Pedziwiatr, M., Pisarska, M., Radkowiak, D., Rubinkiewicz, M., Rzepa, A., Skoczylas, T., Stanek, M., Truszkiewicz, K., Wierdak, M., Winiarski, M., Zarzycki, P., Zub-Pokrowiecka, A., Kowalewski, P., Roszkowski, R., Waledziak, M., Tome, M., Patrocinio, S., Guerreiro, I., Almeida, F., de Sousa, X., Monteiro, N., Costa Santos, M. T., de Oliveira, D., Lopes Serra, M., Morgado, D., Neves, C., Oliveira, A. C., Pimentel, A., Silva, S., Carvalho, M., Carvalho, L., Magalhaes, J., Matos, L., Monteiro, T., Ramos, C., Santos, V., Barbosa, J., Costa-Maia, J., Devezas, V., Fareleira, A., Fernandes, C., Goncalves, D., Mora, H., Morais, M., Silva de Sousa, F., Catarino Santos, S., Logrado, A., Tojal, A., Amorim, E., Cunha, M. F., Fazenda, A., Melo Neves, J. P., Sampaio da Novoa Gomes Miguel, I. 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C., Robertson, H., Lennon, H., Loi, L., Kirkham, E., Mccann, C., Watts, D., Gurung, B., Wilson, M., Tribedi, T., Garofalo, E., Zahra, B., Macdonald, S., Daniels, I., Ng, N., Khosla, S., Olivier, J., Yue, S. Y. P., Suresh, G., Wellington, J., Lorejo, E., Mossaad, M., Crutcher, M., Alimi, M., Baiu, I., Abdou, H., Conway, A., Peck, C., Perdomo Perez, M. 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Garcia-Granero, Alvaro, Abad Gurumeta, Alfredo, Abad-Motos, Ane, Lucena-de Pablo, Elena, Nozal, Beatriz, Ripollés-Melchor, Javier, Salvachúa, Rut, Ferrero, Esther, Garcia-Sancho Tellez, Luis, Picardo, Antonio L, Rojo López, Jose Alberto, Zorrilla Matilla, Laura Patricia, Cagigas Fernandez, Carmen, Castanedo Bezanilla, Sonia, Estevez Tesouro, José, Fernandez-Diaz, Maria Jose, García Cardo, Juan, Gomez Ruiz, Marcos, Gonzalez-Tolaretxipi, Erik, Jimeno Fraile, Jaime, Poch, Cristobal, Rodriguez-Aguirre, Montserrat, Troche Pesqueira, Noemí, Trugeda-Carrera, Maria Soledad, de la Torre, Javier, Blanco-Colino, Ruth, Espin-Basany, Eloy, Espinosa-Bravo, Martin, Morales Comas, Clara, Reyes Afonso, Eduardo, Rivero Déniz, Joaquín, Siso Raber, Christian, Verdaguer Tremolosa, Mireia, Chandrasinghe, Pramodh, Kumarage, Sumudu, Wijekoon Arachchilage, Nimeshi, Abdalla Ahmed Elkamel, Ahmed, A Adam, Mohammed, Blomme, Nina, Thorell, Anders, Wogensen, Fredrik, Älgå, Andreas, Ansarei, Dhirar, Celebioglu, Fuat, Heinius, Göran, Nigard, Linda, Pieniowski, Emil, Ahlqvist, Sandra, Björklund, Ida, Frånberg, Andreas, Håkansson, Martina, Adamo, Karin, Franklin, Oskar, Sund, Malin, Wiberg, Rebecca, Andersson, Yvette, Chabok, Abbas, Nikberg, Maziar, Kugelberg, Alexander, Canonica, Claudia, Christoforidis, Dimitrios, Fasolini, Fabrizio, Gaffuri, Paolo, Giuliani, Mauro, Meani, Francesco, Popeskou, Sotirios Georgios, Pozza, Silvia, Wandschneider, Wiebke, Peterer, Lorenz, Widmer, Lukas Werner, Zimmermann, Bernd, Bakoleas, Panagiotis, Chanousi, Iris, Charalampidou, Lydia, Grochola, Lukasz Filip, Heid, Franziska, Ntaoulas, Sotirios, Outos, Michail, Peros, Georgios, Podolska-Skoczek, Hanna, Reinisch, Katharina Beate, Zielasek, Christian, Demartines, Nicolas, Gilgien, Jérôme, Kefleyesus, Amaniel, St-Amour, Pénélope, Toussaint, Arnaud, Alhimyar, Maryam, Alsaid, Bayan, Alyafi, Amr, Alkhaledi, Ahmad, Kouz, Basel, Omarain, Ahmad, Al-Sabbagh, Yusra, Alkhatib, Haya, Sara, Samer, Alhaj, Ahmad, Danial, Aghyad, 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Townson, Adam, Williams, Christopher Yee Khang, Gray, Timothy, Greig, Robert, Husain, Mansoor, Murray, Elspeth, Mustafa, Ahmed, Asif, Ashar, Gokul, Arya, Shah, Max, Akitikori, Mabel Temisanren, Charalabopoulos, Alexandros, Davidson, Sophie, McNally, Sinead, Rupani, Shamil, Juma, Fatema, Mills, Sarah Catherine, Muirhead, Laura, Sellars, Kate, Walsh, Una, Warren, Oliver, Chambers, Alice, Hunt, Richard, Boyce, Stephen, Cornwall, Hannah, Tol, Isabel, Argyriou, Eleftherios Orestis, Eardley, Nicola, Povey, Meical, Aithie, Joanna M S, Irfan, Ahmer, McGuigan, Mari-Claire, Starr, Robert, Warren, Craig Russell, Archibald, Jess, Kirby, Georgia, Kisyov, Ivan, Khoo, Chun Kheng, Lee, Rachel, Photiou, Dana, Davis, Rowan, Prasad, Uday, Yang, P Zichu, Bird, Jonathan, Leung, Edmund, Summerour, Virginia, Currow, Chelise, Kiam, Jianshen, Tan, Gerald Jack Soon, Muthusami, Anitha, Pegba-Otemolu, Ibifunke, Urbonas, Tomas, Nunoo-Mensah, Joseph, Smolskas, Edgaras, Boddy, Alex, Gravante, Gianpiero, Hunter, David, Andrew, David, Koh, Amanda, Thompson, Amari, Adams, Lawrence, Clements, Hollie A, De Silva, Kasun, Ekpete, Ogbonnia, Haque, Seraj, Henderson, Scott, Ibrahim, Bilal, Jayasinghe, Thummini, Livie, Jennifer, Mailley, Keir, Nair, Gopikrishnan, Tan, Daniel, Baggaley, Caitlin, Dawidziuk, Aleksander, Szyszka, Bartosz, Barter, Charlotte, Gandhi, Nirav, Hassell, Karen, Hitchin, Samantha, Kelsall, Jennett, Nagy, Eva, Nessa, Ashrafun, Whisker, Lisa, Yanni, Fady, Ali, Mahmoud, Arora, Deeksha, Hediwattege, Sunanda, Kumarasinghe, Navam, Rathore, Munir, Tennakoon, Athula, Ali Ahmad, Syed Mustafa, Bajomo, Oreoluwa, Nadira, Fahema, Celentano, Valerio, Griffiths, Ewen, Karri, Rama Santhosh, Mak, Jason Kei Chak, Pipe, Michelle, Bhatti, Muhammad Iqbal, Rabie, Mohamed, Boyle, Connor, Hamilton, David, Mihuna, Aishath, Ng, James Chean Khun, Nicholson, Gary, Oliwa, Agata, Pearson, Robert, Rose, Anna, Yong, Shun Qi, Boereboom, Catherine, Hanna, Michael, Walter, Catherine, Greensmith, Thomas Samuel, Mitchell, Rachel, Monaghan, Eimear, Crawford, James, Moug, Susan, Blackwell, James, Boyd-Carson, Hannah, Herrod, Philip, Al-Allaf, Omar, Beattie, Miriam, Bullock, Cameron, Burman, Shivang, Clark, Gemma, Flamey, Nicolas, Flannery, Oliver, Harding, Alexander, Kodiatt, Ben, Lawday, Samuel, Mahapatra, Shivani, Mukundu Nagesh, Navin, Ng, Michael, Rye, Dupinderjit, Yoong, Andrel, Clark, Laura, Deans, Chris, Edirisooriya, Monisha, Carrington, Emma Victoria, Wong, Tsz Lun Ernest, Yusuf, Baasil, Chamberlain, Carla, Duke, Kathryn, Kmiotek, Elizabeth, Botes, Azel, Condie, Natalie, Schrire, Timothy, Shah, Reena, Thomas-Jones, Iolo, Yates, Charlotte, Anthony, Natasha, Matthews, Edward, Sahnan, Kapil, Tankel, James, Tucker, Sally, Winter Beatty, Jasmine, Ziprin, Paul, Duggan, William, Kantartzi, Anastasia, Sridhar, Shruthi, Khaw, Rachel Alys, Srivastava, Prakhar, Underwood, Charlotte, Alves do Canto Brum, Homero, Chopra, Sharat, Davis, Laura, Hughes, Rebecca, Tulley, Joshua, Alberts, Justin, 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González, María Catalina, Zubiaurre, Vanessa, Demolin, Rodrigo, Giroff, Nicolas, Sciuto, Pablo, Campos, Maite, Rodríguez Cantera, Gabriela, Deepika, Garg, Simuchimba, Elliot, Bulaya, Anadi, Chibuye, Chali, Chirengendure, Bright, Kabale, Mary-Rose, Kabongo, Kizito, Munthali, James, Mweso, Oliver, Pikiti, Francis, Otieno, James, Lai, Log Tung, Blackman, Brighid, Richards, Sophie, Subramaniam, Suren, Karim, Rafid, Kok, Nathan, Lee, Yanni Dion, Ali, Shabina, Sinha, Aanjaneya, Corrigan, Robert, Barnes, Nicole, Wong, Florence, Dennis, Grace, Jedamzik, Julia, Phillips, Emil, Piette, Wivine, Van Hentenryck, Marie, Koco, Houenoukpo, Lawani, Souliath, Kassa, Mamo Woldu, Santos Bezerra, Tainá, Gribnev, Petar, Dimitrov, Dobromir, Krastev, Panche, Oum, Sovannarith, Bonghaseh, Divine Tim, Al Farsi, Maryam, Alsharqawi, Nourah, Acevedo, Veronica, Castillo Barbosa, Andrea Carolina, Giron, Felipe, Leon Rodriguez, Jimmy Paul, Kucan, Darko, Rosko, Damir, Barsic, Neven, Župan, Domagoj, Hegazi, Amgad, 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Veronica, Russo, Alfio Alessandro, Braccio, Bartolomeo, Al-Taher, Raed, Athamneh, Sarah, Parker, Andrea, Sawiee, Adnan, Kattia, Amina, Salem, Malik, Tababa, Osama, Shaeeb, Zuhour, Syminas, Vilius, Jurgaitis, Jonas, Damuleviciene, Gyte, Svagzdys, Saulius, Poskus, Tomas, Razafimanjato, Narindra Njarasoa Mihaja, Chieng Loo, Ling, Tiong, Ing Ching, Wan Muhmad, Wan Farahiyah, Vijeyan, Harinthiran, Li Ying, Teoh, Grech, Gabriella, Arrangoiz, Rodrigo, Jimenez Ley, Vania Brickelia, Arizpe, Daniel, Lagunes Lara, Elizabeth, Castro López, Elizabeth Victoria, Eaazim, Jose, Gordinou de Gouberville, Marije, Bastiaenen, Vivian, Rottier, Simone, Nahab, Fouad, Ji, Maria Yeonhee, Seyoji, Mohammed, Nwachukwu, Callistus, Emeghara, Okechukwu, Muhammed, Sayyid Egbunu, Idowu, Ayodeji, Sowemimo, Olamiposi, Ogundoyin, Olakayode, Akande, Oluwatosin, Lott, Alexander, Nadeem, Maliha, Laghari, Ahsan Ali, Loya, Asif, Mushtaq, Hassan, Abdullah, Muhammad Tariq, Abuhilal, Baseel, Atawneh, Mohammad, Hamdan, Hamdan, Alhabil, Belal, Srour, Abedelrahman, Mousa, Ibrahim, Da Silva Medina, Luis, Bartosiak, Katarzyna, Ferreira, Pedro, Francisco, Vítor, Lemos, Ricardo, Frutuoso, Luísa, Fernandes, Sara, Fonseca, Telma, Pereira, Jorge, Rachadell, Juan, Torre, Ana, Madeira Martins, Filipe, Carvalho, Ana Cristina, Rodrigues Ferreira, Joana, Ribeiro da Silva, Bruno, Devesa, Helena, Vieira, Ana, Mónica, Inês, Amaro, Margarida, Sousa, Diogo, Reia, Marta, Louro, João, Martins, Ana, Dominguez, Joaquina, Santos, Inês, Freitas Oliveira, Nuno Miguel, Pereira, José Carlos, Silva-Vaz, Pedro, Freire, Ligia, Escrevente, Ricardo, Negoita, Valentina Madalina, Shakhmatov, Dmitry, Nezerwa, Yves, Radulovic, Radosav, Obery, Gareth, Viljoen, Francois, Mendes, Tome, Suarez, Antonio, Moncada, Enrique, Fernandez-Hevia, Maria, Curtis Martínez, Carolina, Gil Garcia, Julia Maria, González Zunzarren, Mariana, Idris, Tarig, Eklöv, Karolina, Grahn, Oskar, Amin, Leila, Blomqvist, Malin, Ajani, Costanza, Kraus, Rebecca, Seeger, Nico, 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Lesetedi, Chiapo, Mabedi, Charles, Magill, Laura, Makinde Alakaloko, Felix, Makupe, Alex, Monahan, Mark, Mulira, Soloman, Muller, Elmi, Musowoyo, Jospeh, Olory-Togbe, Jean Léon, Roberts, Tracey, Smith, Martin, Tayler, Viki, Windsor, John, Yepez, Raul, Sundar, Sudha, Runigamugabo, Emmy, Verjee, Azmina, Chen, José, Daya, Leonid, El Aroussi, Nouhaila, Farina, Valeria, Gnintedeme Olivier, Tchianze, Gonzales Nacarino, Mauricio, Hammani, Aamr, Honjo, Sarah, Jacobs, Rebecca, Kimura, Hitomi, Nkoronko, Mugisha, Oscullo Yepez, Jasson Javier, Pin Hung, Wei, Raj, Ankit, Romani Pozo, Alina, Rommaneh, Muna, Sassamela Fabiano, Samuel Chimbioputo, Shiroma Gago, Camila Milagros, Srinivas, Abhishekh, Sung, Chia-Yen, Tai, Aswan, Valle Aranda, Yener Cristyell, Venturini, Sara, and Wilguens Lartigue, Jean
Subjects: Pediatrics, Colorectal cancer, IMPACT, Disease, Colorectal Neoplasm, 030204 cardiovascular system & hematology, Cancer, surgery, postoperative mortality, 0302 clinical medicine, Postoperative Complications, Global health, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, General Medicine, DISEASES, Income, cancer surgery, Colorectal Neoplasms, Breast Neoplasm, Cohort study, Human, Adult, Developed Countrie, medicine.medical_specialty, Global surgery, General surgery, International multicentre study, Cancer surgery, Breast Neoplasms, Department of Error, NO, Developing Countrie, 03 medical and health sciences, Breast cancer, Stomach Neoplasms, medicine, Humans, Developing Countries, Neoplasm Staging, business.industry, Developed Countries, Odds ratio, CARE, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, Prospective Studie, Postoperative Complication, business
Abstract: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit.
Published: 2021
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19. Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019

