141 results on '"lobomycosis"'
Search Results
2. Epidemiologic and Clinical Progression of Lobomycosis among Kaiabi Indians, Brazil, 1965–2019
- Author
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Marcos C. Florian, Douglas A. Rodrigues, Sofia B.M. de Mendonça, Arnaldo L. Colombo, and Jane Tomimori
- Subjects
lobomycosis ,epidemiology ,fungus ,Lacazia loboi ,Kaiabi Indians ,South American ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Lobomycosis is a rare granulomatous skin disease with a high prevalence in the Amazon region. The Kaiabi Indians are an especially affected group. We studied the current epidemiologic and clinical progression of lobomycosis among the Kaiabi in Brazil, from initial case reports in 1965 through 2019. A total of 60 lobomycosis cases had been reported among the Kaiabi, and we identified 3 new cases in our review. Of 550 cases of lobomycosis ever reported worldwide, 11.5% were among the Kaiabi. We note a high incidence among female Kaiabi and a precocious onset of disease in this indigenous population. Male Kaiabi frequently are infected with the multicentric form and women more frequently exhibit the localized form. Ulcerated lesions are observed more often in the multicentric form. The prevalence among this indigenous group could be explained by genetic susceptibility and lifestyle, which exposes them to a particular agent in the habitats in which they live.
- Published
- 2020
- Full Text
- View/download PDF
3. Lobomycosis in Soldiers, Colombia
- Author
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Claudia M. Arenas, Gerzain Rodriguez-Toro, Andrea Ortiz-Florez, and Ingrid Serrato
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lobomycosis ,Jorge Lobo disease ,lacaziosis ,Lacazia loboi ,fungi ,fungal infections ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Lobomycosis is a disease that is endemic to the Amazon rainforest and is caused by the still uncultured fungus Lacazia loboi. This disease occurs in loggers, farmers, miners, fishermen, and persons living near coastal rivers of this region. We report 6 soldiers in Colombia in whom lobomycosis developed after military service in the Amazon area. The patients had nodular and keloid-like lesions on the face, neck, trunk, and limbs. The duration of illness ranged from 2 years to 15 years. The initial diagnosis was leishmaniasis on the basis of clinical manifestations and direct smear results, but biopsies confirmed the final diagnosis of lobomycosis. Treatment with surgical excision, itraconazole and clofazimine was satisfactory. However, the follow-up time was short. Healthcare professionals responsible for the diagnosis and treatment of skin diseases need to be able to recognize the clinical signs of lobomycosis and differentiate them from those of cutaneous leishmaniasis.
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- 2019
- Full Text
- View/download PDF
4. Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis
- Author
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Raquel Vilela, Gregory D. Bossart, Judy A. St. Leger, Leslie M. Dalton, John S. Reif, Adam M. Schaefer, Peter J. McCarthy, Patricia A. Fair, and Leonel Mendoza
- Subjects
lacaziosis ,lobomycosis ,cutaneous granulomas ,Lacazia loboi ,Paracoccidioides brasiliensis ,P. lutzii ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Kex gene sequences of P. brasiliensis from dolphins showed 100% homology with sequences from cultivated P. brasiliensis, 73% with those of L. loboi, and 93% with those of P. lutzii. Parsimony analysis placed DNA sequences from dolphins within a cluster with human P. brasiliensis strains. This cluster was the sister taxon to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins is probably the cause of lacaziosis/lobomycosis, herein referred to as paracoccidioidomycosis ceti.
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- 2016
- Full Text
- View/download PDF
5. Jorge Lobo’s disease with malignant degeneration to squamous cell carcinoma: case report☆☆
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Maraya de Jesus Semblano Bittencourt, Arival Cardoso de Brito, Thainá da Silva Gonçalves, and Renata Henriques Cavalcante
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Pathology ,medicine.medical_specialty ,biology ,business.industry ,squamous cell ,Lacazia ,Carcinoma ,Carcinoma, squamous cell ,Traumatic implantation ,Dermatology ,Degeneration (medical) ,Lobo's disease ,medicine.disease ,biology.organism_classification ,Tropical/Infectoparasitary Dermatology ,Lesion ,Male patient ,medicine ,Lobomycosis ,Basal cell ,medicine.symptom ,business ,skin and connective tissue diseases - Abstract
Jorge Lobo’s disease (JLD) is a chronic, granulomatous fungal infection caused by the traumatic implantation of the fungus Lacazia loboi in the cutaneous and subcutaneous tissues, with the presence of isolated nodular and coalescent keloidal lesions. Malignant degeneration is rare. This case report describes a 64-year-old male patient with JLD for 30-years who showed a change in the aspect of a lesion in the left lower limb. Histopathological examination confirmed the progression to well-differentiated squamous cell carcinoma (SSC). JLD is highly prevalent in tropical and subtropical regions, requiring monitoring concerning the transformation into SSC in long-term lesions.
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- 2021
6. A global view on fungal infections in humans and animals: infections caused by dimorphic fungi and dermatophytoses
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Mariusz Dyląg, Dominik Łagowski, Aneta Nowakiewicz, and Sebastian Gnat
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medicine.medical_specialty ,Biology ,Applied Microbiology and Biotechnology ,Histoplasmosis ,03 medical and health sciences ,Tinea ,Environmental health ,Epidemiology ,medicine ,Animals ,Dermatomycoses ,Humans ,030304 developmental biology ,0303 health sciences ,Sporotrichosis ,030306 microbiology ,Public health ,Fungi ,General Medicine ,medicine.disease ,Geographic distribution ,Mycoses ,Lobomycosis ,Blastomycosis ,Dimorphic fungus ,Biotechnology - Abstract
Fungal infections are still underappreciated and their prevalence is underestimated, which renders them a serious public health problem. Realistic discussions about their distribution, symptoms, and control can improve management and diagnosis and contribute to refinement of preventive actions using currently available tools. This article represents an overview of dermatophytes and endemic fungi that cause infections in humans and animals. In addition, the impact of climate change on the fungal spread is discussed. The endemic fungal infections characterized in this article include coccidioidomycosis, histoplasmosis, blastomycosis, lobomycosis, emergomycosis, and sporotrichosis. Moreover, the geographic distribution of these fungi, which are known to be climate sensitive and/or limited to endemic tropical and subtropical areas, is highlighted. In turn, dermatophytes cause superficial fungal infections of skin, hairs, and nails, which are the most prevalent mycoses worldwide with a high economic burden. Therefore, the possibility of causing zoonoses and reverse zoonoses by dermatophytes is highly important. In conclusion, the article illustrates the current issues of the epidemiology and distribution of fungal diseases, emphasizing the lack of public programs for prevention and control of these types of infection.
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- 2021
7. Extensive, multifocal lobomycosis
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Justin P Bandino, Maria M. Hornberger, Leonel Mendoza, G. Strider Farnsworth, and Raquel Vilela
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Pathology ,medicine.medical_specialty ,Histology ,business.industry ,Biopsy ,Dermatology ,medicine.disease ,DNA sequencing ,Pathology and Forensic Medicine ,Humans ,Medicine ,Lobomycosis ,business ,Blastomycosis - Published
- 2021
8. Comparative effect of osmium tetroxide and ruthenium tetroxide on <scp> Lacazia loboi </scp> ultrastructure
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Gerzain Rodríguez-Toro, Jorge Rivera, Orlando Torres-Fernández, and Ladys Sarmiento‐Lacera
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Histology ,Osmium Tetroxide ,Lacazia ,Combined use ,02 engineering and technology ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,law ,medicine ,Humans ,Instrumentation ,biology ,030206 dentistry ,021001 nanoscience & nanotechnology ,medicine.disease ,biology.organism_classification ,Molecular biology ,Ruthenium tetroxide ,Microscopy, Electron ,Medical Laboratory Technology ,Osmium tetroxide ,chemistry ,Ultrastructure ,Ruthenium Compounds ,Lobomycosis ,Glutaraldehyde ,Anatomy ,Electron microscope ,0210 nano-technology - Abstract
Lobomycosis is a skin infection produced by the fungus Lacazia loboi, which mainly affects some indigenous and afro-descendant populations in Tropical America. We previously reported the comparative effect of osmium tetroxide (OsO4 ) and ruthenium tetroxide (RuO4 ) in the electron microscopy (EM) of other related microorganisms. The objective of this study is to compare the effect of postfixation with OsO4 and RuO4 in the ultrastructure of L. loboi yeasts. Skin biopsies on patients diagnosed with lobomycosis were fixed in glutaraldehyde at 3% and postfixed in the following solutions: (a) 1% OsO4 , (b) 0.2% RuO4 , and (c) OsO4 at 1% followed by RuO4 at 0.2%. They were then processed using the conventional method for EM. Unlike OsO4, the treatment with RuO4 revealed different shades of gray and electron dense bands in the cell wall and other cell components of L. loboi. The most notable finding was the presence of radial filamentous structures around the yeast, which made the image look like the sun. Postfixation with RuO4 revealed ultrastructural details that had not been previously reported for L loboi. The combined use of OsO4 and RuO4 in EM of microorganisms with cell walls can be useful to evaluate the effect of microbicide substances.
