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Preeclampsia Predicts Risk of Hospitalization for Heart Failure With Preserved Ejection Fraction
- Source :
- Journal of the American College of Cardiology. 78:2281-2290
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Preeclampsia is associated with increased risk of future heart failure (HF), but the relationship between preeclampsia and HF subtypes are not well-established. Objectives The objective of this analysis was to identify the risk of HF with preserved ejection fraction (HFpEF) following a delivery complicated by preeclampsia/eclampsia. Methods A retrospective cohort study using the New York and Florida state Healthcare Cost and Utilization Project State Inpatient Databases identified delivery hospitalizations between 2006 and 2014 for women with and without preeclampsia/eclampsia. The authors identified women admitted for HF after discharge from index delivery hospitalization until September 30, 2015, using International Classification of Diseases-9th Revision-Clinical Modification diagnosis codes. Patients were followed from discharge to the first instance of primary outcome (HFpEF hospitalization), death, or end of study period. Secondary outcomes included hospitalization for any HF and HF with reduced ejection fraction, separately. The association between preeclampsia/eclampsia and HFpEF was analyzed using Cox proportional hazards models. Results There were 2,532,515 women included in the study: 2,404,486 without and 128,029 with preeclampsia/eclampsia. HFpEF hospitalization was significantly more likely among women with preeclampsia/eclampsia, after adjusting for baseline hypertension and other covariates (aHR: 2.09; 95% CI: 1.80-2.44). Median time to onset of HFpEF was 32.2 months (interquartile range: 0.3-65.0 months), and median age at HFpEF onset was 34.0 years (interquartile range: 29.0-39.0 years). Both traditional (hypertension, diabetes mellitus) and sociodemographic (Black race, rurality, low income) risk factors were also associated with HFpEF and secondary outcomes. Conclusions Preeclampsia/eclampsia is an independent risk factor for future hospitalizations for HFpEF.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
Risk Assessment
Ventricular Function, Left
Preeclampsia
Young Adult
Pre-Eclampsia
Pregnancy
Risk Factors
Interquartile range
Internal medicine
medicine
Humans
Risk factor
reproductive and urinary physiology
Retrospective Studies
Heart Failure
Ejection fraction
Eclampsia
business.industry
Proportional hazards model
Incidence
Stroke Volume
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
United States
female genital diseases and pregnancy complications
Hospitalization
embryonic structures
Female
Cardiology and Cardiovascular Medicine
Heart failure with preserved ejection fraction
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....1a989b6810a164710406a9d52ce8051f