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Skeleton and Glucose Metabolism: A Bone-Pancreas Loop
- Source :
- International Journal of Endocrinology, Vol 2015 (2015), International Journal of Endocrinology
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine “gland” and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.
- Subjects :
- medicine.medical_specialty
lcsh:RC648-665
Endocrine and Autonomic Systems
Endocrinology, Diabetes and Metabolism
Insulin
medicine.medical_treatment
Review Article
Biology
Carbohydrate metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Bone remodeling
Insulin receptor
Endocrinology
medicine.anatomical_structure
Osteoprotegerin
Internal medicine
medicine
Osteocalcin
biology.protein
Endocrine system
Pancreas
Subjects
Details
- Language :
- English
- ISSN :
- 16878345 and 16878337
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- International Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....2e130026e0a4b0017c02e4af954bfd7e