- Published
- 2020
9. M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis
- Author
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Arival Cardoso de Brito, Juarez Antônio Simões Quaresma, Tania Cristina Barboza, Luciane Kanashiro-Galo, Mirian Nacagami Sotto, Maria Irma Seixas Duarte, and Carla Pagliari
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0301 basic medicine ,Immunopathogenesis ,Lacazia ,Veterinary (miscellaneous) ,Biopsy ,030106 microbiology ,Population ,Cell Plasticity ,Antigens, Differentiation, Myelomonocytic ,Nitric Oxide Synthase Type II ,Receptors, Cell Surface ,Lacaziosis ,Applied Microbiology and Biotechnology ,Microbiology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Antigens, CD ,medicine ,Macrophage ,M2 macrophages ,Humans ,education ,Lobomycosis ,Mycosis ,M1 macrophages ,education.field_of_study ,biology ,Arginase ,Macrophages ,medicine.disease ,biology.organism_classification ,Immunohistochemistry ,Immunoglobulin J Recombination Signal Sequence-Binding Protein ,Proto-Oncogene Proteins c-maf ,Immunology ,biology.protein ,Original Article ,Antibody ,Epidermis ,Agronomy and Crop Science ,CD163 - Abstract
Lacaziosis is a cutaneous chronic mycosis caused by Lacazia loboi. Macrophages are important cells in the host immune response in fungal infections. The macrophage population exhibits strong plasticity that varies according to the stimuli in the microenvironment of lesions M1 profile promotes a Th1 pattern of cytokines and a microbicidal function and M2 is related to Th2 cytokines and immunomodulatory response. We investigated the population of M1 and M2 polarized macrophages in human cutaneous lesions. A total of 27 biopsies from human lesions were submitted to an immunohistochemistry protocol using antibodies to detect M1 and M2 macrophages (Arginase-1, CD163, iNOS, RBP-J and cMAF). We could observe high number of cells expressing Arginase1, CD163 and c-MAF that correspond to elements of the M2 profile of macrophage, over iNOS and RBP-J (elements of the M1 profile). The results suggest a predominant phenotype of M2 macrophages, which have an immunomodulatory role and probably contributing to chronicity of Lacaziosis. Electronic supplementary material The online version of this article (10.1007/s11046-020-00450-z) contains supplementary material, which is available to authorized users.
- Published
- 2020
10. What is your diagnosis? Keloidal cord-like lesion on the leg
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Carolina Talhari, Antonio Pedro Mendes Schettini, Flaviano da Silva Oliveira, and Nadya Picanço Lopes
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medicine.medical_specialty ,Histology ,Cord ,Lacazia ,Dermatology ,Lesion ,Silver stain ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Lobomycosis ,biology ,business.industry ,Anatomy ,biology.organism_classification ,medicine.disease ,What is your Diagnosis? ,030220 oncology & carcinogenesis ,Histopathology ,medicine.symptom ,business ,Reticular Dermis - Abstract
We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. The diagnosis was lobomycosis. Although the keloidal lesions presented by this patient are typical of lobomycosis, their linear distribution along the left lower limb is unusual.
- Published
- 2020
11. Lobomycosis: exuberant presentation with malignant transformation
- Author
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Virginia Vilasboas Figueiras, Wanessa da Costa Lima, Mara Lúcia Gomes de Souza, and Sidharta Quercia Gadelha
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Mycosis fungoides ,medicine.medical_specialty ,Carcinoma, squamous cell ,Lacazia ,Dermatology ,Malignant transformation ,Medicine ,Basal cell ,Lobomycosis ,biology ,business.industry ,squamous cell ,Carcinoma ,Skin ulcer ,medicine.disease ,biology.organism_classification ,Tropical/Infectoparasitary Dermatology ,Late diagnosis ,RL1-803 ,Presentation (obstetrics) ,medicine.symptom ,business - Abstract
Lobomycosis is a chronic granulomatous infection caused by the yeast Lacazia loboi, typically found in tropical and subtropical geographical areas. Transmission occurs through traumatic inoculation into the skin, especially in exposed areas, of men who work in contact with the soil. Lesions are restricted to the skin and subcutaneous tissue, with a keloid-like appearance in most cases. The occurrence of squamous cell carcinoma on skin lesions with a long evolution is well known; however, there are scarce reports of lobomycosis that developed into squamous cell carcinoma. The authors report a patient from the Brazilian Amazon region, with lobomycosis and carcinomatous degeneration, with an unfavorable outcome, due to late diagnosis.
- Published
- 2022
12. Keloid-like lesions in a farmer from Amazonas
- Author
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Mara Lúcia Gomes de Souza, Virginia Vilasboas Figueiras, Alcidarta dos Reis Gadelha, Gabriela Evangelista de Almeida, and Sidharta Quercia Gadelha
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medicine.medical_specialty ,Co2 laser ,CO2 laser ,Itraconazole ,business.industry ,Dermatology ,excisional surgery ,lobomycosis ,lcsh:RL1-803 ,medicine.disease ,amphotericin B ,itraconazole ,Keloid ,Amphotericin B ,Images in Dermatology ,medicine ,intralesional injection ,lcsh:Dermatology ,Lobomycosis ,business ,medicine.drug - Published
- 2021
13. Human Case of Lobomycosis
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Sameer Elsayed, Susan M. Kuhn, Duane Barber, Deirdre L. Church, Stewart Adams, and Richard Kasper
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Lobomycosis ,Lobo’s disease ,Loboa loboi ,Lacazia loboi ,infection ,human ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
We describe a 42-year-old woman with histologically confirmed lobomycosis, a cutaneous fungal infection rarely reported outside of Latin America. Our case represents the first published report of imported human lobomycosis in Canada and the fifth in an industrialized country.
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- 2004
- Full Text
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14. Lacaziosis (Lobomycosis) From Southern Mexico: A Case Confirmed by Molecular Biology
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Rigoberto Hernández-Castro, Juan Xicohtencatl-Cortes, Lesly Pech-Ortiz, Andrés Tirado-Sánchez, Alexandro Bonifaz, and Susana Maya-Aranda
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Adult ,Male ,Antifungal Agents ,Lacazia ,Veterinary (miscellaneous) ,Zoology ,Biology ,Clofazimine ,Applied Microbiology and Biotechnology ,Microbiology ,Microbial ecology ,Trimethoprim, Sulfamethoxazole Drug Combination ,medicine ,Dermatomycoses ,Humans ,Pathology, Molecular ,Lobomycosis ,Mexico ,Histocytochemistry ,Ear ,medicine.disease ,Fibrosis ,Drug Combinations ,Agronomy and Crop Science ,Ear Auricle - Published
- 2020
15. Plastic surgery for the treatment of contagious diseases: lobomycosis
- Author
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Laryssa Fernanda Feitosa, Cipriano Ferreira-Junior, Ana Elisa Kadri Castilho, Rodolfo Luis Korte, and Anita Sperandio Porto
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medicine.medical_specialty ,Plastic surgery ,business.industry ,Medicine ,Lobomycosis ,Surgery ,business ,medicine.disease ,Dermatology - Published
- 2019
16. Posaconazole for lobomycosis
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Marilia M.S. Severo, Auri F. dos Santos, Maria G. de Sena, Sergio D. Jaskulski Filho, and Alessandro C. Pasqualotto
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Microbiology (medical) ,medicine.medical_specialty ,Posaconazole ,business.industry ,Infectious and parasitic diseases ,RC109-216 ,Triazoles ,medicine.disease ,Dermatology ,Microbiology ,QR1-502 ,Infectious Diseases ,medicine ,Humans ,Lobomycosis ,business ,medicine.drug - Published
- 2021
17. Lobomycosis in Man and Lobomycosis-like Disease in Bottlenose Dolphin, Venezuela
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Luis Bermudez, Marie-Françoise Van Bressem, Oscar Reyes-Jaimes, Alejandro J. Sayegh, and Alberto Enrique Paniz-Mondolfi
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Lobomycosis ,lacaziosis ,lobomycosis-like disease ,Tursiops truncatus ,skin disease ,bottlenose dolphin ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
We report 1 case of lobomycosis caused by Lacazia loboi in a fisherman and 1 case of lobomycosis-like disease in a bottlenose dolphin (Tursiops truncatus) along the coast of Venezuela. These findings suggest that the marine environment is a likely habitat for L. loboi and a reservoir for infection.
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- 2009
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18. Lobomycosis in Offshore Bottlenose Dolphins (Tursiops truncatus), North Carolina
- Author
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David S. Rotstein, Leslie G. Burdett, William McLellan, Lori Schwacke, Teri Rowles, Karen A. Terio, Stacy Schultz, and Ann Pabst
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Dolphin ,Tursiops truncatus ,Lacazia loboi ,lobomycosis ,granulomatous dermatitis ,North America ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Lacazia loboi, a cutaneous fungus, is found in humans and dolphins from transitional tropical (Florida) and tropical (South America) regions. We report 2 cases of lobomycosis in stranded bottlenose dolphins (Tursiops truncatus) and 1 case of lobomycosis-like disease in 1 free-swimming, pelagic, offshore bottlenose dolphin from North Carolina, where no cases have previously been observed.
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- 2009
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19. Subcutaneous and Systemic Mycoses
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Ranthilaka R. Ranawaka, S. N. Arseculeratne, and Archana Singal
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medicine.medical_specialty ,Chromoblastomycosis ,Sporotrichosis ,business.industry ,health care facilities, manpower, and services ,Mucormycosis ,social sciences ,medicine.disease ,Dermatology ,Phaeohyphomycosis ,parasitic diseases ,medicine ,Rhinosporidiosis ,Lobomycosis ,Zygomycosis ,business ,geographic locations ,health care economics and organizations ,Blastomycosis - Abstract
This chapter on subcutaneous and systemic mycoses is authored by five authors who have done research on different areas of fungal infections. Of these chromoblastomycosis is the most common in Sri Lanka, which accounts 1–2 patients annually in one skin center. Rhinosporidiosis is also common in endemic areas such as Anuradhapura and Polonnaruwa, dry zone of Sri Lanka, where main water supply is from water reservoirs. While mycetoma and sporotrichosis are very rare today in Sri Lanka, there are several subcutaneous fungi such as phaeohyphomycosis isolated from renal transplant patients in Anuradhapura where renal failure of unidentified cause is much prevalent. While some of the deep fungal infections are disappearing possibly due to urbanization, change of farming methods, or using pesticides, some unidentified species are appearing in immune suppressed patients.