Author: Paulson, K. R., Kamath, A. M., Alam, T., Bienhoff, K., Abady, G. G., Abbas, J., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abd-Elsalam, S. M., Abdoli, A., Abedi, A., Abolhassani, H., Abreu, L. G., Abu-Gharbieh, E., Abu-Rmeileh, N. M. E., Abushouk, A. I., Adamu, A. L., Adebayo, O. M., Adegbosin, A. E., Adekanmbi, V., Adetokunboh, O. O., Adeyinka, D. A., Adsuar, J. C., Afshari, K., Aghaali, M., Agudelo-Botero, M., Ahinkorah, B. O., Ahmad, T., Ahmadi, K., Ahmed, M. B., Aji, B., Akalu, Y., Akinyemi, O. O., Aklilu, A., Al-Aly, Z., Alam, K., Alanezi, F. M., Alanzi, T. M., Alcalde-Rabanal, J. E., Al-Eyadhy, A., Ali, T., Alicandro, G., Alif, S. M., Alipour, V., Alizade, H., Aljunid, S. M., Almasi-Hashiani, A., Almasri, N. A., Al-Mekhlafi, H. M., Alonso, J., Al-Raddadi, R. M., Altirkawi, K. A., Alumran, A. K., Alvis-Guzman, N., Alvis-Zakzuk, N. J., Ameyaw, E. K., Amini, S., Amini-Rarani, M., Amit, A. M. L., Amugsi, D. A., Ancuceanu, R., Anderlini, D., Andrei, C. L., Ansari, F., Ansari-Moghaddam, A., Antonio, C. A. T., Antriyandarti, E., Anvari, D., Anwer, R., Aqeel, M., Arabloo, J., Arab-Zozani, M., Aripov, T., Arnlov, J., Artanti, K. D., Arzani, A., Asaad, M., Asadi-Aliabadi, M., Asadi-Pooya, Ali A, Jafarabadi, M. A., Athari, S. S., Athari, S. M., Atnafu, D. D., Atreya, A., Atteraya, M. S., Ausloos, M., Awan, A. T., Quintanilla, B. P. A., Ayano, G., Ayanore, M. A., Aynalem, Y. A., Azari, S., Azarian, G., Azene, Z. N., Darshan, BB, Babaee, E., Badiye, A. D., Baig, A. A., Banach, M., Banik, P. C., Barker-Collo, S. L., Barqawi, H. J., Bassat, Q., Basu, S., Baune, B.T., Bayati, M., Bedi, N., Beghi, E., Beghi, M., Bell, M. L., Bendak, S., Bennett, D. A., Bensenor, I. M., Berhe, K., Berman, A. E., Bezabih, Y. M., Bhagavathula, A. S., Bhandari, D., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bhattarai, S., Bhutta, Z. A., Bikbov, B., Biondi, A., Birihane, B. M., Biswas, R. K., Bohlouli, S., Bragazzi, N. L., Breusov, A. V., Brunoni, A. R., Burkart, K., Nagaraja, S. B., Busse, R., Butt, Z. A., dos Santos, F. L. C., Cahuana-Hurtado, L., Camargos, P., Camera, L. A., Cardenas, R., Carreras, G., Carrero, J. J., Carvalho, F., Castaldelli-Maia, J. M., Castaneda-Orjuela, C. A., Castelpietra, G., Cerin, E., Chang, J-C., Chanie, W. F., Charan, J., Chatterjee, S., Chattu, S. K., Chattu, V. K., Chaturvedi, S., Chen, S., Cho, D. Y., Choi, J-Y. J., Chu, D-T., Ciobanu, L. G., Cirillo, M., Conde, J., Costa, V. M., Couto, R. A. S., Dachew, B. A., Dahlawi, S. M. A., Dai, H., Dai, X., Dandona, L., Dandona, R., Daneshpajouhnejad, P., Darmstadt, G. L., Das, J. K., Davila-Cervantes, C. A., Davis, A. C., Davletov, K., De la Hoz, F. P., De Leo, D., Deeba, F., Denova-Gutierrez, E., Dervenis, N., Desalew, A., Deuba, K., Dey, S., Dharmaratne, S. D., Dhingra, S., Dhungana, G. P., da Silva, D. D., Diaz, D., Dorostkar, F., Doshmangir, L., Dubljanin, E., Duraes, A. R., Eagan, A. W., Edinur, H. A., Efendi, F., Eftekharzadeh, S., El Sayed, I., El Tantawi, M., Elbarazi, I., Elgendy, I. Y., El-Jaafary, S. I., Emami, A., Enany, S., Eyawo, O., Ezzikouri, S., Faris, P. S., Farzadfar, F., Fattahi, N., Fauk, N. K., Fazlzadeh, M., Feigin, V. L., Ferede, T. Y., Fereshtehnejad, S-M., Fernandes, E., Ferrara, P., Filip, I., Fischer, F., Fisher, J. L., Foigt, N. A., Folayan, M. O., Foroutan, M., Franklin, R. C., Freitas, M., Friedman, S. D., Fukumoto, T., Gad, M. M., Gaidhane, A. M., Gaidhane, S., Gaihre, S., Gallus, S., Garcia-Basteiro, A. L., Garcia-Gordillo, M., Gardner, W. M., Fonseca, M. G., Gebremedhin, K. B., Getacher, L., Ghashghaee, A., Gholamian, A., Gilani, S.A., Gill, T. K., Giussani, G., Gnedovskaya, E. V., Godinho, M. A., Goel, A., Golechha, M., Gona, P. N., Gopalani, S. V., Goudarzi, H., Grivna, M., Gugnani, H. C., Guido, D., Guimaraes, R. A., Das Gupta, R., Gupta, R., Hafezi-Nejad, N., Haider, M. R., Haj-Mirzaian, A., Hamidi, S., Hanif, A., Hankey, G. 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Antriyandarti, E, Anvari, D, Anwer, R, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aripov, T, Arnlov, J, Artanti, K, Arzani, A, Asaad, M, Asadi-Aliabadi, M, Asadi-Pooya, A, Asghari Jafarabadi, M, Athari, S, Atnafu, D, Atreya, A, Atteraya, M, Ausloos, M, Awan, A, Ayala Quintanilla, B, Ayano, G, Ayanore, M, Aynalem, Y, Azari, S, Azarian, G, Azene, Z, B, D, Babaee, E, Badiye, A, Baig, A, Banach, M, Banik, P, Barker-Collo, S, Barqawi, H, Bassat, Q, Basu, S, Baune, B, Bayati, M, Bedi, N, Beghi, E, Beghi, M, Bell, M, Bendak, S, Bennett, D, Bensenor, I, Berhe, K, Berman, A, Bezabih, Y, Bhagavathula, A, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhattarai, S, Bhutta, Z, Bikbov, B, Biondi, A, Birihane, B, Biswas, R, Bohlouli, S, Bragazzi, N, Breusov, A, Brunoni, A, Burkart, K, Burugina Nagaraja, S, Busse, R, Butt, Z, Caetano dos Santos, F, Cahuana-Hurtado, L, Camargos, P, Camera, L, Cardenas, R, Carreras, G, Carrero, J, Carvalho, F, Castaldelli-Maia, J, Castaneda-Orjuela, C, Castelpietra, G, Cerin, E, Chang, J, Chanie, W, Charan, J, Chatterjee, S, Chattu, S, Chattu, V, Chaturvedi, S, Chen, S, Cho, D, Choi, J, Chu, D, Ciobanu, L, Cirillo, M, Conde, J, Costa, V, Couto, R, Dachew, B, Dahlawi, S, Dai, H, Dai, X, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Darmstadt, G, Das, J, Davila-Cervantes, C, Davis, A, Davletov, K, De la Hoz, F, De Leo, D, Deeba, F, Denova-Gutierrez, E, Dervenis, N, Desalew, A, Deuba, K, Dey, S, Dharmaratne, S, Dhingra, S, Dhungana, G, Dias da Silva, D, Diaz, D, Dorostkar, F, Doshmangir, L, Dubljanin, E, Duraes, A, Eagan, A, Edinur, H, Efendi, F, Eftekharzadeh, S, El Sayed, I, El Tantawi, M, Elbarazi, I, Elgendy, I, El-Jaafary, S, Emami, A, Enany, S, Eyawo, O, Ezzikouri, S, Faris, P, Farzadfar, F, Fattahi, N, Fauk, N, Fazlzadeh, M, Feigin, V, Ferede, T, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Fisher, J, Foigt, N, Folayan, M, Foroutan, M, Franklin, R, Freitas, M, Friedman, S, Fukumoto, T, Gad, M, Gaidhane, A, Gaidhane, S, Gaihre, S, Gallus, S, Garcia-Basteiro, A, Garcia-Gordillo, M, Gardner, W, Gaspar Fonseca, M, Gebremedhin, K, Getacher, L, Ghashghaee, A, Gholamian, A, Gilani, S, Gill, T, Giussani, G, Gnedovskaya, E, Godinho, M, Goel, A, Golechha, M, Gona, P, Gopalani, S, Goudarzi, H, Grivna, M, Gugnani, H, Guido, D, Guimaraes, R, Gupta, R, Hafezi-Nejad, N, Haider, M, Haj-Mirzaian, A, Hamidi, S, Hanif, A, Hankey, G, Hargono, A, Hasaballah, A, Hasan, M, Hasan, S, Hassan, A, Hassanipour, S, Hassankhani, H, Havmoeller, R, Hayat, K, Heidari-Soureshjani, R, Henry, N, Herteliu, C, Hole, M, Holla, R, Hossain, N, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Hwang, B, Iavicoli, I, Ibitoye, S, Ikuta, K, Ilesanmi, O, Ilic, I, Ilic, M, Inamdar, S, Inbaraj, L, Iqbal, K, Iqbal, U, Islam, M, Islam, S, Iso, H, Iwagami, M, Iwu, C, Jaafari, J, Jacobsen, K, Jagnoor, J, Jain, V, Janodia, M, Javaheri, T, Javanmardi, F, Jayaram, S, Jayatilleke, A, Jenabi, E, Jha, R, Ji, J, John, O, Jonas, J, Joo, T, Joseph, N, Joukar, F, Jozwiak, J, Jurisson, M, Kabir, A, Kabir, Z, Kalankesh, L, Kamyari, N, Kanchan, T, Kapoor, N, Karami Matin, B, Karch, A, Karimi, S, Kassahun, G, Kayode, G, Kazemi Karyani, A, Kemmer, L, Khalid, N, Khalilov, R, Khammarnia, M, Khan, E, Khan, G, Khan, M, Khang, Y, Khatab, K, Khater, A, Khater, M, Khayamzadeh, M, Khosravi, A, Kim, D, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Kissoon, N, Kopec, J, Kosen, S, Koul, P, Koulmane Laxminarayana, S, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Kuate Defo, B, Kucuk Bicer, B, Kulkarni, V, Kumar, G, Kumar, M, Kumar, N, Kurmi, O, Kusuma, D, La Vecchia, C, Lacey, B, Lalloo, R, Lami, F, Landires, I, Larsson, A, Lasrado, S, Lassi, Z, Lauriola, P, Lee, P, Lee, S, Lee, Y, Leigh, J, Leonardi, M, Lewycka, S, Li, B, Li, S, Liang, J, Lim, L, Limenih, M, Lin, R, Liu, X, Lodha, R, Lopez, A, Lozano, R, Lugo, A, Lunevicius, R, Mackay, M, Madhava Kunjathur, S, Magnani, F, Mahadeshwara Prasad, D, Maheri, M, Mahmoudi, M, Majeed, A, Maled, V, Maleki, A, Maleki, S, Malekzadeh, R, Malik, A, Malta, D, Mamun, A, Mansouri, B, Mansournia, M, Martinez, G, Martini, S, Martins-Melo, F, Masoumi, S, Maulik, P, Mcalinden, C, Mcgrath, J, Medina-Solis, C, Mehrabi Nasab, E, Mejia-Rodriguez, F, Memish, Z, Mendoza, W, Menezes, R, Mengesha, E, Mensah, G, Meretoja, A, Meretoja, T, Mersha, A, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, I, Miller, T, Mini, G, Miri, M, Mirica, A, Mirrakhimov, E, Mirzaei, H, Mirzaei, M, Moazen, B, Moghadaszadeh, M, Mohajer, B, Mohamad, O, Mohammad, Y, Mohammadi, S, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, A, Molokhia, M, Monasta, L, Mondello, S, Moni, M, Moore, C, Moradi, G, Moradi, M, Moradzadeh, R, Moraga, P, Morawska, L, Morrison, S, Mosser, J, Mousavi Khaneghah, A, Mustafa, G, Naderi, M, Nagarajan, A, Nagaraju, S, Naghavi, M, Naghshtabrizi, B, Naimzada, M, Nangia, V, Narasimha