15 results on '"Yohei Yurugi"'
Search Results
2. A case of congenital cystic adenomatoid malformation with repeated pulmonary infection in adulthood and review of thirteen cases in Japan
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Yohei Yurugi, Hiroshige Nakamura, W. Fujiwara, Yasuaki Kubouchi, Ken Miwa, and Yoshiteru Kidokoro
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,Medicine ,030204 cardiovascular system & hematology ,business - Published
- 2018
3. Podoplanin Expression in Cancer-associated Fibroblasts Predicts Poor Prognosis in Patients with Squamous Cell Carcinoma of the Lung
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Kanae Nosaka, Yohei Yurugi, Yuki Matsuoka, Yasuaki Kubouchi, Hiroshige Nakamura, Makoto Wakahara, Yoshihisa Umekita, Tomohiro Haruki, Tatsushi Shiomi, Ken Miwa, Kunio Araki, Yuji Taniguchi, and Tomohiko Sakabe
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Male ,0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Lymphovascular invasion ,Kaplan-Meier Estimate ,03 medical and health sciences ,0302 clinical medicine ,Cancer-Associated Fibroblasts ,Cancer stem cell ,Internal medicine ,medicine ,Humans ,Aged ,Aged, 80 and over ,Membrane Glycoproteins ,Squamous-cell carcinoma of the lung ,Lung ,biology ,business.industry ,General Medicine ,Prognosis ,stomatognathic diseases ,030104 developmental biology ,medicine.anatomical_structure ,Podoplanin ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,biology.protein ,Immunohistochemistry ,Female ,Antibody ,business - Abstract
Background/Aim: Podoplanin is a candidate cancer stem cell marker in squamous cell carcinoma (SCC). Several studies have reported the prognostic value of podoplanin expression in tumor cells in lung SCC but few have focused on its expression in cancer-associated fibroblasts (CAFs). The aim of this study was to analyze the prognostic significance of podoplanin expression, with special reference to the expression pattern in both tumor cells and CAFs. Patients and Methods: Immunohistochemical analyses using anti-podoplanin antibody were performed on 126 resected specimens of lung SCC. When more than 10% of tumor cells or CAFs showed immunoreactivity with podoplanin levels as strong as those of the positive controls, the specimens were classified as a podoplanin-positive. Results: Podoplanin-positive status in tumor cells (n=54) was correlated with a lower incidence of lymphatic invasion (p=0.031) but there were no significant differences in disease-free survival (DFS) and disease-specific survival (DSS) by the log-rank test. Podoplanin-positive status in CAFs (n=41) was correlated with more advanced stage (p=0.008), higher frequency of pleural invasion (p=0.002) and both shorter DFS (p=0.006) and DSS (p=0.006). In Cox's multivariate analysis, podoplanin-positive status in CAFs was an independent negative prognostic factor for DFS (p=0.027) and DSS (p=0.027). Conclusion: Podoplanin expression in CAFs might be an independent unfavorable prognostic indicator in patients with lung SCC, irrespective of the expression status of tumor cells.
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- 2017
4. The utility of needle biopsy examinations of resected surgical specimens for diagnosing small lung cancer
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Yohei Yurugi, Hiroshige Nakamura, Yuji Taniguchi, Kunio Araki, Makoto Wakahara, and Ken Miwa
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,030228 respiratory system ,business.industry ,030220 oncology & carcinogenesis ,Needle biopsy ,medicine ,Radiology ,Lung cancer ,medicine.disease ,business - Published
- 2017
5. Initial Results of Robotic Surgery for Primary Lung Cancer: Feasibility, Safety and Learning Curve
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W. Fujiwara, Yoshiteru Kidokoro, Yuzo Takagi, Yasuaki Kubouchi, Yuji Taniguchi, Makoto Wakahara, Tomohiro Haruki, Takashi Ohno, Ken Miwa, Kunio Araki, Yohei Yurugi, and Hiroshige Nakamura
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Blood loss ,National health insurance ,030220 oncology & carcinogenesis ,Operating time ,medicine ,Robotic surgery ,Thoracotomy ,Pulmonary resection ,Lung cancer ,business ,Carbon dioxide insufflation - Abstract
Background At the end of 2016, robot-assisted thoracoscopic surgery (RATS) was still not covered by Japanese national health insurance. Therefore, few institutions in Japan perform RATS and even fewer have reported procedures as they occurred earlier. So, we decided to focus on the initial results of RATS for primary lung cancer. Methods We retrospectively reviewed 44 patients who underwent RATS for primary lung cancer from January 2011 to August 2016. After mastering the initial procedure, we introduced a completely portal robotic pulmonary resection procedure using a carbon dioxide insufflation system. Cases were divided into 2 groups: the early period (20 cases) and the later period (24 cases). Results There was no case of conversion to video-assisted thoracoscopic surgery or thoracotomy. In the 44 cases of primary lung cancer, median operating time was 239.5 min, console time was 179 min, blood loss was 10 mL, drainage period was 2 days, morbidity of Grade 2 or more (Clavien-Dindo classification) was 18.2%, morbidity of Grade 3 or more was only 4.6%, and there was no 30-day mortality. Median operating and console times were significantly shorter in the later period (215 min and 159.5 min, respectively) than in the initial period (300.5 min and 228 min, respectively). Median blood loss was significantly lower in the later period (5 mL) than in the initial period (50 mL). Five-year overall and disease-free survival rates were 100% and 88.9%, respectively. Conclusion RATS for primary lung cancer is feasible and safe, has a faster learning curve, and provides satisfactory. Studies with longer follow-ups and larger numbers of cases are necessary.