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- 2020
20. Dermatoses from Brazil
- Author
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Carolina Chrusciak Talhari Cortez and Sinésio Talhari
- Subjects
medicine.medical_specialty ,Paracoccidioidomycosis ,business.industry ,Dermatological diseases ,Leishmaniasis ,medicine.disease ,Dermatology ,South american ,medicine ,Endemic pemphigus foliaceus ,Fogo selvagem ,Lobomycosis ,business ,Blastomycosis - Abstract
This chapter gives brief descriptions on four dermatological diseases which are more prevalent in Brazil; namely, endemic pemphigus foliaceus (fogo selvagem), New World leishmaniasis, lobomycosis and paracoccidioidomycosis (South American blastomycosis).
- Published
- 2020
21. Epidemiologic and Clinical Progression of Lobomycosis among Kaiabi Indians, Brazil, 1965-2019
- Author
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Sofia Mendonça, Arnaldo Lopes Colombo, Marcos Cesar Florian, Douglas Rodrigues, and Jane Tomimori
- Subjects
Microbiology (medical) ,Male ,medicine.medical_specialty ,Kaiabi Indians ,Lacazia ,030231 tropical medicine ,Population ,lcsh:Medicine ,Disease ,lobomycosis ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,0302 clinical medicine ,Indians ,Epidemiology ,medicine ,Genetic predisposition ,Prevalence ,South American ,Humans ,lcsh:RC109-216 ,030212 general & internal medicine ,Epidemiologic and Clinical Progression of Lobomycosis among Kaiabi Indians, Brazil, 1965–2019 ,education ,Mycosis ,education.field_of_study ,Lacazia loboi ,Granuloma ,business.industry ,Incidence (epidemiology) ,Research ,fungus ,lcsh:R ,mycosis ,medicine.disease ,Dermatology ,Infectious Diseases ,Lobomycosis ,Female ,epidemiology ,fungi ,business ,Clinical progression ,Brazil - Abstract
Lobomycosis is a rare granulomatous skin disease with a high prevalence in the Amazon region. The Kaiabi Indians are an especially affected group. We studied the current epidemiologic and clinical progression of lobomycosis among the Kaiabi in Brazil, from initial case reports in 1965 through 2019. A total of 60 lobomycosis cases had been reported among the Kaiabi, and we identified 3 new cases in our review. Of 550 cases of lobomycosis ever reported worldwide, 11.5% were among the Kaiabi. We note a high incidence among female Kaiabi and a precocious onset of disease in this indigenous population. Male Kaiabi frequently are infected with the multicentric form and women more frequently exhibit the localized form. Ulcerated lesions are observed more often in the multicentric form. The prevalence among this indigenous group could be explained by genetic susceptibility and lifestyle, which exposes them to a particular agent in the habitats in which they live.
- Published
- 2020
22. Lacaziosis: immunohistochemical evaluation of elements of the humoral response in cutaneous lesions
- Author
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Tânia Cristina Barboza, Gabriela Yasmin Francisca da Silva do Nascimento, Carla Pagliari, Juarez Antônio Simões Quaresma, Wagner Luiz Tafuri, Luciane Kanashiro-Galo, Mirian Nacagami Sotto, Ariane Fernandes Alexandre, Arival Cardoso de Brito, and Antonio dos Santos Filho
- Subjects
Pathology ,medicine.medical_specialty ,Human lesions ,Lacazia ,Biopsy ,RC955-962 ,030231 tropical medicine ,Lacaziosis ,Brief Communication ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Dermis ,Arctic medicine. Tropical medicine ,medicine ,Dermatomycoses ,Humans ,Humoral response ,Lobomycosis ,Skin ,medicine.diagnostic_test ,biology ,Epidermis (botany) ,Immunochemistry ,Immunohistochemistry ,Staining ,medicine.anatomical_structure ,Giant cell ,biology.protein ,Antibody - Abstract
Lacaziosis is a cutaneous mycosis caused by the fungus Lacazia loboi, described in different countries of Latin America and prevalent in the Amazon region. The ineffective immune response against the agent seems to be related to a Th2 pattern of cytokines. There are few reports exploring elements of the humoral response in these lesions. Our aim was to investigate some elements focusing on B cells, plasma cells and local expression of IgG and IgM antibodies. Forty skin biopsies of lower limbs were selected. The diagnosis of lacaziosis was based on direct mycological examination and histological analysis. The visualization of fungal cells was improved by using Gridley’s staining. An immunohistochemical protocol was performed to detect the expression of B cells, plasma cells, IgG and IgM. A double staining was performed to explore the presence of yeasts in the cytoplasm of keratinocytes, using an anti-AE1 AE3 antibody over Gridley’s staining. The inflammatory infiltrate consisted of macrophages, multinucleated giant cells, lymphocytes, and fibrosis. Fungal cells were frequent in the stratum corneum and in both, the dermis and, in 50% of the specimens, also in the epidermis. Cells expressing IgG were more abundant when compared to cells expressing IgM. B cells and the presence of IgG might indicate that the humoral response promotes a Th2 immune response resulting in an anti-inflammatory phenotype. Our results lead us to suggest a possible role of B cells and immunoglobulins in the mechanisms of lacaziosis pathogenesis.
- Published
- 2020
23. Lobomycosis-like disease in common bottlenose dolphins Tursiops truncatus from Belize and Mexico: bridging the gap between the Americas
- Author
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Eric A. Ramos, Delma Nataly Castelblanco-Martínez, Katherina Audley, Jazmin Garcia, Koen Van Waerebeek, Marie-Françoise Van Bressem, James R. Foley, and Jorge Rojas Arias
- Subjects
0301 basic medicine ,040301 veterinary sciences ,030106 microbiology ,Subtropics ,Aquatic Science ,Aquatic organisms ,0403 veterinary science ,03 medical and health sciences ,biology.animal ,medicine ,Animals ,Spotted Dolphin ,Lobomycosis ,Mexico ,Ecology, Evolution, Behavior and Systematics ,Cutaneous infections ,Tropical pacific ,biology ,04 agricultural and veterinary sciences ,Stenella ,medicine.disease ,Belize ,Bottle-Nosed Dolphin ,Fishery ,Caribbean Region - Abstract
Lobomycosis and lobomycosis-like diseases (LLD) (also: paracoccidioidomycosis) are chronic cutaneous infections that affect Delphinidae in tropical and subtropical regions worldwide. In the Americas, these diseases have been relatively well-described, but gaps still exist in our understanding of their distribution across the continent. Here we report on LLD affecting inshore bottlenose dolphins Tursiops truncatus from the Caribbean waters of Belize and from the eastern tropical Pacific Ocean off the southwestern coast of Mexico. Photo-identification and catalog data gathered between 1992 and 2017 for 371 and 41 individuals, respectively from Belize and Mexico, were examined for the presence of LLD. In Belize, 5 free-ranging and 1 stranded dolphin were found positive in at least 3 communities with the highest prevalence in the south. In Guerrero, Mexico, 4 inshore bottlenose dolphins sighted in 2014-2017 were affected by LLD. These data highlight the need for histological and molecular studies to confirm the etiological agent. Additionally, we document a single case of LLD in an adult Atlantic spotted dolphin Stenella frontalis in southern Belize, the first report in this species. The role of environmental and anthropogenic factors in the occurrence, severity, and epidemiology of LLD in South and Central America requires further investigation.
- Published
- 2018
24. Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela
- Author
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Paola Rodari, Pierantonio Orza, Patrizia Danesi, Francesca Perandin, Claudia Zanardello, Silvia Staffolani, Anna Beltrame, Zeno Bisoffi, and Claudio Farina
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Antifungal Agents ,Lacazia ,030106 microbiology ,Clofazimine ,Lesion ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Virology ,Biopsy ,Humans ,Medicine ,Lobomycosis ,Mycosis ,Skin ,Travel ,medicine.diagnostic_test ,biology ,business.industry ,Amazon rainforest ,Articles ,Middle Aged ,Venezuela ,medicine.disease ,biology.organism_classification ,Dermatology ,Italy ,Itraconazole ,Infectious Diseases ,Cryptococcosis ,Parasitology ,medicine.symptom ,business ,Blastomycosis - Abstract
Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by Lacazia loboi, an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Several weeks after return, he recalled pruritus and papular skin lesions on the left lower limb, subsequently evolving to a plaque-like lesion. Blastomycosis and cryptococcosis were hypothesized based on microscopic morphology of yeast-like bodies found in three consecutive biopsies, although fungal cultures were always negative. In 2016, exfoliative cytology and a biopsy specimen examination showed round yeast-like organisms (6–12 μm), isolated or in a chain, connected by short tubular projections fulfilling the morphologic diagnostic criteria of Lacazia spp. The microscopic diagnosis was confirmed by molecular identification.