Swamy, S, Nascimento, B, Naveed, M, Nazari, J, Ndejjo, R, Negoi, I, Negoi, R, Nena, E, Nepal, S, Netsere, H, Nguefack-Tsague, G, Ngunjiri, J, Nguyen, C, Nguyen, H, Nigatu, Y, Nigussie, S, Nixon, M, Nnaji, C, Nomura, S, Noor, N, Noubiap, J, Nunez-Samudio, V, Nwatah, V, Oancea, B, Odukoya, O, Ogbo, F, Olusanya, B, Olusanya, J, Omar Bali, A, Onwujekwe, O, Ortiz, A, Otoiu, A, Otstavnov, N, Otstavnov, S, Owolabi, M, P A, M, Padubidri, J, Pakhale, S, Pakshir, K, Pal, P, Palladino, R, Pana, A, Panda-Jonas, S, Pandey, A, Pandi-Perumal, S, Pangaribuan, H, Pardo-Montano, A, Park, E, Patel, S, Patton, G, Pawar, S, Pazoki Toroudi, H, Peden, A, Pepito, V, Peprah, E, Pereira, J, Perez-Gomez, J, Perico, N, Pesudovs, K, Pilgrim, T, Pinheiro, M, Piradov, M, Pirsaheb, M, Platts-Mills, J, Pokhrel, K, Postma, M, Pourjafar, H, Prada, S, Prakash, S, Pupillo, E, Quazi Syed, Z, Rabiee, N, Radfar, A, Rafiee, A, Rafiei, A, Raggi, A, Rahimzadeh, S, Rahman, M, Rahmani, A, Ramezanzadeh, K, Rana, J, Ranabhat, C, Rao, S, Rasella, D, Rastogi, P, Rathi, P, Rawaf, D, Rawaf, S, Rawasia, W, Rawassizadeh, R, Reiner, R, Remuzzi, G, Renzaho, A, Reshmi, B, Resnikoff, S, Rezaei, N, Rezapour, A, Riahi, S, Ribeiro, D, Rickard, J, Roever, L, Ronfani, L, Rothenbacher, D, Rubagotti, E, Rumisha, S, Ryan, P, Saddik, B, Sadeghi, E, Saeedi Moghaddam, S, Sagar, R, Sahebkar, A, Salahshoor, M, Salehi, S, Salem, M, Salimzadeh, H, Salomon, J, Samodra, Y, Samy, A, Sanabria, J, Santric-Milicevic, M, Saraswathy, S, Sarker, A, Sarrafzadegan, N, Sarveazad, A, Sathian, B, Sathish, T, Sattin, D, Saxena, S, Saya, G, Saylan, M, Schiavolin, S, Schlaich, M, Schwebel, D, Schwendicke, F, Senthilkumaran, S, Sepanlou, S, Servan-Mori, E, Sha, F, Shafaat, O, Shahabi, S, Shahbaz, M, Shaheen, A, Shahid, I, Shaikh, M, Shakiba, S, Shalash, A, Shams-Beyranvand, M, Shannawaz, M, Sharafi, K, Sheikh, A, Sheikhbahaei, S, Shiferaw, W, Shigematsu, M, Shin, J, Shiri, R, Shiue, I, Shuval, K, Siddiqi, T, Sidemo, N, Sigfusdottir, I, Sigurvinsdottir, R, Silva, J, Silverberg, J, Simonetti, B, Singh, B, Singh, J, Singhal, D, Sinha, D, Skiadaresi, E, Skryabin, V, Skryabina, A, Sleet, D, Sobaih, B, Sobhiyeh, M, Soltani, S, Soriano, J, Spurlock, E, Sreeramareddy, C, Steiropoulos, P, Stokes, M, Stortecky, S, Sufiyan, M, Suliankatchi Abdulkader, R, Sulo, G, Swope, C, Sykes, B, Szeto, M, Szocska, M, Tabares-Seisdedos, R, Tadesse, E, Taherkhani, A, Tamiru, A, Tareque, M, Tehrani-Banihashemi, A, Temsah, M, Tesfay, F, Tessema, G, Tessema, Z, Thankappan, K, Thapar, R, Tolani, M, Tovani-Palone, M, Traini, E, Tran, B, Tripathy, J, Tsapparellas, G, Tsatsakis, A, Tudor Car, L, Uddin, R, Ullah, A, Umeokonkwo, C, Unim, B, Unnikrishnan, B, Upadhyay, E, Usman, M, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Valdez, P, Vasankari, T, Venketasubramanian, N, Verma, M, Violante, F, Vlassov, V, Vo, B, Vu, G, Wado, Y, Waheed, Y, Wamai, R, Wang, Y, Ward, P, Werdecker, A, Westerman, R, Wickramasinghe, N, Wilner, L, Wiysonge, C, Wu, A, Wu, C, Xie, Y, Yahyazadeh Jabbari, S, Yamagishi, K, Yandrapalli, S, Yaya, S, Yazdi-Feyzabadi, V, Yip, P, Yonemoto, N, Yoon, S, Younis, M, Yousefi, Z, Yousefinezhadi, T, Yu, C, Yusuf, S, Zaidi, S, Zaman, S, Zamani, M, Zamanian, M, Zastrozhin, M, Zastrozhina, A, Zhang, Y, Zhang, Z, Zhao, X, Ziapour, A, Hay, S, Murray, C, Wang, H, Kassebaum, N, and Lee Kong Chian School of Medicine (LKCMedicine)
Subjects: Male, Perinatal care, Newborn care, STILLBIRTHS, RJ101, UNDER-5 MORTALITY, Psychological intervention, 010501 environmental sciences, Infant mortality, Global Health, 01 natural sciences, 0302 clinical medicine, RA0421, Cause of Death, Infant Mortality, Global health, Life Tables, Healthcare improvements, 030212 general & internal medicine, 610 Medicine & health, Child, COVID-19, Humans, Infant, SARS-CoV-2, Sustainable Development, 11 Medical and Health Sciences, Cause of death, Life Table, Mortality rate, 1. No poverty, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Articles, Hälsovetenskaper, Mortality analyses, 3. Good health, Child, Preschool, SDG 1 - No Poverty, Child Mortality, Female, Life Sciences & Biomedicine, Human, Child mortality, COUNTRIES, DEATHS, Infants -- Mortalitat, GBD, 03 medical and health sciences, Medicine, General & Internal, SDG 3 - Good Health and Well-being, Life tables, under-5 mortality rate, General & Internal Medicine, Health Sciences, Neonatal deaths, medicine, SYSTEMATIC ANALYSIS, Medicine [Science], Infants -- Salut, Preschool, 0105 earth and related environmental sciences, Science & Technology, Infants nadons -- Salut, business.industry, Infants nadons -- Mortalitat, INFORM, Infant, Newborn, Neonatal and child health, Sustainable Development Goal 3.2, GBD 2019 Under-5 Mortality Collaborators, medicine.disease, Newborn, TRENDS, Sustainable Development Goal, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Deaths, 3121 General medicine, internal medicine and other clinical medicine, RG, business, Systematic Analysis, Malaria, Demography
Abstract: Background: Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 findings for all-cause mortality and cause-specific mortality in children younger than 5 years of age, with multiple scenarios for child mortality in 2030 that include the consideration of potential effects of COVID-19, and a novel framework for quantifying optimal child survival. Methods: We completed all-cause mortality and cause-specific mortality analyses from 204 countries and territories for detailed age groups separately, with aggregated mortality probabilities per 1000 livebirths computed for neonatal mortality rate (NMR) and under-5 mortality rate (U5MR). Scenarios for 2030 represent different potential trajectories, notably including potential effects of the COVID-19 pandemic and the potential impact of improvements preferentially targeting neonatal survival. Optimal child survival metrics were developed by age, sex, and cause of death across all GBD location-years. The first metric is a global optimum and is based on the lowest observed mortality, and the second is a survival potential frontier that is based on stochastic frontier analysis of observed mortality and Healthcare Access and Quality Index. Findings: Global U5MR decreased from 71·2 deaths per 1000 livebirths (95% uncertainty interval [UI] 68·3-74·0) in 2000 to 37·1 (33·2-41·7) in 2019 while global NMR correspondingly declined more slowly from 28·0 deaths per 1000 live births (26·8-29·5) in 2000 to 17·9 (16·3-19·8) in 2019. In 2019, 136 (67%) of 204 countries had a U5MR at or below the SDG 3.2 threshold and 133 (65%) had an NMR at or below the SDG 3.2 threshold, and the reference scenario suggests that by 2030, 154 (75%) of all countries could meet the U5MR targets, and 139 (68%) could meet the NMR targets. Deaths of children younger than 5 years totalled 9·65 million (95% UI 9·05-10·30) in 2000 and 5·05 million (4·27-6·02) in 2019, with the neonatal fraction of these deaths increasing from 39% (3·76 million [95% UI 3·53-4·02]) in 2000 to 48% (2·42 million; 2·06-2·86) in 2019. NMR and U5MR were generally higher in males than in females, although there was no statistically significant difference at the global level. Neonatal disorders remained the leading cause of death in children younger than 5 years in 2019, followed by lower respiratory infections, diarrhoeal diseases, congenital birth defects, and malaria. The global optimum analysis suggests NMR could be reduced to as low as 0·80 (95% UI 0·71-0·86) deaths per 1000 livebirths and U5MR to 1·44 (95% UI 1·27-1·58) deaths per 1000 livebirths, and in 2019, there were as many as 1·87 million (95% UI 1·35-2·58; 37% [95% UI 32-43]) of 5·05 million more deaths of children younger than 5 years than the survival potential frontier. Interpretation: Global child mortality declined by almost half between 2000 and 2019, but progress remains slower in neonates and 65 (32%) of 204 countries, mostly in sub-Saharan Africa and south Asia, are not on track to meet either SDG 3.2 target by 2030. Focused improvements in perinatal and newborn care, continued and expanded delivery of essential interventions such as vaccination and infection prevention, an enhanced focus on equity, continued focus on poverty reduction and education, and investment in strengthening health systems across the development spectrum have the potential to substantially improve U5MR. Given the widespread effects of COVID-19, considerable effort will be required to maintain and accelerate progress. This article was supported by the European Research Council, ERC 848325. Alberto Ortiz was supported by FIS/Fondos FEDER (PI18/01366, PI19/00588, PI19/00815, DTS18/00032, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071, ISCIII-RETIC REDinREN RD016/0009). Daniela Ribeiro acknowledges the financial support from the European Union [FEDER funds through COMPETE, POCI-01-0145-FEDER-029253). Joan B Soriano acknowledges support from the Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain Funding: Bill & Melinda Gates Foundation
Published: 2021
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20. New aspects in nonsurgical treatment of Marshall syndrome