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- 2017
6. Simplified comorbidity score for elderly patients undergoing thoracoscopic surgery for lung cancer
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Yuki Matsuoka, Kunio Araki, Yuji Taniguchi, Makoto Wakahara, Ken Miwa, Yohei Yurugi, Hiroshige Nakamura, and Tomohiro Haruki
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Male ,medicine.medical_specialty ,Lung Neoplasms ,medicine.medical_treatment ,Comorbidity ,030204 cardiovascular system & hematology ,Logistic regression ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Diabetes mellitus ,Diabetes Mellitus ,Prevalence ,medicine ,Humans ,Renal Insufficiency ,Pneumonectomy ,Lung cancer ,Aged ,Retrospective Studies ,Aged, 80 and over ,Lung ,integumentary system ,Thoracic Surgery, Video-Assisted ,business.industry ,Smoking ,General Medicine ,Perioperative ,Odds ratio ,Prognosis ,medicine.disease ,Surgery ,medicine.anatomical_structure ,nervous system ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Video-assisted thoracoscopic surgery ,Female ,Complication ,business ,tissues ,Forecasting - Abstract
We investigated the efficiency of the Simplified Comorbidity Score (SCS) for predicting postoperative complications and prognosis in elderly patients undergoing video-assisted thoracoscopic surgery (VATS) for lung cancer. We reviewed 216 patients aged 75 years or older, who underwent pulmonary resection by VATS for lung cancer between January, 2005 and December, 2012. The SCS assigns different scores to patients’ comorbidities; namely, smoking (n = 7); diabetes mellitus (n = 5); renal insufficiency (n = 4); and respiratory, neoplastic, and cardiovascular comorbidities or alcoholism (n = 1 each). Patients were divided into a high SCS group (SCS ≥ 9; n = 154) and a low SCS group (
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- 2016
7. Prognostic Significance of Solid and Micropapillary Components in Invasive Lung Adenocarcinomas Measuring ≤3 cm
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Yoshihisa Umekita, Yohei Yurugi, Hiroshige Nakamura, Tomohiko Sakabe, Tomohiro Haruki, Yasuaki Kubouchi, Yuji Taniguchi, Makoto Wakahara, Yuzo Takagi, Kunio Araki, and Yuki Matsuoka
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Adult ,Male ,0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Pathology ,Lung Neoplasms ,Multivariate analysis ,Adenocarcinoma of Lung ,Kaplan-Meier Estimate ,Adenocarcinoma ,Gastroenterology ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Neoplasm Invasiveness ,In patient ,Lung cancer ,Aged ,Neoplasm Staging ,Lung ,business.industry ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Adenocarcinoma, Papillary ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Female ,Neoplasm Recurrence, Local ,business - Abstract
Background/aim We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. Patients and methods A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and the European Respiratory Society classification. The presence of solid (S+) or micropapillary component (MP+) was defined when the component constituted ≥1% of the entire tumor. The impact of these components on disease-free (DFS) and disease-specific (DSS) survival was analyzed. Results Thirty (26.1%) cases with S+ and 27 (23.5%) with MP+ were identified, and multivariate analysis indicated that S+ status significantly reduced the duration of DFS and DSS. In 86 patients of acinar- and papillary-predominant subgroups, S+ and/or MP+ had the most significant effect on DFS and DSS by multivariate analysis. Conclusion S+ and/or MP+ status predict worse prognosis in patients with acinar- and papillary-predominant lung adenocarcinoma.