- Published
- 2017
25. Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease
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Mph Max Carlos Ramírez Soto BSc and Germán Málaga
- Subjects
0301 basic medicine ,Burden of disease ,medicine.medical_specialty ,Endemic Diseases ,030106 microbiology ,Dermatology ,Eumycetoma ,03 medical and health sciences ,Subcutaneous Tissue ,Sporotrichosis/epidemiology ,Peru ,parasitic diseases ,Epidemiology ,medicine ,Humans ,Lobomycosis/epidemiology ,Lobomycosis ,Disease burden ,Chromoblastomycosis ,Sporotrichosis ,business.industry ,purl.org/pe-repo/ocde/ford#3.02.15 [https] ,medicine.disease ,Surgery ,Phaeohyphomycosis ,Phaeohyphomycosis/epidemiology ,Meta-analysis ,business ,Peru/epidemiology ,Chromoblastomycosis/epidemiology - Abstract
Background There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs. Objectives This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses. Methods We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. The disease burden was determined in terms of prevalence (number of cases per 100,000 inhabitants) and the number of reported cases per year per region. Results A total of 26 studies were eligible for inclusion. Results showed that sporotrichosis was the most common subcutaneous mycosis (99.7%), whereas lobomycosis, chromoblastomycosis, and subcutaneous phaeohyphomycosis were rare. Cases of eumycetoma and subcutaneous zygomycosis were not found. Of the 25 regions, the burden of sporotrichosis was estimated for four regions classified as endemic; in nine regions, only isolated cases were reported. The highest burden of sporotrichosis was in Apurimac (15 cases/100,000 inhabitants; 57 cases/year), followed by Cajamarca (3/100,000 inhabitants; 30/year), Cusco (0.5/100,000 inhabitants; 4/year), and La Libertad (0.2/100,000 inhabitants; 2/year). In two regions, the mycoses predominantly affected children. Conclusions Sporotrichosis is the most common subcutaneous mycosis in Peru, with a high disease burden in Apurimac. Chromoblastomycosis, lobomycosis, and subcutaneous phaeohyphomycosis are rare mycoses in Peru.
- Published
- 2017
26. Comparative Innate and Adaptive Immune Responses in Atlantic Bottlenose Dolphins (Tursiops truncatus) With Viral, Bacterial, and Fungal Infections
- Author
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Gregory D. Bossart, Tracy A. Romano, Margie M. Peden-Adams, Adam M. Schaefer, Charles D. Rice, Patricia A. Fair, and John S. Reif
- Subjects
0301 basic medicine ,lcsh:Immunologic diseases. Allergy ,bottlenose dolphin ,infectious disease ,Immunology ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,medicine ,Immunology and Allergy ,Subclinical infection ,Innate immune system ,medicine.disease ,Acquired immune system ,Bottlenose dolphin ,biology.organism_classification ,adaptive immune response ,Cetacean morbillivirus ,030104 developmental biology ,Tursiops truncatus ,Infectious disease (medical specialty) ,innate immune response ,Lobomycosis ,lcsh:RC581-607 ,030215 immunology - Abstract
Free-ranging Atlantic bottlenose dolphins (n = 360) from two southeastern U.S. estuarine sites were given comprehensive health examinations between 2003 and 2015 as part of a multi-disciplinary research project focused on individual and population health. The study sites (and sample sizes) included the Indian River Lagoon (IRL), Florida, USA (n = 246) and Charleston harbor and associated rivers (CHS), South Carolina, USA (n = 114). Results of a suite of clinicoimmunopathologic tests revealed that both populations have a high prevalence of infectious and neoplastic disease and a variety of abnormalities of their innate and adaptive immune systems. Subclinical infections with cetacean morbillivirus and Chlamydiaceae were detected serologically. Clinical evidence of orogenital papillomatosis was supported by the detection of a new strain of dolphin papillomavirus and herpesvirus by molecular pathology. Dolphins with cutaneous lobomycosis/lacaziasis were subsequently shown to be infected with a novel, uncultivated strain of Paracoccidioides brasiliensis, now established as the etiologic agent of this enigmatic disease in dolphins. In this review, innate and adaptive immunologic responses are compared between healthy dolphins and those with clinical and/or immunopathologic evidence of infection with these specific viral, bacterial, and fungal pathogens. A wide range of immunologic host responses was associated with each pathogen, reflecting the dynamic and complex interplay between the innate, humoral, and cell-mediated immune systems in the dolphin. Collectively, these studies document the comparative innate and adaptive immune responses to various types of infectious diseases in free-ranging Atlantic bottlenose dolphins. Evaluation of the type, pattern, and degree of immunologic response to these pathogens provides novel insight on disease immunopathogenesis in this species and as a comparative model. Importantly, the data suggest that in some cases infection may be associated with subclinical immunopathologic perturbations that could impact overall individual and population health.
- Published
- 2019
27. Role of social behaviour in the epidemiology of lobomycosis-like disease (LLD) in estuarine common bottlenose dolphins from Ecuador
- Author
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Marie-Françoise Van Bressem, Fernando Félix, and Koen Van Waerebeek
- Subjects
Male ,medicine.medical_specialty ,040301 veterinary sciences ,Home range ,Common Dolphins ,Population ,Disease ,Aquatic Science ,Biology ,0403 veterinary science ,Epidemiology ,medicine ,Animals ,Risk factor ,education ,Social Behavior ,Lobomycosis ,Ecology, Evolution, Behavior and Systematics ,geography ,education.field_of_study ,geography.geographical_feature_category ,Estuary ,04 agricultural and veterinary sciences ,medicine.disease ,Bottle-Nosed Dolphin ,040102 fisheries ,0401 agriculture, forestry, and fisheries ,Female ,Ecuador ,human activities ,Horizontal transmission ,Demography - Abstract
Lobomycosis-like disease (LLD) is a chronic granulomatous skin disorder that affects Delphinidae worldwide. LLD has been observed in common bottlenose dolphins Tursiops truncatus from the Gulf of Guayaquil, Ecuador, since 1990. Although exogenous factors such as salinity and pollution may play a role in the pathogenesis of this disease in estuarine and coastal dolphin communities, we hypothesized that demography and social behaviour may also influence its epidemiology. To address this issue, the role of social behaviour in the distribution and prevalence of LLD was assessed through hierarchical cluster analysis and spatial distribution analysis in 7 dolphin communities inhabiting the inner estuary. Individuals with LLD lesions were observed in 5 of the 7 dolphin communities, with 13 of the 163 (8%) animals being positive, all adults. Among 8 dolphins of known sex, LLD affected mostly males (86%), who usually were found in pairs. Prevalence was low to moderate (5.1-13%) in dolphin communities where low-rank males had LLD. Conversely, it was high (44.4%, n = 9) in a small community where a high-rank male was infected. LLD affected both dolphins in 2 of the 4 male pairs for which large time series data were available, suggesting horizontal transmission due to contact. Thus, association with LLD-positive males seems to be an important risk factor for infections. Additionally, low-rank males had larger home ranges than high-rank males, indicating that low-status LLD-affected dolphins are likely responsible for the geographic dissemination of the disease in this population.
- Published
- 2019
28. Lobomycosis in Inshore and Estuarine Dolphins
- Author
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Alberto Enrique Paniz-Mondolfi and Lilian Sander-Hoffmann
- Subjects
Zoonoses ,lobomycosis ,dolphins ,inshore ,Tursiops truncatus ,Sotalia guianensis ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Published
- 2009
- Full Text
- View/download PDF
29. Toward the identification, characterization and experimental culture ofLacazia loboifrom Atlantic bottlenose dolphin (Tursiops truncatus)
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Gregory D. Bossart, Patricia A. Fair, Neil S Medalie, Ralph Rosato, Sushan Han, Peter J. McCarthy, Adam M. Schaefer, Patrick Ottuso, John S. Reif, Esther A. Guzmán, and Joseph Snyder
- Subjects
Microbiological Techniques ,0301 basic medicine ,Bottle-nosed dolphin ,Lacazia ,030106 microbiology ,030231 tropical medicine ,Biology ,Microbiology ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Animals ,Atlantic Ocean ,Lobomycosis ,Organism ,Microscopy ,Granuloma ,Histocytochemistry ,General Medicine ,medicine.disease ,Bottlenose dolphin ,biology.organism_classification ,Bottle-Nosed Dolphin ,Infectious Diseases ,Identification (biology) - Abstract
Lobomycosis (lacaziosis) is a chronic, granulomatous, fungal infection of the skin and subcutaneous tissues of humans and dolphins. To date, the causative agent, the yeast-like organism Lacazia loboi, has not been grown in the laboratory, and there have been no recent reports describing attempts to culture the organism. As a result, studies on the efficacy of therapeutics and potential environmental reservoirs have not been conducted. Therefore, the objective of the current study was to utilize both classical and novel microbiological methods in order to stimulate growth of Lacazia cells collected from dolphin lesions. This included the experimental inoculation of novel media, cell culture, and the use of artificial skin matrices. Although unsuccessful, the methods and results of this study provide important insight into new approaches that could be utilized in future investigations of this elusive organism.
- Published
- 2016
30. Paracoccidioidomycosis ceti (Lacaziosis/Lobomycosis) in Dolphins
- Author
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Leonel Mendoza and Raquel Vilela
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0301 basic medicine ,Paracoccidioides brasiliensis ,biology ,Paracoccidioidomycosis ,030106 microbiology ,Lacazia ,Fungal pathogen ,biology.organism_classification ,medicine.disease ,Serology ,Microbiology ,03 medical and health sciences ,030104 developmental biology ,medicine ,Lobomycosis ,Skin lesion ,human activities - Abstract
Infections caused by the fungal pathogen Lacazia loboi were first reported in 1931 by Jorge de Oliveira Lobo in a human with granulomatous skin lesions in Pernambuco, Brazil. Early histopathological and serological analyses found morphological similarities and cross-reactive antigens with Paracoccidioides brasiliensis. In 1971, veterinarians working with dolphins in Florida, USA, reported granulomatous skin lesions in a dolphin, similar to that in human lacaziosis. Based on histopathological findings, L. loboi was initially believed to be also the etiologic agent of cutaneous disease in dolphins. Ever since, cutaneous granulomas have been reported in different dolphin species around the coast of Asia, Europe, and North and South America. Recently, using molecular biology approaches, some investigators stated that the DNA sequences extracted from cases of cutaneous granulomas in dolphins were closely related to those of P. brasiliensis. This chapter deals with the history, taxonomy, and other features of L. loboi in humans and the unculturable P. brasiliensis var. ceti type affecting the skin of dolphins.