Author: Veronica Epure, Universitatea de Medicină şi Farmacie „Carol Davila', Bucureşti, România, and Dan Cristian Gheorghe
Subjects: fever, adenitis, Medicine (General), medicine.medical_specialty, business.industry, General surgery, medicine.disease, Nonsurgical treatment, angina, R5-920, montelukast, Materials Chemistry, medicine, Medicine, business, Marshall syndrome
Abstract: Marshall syndrome, defined by recurrent fever episodes, angina, adenitis and stomatitis, is frequently encountered in childhood. Medical treatment consists of corticosteroids in order to solve the acute symptoms; adenotonsillectomy or alternative medication can be administered on the long term in order to prevent recurrence of symptoms. The authors present a case of Marshall syndrome; based on personal experience and data from literature, the authors draw attention on the efficiency of montelukast in preventing recurrence of episodes, as an alternative option to surgery
Published: 2021
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21. UPDATE OF CARDIOVASCULAR AUTONOMIC NEUROPATHY IN PATIENTS WITH DIABETES

Author: Andra-Elena Nica, Spitalul Clinic „Nicolae Malaxa', Bucureşti, România, Oana Andreea Parlițeanu, Emilia Rusu, Gabriela Radulian, Universitatea de Medicină și Farmacie „Carol Davila', Bucureşti, România, and Carmen Dobjansch
Subjects: Medicine (General), medicine.medical_specialty, business.industry, fungi, food and beverages, General Medicine, cardiovascular reflex tests, medicine.disease, R5-920, Internal medicine, Diabetes mellitus, diabetes mellitus, medicine, Cardiology, Medicine, In patient, Autonomic neuropathy, business, cardiovascular autonomic neuropathy
Abstract: The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Efforts to overcome CAN under-diagnosis are: by promoting screening for symptoms and signs; by simplifying cardiovascular reflex tests.
Published: 2021
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22. POSSIBLE ASSOCIATION BETWEEN TYPE 2 DIABETES MELLITUS AND HASHIMOTO'S AUTOIMMUNE THYROIDITIS – FINAL RESULTS

Author: Oana-Andreea Parlițeanu, Universitatea de Medicină și Farmacie „Carol Davila', București, România, Institutul Național de Pneumoftiziologie „Marius Nasta', București, România, and Dan-Mircea Cheța
Subjects: Medicine (General), business.industry, association, Type 2 Diabetes Mellitus, General Medicine, medicine.disease, Autoimmune thyroiditis, R5-920, Immunology, hashimoto atoimmune thyroiditis, medicine, Medicine, type 2 diabetes, business
Abstract: Introduction. The idea for our clinical research came from the association between type 2 diabetes and autoimmune thyroiditis that we often see in our daily practice. We wanted to study this to see if it is only a coincidence or if indeed this association really exists. Method. We created an observational retrospective research using 5,064 patients with type 2 diabetes, patients from Sanamed Hospital, which came at site between January 2016 and December 2018. Out of the large group of patients, we created 3 secondary groups: one containing 50 patients with type 2 diabetes, one with 50 patients with autoimmune thyroiditis and one with 50 patients which had both diseases. We initially evalueted the large group and after that we studied the 3 smaller groups. Results. We were able to prove the main hypothesis of our study by showing that the incidence of thyroiditis was significantly higher in the population with type 2 diabetes from our main group, the 5,064 patients, in contrast with the incidence that thyroiditis has in the healthy population from Europe. In our study we also demonstrated that the association between this 2 diseases has a protective role in regards with the incidence of obesity, arterial hypertension, dyslipidemia and macrovascular complications of the type 2 diabetes. Also, we found out that in the case of this association there are significant differences for a serial of biochemical parameters as well, such as blood glucose, uric acid, elements of the lipid profile. Discussions. The results from our study were consistent with the results form other international studies regarding this topic. This finding led us to the conclusion that our initial observation, that this two conditions might be associated, was not only a coincidence, but it is a definite association proved by us in this study. Conclusions. We proved our initial hypothesis to be true by the significant difference in incidence of thyroiditis in the population of our study in comparison with the incidence of thyroiditis in the healthy European population. We also managed to prove the secondary hypothesis to be correct.
Published: 2021
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23. Frequent POLE-driven hypermutation in ovarian endometrioid cancer revealed by mutational signatures in RNA sequencing

Author: Jaime I. Davila, Vivekananda Sarangi, Ellen L. Goode, Pritha Chanana, S. John Weroha, Yajue Huang, Chen Wang, Zachary C. Fogarty, and Ruifeng Guo
Subjects: COSMIC cancer database, Colorectal cancer, Research, Hypermutation, DNA polymerase epsilon, Mutational signatures, Cancer, Somatic hypermutation, Biology, QH426-470, medicine.disease, RC31-1245, Human genetics, Ovarian endometrioid cancer, POLE, medicine, Cancer research, Genetics, RNA-seq, Ovarian cancer, Carcinoma, Endometrioid, Gene, Internal medicine, Genetics (clinical)
Abstract: Background DNA polymerase epsilon (POLE) is encoded by the POLE gene, and POLE-driven tumors are characterized by high mutational rates. POLE-driven tumors are relatively common in endometrial and colorectal cancer, and their presence is increasingly recognized in ovarian cancer (OC) of endometrioid type. POLE-driven cases possess an abundance of TCT > TAT and TCG > TTG somatic mutations characterized by mutational signature 10 from the Catalog of Somatic Mutations in Cancer (COSMIC). By quantifying the contribution of COSMIC mutational signature 10 in RNA sequencing (RNA-seq) we set out to identify POLE-driven tumors in a set of unselected Mayo Clinic OC. Methods Mutational profiles were calculated using expressed single-nucleotide variants (eSNV) in the Mayo Clinic OC tumors (n = 195), The Cancer Genome Atlas (TCGA) OC tumors (n = 419), and the Genotype-Tissue Expression (GTEx) normal ovarian tissues (n = 84). Non-negative Matrix Factorization (NMF) of the mutational profiles inferred the contribution per sample of four distinct mutational signatures, one of which corresponds to COSMIC mutational signature 10. Results In the Mayo Clinic OC cohort we identified six tumors with a predicted contribution from COSMIC mutational signature 10 of over five mutations per megabase. These six cases harbored known POLE hotspot mutations (P286R, S297F, V411L, and A456P) and were of endometrioid histotype (P = 5e−04). These six tumors had an early onset (average age of patients at onset, 48.33 years) when compared to non-POLE endometrioid OC cohort (average age at onset, 60.13 years; P = .008). Samples from TCGA and GTEx had a low COSMIC signature 10 contribution (median 0.16 mutations per megabase; maximum 1.78 mutations per megabase) and carried no POLE hotspot mutations. Conclusions From the largest cohort of RNA-seq from endometrioid OC to date (n = 53), we identified six hypermutated samples likely driven by POLE (frequency, 11%). Our result suggests the clinical need to screen for POLE driver mutations in endometrioid OC, which can guide enrollment in immunotherapy clinical trials.
Published: 2021

24. Acute pancreatitis prevalence in children with cystic fibrosis and PIP score prediction applicability

Author: Mihai Craiu, Departamentul Pediatrie Insmc „Alessandrescu Rusescu', București, România, Valentina-Daniela Comănici, Mirela-Elena Ritivoiu, Dumitru Matei, Iustina Violeta Stan, Alina Angelica Belivacă, Umf „Carol Davila', București, România, Anca Bălănescu, and Ioana Florentina Codreanu
Subjects: medicine.medical_specialty, Medicine (General), acute pancreatitis, business.industry, medicine.disease, Gastroenterology, Cystic fibrosis, cystic fibrosis, R5-920, Internal medicine, Materials Chemistry, medicine, pip score, Acute pancreatitis, Medicine, business
Abstract: One of the affected organs in cystic fibrosis (CF) is the pancreas, mainly translated into exocrine pancreatic insufficiency. Although rare, acute pancreatitis (AP) has been described, mostly in pancreatic sufficient patients. Objectives. Estimating AP prevalence in CF pediatric population of the I.N.S.M.C. „AlessandrescuRusescu” CF centre. Material and methods. 5 year retrospective study (2011-2016) including INSMC CF centre pediatric population aged 3-18 years. PA diagnosis was established on the presence of minimum 2 criteria between: characteristic abdominal pain, x3 normal value for age elevation of amylase/lipase, medical imaging evaluation suggestive for AP. Patients were evaluated with different criteria including PIP score of predicting AP risk. Outcomes. 48 patients were included with a slight female predominance (54%). 3 of them presented diagnostic criteria for AP (6,25%), all heaving pancreatic insufficiency and high PIP score (low risk of developing AP); 2 of them have low compliance with pancreatic enzymes substitution therapy; one of them presented recurrent episodes of AP. Conclusions. AP is a rare CF complication. It can be easily missed due to a large number of abdominal pain and emesis causes in CF patients. Although it is usually associated with pancreatic sufficiency, all our patients were pancreatic insufficient.
Published: 2021

25. Evolutionary and prognostic implications in patient with acute coronary syndrome and dysthyroidism

Author: Universitatea de Medicină și Farmacie „Carol Davila', București, România, Clinica de Cardiologie, Spitalul Clinic de Urgență „Bagdasar-Arseni', București, România, Catalina Liliana Andrei, Maria Suzana Guberna, Crina-Julieta Sinescu, and Eleonora Drăgan
Subjects: medicine.medical_specialty, Acute coronary syndrome, Medicine (General), business.industry, thyroid dysfunction, medicine.disease, acute coronary syndrome, R5-920, Internal medicine, Materials Chemistry, medicine, Cardiology, outcome, Medicine, In patient, syntax score, business
Abstract: Purpose. The study aims to determine the impact of dysthyroidism on the severity and type of coronary lesion, on vascular function, as well as on the morbidity and mortality of patients with acute coronary syndrome, by finding predictive markers that can be translated into preventive measures that contribute substantially to reduce the number of newly diagnosed patients with coronary heart disease. Methods. We introduced in the study 100 patients recently diagnosed with acute coronary syndrome, without history of ischemic heart disease or thyroid disease, hospitalized in the Cardiology Clinic of the “Bagdasar-Arseni“ Emergency Clinical Hospital Bucharest, for the interventional treatment of acute coronary syndrome. The studied patients were hospitalized between November 2014 and April 2015, with regular follow-up of up to 5 years (telephone or direct interview, conducted at 6 months, 12 months, 24 months, 36 months, 48 months, 60 months), with an average period follow-up of 1006 days, evaluated clinically, bio-humorally, by echocardiography, explored with coronary angiography with the calculation of the SYNTAX score and with the performance of electrocardiogram and pulse wave. The obtained data were integrated in Excel sheets and statistically processed with the Python program. Results. The mortality rate in the patient group was 7% (7 deaths). Descriptively, of the deceased, 6 patients (86%) were male, and as thyroid status 1 hyperthyroid patient (14%), 3 hypothyroid patients (43%) and 3 patients (43%) normothyroid. There were 4 deaths (8%) in the group of patients with unstable angina and 3 deaths (8%) in the group of patients with myocardial infarction without ST-segment elevation. There were no deaths in the group of patients with acute myocardial infarction with ST-segment elevation. At follow-up, 41 patients (41%) were readmitted. Re-hospitalization was influenced by elevated values of mean blood pressure, diastolic blood pressure and C-reactive protein, unicoronary atherosclerotic disease and unstable angina at admission. At follow-up, the development of noncardiac events was noted in the evolution of patients, diabetes mellitus occurring in the majority, in almost a quarter of patients (22 patients, respectively 24% developed diabetes over time), 34% (19 patients) in euthyroidism and 8% (3 patients) dysthyroidism. Discussions. Predictive factors for the readmission of the patient with acute coronary syndrome are highlighted the following: increased level of C-reactive protein (p = 0.017), tricoronary vascular damage (p = 0.01), diastolic blood pressure greater than 80 mmHg (p = 0.025), and euthyroid status (p = 0.04). The probability of death for the patient with acute coronary syndrome rises to 66% in the presence of severe systolic dysfunction of the left ventricle (p = 0.006), and to 61% in the case of elevated values of hs troponin I (p = 0.008). In our study, the presence of dysthyroidism in the patient with acute coronary syndrome has a protective role in the development of diabetes in the first 5 years (p = 0.025). Conclusion. Dysthyroidism is associated with increased morbidity and mortality from cardiovascular disease.
Published: 2021

