1. Myokines and Osteokines in the Pathogenesis of Muscle and Bone Diseases
- Author
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Giuseppina Storlino, Maria Grano, Silvia Colucci, Lorenzo Sanesi, and Graziana Colaianni
- Subjects
0301 basic medicine ,Sarcopenia ,Aminoisobutyric Acids ,Endocrinology, Diabetes and Metabolism ,Osteocalcin ,Osteoporosis ,030209 endocrinology & metabolism ,Bone tissue ,Bioinformatics ,Bone and Bones ,03 medical and health sciences ,0302 clinical medicine ,Myokine ,Humans ,Medicine ,Muscle, Skeletal ,biology ,business.industry ,RANK Ligand ,Skeletal muscle ,Bone fracture ,medicine.disease ,Fibronectins ,030104 developmental biology ,medicine.anatomical_structure ,RANKL ,biology.protein ,business - Abstract
In this review we aim to summarize the latest findings on the network of molecules produced by muscle and bone under physiological and pathological conditions. The concomitant onset of osteoporosis and sarcopenia is currently one of the main threats that can increase the risk of falling fractures during aging, generating high health care costs due to hospitalization for bone fracture surgery. With the growing emergence of developing innovative therapies to treat these two age-related conditions that often have common onset, a broader understanding of molecular messengers regulating the communication between muscle and bone tissue became imperative. Recently it has been highlighted that two muscle-derived signals, such as the myokines Irisin and L-BAIBA, positively affect bone tissue. In parallel, there are signals derived from bone that affect either positively the skeletal muscle, such as osteocalcin, or negatively, such as RANKL.
- Published
- 2020