- Published
- 2018
31. Mucocutaneous lesions in free-ranging Atlantic bottlenose dolphins Tursiops truncatus from the southeastern USA
- Author
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Gregory D. Bossart, Stephen D. McCulloch, Patricia A. Fair, Juli D. Goldstein, John S. Reif, and Adam M. Schaefer
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Biopsy ,Mucocutaneous zone ,Genitalia, Male ,Aquatic Science ,Biology ,Skin Diseases ,medicine ,Animals ,Sex organ ,Atlantic Ocean ,Ecology, Evolution, Behavior and Systematics ,Mucous Membrane ,Papilloma ,Free ranging ,medicine.diagnostic_test ,Zoonosis ,Genitalia, Female ,Hyperplasia ,medicine.disease ,Bottle-Nosed Dolphin ,Florida ,Lobomycosis ,Female ,Mouth Diseases ,human activities - Abstract
Mucocutaneous lesions were biopsied from free-ranging Atlantic bottlenose dolphins Tursiops truncatus inhabiting the Indian River Lagoon (IRL), Florida, and estuarine waters of Charleston (CHS), South Carolina, USA, between 2003 and 2013. A total of 78 incisional biopsies from 58 dolphins (n=43 IRL, n=15 CHS) were examined. Thirteen dolphins had 2 lesions biopsied at the same examination, and 6 dolphins were re-examined and re-biopsied at time intervals varying from 1 to 8 yr. Biopsy sites included the skin (n=47), tongue (n=2), and genital mucosa (n=29). Pathologic diagnoses were: orogenital sessile papilloma (39.7%), cutaneous lobomycosis (16.7%), tattoo skin disease (TSD; 15.4%), nonspecific chronic to chronic-active dermatitis (15.4%), and epidermal hyperplasia (12.8%). Pathologic diagnoses from dolphins with 2 lesions were predominately orogenital sessile papillomas (n=9) with nonspecific chronic to chronic-active dermatitis (n=4), TSD (n=3), lobomycosis (n=1), and epidermal hyperplasia (n=1). Persistent pathologic diagnoses from the same dolphins re-examined and re-biopsied at different times included genital sessile papillomas (n=3), lobomycosis (n=2), and nonspecific dermatitis (n=2). This is the first study documenting the various types, combined prevalence, and progression of mucocutaneous lesions in dolphins from the southeastern USA. The data support other published findings describing the health patterns in dolphins from these geographic regions. Potential health impacts related to the observed suite of lesions are important for the IRL and CHS dolphin populations, since previous studies have indicated that both populations are affected by complex infectious diseases often associated with immunologic disturbances and anthropogenic contaminants.
- Published
- 2015
32. A case of stranded Indo-Pacific bottlenose dolphin (Tursiops aduncus) with lobomycosis-like skin lesions in Kinko-wan, Kagoshima, Japan
- Author
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Kyoko Sasaki, Tadasu K. Yamada, Nobuyuki Kashiwagi, and Yuko Tajima
- Subjects
Pathology ,medicine.medical_specialty ,General Veterinary ,biology ,digestive, oral, and skin physiology ,Hyperkeratosis ,Lacazia ,biology.organism_classification ,medicine.disease ,Bottlenose dolphin ,Fungal disease ,medicine ,Lobomycosis ,Tursiops aduncus ,Skin lesion ,human activities ,Indo-Pacific - Abstract
Lobomycosis is a chronic fungal disease caused by the etiologic agent, Lacazia loboi, in the skin and subcutaneous tissues in humans and dolphins in tropical and transitional tropical climates. An Indo-Pacific bottlenose dolphin (Tursiops aduncus) stranded in Kagoshima, Japan, had severe skin lesions characterized by granulomatous reactions and hyperkeratosis that were similar to those of the lobomycosis, but no fungal organism was observed in the skin lesion. In this paper, we report a stranded Indo-Pacific bottlenose dolphin with lobomycosis-like lesions based on pathological examinations in Japan.
- Published
- 2015
33. THE RELEVANCE OF NUTRITIONAL STATUS AND HISTOPATHOLOGICAL FINDINGS ON THE INFECTIOUS PROCESS OF BALB/C MICE INOCULATED WITH Lacazia loboi
- Author
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Paulo Câmara Marques Pereira, Andréa de Faria Fernandes Belone, Fátima Regina Vilani-Moreno, Adriana Sierra Assencio Almeida Barbosa, Sueli Aparecida Calvi, Adauto José Ferreira Nunes, Beatriz Gomes Carreira Sartori, Suzana Madeira Diório, Sônia Maria Usó Ruiz Silva, and Sílvia Cristina Barboza Pedrini
- Subjects
Male ,Pathology ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,Protein–energy malnutrition ,lcsh:RC955-962 ,Lacazia ,Histopathology ,Nutritional Status ,Spleen ,Mycology ,Protein-Energy Malnutrition ,BALB/c ,Mice ,medicine ,Animals ,Lobomycosis ,Lacazia loboi ,Mice, Inbred BALB C ,biology ,Jorge Lobo's disease ,Malnutrition ,General Medicine ,Organ Size ,biology.organism_classification ,medicine.disease ,Disease Models, Animal ,Infectious Diseases ,medicine.anatomical_structure ,Liver ,Giant cell ,Granuloma - Abstract
SUMMARY The aim of this study was to evaluate the effects of the protein-calorie malnutrition in BALB/c isogenic mice infected with Lacazia loboi, employing nutritional and histopathological parameters. Four groups were composed: G1: inoculated with restricted diet, G2: not inoculated with restricted diet, G3: inoculated with regular diet, G4: not inoculated with regular diet. Once malnutrition had been imposed, the animals were inoculated intradermally in the footpad and after four months, were sacrificed for the excision of the footpad, liver and spleen. The infection did not exert great influence on the body weight of the mice. The weight of the liver and spleen showed reduction in the undernourished groups when compared to the nourished groups. The macroscopic lesions, viability index and total number of fungi found in the footpads of the infected mice were increased in G3 when compared to G1. Regarding the histopathological analysis of the footpad, a global cellularity increase in the composition of the granuloma was observed in G3 when compared to G1, with large numbers of macrophages and multinucleated giant cells, discrete numbers of lymphocytes were present in G3 and an increase was observed in G1. The results suggest that there is considerable interaction between Jorge Lobo's disease and nutrition.
- Published
- 2015
34. Jorge Lobo’s Disease: Immunohistochemical Characterization of Dendritic Cells in Cutaneous Lesions
- Author
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Mirian Nacagami Sotto, Arival Cardoso de Brito, Juarez Antônio Simões Quaresma, Clivia Maria Moraes de Oliveira, Carla Pagliari, Marília Brasil Xavier, Maria Irma Seixas Duarte, Tania Cristina Barboza, and Deborah Aben Athar Unger
- Subjects
Pathology ,medicine.medical_specialty ,Langerin ,Lacazia ,Veterinary (miscellaneous) ,Applied Microbiology and Biotechnology ,Microbiology ,S100 protein ,Immune system ,Antigen ,Dermis ,Antigens, CD ,medicine ,Humans ,Lectins, C-Type ,Lobomycosis ,Skin ,Staining and Labeling ,integumentary system ,biology ,S100 Proteins ,biology.organism_classification ,medicine.disease ,Immunohistochemistry ,Mannose-Binding Lectins ,medicine.anatomical_structure ,Giant cell ,Langerhans Cells ,biology.protein ,Agronomy and Crop Science - Abstract
Jorge Lobo’s disease (JLD) is a cutaneous chronic mycosis caused by Lacazia loboi. We studied Factor XIIIa + dermal dendrocytes (FXIIIa + DD), Langerhans cells (LC) through the expression of langerin and the expression of S100 protein. A total of 41 biopsies and 10 normal skins (control) were developed with a polymer-based immunohistochemical method. Lesions presented infiltrate comprising macrophages, some asteroid corpuscles, lymphocytes, multinucleated giant cells and a large number of fungi. LCs presented short dendrites and were scarcely distributed. Dermal langerin + cells were detected in nine JLD lesions. FXIIIa + DD were hypertrophic, visualized in the inflammatory infiltrate of JLD lesions. Cells S100+ were present in JLD and control group with a similar number of cells. A total of 14 specimens did not express FXIIIa, and this considerable number probably contributed to the statistical similarity with the control group. The results indicate that LCs are present in the immune response against Lacazia loboi. Some dermal langerin + cells could be another subset of dendritic cells. Our data indicate changes of LCs in JLD cutaneous lesions and present, for the first time, results that show langerin + cells in the dermis and corroborate previous observations on the participation of FXIIIa + DD in the in situ immune response in JLD.