26. Therapeutic options for coarctation of the aorta

Author: Gabriela Ganea, Dumitru Matei, Universitatea de Medicină și Farmacie „Carol Davila', București, România, Mihaela Adela Iancu, and Institutul Național pentru Sănătatea Mamei și Copilului „Alessandrescu-Rusescu', București, România
Subjects: medicine.medical_specialty, Medicine (General), business.industry, surgical treatment, Coarctation of the aorta, medicine.disease, R5-920, Internal medicine, Materials Chemistry, Cardiology, balloon angioplasty, Medicine, coarctation of the aorta, recoarctation, stent, business
Abstract: Coarctation of the aorta is a relatively frequent congenital heart disease. Depending on the severity of the coarctation and the possible existence of other congenital heart defects, the symptoms may vary. In the neonatal period, the patients may have signs of heart failure, hypoperfusion or even shock. Coarctation of the aorta can be diagnosed incidentally in adolescence or adulthood, usually presented with mild symptoms. The patient’s anatomy, size, age, and clinical course are taken into consideration when choosing the appropriate treatment. Although associated morbidity and mortality risks regarding surgical or interventional treatment are relatively low, it is neccesary to etabilsh a long term follow-up, given the possible post-surgical complications that may occur: recoarctation, aortic aneurysm, aortic dissection and hypertension. Long term prognosis of these patients mostly depends on the presence of systemic hypertension with its consequences leading to premature cardiovascular events. Another factor is the severity of associated defects: aortic stenosis, mitral valve abnormalities. The purpose of this review is to describe the main treatmet methods, indications for intervention and possible complications of the surgical and interventional treatment.
Published: 2021

27. Thyroid dysfunction in the patient with acute coronary syndrome

Author: Maria Suzana Guberna, Catalina Liliana Andrei, Eleonora Drăgan, Universitatea de Medicină și Farmacie „Carol Davila', București, România, Crina-Julieta Sinescu, and Clinica de Cardiologie, Spitalul Clinic de Urgență „Bagdasar-Arseni', București, România
Subjects: medicine.medical_specialty, Acute coronary syndrome, endocrine system, Medicine (General), endocrine system diseases, business.industry, General Medicine, medicine.disease, acute coronary syndrome, R5-920, Thyroid dysfunction, Internal medicine, Cardiology, medicine, hyperthyroidism, Medicine, hypothyroidism, business
Abstract: Purpose. The study aims to determine the impact of dystyroidism on the type of acute coronary syndrome, on vascular function and coronary impairment, as well as on the myocardium and last but not least the general biological resonance of these hormones, emphasizing the role of thyroid hormones in the cardiovascular system. Methods. We introduced in the study 100 patients recently diagnosed with acute coronary syndrome, without history of ischemic heart disease or thyroid disease, hospitalized in the Cardiology Clinic of the Emergency Clinical Hospital Bagdasar-Arseni Bucharest, for the interventional treatment of acute coronary syndrome. The studied patients were hospitalized between November 2014 - April 2015, with follow-up up to 5 years, evaluated clinically, bio-humorally, by echocardiography, coronary angiography with SYNTAX score calculation and electrocardiogram and pulse wave. The obtained data were integrated in Excel sheets and statistically processed with the Python program. Results. The prevalence of dystyroidism in the study group was 44% (44 patients). Hypothyroidism is predominant (34 patients; 77%), and subclinical hypothyroidism occurs in 20 (59%) of subjects with hypothyroidism. Unstable angina is the predominant type of acute coronary syndrome, both in the whole group (54 patients; 54%) and in the group of patients with hyperthyroidism (7 patients; 70%), while acute myocardial infarction without ST-segment elevation was the type majority of presentation in patients with hypothyroidism (19 patients, 56%). Coronary heart disease varied as follows: in the total group unicoronary lesion (31 subjects; 31%), in patients with hyperthyroidism unicoronary lesion (5 subjects; 50%), in patients with hypothyroidism bicoronary lesion (10 subjects; 29%). And the calculated SYNTAX score is higher in the group of patients with dysthyroidism compared to the group of patients with euthyroidism. Discussions. Unstable angina (p = 0.006) and ventricular wall hypertrophy (p = 0.008) are predictive factors for dysthyroidism. Hypothyroidism correlates with high LDL-cholesterol levels (p = 0.0176) and hyposideremia (p = 0.0083), while hyperthyroidism correlates with thrombocytosis (p = 0.0122) and a significant nonspecific inflammatory syndrome (p = 0.0043). Dystyroidism has a direct correlation with the presence of kinetic disorders (Person correlation coefficient 0.21). Conclusion. Thyroid disease, with hypothyroidism or hyperthyroidism, can also be a risk factor for cardiovascular disease, and especially for ischemic heart disease.
Published: 2021

28. Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency

Author: Donald B. Kohn, Claire Booth, Kit L. Shaw, Jinhua Xu-Bayford, Elizabeth Garabedian, Valentina Trevisan, Denise A. Carbonaro-Sarracino, Kajal Soni, Dayna Terrazas, Katie Snell, Alan Ikeda, Diego Leon-Rico, Theodore B. Moore, Karen F. Buckland, Ami J. Shah, Kimberly C. Gilmour, Satiro De Oliveira, Christine Rivat, Gay M. Crooks, Natalia Izotova, John Tse, Stuart Adams, Sally Shupien, Hilory Ricketts, Alejandra Davila, Chilenwa Uzowuru, Amalia Icreverzi, Provaboti Barman, Beatriz Campo Fernandez, Roger P. Hollis, Maritess Coronel, Allen Yu, Krista M. Chun, Christian E. Casas, Ruixue Zhang, Serena Arduini, Frances Lynn, Mahesh Kudari, Andrea Spezzi, Marco Zahn, Rene Heimke, Ivan Labik, Roberta Parrott, Rebecca H. Buckley, Lilith Reeves, Kenneth Cornetta, Robert Sokolic, Michael Hershfield, Manfred Schmidt, Fabio Candotti, Harry L. Malech, Adrian J. Thrasher, and H. Bobby Gaspar
Subjects: Adenosine Deaminase, Genetic enhancement, 030204 cardiovascular system & hematology, Regenerative Medicine, Medical and Health Sciences, 0302 clinical medicine, Adenosine deaminase, Stem Cell Research - Nonembryonic - Human, Agammaglobulinemia, immune system diseases, Medicine, Prospective Studies, 030212 general & internal medicine, Child, 6.2 Cellular and gene therapies, biology, Hematopoietic Stem Cell Transplantation, hemic and immune systems, Gene Therapy, General Medicine, Progression-Free Survival, Child, Preschool, Development of treatments and therapeutic interventions, Autologous, Biotechnology, congenital, hereditary, and neonatal diseases and abnormalities, Adolescent, Genetic Vectors, Transplantation, Autologous, Article, 03 medical and health sciences, Clinical Research, General & Internal Medicine, Genetics, Humans, Lymphocyte Count, Preschool, Transplantation, Severe combined immunodeficiency, 5.2 Cellular and gene therapies, business.industry, Extramural, Lentivirus, Evaluation of treatments and therapeutic interventions, Infant, nutritional and metabolic diseases, Genetic Therapy, Stem Cell Research, medicine.disease, Adenosine deaminase deficiency, enzymes and coenzymes (carbohydrates), Good Health and Well Being, Primary immunodeficiency, Cancer research, biology.protein, Severe Combined Immunodeficiency, business, Ex vivo
Abstract: BACKGROUND: Severe combined immunodeficiency due to adenosine deaminase (ADA) deficiency (ADA-SCID) is a rare and life-threatening primary immunodeficiency. METHODS: We treated 50 patients with ADA-SCID (30 in the United States and 20 in the United Kingdom) with an investigational gene therapy composed of autologous CD34+ hematopoietic stem and progenitor cells (HSPCs) transduced ex vivo with a self-inactivating lentiviral vector encoding human ADA. Data from the two U.S. studies (in which fresh and cryopreserved formulations were used) at 24 months of follow-up were analyzed alongside data from the U.K. study (in which a fresh formulation was used) at 36 months of follow-up. RESULTS: Overall survival was 100% in all studies up to 24 and 36 months. Event-free survival (in the absence of reinitiation of enzyme-replacement therapy or rescue allogeneic hematopoietic stem-cell transplantation) was 97% (U.S. studies) and 100% (U.K. study) at 12 months; 97% and 95%, respectively, at 24 months; and 95% (U.K. study) at 36 months. Engraftment of genetically modified HSPCs persisted in 29 of 30 patients in the U.S. studies and in 19 of 20 patients in the U.K. study. Patients had sustained metabolic detoxification and normalization of ADA activity levels. Immune reconstitution was robust, with 90% of the patients in the U.S. studies and 100% of those in the U.K. study discontinuing immunoglobulin-replacement therapy by 24 months and 36 months, respectively. No evidence of monoclonal expansion, leukoproliferative complications, or emergence of replication-competent lentivirus was noted, and no events of autoimmunity or graft-versus-host disease occurred. Most adverse events were of low grade. CONCLUSIONS: Treatment of ADA-SCID with ex vivo lentiviral HSPC gene therapy resulted in high overall and event-free survival with sustained ADA expression, metabolic correction, and functional immune reconstitution. (Funded by the National Institutes of Health and others; ClinicalTrials.gov numbers, NCT01852071, NCT02999984, and NCT01380990.)
Published: 2021
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29. The Effect of Obstructive Sleep Apnea Treatment and Severity on Choroidal Thickness in Patients With Central Serous Chorioretinopathy

Author: Jose R. Davila, Amee D. Azad, Nadim Rayess, Michelle Cao, Prithvi Mruthyunjaya, and Carolyn K. Pan
Subjects: medicine.medical_specialty, business.industry, medicine.disease, Obstructive sleep apnea, 03 medical and health sciences, Serous fluid, 0302 clinical medicine, Internal medicine, 030221 ophthalmology & optometry, medicine, Cardiology, Original Manuscripts, In patient, business, 030217 neurology & neurosurgery
Abstract: Purpose: This work aimed to analyze the association of obstructive sleep apnea (OSA) with choroidal thickness (CT) in patients with central serous chorioretinopathy (CSC). Methods: We identified patients in the Stanford Research Repository with a diagnosis of CSC and OSA. Age- and sex-matched controls with either CSC or OSA only were also identified. CT was measured at 5 points (subfoveal, and 1500 and 3000 µm nasal and temporal) by 2 graders. In addition to OSA treatment and severity, we also investigated the association of Oxygen Desaturation Index and nocturnal oxygen saturation nadir with subfoveal CT (SFCT). Results: A total of 57 patients and 72 eyes met the study inclusion criteria. The mean SFCT was significantly different across the 3 groups: OSA-only was the thinnest, followed by CSC with OSA, and CSC-only was the thickest (194.2 μm, 295.1 μm, and 357.8 μm, respectively, P < .001). SFCT was thicker in CSC with OSA compared with those with only OSA ( P < .05). OSA treatment status and OSA severity did not show a significant difference in SFCT in multivariable modeling. Nocturnal oxygen saturation nadir was positively associated with SFCT, but this did not reach significance.. Conclusions: SFCT is significantly different in patients with OSA alone, CSC with OSA, and CSC alone. While OSA treatment status did not demonstrate a significant difference in SFCT in this study, future studies should evaluate patients for OSA in patients known to have CSC and atypically thin CT to further investigate the novel metrics leveraged in this study.
Published: 2021
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30. Use of different strategies to make one’s bisexual+ identity visible: Associations with dimensions of identity, minority stress, and health

Author: Joanne Davila, Brian A. Feinstein, Christina Dyar, Jeremy Jabbour, and J. Samuel Milstone
Subjects: Generalized anxiety disorder, Social Psychology, Community engagement, Health Policy, Public Health, Environmental and Occupational Health, Identity (social science), medicine.disease, Minority stress, Mental health, Article, Psychiatry and Mental health, Clinical Psychology, medicine, Anxiety, Lesbian, medicine.symptom, Psychology, Centrality, Social psychology
Abstract: Bisexual+ people (i.e., those who are attracted to more than one gender or regardless of gender) use a variety of strategies to make their identity visible to others, but little is known about the extent to which using different strategies is related to other dimensions of identity, minority stress, and health. To address this, we surveyed 715 bi+ people about their use of five different types of visibility strategies (direct communication, indirect communication, community engagement, gender-based visual displays, and public behavioral displays). Results indicated that people who used visibility strategies more often (aggregated across types) reported higher identity centrality and affirmation, and lower internalized bi-illegitimacy and internalized binegativity. However, they also reported more discrimination from heterosexual and gay/lesbian individuals and higher depression and anxiety. When we examined the unique associations between each of the five types of visibility strategies and our other variables, we found different patterns of associations for different strategies. For example, direct communication was uniquely associated with more discrimination from gay/lesbian individuals, while indirect communication, gender-based visual displays, and public behavioral displays were uniquely associated with more discrimination from heterosexual individuals. Only indirect communication was uniquely associated with higher depression and anxiety, while community engagement was uniquely associated with lower anxiety. Finally, public behavioral displays were uniquely associated with more alcohol use problems and a higher likelihood of cigarette use. These findings highlight the importance of examining the specific strategies that people use to make their bi+ identity visible in order to understand their experiences and health.
Published: 2021
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31. RNA-Seq Reveals Differences in Expressed Tumor Mutation Burden in Colorectal and Endometrial Cancers with and without Defective DNA-Mismatch Repair