- Published
- 2014
35. Health and Environmental Risk Assessment Project for bottlenose dolphins Tursiops truncatus from the southeastern USA. I. Infectious diseases
- Author
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Adam M. Schaefer, John S. Reif, Patricia A. Fair, and Gregory D. Bossart
- Subjects
0301 basic medicine ,medicine.medical_specialty ,040301 veterinary sciences ,Zoology ,Population health ,Aquatic Science ,Arbovirus ,Communicable Diseases ,Risk Assessment ,0403 veterinary science ,03 medical and health sciences ,medicine ,Seroprevalence ,Animals ,Ecology, Evolution, Behavior and Systematics ,Environmental risk assessment ,biology ,Public health ,04 agricultural and veterinary sciences ,medicine.disease ,Bottlenose dolphin ,biology.organism_classification ,Virology ,Southeastern United States ,Cetacean morbillivirus ,Bottle-Nosed Dolphin ,030104 developmental biology ,Lobomycosis ,human activities ,Environmental Monitoring - Abstract
From 2003 to 2015, 360 free-ranging Atlantic bottlenose dolphins Tursiops truncatus inhabiting the Indian River Lagoon (IRL, n = 246), Florida, and coastal waters of Charleston (CHS, n = 114), South Carolina, USA, were captured, given comprehensive health examinations, and released as part of a multidisciplinary and multi-institutional study of individual and population health. The aim of this review is to summarize the substantial health data generated by this study and to examine morbidity between capture sites and over time. The IRL and CHS dolphin populations are affected by complex infectious and neoplastic diseases often associated with immunologic disturbances. We found evidence of infection with cetacean morbillivirus, dolphin papilloma and herpes viruses, Chlamydiaceae, a novel uncultivated strain of Paracoccidioides brasiliensis (recently identified as the causal agent of dolphin lobomycosis/lacaziasis), and other pathogens. This is the first long-term study documenting the various types, progression, seroprevalence, and pathologic interrelationships of infectious diseases in dolphins from the southeastern USA. Additionally, the study has demonstrated that the bottlenose dolphin is a valuable sentinel animal that may reflect environmental health concerns and parallel emerging public health issues.
- Published
- 2017
36. Morphological Findings of Deep Cutaneous Fungal Infections
- Author
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Marcela Saeb-Lima, Roberto Arenas-Guzman, and Angel Fernandez-Flores
- Subjects
Chromoblastomycosis ,Sporotrichosis ,Paracoccidioidomycosis ,Dermatology ,General Medicine ,Eumycetoma ,Biology ,medicine.disease ,Histoplasmosis ,Pathology and Forensic Medicine ,Immunology ,medicine ,Rhinosporidiosis ,Dermatomycoses ,Humans ,Lobomycosis ,Zygomycosis - Abstract
Cutaneous fungal infections used to be rare in most developed countries. However, they have become more common due to immunosuppression and globalization. In this report, we summarize the histopathologic findings of the main cutaneous fungal infections that are commonly seen in daily practice, including eumycetoma, sporotrichosis, histoplasmosis, cryptococcosis, coccidioidomycosis, aspergillosis, zygomycosis, phaeohyphomycosis, alternariosis, blastomycosis, paracoccidioidomycosis, lobomycosis, and chromoblastomycosis. We also include protothecosis (despite the fact that the infectious agent of this disease is algal and not fungal) and rhinosporidiosis (despite being caused by mesomycetozoea, which are not fungi).
- Published
- 2014
37. Jorge Lobo’s disease: a case of keloidal blastomycosis (lobomycosis) in a nonendemic area
- Author
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Shah Giashuddin, Jiten P. Kothadia, Sherly Abraham, Monica Kaminski, and Rezina Arju
- Subjects
Blastomyces ,Pathology ,medicine.medical_specialty ,Keloidal Blastomycosis ,biology ,business.industry ,Lacazia ,Reviews ,Disease ,biology.organism_classification ,medicine.disease ,Dermatology ,Paracoccidioides ,Infectious Diseases ,Histoplasma ,medicine ,Lobomycosis ,Pharmacology (medical) ,Coccidioides ,business - Abstract
Lobomycosis or lacaziosis is a chronic subcutaneous fungal infection, caused by the fungus Lacazia loboi, which is phylogenetically related to Coccidioides, Blastomyces, Histoplasma, and Paracoccidioides. The disease was first recognized in 1931 by Jorge Lobo, who found the disease to be a keloidal blastomycosis and named it Jorge Lobo’s disease. This case was perplexing initially as this fungal infection is very uncommon in the USA. However, with the ever-increasing frequency of international travel, many more cases of lobomycosis have been diagnosed in areas of nonendemicity, such as the USA, Europe, and South Africa. The clinical histories of such imported fungal infections often illustrate their long latency periods. In lobomycosis, the onset of the disease is usually insidious and often difficult to document. We describe a case of a New York resident who presented with multiple skin nodules over both his arms and forearms, and was subsequently diagnosed with Jorge Lobo’s disease. The case, diagnosis, histopathologic findings, complication, and management of this rare clinical disease are discussed.
- Published
- 2014
38. Lacaziosis-like disease among bottlenose dolphins Tursiops truncatus photographed in Golfo Dulce, Costa Rica
- Author
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David Herra-Miranda, Brooke L. Bessesen, Luis Bermúdez-Villapol, Leslie B. Hart, Alejandro Acevedo-Gutiérrez, Guido Saborío-Rodriguez, Lenin Oviedo, Juan Diego Pacheco-Polanco, and Lesli Baker
- Subjects
Costa Rica ,Fungal agent ,education.field_of_study ,Pacific Ocean ,biology ,Range (biology) ,Population ,Lacazia ,Aquatic Science ,Time gap ,biology.organism_classification ,medicine.disease ,Bottle-Nosed Dolphin ,Fishery ,Environmental protection ,medicine ,Animals ,Lobomycosis ,Central american ,Skin lesion ,education ,human activities ,Ecology, Evolution, Behavior and Systematics - Abstract
Lacaziosis (also known as lobomycosis) is a chronic dermal disease caused by the fungal agent Lacazia loboi, which affects both humans and dolphins. Photographic data have been used to identify lacaziosis-like disease (LLD) among dolphins in the waters of North and South America, and here we report LLD in bottlenose dolphins Tursiops truncatus off the coast of Costa Rica, the first reporting in Central American waters. During the periods of 1991 to 1992 and 2010 to 2011, 3 research teams conducted separate dolphin surveys in the Pacific tropical fiord Golfo Dulce, and each documented skin lesions in the resident population of bottlenose dolphins. Photo-ID records were used to identify LLD-affected bottlenose dolphins and to assess their lesions. Findings showed between 13.2 and 16.1% of the identified dolphins exhibited lesions grossly resembling lacaziosis. By combining efforts and cross-referencing photographic data, the teams explored the presence of LLD in Golfo Dulce over a time gap of approximately 20 yr. Our findings expand the geographical range of the disease and offer insight into its longevity within a given population of dolphins.
- Published
- 2014
39. Keloids on the ears
- Author
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Luis Fernando González, Boris F. Sánchez, Carolina Cabrera-Salom, Mariam Rolón, and Sánchez Polania, Boris Fernando [0000-0002-6096-136X]
- Subjects
Adult ,Male ,medicine.medical_specialty ,Endemic Diseases ,business.industry ,Biopsy, Needle ,Dermatology ,030204 cardiovascular system & hematology ,Colombia ,Cryosurgery ,Immunohistochemistry ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Rare Diseases ,Treatment Outcome ,Keloid ,Disease Progression ,Medicine ,Humans ,Ear, External ,business ,Lobomycosis - Published
- 2016
40. Jorge Lobo’s disease
- Author
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Kalline Andrade de Carvalho, Marcos C. Floriano, Milvia Maria Simões e Silva Enokihara, and Marta Regina Machado Mascarenhas
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Chronic granulomatous ,Lacazia ,Dermatology ,Cutaneous mycosis ,Blastomycosis ,Rare Diseases ,medicine ,Humans ,Lobomycosis ,Skin ,biology ,Paracoccidioidomycosis ,business.industry ,Images in Tropical Dermatology ,Traumatic implantation ,Lobo's disease ,Middle Aged ,medicine.disease ,biology.organism_classification ,RL1-803 ,business ,Brazil - Abstract
Jorge Lobo's Disease is a rare, chronic granulomatous cutaneous mycosis, which is typical of tropical and subtropical regions. It is caused by the traumatic implantation of the fungus Lacazia loboi into the skin and subcutaneous tissue. The disease was first described in 1931 by Jorge Lobo, in Recife (PE), Brazil. It is common in Central and South America, and predominates in the Amazon region. We report a case of Jorge Lobo's Disease, which had been initially referred as being paracoccidioidomycosis. We emphasize clinical and diagnostic features of the disease.
- Published
- 2015
41. Lobomycosis: Risk of Zoonotic Transmission from Dolphins to Humans
- Author
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John S. Reif, Adam M. Schaefer, and Gregory D. Bossart
- Subjects
Lacazia ,Dolphins ,Zoology ,Review ,Disease ,Microbiology ,Zoonotic disease ,Zoonoses ,Virology ,Prevalence ,medicine ,Animals ,Humans ,Lobomycosis ,Skin ,biology ,Ecology ,Transmission (medicine) ,biology.organism_classification ,medicine.disease ,Geographic distribution ,Fungal disease ,Infectious Diseases ,Florida ,human activities - Abstract
Lobomycosis, a fungal disease of the skin and subcutaneous tissues caused by Lacazia loboi, is sometimes referred to as a zoonotic disease because it affects only specific delphinidae and humans; however, the evidence that it can be transferred directly to humans from dolphins is weak. Dolphins have also been postulated to be responsible for an apparent geographic expansion of the disease in humans. Morphological and molecular differences between the human and dolphin organisms, differences in geographic distribution of the diseases between dolphins and humans, the existence of only a single documented case of presumed zoonotic transmission, and anecdotal evidence of lack of transmission to humans following accidental inoculation of tissue from infected dolphins do not support the hypothesis that dolphins infected with L. loboi represent a zoonotic hazard for humans. In addition, the lack of human cases in communities adjacent to coastal estuaries with a high prevalence of lobomycosis in dolphins, such as the Indian River Lagoon in Florida (IRL), suggests that direct or indirect transmission of L. loboi from dolphins to humans occurs rarely, if at all. Nonetheless, attention to personal hygiene and general principals of infection control are always appropriate when handling tissues from an animal with a presumptive diagnosis of a mycotic or fungal disease.
- Published
- 2013
42. The cytotoxic T cells may contribute to the in situ immune response in Jorge Lobo's Disease human lesions
- Author
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Arival Cardoso de Brito, Mirian Nacagami Sotto, Luciane Kanashiro-Galo, Clivia Maria Moraes de Oliveira, Juarez Antônio Simões Quaresma, Ariane Fernandes Alexandre, Tânia Cristina Barboza, Marília Brasil Xavier, Maria Irma Seixas Duarte, Carla Pagliari, and Deborah Aben Athar Unger
- Subjects
0301 basic medicine ,Adult ,CD4-Positive T-Lymphocytes ,Male ,Pathology ,medicine.medical_specialty ,Lacazia ,Lymphocyte ,Biopsy ,Giant Cells ,Granzymes ,03 medical and health sciences ,Immune system ,medicine ,Macrophage ,Cytotoxic T cell ,Humans ,Lobomycosis ,Aged ,Skin ,Aged, 80 and over ,Microscopy ,biology ,Macrophages ,General Medicine ,Middle Aged ,biology.organism_classification ,Immunohistochemistry ,Granzyme B ,Killer Cells, Natural ,030104 developmental biology ,Infectious Diseases ,medicine.anatomical_structure ,Granzyme ,Giant cell ,Immunology ,biology.protein ,Female ,T-Lymphocytes, Cytotoxic - Abstract
Jorge Lobo's Disease (JLD) is a cutaneous chronic granulomatous disease caused by the pathogenic fungus Lacazia loboi. It is characterized by a granulomatous reaction with multinucleated giant cells and high number of fungal cells. In order to contribute to the comprehension of immune mechanisms in JLD human lesions, we studied the cytotoxic immune response, focusing on TCD8+ and NK cells, and granzyme B. Forty skin biopsies of lower limbs were selected and an immunohistochemistry protocol was developed to detect CD8+ T cells, NK cells and Granzyme B. In order to compare the cellular populations, we also performed a protocol to visualize TCD4+ cells. Immunolabeled cells were quantified in nine randomized fields in the dermis. Lesions were characterized by inflammatory infiltrate of macrophages, lymphocytes, epithelioid and multinucleated giant cells with intense number of fungal forms. There was a prevalence of CD8 over CD4 cells, followed by NK cells. Our results suggest that in JLD the cytotoxic immune response could represent another important mechanism to control Lacazia loboi infection. We may suggest that, although CD4+ T cells are essential for host defense in JLD, CD8+ T cells could play a role in the elimination of the fungus.
- Published
- 2016
43. Cutaneous granulomas in dolphins caused by novel uncultivated Paracoccidioides brasiliensis
- Author
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Patricia A. Fair, Judy St. Leger, Raquel Vilela, Leonel Mendoza, Leslie M. Dalton, Adam M. Schaefer, John S. Reif, Gregory D. Bossart, and Peter J. McCarthy
- Subjects
0301 basic medicine ,Epidemiology ,Biopsy ,Lacazia ,lcsh:Medicine ,lobomycosis ,P. lutzii ,Animal Diseases ,DNA, Fungal ,Pathogen ,Phylogeny ,Granuloma ,biology ,Phylogenetic tree ,Paracoccidioidomycosis ,paracoccidioidomycosis ceti ,Infectious Diseases ,Sister group ,lacaziosis ,Paracoccidioides brasiliensis ,Microbiology (medical) ,Dolphins ,030106 microbiology ,DNA sequencing ,Microbiology ,lcsh:Infectious and parasitic diseases ,bottlenose dolphins ,03 medical and health sciences ,paracoccidioidomycosis ,medicine ,Animals ,Dermatomycoses ,cutaneous granulomas ,lcsh:RC109-216 ,Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis ,Lacazia loboi ,Base Sequence ,Research ,phylogenetic analysis ,fungi ,lcsh:R ,Golfinhos ,Paracoccidioides ,Paracoccidioidomicose ,biology.organism_classification ,medicine.disease ,Tursiops truncatus ,Lobomycosis ,Fungos ,human activities - Abstract
Our findings could stimulate study of public health implications of diseases caused by this fungus., Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Kex gene sequences of P. brasiliensis from dolphins showed 100% homology with sequences from cultivated P. brasiliensis, 73% with those of L. loboi, and 93% with those of P. lutzii. Parsimony analysis placed DNA sequences from dolphins within a cluster with human P. brasiliensis strains. This cluster was the sister taxon to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins is probably the cause of lacaziosis/lobomycosis, herein referred to as paracoccidioidomycosis ceti.
- Published
- 2016
44. Lacaziosis-like disease in Tursiops truncates from Brazil A histopathological and immunohistochemical approach
- Author
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Natália Coelho Couto de Azevedo Fernandes, Kátia R. Groch, Pedro Volkmer de Castilho, Paulo C. Simões-Lopes, Carlos Sacristán, Rodrigo Albergaria Réssio, Angélica María Sánchez-Sarmiento, Cristiane K. M. Kolesnikovas, José Luiz Catão-Dias, Fábio G. Daura-Jorge, Paulo Henrique Ott, Larissa Rosa de Oliveira, Juliana Marigo, Fernando Esperón, and Samira Costa-Silva
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Pathology ,IMUNOHISTOQUÍMICA ,040301 veterinary sciences ,030106 microbiology ,Lacazia ,Aquatic Science ,Grocott's methenamine silver stain ,Paracoccidioides ,Tursiops ,0403 veterinary science ,03 medical and health sciences ,medicine ,Animals ,Lobomycosis ,Ecology, Evolution, Behavior and Systematics ,Paracoccidioides brasiliensis ,biology ,Paracoccidioidomycosis ,Bottlenose dolphin ,Histology ,04 agricultural and veterinary sciences ,Cetacean ,medicine.disease ,biology.organism_classification ,Immunohistochemistry ,Yeast ,Bottle-Nosed Dolphin ,Immunohisto - chemistry ,Histopathology ,Brazil - Abstract
Cetacean lacaziosis-like disease or lobomycosis-like disease (LLD) is a chronic skin condition caused by a non-cultivable yeast of the order Onygenales, which also includes Lacazia loboi, as well as Paracoccidioides brasiliensis and P. lutzii, respectively responsible for lacaziosis and paracoccidioidomycosis in humans. Complete identification and phylogenetic classification of the LLD etiological agent still needs to be elucidated, but preliminary phylogenetic analyses have shown a closer relationship of the LLD agent to Paracoccidioides spp. than to L. loboi. Cases of LLD in South American cetaceans based on photographic identification have been reported; however, to date, only 3 histologically confirmed cases of LLD have been described. We evaluated multiple tissue samples from 4 Tursiops truncatus stranded in the states of Santa Catarina (n = 3) and Rio Grande do Sul (n = 1), southern Brazil. Macroscopically, all animals presented lesions consistent with LLD. Hematoxylin-eosin, periodic acid-Schiff, Grocott's methenamine silver, and Mayer's mucicarmin stains were used for histological evaluation. Microscopically, numerous refractile yeasts (4-9 μm in diameter) were observed in skin samples (4/4), and for the first time in dolphins, also in a skeletal muscle abscess (1/4). Immunohistochemistry using anti-P. brasiliensis glycoprotein gp43 as a primary antibody, which is known to cross-react with L. loboi and the LLD agent, was performed and results were positive in all 4 cases. We describe 3 new cases of LLD in cetaceans based on histopathology and immunohistochemistry. This is the first report of LLD in the muscle of cetaceans. © 2016 Inter-Research.
- Published
- 2016
45. Epidemiología actual y diagnóstico de laboratorio de las micosis endémicas en España
- Author
-
Manuel Cuenca-Estrella and María José Buitrago
- Subjects
Microbiology (medical) ,medicine.medical_specialty ,Sporotrichosis ,Paracoccidioidomycosis ,business.industry ,medicine.disease ,Dermatology ,Histoplasmosis ,Pythiosis ,Epidemiology ,medicine ,Lobomycosis ,Solid organ transplantation ,business ,Blastomycosis - Abstract
Histoplasmosis and paracoccidioidomycosis are emerging infections in Spain associated with immigration and travelling. In last three decades a total of 128 cases of histoplasmosis have been reported in Spain, 59 in travellers, 63 in immigrants, three associated to drug abuse, two in laboratory workers, and one in a solid organ transplant receptor. In 1969 the first Spanish case of paracoccidioidomycosis was published and a total of 21 cases have been reported so far. Those patients suffered from the chronic form of the disease with period of latency as long as 50 years. Other endemic mycoses such as blastomycosis, coccidioidomycosis, lobomycosis, pythiosis and sporotrichosis have not increased in frequency. Microbiological cultures of endemic fungi must be handled in facilities which comply with international biosafety regulations and must also be taken into account for cultures from patients with suspected endemic mycosis.