Author: Bruce W. Eckloff, Rory A. Jackson, Mazen A. Atiq, Sarah E. Kerr, Margaret A. DiGuardo, Asha Nair, Kevin C. Halling, Jin Jen, Kandelaria M. Rumilla, Jesse S. Voss, Rondell P. Graham, Jaime I. Davila, Andrew M. Bellizzi, Benjamin R. Kipp, Numrah Fadra, Kay Minn, Dora Lam-Himlin, Shannon M. Knight, Shabnam Zarei, Joseph H. Blommel, and Robert B. Jenkins
Subjects: Adult, Male, 0301 basic medicine, Biology, medicine.disease_cause, MLH1, DNA Mismatch Repair, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Biomarkers, Tumor, medicine, Humans, RNA-Seq, Aged, Retrospective Studies, Aged, 80 and over, Mutation, Endometrial cancer, RNA, Middle Aged, Prognosis, medicine.disease, digestive system diseases, Endometrial Neoplasms, 030104 developmental biology, 030220 oncology & carcinogenesis, DNA methylation, Cancer research, Molecular Medicine, Biomarker (medicine), Microsatellite, Female, DNA mismatch repair, Colorectal Neoplasms, Follow-Up Studies
Abstract: Tumor mutation burden (TMB) is an emerging biomarker of immunotherapy response. RNA sequencing in FFPE tissue samples was used for determining TMB in microsatellite-stable (MSS) and microsatellite instability–high (MSI-H) tumors in patients with colorectal or endometrial cancer. Tissue from tumors and paired normal tissue from 46 MSI-H and 12 MSS cases were included. Of the MSI-H tumors, 29 had defective DNA mismatch–repair mutations, and 17 had MLH1 promoter hypermethylation. TMB was measured using the expressed somatic nucleotide variants (eTMB). A method of accurate measurement of eTMB was developed that removes FFPE-derived artifacts by leveraging mutation signatures. There was a significant difference in the median eTMB values observed between MSI-H and MSS cases: 27.3 versus 6.7 mutations/megabase (mut/Mb) (P = 3.5 × 10−9). Among tumors with defective DNA-mismatch repair, those with mismatch-repair mutations had a significantly higher median eTMB than those with hypermethylation: 28.1 versus 17.5 mut/Mb (P = 0.037). Multivariate analysis showed that MSI status, tumor type (endometrial or colorectal), and age were significantly associated with eTMB. Additionally, using whole-exome sequencing in a subset of these patients, it was determined that DNA TMB correlated well with eTMB (Spearman correlation coefficient, 0.83). These results demonstrate that RNA sequencing can be used for measuring eTMB in FFPE tumor specimens.
Published: 2021
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32. Congenital diaphragmatic hernia: a retrospective study regarding the clinical experience of Bihor County Genetics Center

Author: Romania Pharmacy 'Carol Davila' Bucharest, Dorina Galusca, Dana Carmen Zaha, Codruța Diana Petchesi, Alina Sklerniacof, Amorin Remus Popa, Emilia Severin, Kinga Kozma, Sânziana Jurca, Cristian Daina, Marius Bembea, Claudia Jurca, Cosmin Mihai Vesa, and Alexandru Daniel Jurcă
Subjects: medicine.medical_specialty, business.industry, General surgery, Genetics, medicine, Congenital diaphragmatic hernia, Center (algebra and category theory), Retrospective cohort study, medicine.disease, business, Agronomy and Crop Science, Applied Microbiology and Biotechnology, Biotechnology
Abstract: Congenital diaphragmatic hernia is an abnormality of embryologic development characterized by the persistence of communication between the thoracic and abdominal cavities, followed by an extremely high death rate despite medical progress. In Bihor county, according to a retrospective analysis of patient records from the Regional Center of Genetics, 30 children were diagnosed with congenital diaphragmatic hernia over a span of 28 years, from 1990 to 2018, most being male (73.3%). Predominant were the complex congenital diaphragmatic cases, meaning the cases of diaphragmatic hernia associated with other congenital abnormalities, 67% (20 patients) presenting at least one other congenital malformation. 95% (19 cases) of patients with complex congenital diaphragmatic hernia presented pulmonary abnormalities, the most frequent being pulmonary hypoplasia; 35% (7 cases) presented cardiac abnormalities. The Apgar score at 5 minutes after birth was significantly lower for patients with the clinical form of complex congenital diaphragmatic hernia. The mortality for the patients presenting the complex form was 100%, and for the patients presenting the isolated form was 20%. Karyotype analysis was performed for 17 patients, and 23.53% of them (4 patients) presented chromosomal abnormalities.
Published: 2021
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33. Diagnostic Performance of Erythropoietin Levels in Polycythemia Vera: Experience at a Comprehensive Cancer Center

Author: Cristhiam M. Rojas-Hernandez, Lee Cheng, Lucia Masarova, Srdan Verstovsek, Alanna Barrios-Ruiz, Eric Fountain, and Daniel Davila-Gonzalez
Subjects: Male, Cancer Research, medicine.medical_specialty, Secondary Polycythemia, Polycythemia, Cancer Care Facilities, 03 medical and health sciences, 0302 clinical medicine, Polycythemia vera, Predictive Value of Tests, hemic and lymphatic diseases, Internal medicine, Biomarkers, Tumor, medicine, Humans, Genetic Testing, Erythropoietin, Polycythemia Vera, Retrospective Studies, Predictive marker, business.industry, Area under the curve, Cancer, Retrospective cohort study, Hematology, Janus Kinase 2, Middle Aged, medicine.disease, ROC Curve, Oncology, 030220 oncology & carcinogenesis, Mutation, Etiology, Female, business, 030215 immunology, medicine.drug
Abstract: Introduction Considering the evolving diagnostic criteria of polycythemia vera (PV), we analyzed the utility of serum erythropoietin (EPO) as a predictive marker for differentiating polycythemia vera (PV) from other etiologies of erythrocytosis. Patients and Methods We conducted a retrospective study after a review of electronical medical records from January 2005 to December 2016 with diagnosis of erythrocytosis using International Classification of Disease–specific codes. To evaluate the diagnostic performance of EPO levels and JAK2-V617F mutation, we constructed a receiver-operated characteristic curve of sensitivity versus 1-specificity for serum EPO levels and JAK2-V617F mutation as predictive markers for differentiating PV from other causes of erythrocytosis. Results We surveyed 577 patients with erythrocytosis. Median patient age was 59.2 years, 57.72% (n = 329) were male, 86.3% (n = 491) were white, and only 3.3% (n = 19) were African American. A total of 80.88% (n = 351) of those diagnosed with PV had a JAK2-V617F mutation compared to only 1.47% (n = 2) whose primary diagnosis was secondary polycythemia. When comparing JAK2-V617 mutation to the EPO level, the area under the curve of JAK2-V617 (0.8970) was statistically larger than that of EPO test (0.6765). Therefore, the PV diagnostic methodology using JAK2-V617 is better than the EPO test. An EPO level of 99% specific to predict PV but was only 12% sensitive. Conclusion In the appropriate clinical setting, cytogenetic and molecular studies such as JAK2 mutation status prevail as the most useful tools for PV case identification. The use of isolated EPO to screen patients with erythrocytosis is not a good diagnostic approach.
Published: 2021
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34. The importance of NT proBNP in hypertensive patients management for preventing heart failure

Author: Irina Cuciureanu, Catalina Liliana Andrei, Anamaria-Georgiana Avram, Universitatea de Medicină şi Farmacie „Carol Davila', Bucureşti, România, Crina-Julieta Sinescu, and Maria Suzana Guberna
Subjects: Medicine (General), medicine.medical_specialty, business.industry, heart failure, General Medicine, nt probnp, medicine.disease, R5-920, prevention, Internal medicine, Heart failure, medicine, Cardiology, Medicine, business
Abstract: Purpose. NT proBNP is routinely used in the diagnosis and prognosis of HF. The study aimed to determine whether the value of NT proBNP can be used in hypertensive patients to detect patients at risk of developing HF and whether in these patients medical management guided by NT proBNP can prevent the development of HF. Material and methods. We included 275 hypertensive patients who presented to the Bagdasar-Arseni Emergency Hospital for cardiological consultation for a period of 3 years. Patients diagnosed with heart failure or left ventricular systolic dysfunction and patients with symptoms of heart failure at enrollment were excluded. We divided the patients into 2 groups, a control group and an intervention group. Patients in the intervention group were managed according to the NT proBNP value, and patients in the control group received standard treatment. Results. The objectives pursued at 3 years were: diagnosis of heart failure, systolic or diastolic dysfunction of the left ventricle and hospitalization for cardiovascular pathology. After 3 years, in the control group there were 34 patients (25.4%) who developed HF, compared to 24 patients (17.0%) in the intervention group. In the control group, 51 patients (38.1%) were diagnosed with LV systolic dysfunction compared to 37 patients (26.2%) in the intervention group. Regarding diastolic LV dysfunction, in the control group there were 83 patients (61.9%), and in the intervention group there were 73 patients (51.8%). Also, the rate of hospitalizations for cardiovascular pathology was higher in the control group 47 patients (35.1%) compared to 27 patients (19.1%) in the intervention group. Discussions. Hypertensive patients in the intervention group, who were managed according to the NT proBNP value, had a lower incidence rate of heart failure, LV systolic or diastolic dysfunction, or hospitalizations for cardiovascular events than in the control group. Conclusions. The value of NT proBNP may be useful for detecting hypertensive patients at risk of developing HF, and NT proBNP-guided medical management may prevent or delay the onset of HF.
Published: 2021
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35. Reno-urinary changes during pregnancy and monitoring of the pregnant woman in primary care

Author: Laura Condur, Institutul Naţional pentru Sănătatea Mamei şi Copilului „Alessandrescu-Rusescu', Bucureşti, România, Mihaela Adela Iancu, Facultatea de Medicină Universitatea „Ovidius', Constanţa, România, Bucureşti Universitatea de Medicină şi Farmacie „Carol Davila', Camelia Cristina Diaconu, Spitalul Clinic de Urgenţă, Bucureşti, România, and Dumitru Matei
Subjects: kidneys, Medicine (General), Pregnancy, medicine.medical_specialty, business.industry, Obstetrics, Urinary system, General Medicine, Primary care, morphofunctional changes, medicine.disease, R5-920, general practitioner, medicine, Medicine, pregnancy, sense organs, skin and connective tissue diseases, business
Abstract: During pregnancy, anatomical and functional changes occur in all organs and systems of the body. The family doctor evaluates the morphofunctional changes in the reno-urinary system throughout the pregnancy. These morphological and functional changes often have no clinical expression. Morphofunctional changes in the reno-urinary system cause changes in laboratory tests results and are the basis for the appearance of urinary tract symptoms. The family doctor has an important role in assessing the pregnant woman, and in diagnosing renal pathology early. Although the pregnant woman has an increased risk of developing various urinary tract diseases, frequently, under active monitoring and conservative treatment, the evolution can be favorable.
Published: 2021
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36. QIM21-081: Shared Medical Appointments for Cancer Survivors: A Feist Weiller Cancer Center Pilot Study

Author: Ghanshyam Mudigonda, Carol Crooms, Rupa Mahadevan, Udhayvir Singh Grewal, Jennifer Singh, and Cesar Davila-Chapa
Subjects: medicine.medical_specialty, Oncology, business.industry, Family medicine, medicine, Cancer, Center (algebra and category theory), medicine.disease, business
Published: 2021
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37. EPR21-035: Immune Checkpoint Inhibitor-Related Hemophagocytic Lymphohistiocytosis: A Food and Drug Association Adverse Event Reporting System (FAERS) Analysis

Author: Shiva Jashwanth Gaddam, Jasmeen Kaur Uppal, Parth Shah, Sahith Reddy Thotamgari, Udhayvir Singh Grewal, and Cesar Davila-Chapa
Subjects: Drug, Hemophagocytic lymphohistiocytosis, Adverse Event Reporting System, Oncology, business.industry, Immune checkpoint inhibitors, media_common.quotation_subject, Immunology, Medicine, business, medicine.disease, media_common
Published: 2021
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38. A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review