- Published
- 2012
46. Lobomycosis: an emerging disease in humans and delphinidae
- Author
-
M. F. Van Bressem, D. L. Connor, L. Sander Hoffmann, M. Hernandez-Perez, A. Paniz-Mondolfi, Sinésio Talhari, L. Bermudez-Villapol, and Carolina Talhari
- Subjects
Antifungal ,Pathology ,medicine.medical_specialty ,medicine.drug_class ,Lacazia ,Dermatology ,General Medicine ,Disease ,Biology ,medicine.disease ,biology.organism_classification ,Infectious Diseases ,Aquatic environment ,medicine ,Lobomycosis - Abstract
Summary Lobomycosis, a disease caused by the uncultivable dimorphic onygenale fungi Lacazia loboi, remains to date as an enigmatic illness, both due to the impossibility of its aetiological agent to be cultured and grown in vitro, as well as because of its unresponsiveness to specific antifungal treatments. It was first described in the 1930s by Brazilian dermatologist Jorge Lobo and is known to cause cutaneous and subcutaneous localised and widespread infections in humans and dolphins. Soil and vegetation are believed to be the chief habitat of the fungus, however, increasing reports in marine mammals has shifted the attention to the aquatic environment. Infection in humans has also been associated with proximity to water, raising the hypothesis that L. loboi may be a hydrophilic microorganism that penetrates the skin by trauma. Although its occurrence was once thought to be restricted to New World tropical countries, its recent description in African patients has wrecked this belief. Antifungals noted to be effective in the empirical management of other cutaneous/subcutaneous mycoses have proven unsuccessful and unfortunately, no satisfactory therapeutic approach for this cutaneous infection currently exists.
- Published
- 2012
47. Molecular diagnosis of lobomycosis-like disease in a bottlenose dolphin in captivity
- Author
-
Daniel García-Párraga, José Manuel Sánchez-Vizcaíno, Edwige Nina Bellière, and Fernando Esperón
- Subjects
Pathology ,medicine.medical_specialty ,Molecular Sequence Data ,Lacazia ,Captivity ,Zoology ,Paracoccidioides ,medicine ,Animals ,DNA, Fungal ,Lobomycosis ,Ribosomal DNA ,biology ,Phylogenetic tree ,Bottlenose dolphin ,Onygenales ,Sequence Analysis, DNA ,General Medicine ,medicine.disease ,biology.organism_classification ,Bottle-Nosed Dolphin ,Infectious Diseases ,Animals, Zoo ,Molecular diagnosis ,Paracoccidioidomycosis - Abstract
We report the diagnosis and molecular characterization of lobomycosis-like lesions in a captive bottlenose dolphin. The clinical picture and the absence of growth in conventional media resembled the features associated with Lacazia loboi. However sequencing of ribosomal DNA and further phylogenetic analyses showed a novel sequence more related to Paracoccidioides brasilensis than to L. loboi. Moreover, the morphology of the yeast cells differed from those L. loboi causing infections humans. These facts suggest that the dolphin lobomycosis-like lesions might have been be caused by different a different fungus clustered inside the order Onygenales. A successful treatment protocol based on topic and systemic terbinafine is also detailed. © 2012 ISHAM.
- Published
- 2012
48. Epidemiology of lobomycosis-like disease in bottlenose dolphins Tursiops spp. from South America and southern Africa
- Author
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Leonardo Flach, Isabel Cristina Avila, Koen Van Waerebeek, Kate Du Toit, Jeanne Wagner, Fábio G. Daura-Jorge, Marie-Françoise Van Bressem, Paulo Henrique Ott, Eduardo R. Secchi, Amanda Baron Di Giacomo, Pedro F. Fruet, Aaron Banks, Jeremy J. Kiszka, Fernando Félix, Simon Harvey Elwen, and Paulo C. Simões-Lopes
- Subjects
medicine.medical_specialty ,Bottle-nosed dolphin ,Range (biology) ,Aquatic Science ,Biology ,South Africa ,parasitic diseases ,Epidemiology ,medicine ,Animals ,Residence.status ,Southern Hemisphere ,Atlantic Ocean ,Lobomycosis ,Ecology, Evolution, Behavior and Systematics ,Mozambique ,geography ,geography.geographical_feature_category ,Pacific Ocean ,National park ,Estuary ,South America ,medicine.disease ,Fishery ,Bottle-Nosed Dolphin ,human activities - Abstract
We report on the epidemiology of lobomycosis-like disease (LLD), a cutaneous disorder evoking lobomycosis, in 658 common bottlenose dolphins Tursiops truncatus from South America and 94 Indo-Pacific bottlenose dolphins T. aduncus from southern Africa. Photographs and stranding records of 387 inshore residents, 60 inshore non-residents and 305 specimens of undetermined origin (inshore and offshore) were examined for the presence of LLD lesions from 2004 to 2015. Seventeen residents, 3 non-residents and 1 inshore dolphin of unknown residence status were positive. LLD lesions appeared as single or multiple, light grey to whitish nodules and plaques that may ulcerate and increase in size over time. Among resident dolphins, prevalence varied significantly among 4 communities, being low in Posorja (2.35%, n = 85), Ecuador, and high in Salinas, Ecuador (16.7%, n = 18), and Laguna, Brazil (14.3%, n = 42). LLD prevalence increased in 36 T. truncatus from Laguna from 5.6% in 2007-2009 to 13.9% in 2013-2014, albeit not significantly. The disease has persisted for years in dolphins from Mayotte, Laguna, Salinas, the Sanquianga National Park and Bahia Malaga (Colombia) but vanished from the Tramandai Estuary and the Mampituba River (Brazil). The geographical range of LLD has expanded in Brazil, South Africa and Ecuador, in areas that have been regularly surveyed for 10 to 35 yr. Two of the 21 LLD-affected dolphins were found dead with extensive lesions in southern Brazil, and 2 others disappeared, and presumably died, in Ecuador. These observations stress the need for targeted epidemiological, histological and molecular studies of LLD in dolphins, especially in the Southern Hemisphere.
- Published
- 2015
49. Lacaziosis and lacaziosis-like prevalence among wild, common bottlenose dolphins Tursiops truncatus from the west coast of Florida, USA
- Author
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Kim Bassos-Hull, Lori H. Schwacke, Leslie B. Hart, Dave S. Rotstein, and Randall S. Wells
- Subjects
education.field_of_study ,Disease occurrence ,biology ,Population ,Lacazia ,Cetacea ,Aquatic Science ,medicine.disease ,biology.organism_classification ,Bottlenose dolphin ,Bottle-Nosed Dolphin ,Fishery ,Rivers ,Florida ,medicine ,Animals ,Dermatomycoses ,Lobomycosis ,West coast ,education ,Atlantic Ocean ,human activities ,Bay ,Ecology, Evolution, Behavior and Systematics - Abstract
Lacaziosis (lobomycosis; Lacazia loboi) is a fungal skin disease that naturally occurs only in humans and dolphins. The first reported case of lacaziosis in a bottlenose dolphin Tursiops truncatus occurred in 1970 in Sarasota Bay, Florida, USA, and subsequent photo-ID monitoring of the Sarasota Bay dolphin population has revealed persistence of the disease. The objectives of this study were to estimate lacaziosis prevalence (P) in 2 bottlenose dolphin populations on the west coast of Florida (Sarasota Bay and Charlotte Harbor) and compare disease occurrence to other published estimates of lacaziosis in dolphin populations across the globe. Historic photographic records of dolphins captured and released for health assessment purposes (Sarasota Bay) and photo-ID studies (Charlotte Harbor) were screened for evidence of lesions consistent with lacaziosis. Health assessment data revealed a prevalence of lacaziosis in the Sarasota Bay bottlenose dolphin population between 2 and 3%, and analyses of photo-ID data provided a lacaziosis-like prevalence estimate of 2% for Charlotte Harbor dolphins. With the exception of lacaziosis prevalence estimates for dolphins inhabiting the Indian River Lagoon (P = 0.068; P = 0.12), no statistically significant differences were seen among Sarasota Bay, Charlotte Harbor, and other published estimates. Although lacaziosis is a rare disease among these dolphin populations, studies that assess disease burden among different populations can assist with the surveillance of this zoonotic pathogen.
- Published
- 2011
50. Modeling lacaziosis lesion progression in common bottlenose dolphins Tursiops truncatus using long-term photographic records
- Author
-
Lori H. Schwacke, Leslie B. Hart, Jeffrey D. Adams, Dave S. Rotstein, and Randall S. Wells
- Subjects
Pathology ,medicine.medical_specialty ,Time Factors ,Population ,Lacazia ,Cetacea ,Animals, Wild ,Aquatic Science ,Biology ,Models, Biological ,Lesion progression ,Lesion ,Photography ,medicine ,Animals ,Dermatomycoses ,education ,Ecology, Evolution, Behavior and Systematics ,education.field_of_study ,Growth model ,medicine.disease ,biology.organism_classification ,Bottlenose dolphin ,Bottle-Nosed Dolphin ,Lobomycosis ,medicine.symptom - Abstract
Lacaziosis (lobomycosis) is a skin disease caused by Lacazia loboi, occurring naturally only in humans and dolphins. Attempts to culture the pathogen in vitro have been unsuccesstul, and inoculation studies of lacaziosis development in mice have provided only limited, short-term data on the progression and propagation of L. loboi. The present study used photographic data from long-term photo-identification and health assessment projects to model and quantify the progression of lacaziosis lesions in 3 common bottlenose dolphins Tursiops truncatus from Sarasota Bay, Florida, USA. Dorsal fin images throughout each animal's sighting history were examined for lesion growth, and the proportion of lesion coverage in each photograph was estimated using image analysis tools in Adobe Photoshop ® . The progression of lacaziosis lesions and lesion growth rates were modeled using a non-linear monomolecular growth model. As data on lacaziosis development and advancement are limited in humans and laboratory animals, dolphins with a long-term case history of the disease may serve as a good animal model to better understand lacaziosis progression. Furthermore, this study demonstrates the utility of long-term population monitoring data for tracking the progression of a poorly understood disease that is relevant to both dolphin and human health.
- Published
- 2010
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