Author: Kees P. van de Ven, Anne M. J. B. Smets, Raquel Davila Fajardo, Bradley R. Pieters, An Van Damme, Annelies M. C. Mavinkurve-Groothuis, Ronald R. de Krijger, Petra S. Kroon, Marc R. Lilien, Geert O. Janssens, Marry M. van den Heuvel-Eibrink, Marc H. W. A. Wijnen, Hugo A. Heij, Godelieve A.M. Tytgat, Rafal Chrzan, Jim C. H. Wilde, Radiotherapy, CCA - Cancer Treatment and Quality of Life, Paediatric Oncology, Radiology and Nuclear Medicine, APH - Mental Health, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and ARD - Amsterdam Reproduction and Development
Subjects: medicine.medical_specialty, Long term follow up, medicine.medical_treatment, Enucleation, Brachytherapy, Renal function, Kidney Neoplasms / radiotherapy, Wilms Tumor / radiotherapy, Nephrectomy, Brachytherapy / methods, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Retrospective Studies, ddc:618, business.industry, Gold standard, Infant, Newborn, Wilms tumor, Wilms' tumor, Perioperative, medicine.disease, Kidney Neoplasms, Kidney Neoplasms / surgery, Oncology, 030220 oncology & carcinogenesis, Wilms Tumor / surgery, Radiology, business, Follow-Up Studies
Abstract: Purpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature.Results (methods and case description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function.Conclusions: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.
Published: 2021

39. Breast cancer in Romania, a pathology that requires information and education campaigns – risk factors and prophylaxis

Author: Spitalul Clinic „Sfânta Maria', Bucureşti, România, Gabriel Andrei Gangura, Alexandru Chirca, Radu Costea, Spitalul Euroclinic, Regina Maria, Bucureşti, România, Universitatea de Medicină şi Farmacie „Carol Davila', Bucureşti, România, Alexandra Ileana Sanda, Spitalul Universitar de Urgenţă, Bucureşti, România, Roxana Ristea, Daniela Aurora Peşu, Nicoleta Aurelia Sanda, and Marius Răzvan Ristea
Subjects: medicine.medical_specialty, Medicine (General), business.industry, General Medicine, medicine.disease, Breast cancer, breast cancer, R5-920, prevention, medicine, early diagnostic, Medicine, Intensive care medicine, business
Abstract: Breast cancer is the most common type of cancer among women, and its early diagnosis can lead to a survival of over 90% at 5 years. In order to achieve correct education of the population, especially of young women and of the entire medical staff, we consider necessary the review of the risk factors for breast cancer and the possibilities of prophylaxis. Although the survival of breast cancer patients has improved among European Union countries over the last decade (from 79% to 83%), Romania is still at the bottom of the ranking with 75% survival at 5 years, and an assessment of the last 12 months would reveal even more worrying values.
Published: 2021

40. Posttraumatic Stress Disorder Subsequent to Apparent Mild Traumatic Brain Injury

Author: Jake D Rieke, Damon G. Lamb, Gregory F. Lewis, John B. Williamson, Amy B Tran, Ilona M. Schmalfuss, Aidan J. Murphy, Maria I. Davila, and Sarah A Bottari
Subjects: Traumatic brain injury, Cognitive Neuroscience, Uncinate fasciculus, Context (language use), behavioral disciplines and activities, Amygdala, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, mental disorders, medicine, 0501 psychology and cognitive sciences, business.industry, 05 social sciences, General Medicine, medicine.disease, Substance abuse, Psychiatry and Mental health, Distress, Neuropsychology and Physiological Psychology, Traumatic injury, medicine.anatomical_structure, business, Psychosocial, 030217 neurology & neurosurgery, Clinical psychology
Abstract: Posttraumatic stress disorder (PTSD) is prevalent among veterans with a history of traumatic brain injury (TBI); however, the relationship between TBI and PTSD is not well understood. We present the case of a 31-year-old male veteran with PTSD who reported TBI before entering the military. The reported injury appeared to be mild: He was struck on the head by a baseball, losing consciousness for ∼10 seconds. Years later, he developed severe PTSD after combat exposure. He was not receiving clinical services for these issues but was encountered in the context of a research study. We conducted cognitive, autonomic, and MRI assessments to assess brain function, structure, and neurophysiology. Next, we compared amygdala volume, uncinate fasciculus diffusion, functional connectivity, facial affect recognition, and baroreceptor coherence with those of a control group of combat veterans (n = 23). Our veteran's MRI revealed a large right medial-orbital prefrontal lesion with surrounding atrophy, which the study neuroradiologist interpreted as likely caused by traumatic injury. Comparison with controls indicated disrupted structural and functional connectivity of prefrontal-limbic structures and impaired emotional, cognitive, and autonomic responses. Detection of this injury before combat would have been unlikely in a clinical context because our veteran had reported a phenomenologically mild injury, and PTSD is a simple explanation for substance abuse, sleep impairment, and psychosocial distress. However, it may be that right prefrontal-limbic disruption imparted vulnerability for the development of PTSD and exacerbated our veteran's emotional response to, and recovery from, PTSD.
Published: 2021
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41. POEM: clinical outcomes beyond 5 years

Author: Kevin M. Reavis, Steven R. DeMeester, Brett Parker, Reid Fletcher, Ahmed Sharata, Sarah C. McKay, Daniel Davila Bradley, Lee L. Swanstrom, Christy M. Dunst, and Dolores T Müller
Subjects: Myotomy, medicine.medical_specialty, business.industry, General surgery, medicine.medical_treatment, Psychological intervention, Achalasia, medicine.disease, Single Center, Dysphagia, 03 medical and health sciences, 0302 clinical medicine, Esophageal motility disorder, 030220 oncology & carcinogenesis, medicine, Balloon dilation, 030211 gastroenterology & hepatology, Surgery, medicine.symptom, business, Abdominal surgery
Abstract: The short-term success of peroral endoscopic myotomy (POEM) is well documented but the durability of the operation is questioned. The aim of this study was to evaluate the clinical outcomes of the POEM procedure for esophageal motility disorders in a large cohort in which all patients had at least 5 years of follow-up. All patients from a single center who underwent a POEM between October 2010 and September 2014 were followed for long-term clinical outcomes. Postoperative Eckardt symptom scores of short term and ≥ 5 years were collected through phone interview. Clinical success was defined as an Eckardt score
Published: 2021
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42. Power Training in Older Adults With Knee Osteoarthritis

Author: Victoria S. Davila, Margaret K. Danilovich, Craig P. Hensley, Kevin K. Chui, and Marie B. Corkery
Subjects: Power (social and political), medicine.medical_specialty, business.industry, Rehabilitation, Training (meteorology), Physical therapy, medicine, Physical Therapy, Sports Therapy and Rehabilitation, Osteoarthritis, Geriatrics and Gerontology, medicine.disease, business
Published: 2021
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43. Host-Pathogen Molecular Factors Contribute to the Pathogenesis of Rhizopus spp. in Diabetes Mellitus

Author: Mario Nava-Villalba, Yaír Adonaí Sánchez-Nuño, Edgar Octavio Medina-Guerrero, Claudia Lisette Charles-Niño, Perla Davila-Villa, Elsa Janneth Anaya-Ambriz, and Berenice Morales-Franco
Subjects: Fungal infection, Fungal protein, biology, Mucormycosis, Disease, Fungus, biology.organism_classification, medicine.disease, Microbiology, Infectious Diseases, Immune system, Diabetes mellitus, Rhizopus, Evasion, Spore germination, medicine, Tropical Mycoses (L Martinez, Section Editor), Immunology and Allergy, Pathogen
Abstract: Purpose of Review Infectious diseases represent up to 12% of all deaths in people with diabetes mellitus (DM). The development and progression of DM generate a chronic inflammatory state with unique characteristics that have been exploited by some pathogens; one of them is Rhizopus spp., a fungus considered the causative agent of mucormycosis. This disease has a poor prognosis with high mortality rates, and the apparition of resistant isolates each year has become a worrying concern. DM is an actual and continuing health problem, and for that reason, it is of foremost importance to study the pathogenesis of mucormycosis to generate new prevention and treatment strategies. Recent Findings The worldwide incidence of mucormycosis has increased in recent years. The pathogenic mechanisms and factors identified in Rhizopus spp. are the cell wall, spore germination, proteins, and enzymes related to iron sequestration, CotH fungal protein, positive regulation of the GRP78 cell receptor, and immune evasion due to survival within phagocytes, among others. The physiopathology of DM offers favorable conditions for the successful replication of Rhizopus spp. Summary The main reason for increase of incidence of mucormycosis caused by Rhizopus spp. has been associated with the rise of worldwide prevalence of DM. Knowing the fungal pathogenic mechanisms as well as the relationships between Rhizopus with the microenvironment found in the human body will undoubtedly help generate better antifungals to enhance treatment outcomes. Nowadays, some strategies to combat the fungus are based on the knowledge of its proteins, cellular interactions, and iron metabolism.
Published: 2021

44. Patient Satisfaction Index and Quality of Life Measurement with Breast-Q after Breast Reconstruction in a Plastic Surgery Center in Mexico

Author: Carlos I. Navarro-Delgadillo, Jose Carlos Martinez-Lopez, Jaime Aron Garcia-Espinoza, Victor H. Avalos-Gómez, Rodrigo Davila-Diaz, Cuahutemoc Márquez-Espriella, David Flores-Soto, and Esteban I. Campos-Serna
Subjects: medicine.medical_specialty, business.industry, General surgery, medicine.medical_treatment, medicine.disease, Patient satisfaction, Breast cancer, Quality of life, Management of Technology and Innovation, Patient experience, medicine, Patient-reported outcome, skin and connective tissue diseases, Breast reconstruction, business, Psychosocial, Mastectomy
Abstract: Introduction: Cancer is one of the most devastating pathologies to affect the breast. Mastectomy stigmas are associated with depression, body image dysmorphia, and decreasing quality of life. BREAST-Q is a PROM (Patient Reported Outcome Measures) that has proven useful in measuring satisfaction with breast reconstruction results from the patient’s point of view. Objectives: To measure the satisfaction index and improvement in quality of life after breast reconstruction for breast cancer sequelae in our hospital in the last 5 years. Materials and Methods: Descriptive Study that includes patients with Breast cancer diagnosis that underwent mastectomy and breast reconstruction (prosthesis or autologous tissue) in “Hospital Central Sur de Petroleos Mexicanos” (January 2015 to January 2020), whose satisfaction index was measured with BREAST-Q one year after reconstruction. Results: 153 patients were included in the analysis. Mean global satisfaction was 74 points. We observed a tendency towards higher psychosocial, sexual and appearance satisfaction in patients who underwent reconstruction with autologous tissue. The mean satisfaction with provided information was 64 points and with the medical team > 90 points. Conclusion: Breast reconstruction is associated to a high satisfaction index and quality of life improvement regardless of the technique. BREAST-Q proved to be useful in evaluating patient experience and it helped us identify areas of opportunity to improve our care.
Published: 2021
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45. Prospective, multicenter study of P4HB (Phasix™) mesh for hernia repair in cohort at risk for complications: 3-Year follow-up

Author: John Scott Roth, David B. Earle, Corey R. Deeken, John Romanelli, Guy R. Voeller, Raymond M. Dunn, Jasenka Verbarg, Richard A. Pierce, Don J. Selzer, Benjamin K. Poulose, Jacob A. Greenberg, Robert G. Martindale, Jennifer Salluzzo, Matthew I. Goldblatt, James G. Bittner, Bryan J. Sandler, Gary J. Anthone, Gregory J. Mancini, William W. Hope, John G. Linn, and Eduardo Parra-Davila
Subjects: Poly-4-hydroxybutyrate, medicine.medical_specialty, medicine.medical_treatment, 030230 surgery, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Recurrence, medicine, Hernia, Original Research, Mesh, COPD, business.industry, General Medicine, medicine.disease, Hernia repair, Myofascial release, Surgery, Seroma, 030220 oncology & carcinogenesis, Cohort, Infection, business
Abstract: Background This study represents a prospective, multicenter, open-label study to assess the safety, performance, and outcomes of poly-4-hydroxybutyrate (P4HB, Phasix™) mesh for primary ventral, primary incisional, or multiply-recurrent hernia in subjects at risk for complications. This study reports 3-year clinical outcomes. Materials and methods P4HB mesh was implanted in 121 patients via retrorectus or onlay technique. Physical exam and/or quality of life surveys were completed at 1, 3, 6,12, 18, 24, and 36 months, with 5-year (60-month) follow-up ongoing. Results A total of n = 121 patients were implanted with P4HB mesh (n = 75 (62%) female) with a mean age of 54.7 ± 12.0 years and mean BMI of 32.2 ± 4.5 kg/m2 (±standard deviation). Comorbidities included: obesity (78.5%), active smokers (23.1%), COPD (28.1%), diabetes mellitus (33.1%), immunosuppression (8.3%), coronary artery disease (21.5%), chronic corticosteroid use (5.0%), hypo-albuminemia (2.5%), advanced age (5.0%), and renal insufficiency (0.8%). Hernias were repaired via retrorectus (n = 45, 37.2% with myofascial release (MR) or n = 43, 35.5% without MR), onlay (n = 8, 6.6% with MR or n = 24, 19.8% without MR), or not reported (n = 1, 0.8%). 82 patients (67.8%) completed 36-month follow-up. 17 patients (17.9% ± 0.4%) experienced hernia recurrence at 3 years, with n = 9 in the retrorectus group and n = 8 in the onlay group. SSI (n = 11) occurred in 9.3% ± 0.03% of patients. Conclusions Long-term outcomes following ventral hernia repair with P4HB mesh demonstrate low recurrence rates at 3-year (36-month) postoperative time frame with no patients developing late mesh complications or requiring mesh removal. 5-year (60-month) follow-up is ongoing., Highlights • Prospective, multicenter, open-label study of safety, performance, and outcomes. • Poly-4-hydroxybutyrate mesh implanted in n = 121 patients via retrorectus or onlay. • 82 patients (67.8%) completed 36-month follow-up. • Hernia recurrence (n = 17, 17.9% ± 0.4%) and SSI (n = 11, 9.3% ± 0.03%) at 3 years. • No patients developed late mesh complications or required mesh removal.
Published: 2021
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46. Comparison of Methods to Identify Stress Urinary Incontinence in Women With Pelvic Organ Prolapse

Author: Laura Martin, Isildinha M. Reis, Jeffrey S. Schachar, Eric A. Hurtado, G. Willy Davila, Hemikaa Devakumar, Feng Miao, David A. Ossin, and Alexandriah Alas
Subjects: Adult, Stress incontinence, medicine.medical_specialty, Urinary Incontinence, Stress, Urology, Urinary system, 030232 urology & nephrology, Urinary incontinence, Stage ii, Sensitivity and Specificity, Pelvic Organ Prolapse, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, Pelvic organ, 030219 obstetrics & reproductive medicine, business.industry, Significant difference, Obstetrics and Gynecology, Diagnostic Techniques, Urological, Middle Aged, medicine.disease, Occult, Female, Surgery, medicine.symptom, business, human activities
Abstract: Objective The aim of the study was to compare which test is most sensitive in identifying stress urinary incontinence (SUI) in women with pelvic organ prolapse using urodynamics (UDS) as the criterion standard: cough stress test (CST) or pyridium pad test. Methods This was a prospective study of women with pelvic organ prolapse stage II or greater who desired surgical management for prolapse. Each patient underwent preoperative urinary testing: UDS, CST, and a 24-hour pyridium pad test. Results A total of 84 patients were analyzed. Using UDS as the criterion standard, both the CST and the pyridium pad test showed a fair agreement with UDS outcomes (κ = 0.27 for both tests). There was no statistically significant difference between the CST and pyridium pad test, with estimated sensitivities of 34.4% versus 60.6% (P = 0.791) and specificities of 90.4% versus 84.6% (P = 0.508). The pyridium pad test was found to have a statistically significant difference in identifying the subjective complaint of SUI (38.6%, P = 0.003) compared with other tests. Patients with occult incontinence were identified 42.5%, 17.5%, and 10% of the time during UDS, CST, and pyridium pad testing, respectively. Conclusion Our data suggest that the sensitivities of the CST and pyridium pad test for stress incontinence and occult stress incontinence in patients with pelvic organ prolapse are low when compared with UDS as the criterion standard. Urodynamics has an important role in preoperative identification of occult SUI.
Published: 2021
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47. Family history assessment significantly enhances delivery of precision medicine in the genomics era

Author: Sonia Davila, Sylvia Kam, Saumya Shekhar Jamuar, Khung Keong Yeo, Jyn Ling Kuan, Nicolas Bertin, Patrick Tan, Steve Rozen, Bin Tean Teh, Geoffrey S. Ginsburg, Jing Xian Teo, Cheng Xi Yang, Koei Wan Tham, Stuart A. Cook, Lori A. Orlando, Weng Khong Lim, Yasmin Bylstra, Sock Hoai Chan, and R. Ryanne Wu
Subjects: 0301 basic medicine, Male, lcsh:Medicine, Cohort Studies, 0302 clinical medicine, Risk Factors, Medicine, Precision Medicine, Family history, Medical History Taking, Genetics (clinical), Likely pathogenic, Cancer, Aged, 80 and over, Potential impact, High-Throughput Nucleotide Sequencing, Genomics, Middle Aged, 030220 oncology & carcinogenesis, Cohort, Molecular Medicine, Medical genetics, Cancer gene, Female, Adult, medicine.medical_specialty, Adolescent, lcsh:QH426-470, Clinically actionable variants, Genomic data, 03 medical and health sciences, Young Adult, Genetics, Humans, Molecular Biology, Aged, 0604 Genetics, Health risk assessment, Genome, Human, business.industry, Research, lcsh:R, Correction, 1103 Clinical Sciences, Population genomics screening, medicine.disease, Precision medicine, Human genetics, lcsh:Genetics, 030104 developmental biology, Family medicine, business, Delivery of Health Care, Demography
Abstract: Background Family history has traditionally been an essential part of clinical care to assess health risks. However, declining sequencing costs have precipitated a shift towards genomics-first approaches in population screening programs rendering the value of family history unknown. We evaluated the utility of incorporating family history information for genomic sequencing selection. Methods To ascertain the relationship between family histories on such population-level initiatives, we analysed whole genome sequences of 1750 research participants with no known pre-existing conditions, of which half received comprehensive family history assessment of up to four generations, focusing on 95 cancer genes. Results Amongst the 1750 participants, 866 (49.5%) had high-quality standardised family history available. Within this group, 73 (8.4%) participants had an increased family history risk of cancer (increased FH risk cohort) and 1 in 7 participants (n = 10/73) carried a clinically actionable variant inferring a sixfold increase compared with 1 in 47 participants (n = 17/793) assessed at average family history cancer risk (average FH risk cohort) (p = 0.00001) and a sevenfold increase compared to 1 in 52 participants (n = 17/884) where family history was not available (FH not available cohort) (p = 0.00001). The enrichment was further pronounced (up to 18-fold) when assessing only the 25 cancer genes in the American College of Medical Genetics (ACMG) Secondary Findings (SF) genes. Furthermore, 63 (7.3%) participants had an increased family history cancer risk in the absence of an apparent clinically actionable variant. Conclusions These findings demonstrate that the collection and analysis of comprehensive family history and genomic data are complementary and in combination can prioritise individuals for genomic analysis. Thus, family history remains a critical component of health risk assessment, providing important actionable data when implementing genomics screening programs. Trial registration ClinicalTrials.gov NCT02791152. Retrospectively registered on May 31, 2016.
Published: 2021

48. Condylomata acuminata and Candida vulvovaginitis during pregnancy – current facts and therapeutic possibilities

Author: Camelia Cristina Diaconu, Ana Maria Alexandra Stănescu, Bogdan Şerban, Bogdan Socea, Spitalul Clinic de Urgenţă, Bucureşti, România, Constantin Ştefani, Mihaela Adela Iancu, Bucureşti Spitalul Universitar de Urgenţă Militar Central „Dr. Carol Davila', Spitalul Clinic de Urgenţă „Sf. Pantelimon', Bucureşti, România, Ovidiu Gabriel Bratu, Universitatea de Medicină şi Farmacie „Carol Davila', Bucureşti, România, and Ioana Veronica Grăjdeanu
Subjects: condylomata acuminata, Medicine (General), medicine.medical_specialty, Pregnancy, urogenital system, business.industry, virus diseases, General Medicine, Candida vulvovaginitis, medicine.disease, Dermatology, R5-920, medicine, Medicine, pregnancy, skin and connective tissue diseases, business, candida vulvovaginitis
Abstract: Condylomata acuminata during pregnancy represents genital, perineal and perianal hyperplasia as a result of infection with human papillomavirus during pregnancy. Candida vulvovaginitis is a symptomatic vaginitis (inflammation of the vagina and / or vulva) caused by Candida infection, with 10% of women being asymptomatic. These diseases present some particularities and therapeutical problems during pregnancy.
Published: 2019
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49. THE ETIOLOGY AND THERAPEUTIC MANAGEMENT OF PNEUMOTHORAX AND PNEUMOMEDIASTINUM IN CHILDREN

Author: Scuc „Grigore Alexandrescu', Bucureşti, România, Carmen Zăpucioiu, Sorina Stuparu, Alexandru-Ioan Ulmeanu, Umf „Carol Davila', Bucureşti, România, Anamaria Andreia Ulmeanu, and MF „Carol Davila', Bucureşti, România
Subjects: medicine.medical_specialty, Medicine (General), pneumomediastinum, business.industry, pneumothorax, General surgery, medicine.disease, respiratory tract diseases, R5-920, Pneumothorax, Materials Chemistry, medicine, Etiology, Medicine, Pneumomediastinum, pleural drainage, business, pyopneumothorax
Abstract: Introduction. Pneumothorax, pyopneumothorax and pneumomediastinum are rare but severe entities in pediatric respiratory pathology. They are often associated with severe pulmonary infections with multidrugresistant germs and are a major cause of morbidity in children, most of the time being medical emergencies. Material and method. The objective of the study was to analyze retrospectively for a period of 4 years the etiology, the treatment and the clinical and laboratory data of a group of 48 children admitted and treated in SCUC Grigore Alexandrescu Hospital, Bucharest with diagnosis of pneumothorax, pyopneumotorax or pneumomediastinum. Patients with traumatic pneumothorax were excluded. Results. The main etiology was pneumonia followed by primary spontaneous pneumothorax, congenital malformations (especially digestive tract), and asthma. The pneumonia frequency was 42.48%, and Streptococcus pneumoniae was the most frequent etiologic agent The group also included 2 cases of pleuropulmonary tuberculosis and one case with hydatid cyst, Marfan syndrome, cystic fibrosis, foreign body aspiration, lymphoma and pneumonia with Pneumocystis jirovecii. Dyspnea and chest pain dominated the clinical picture. The therapeutic conduct was dictated by the etiology. It included simple oxygen therapy in small pneumothoraces, pleural drainage in the massive ones and pleural drainage and broad spectrum antibiotic therapy in the case of pyopneumothorax. It was considered necessary to establish pleural drainage in 64.29% of children, 52% of those with pneumothorax, and all patients with pyopneumothorax. The duration of pleural drainage ranged from one day to 35 days for the pneumothorax, with a median of 6 days, respectively between one day and 32 days, with a median of 19 days for the pyopneumothorax. The average patient hospitalization was 16 days. Conclusions. Pneumothorax is rare in daily clinical practice, but can be a major pediatric emergency. Treatment aims to ensure full lung expansion and prevent relapses. Management is different depending on etiology and severity. Oxygen therapy is very important, and it increases the rate of reabsorption four times. Prognosis is often good for patients without sequelae, in primary spontaneous pneumothorax, recurrences are frequent.
Published: 2019

50. A META-ANALYSIS AND SYSTEMATIC REVIEW OF THE PRESENCE OF DEPRESSION AMONG PATIENTS WITH VITILIGO

Author: Spitalul Clinic de Urgenţă „Sf. Pantelimon', Bucureşti, România, Ovidiu Gabriel Bratu, Bogdan Socea, Bucureşti Spitalul Universitar de Urgenţă Militar Central „Dr. Carol Davila', Ioana Veronica Grăjdeanu, Camelia Cristina Diaconu, Constantin Ştefani, Ana Maria Alexandra Stănescu, Spitalul Clinic de Urgenţă, Bucureşti, România, Mihaela Adela Iancu, Bogdan Şerban, and Universitatea de Medicină şi Farmacie „Carol Davila', Bucureşti, România
Subjects: vitiligo, medicine.medical_specialty, Medicine (General), integumentary system, business.industry, skin damage, Vitiligo, medicine.disease, Dermatology, R5-920, Meta-analysis, depression, Materials Chemistry, Medicine, business, skin and connective tissue diseases, chronic disease, Depression (differential diagnoses)
Abstract: The link between vitiligo and depression is complex in many ways. Vitiligo predisposes to depression because it is a chronic, unpredictable, without curative treatment that affects the quality of life, especially because of skin damage. This meta-analysis emphasizes the importance of addressing depression in patients with vitiligo in medical practice as well as the predisposing factors of vitiligo that contribute to the further development of depression. There is a need for more studies on this issue.
Published: 2019

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