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- 2016
8. Solitary lung metastasis from occult thyroid papillary carcinoma resected at the 12-year follow up: A case report
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Yoshimasa Suzuki, Yohei Yurugi, and Hiroshige Nakamura
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Oncology ,medicine.medical_specialty ,business.industry ,Lung metastasis ,030209 endocrinology & metabolism ,Occult ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Medicine ,Radiology ,business ,Thyroid papillary carcinoma - Published
- 2016
9. Cushing’s syndrome caused by ACTH-producing thymic typical carcinoid with local invasion and regional lymph node metastasis: a case report
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Takashi Ohno, Yuji Taniguchi, W. Fujiwara, Yoshiteru Kidokoro, Tomohiro Haruki, Yohei Yurugi, Hiroshige Nakamura, and Ken Miwa
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Pathology ,medicine.medical_specialty ,endocrine system ,lcsh:Surgery ,030209 endocrinology & metabolism ,Case Report ,Thymic Typical Carcinoid Tumor ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Lymph node ,Total thymectomy ,Dexamethasone ,business.industry ,lcsh:RD1-811 ,Thymic carcinoid ,medicine.disease ,Hypokalemia ,ACTH ,Dissection ,medicine.anatomical_structure ,Cushing’s syndrome ,030220 oncology & carcinogenesis ,Mediastinal lymph node ,Immunohistochemistry ,medicine.symptom ,business ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Background Ectopic ACTH-producing thymic carcinoid tumors are rare, but often behave aggressively with local invasion and distant metastasis. We herein report a case of ACTH-producing thymic typical carcinoid tumor with lymph node metastasis treated by surgery and postoperative radiation therapy. Case presentation A 61-year-old woman was admitted to be evaluated for hypoglycemia and hypokalemia. Laboratory data revealed elevation of serum cortisol and ACTH levels. Overnight administration of 8 mg dexamethasone did not suppress plasma ACTH. Chest CT demonstrated a tumor of 30 mm in diameter and enlargement of the lymph node at the anterior mediastinum. Ectopic ACTH syndrome was suspected and total thymectomy and lymph node dissection were performed. The histopathological examination indicated typical carcinoid tumor and mediastinal lymph node metastasis, and immunohistochemical staining was positive for ACTH. The plasma ACTH level decreased immediately after surgery. She received postoperative radiation therapy of 60 Gy. Conclusion Ectopic ACTH-producing thymic typical carcinoid tumors are rare, and it is important to consider this disease and perform appropriate treatment.
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- 2018
10. Subcellular Localization of Maspin Correlates with Histone Deacetylase 1 Expression in Human Breast Cancer
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Kanae Nosaka, Makoto Wakahara, Yasuaki Kubouchi, Yohei Yurugi, Hiroshige Nakamura, Hirooka Y, Tomohiko Sakabe, Keiko Hosoya, Yoshihisa Umekita, and Tatsushi Shiomi
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0301 basic medicine ,Adult ,Cancer Research ,Cytoplasm ,Receptor, ErbB-2 ,Breast Neoplasms ,Histone Deacetylase 1 ,Kaplan-Meier Estimate ,Biology ,Immunofluorescence ,Disease-Free Survival ,Cell Line ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Cell Line, Tumor ,medicine ,Humans ,RNA, Messenger ,skin and connective tissue diseases ,Serpins ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,Maspin ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Subcellular localization ,030104 developmental biology ,Real-time polymerase chain reaction ,Oncology ,Receptors, Estrogen ,030220 oncology & carcinogenesis ,Cancer research ,Immunohistochemistry ,Female ,Neoplasm Grading ,Receptors, Progesterone - Abstract
BACKGROUND/AIM Maspin is known to be a tumor suppressor protein. Its nuclear localization and endogenous inhibition of histone deacetylase 1 (HDAC1) are considered crucial for its tumor suppressor activity. However, it remains unclear whether subcellular localization of maspin correlates with HDAC1 expression level in human breast cancer. PATIENTS AND METHODS Immunohistochemical analyses were performed on 164 resected specimens of invasive breast carcinoma using antibodies for maspin and HDAC1. Subcellular localization of maspin protein and HDAC1 mRNA expression level in two human breast cancer cell lines (MCF7, MDA-MB-231) and mammary epithelial cell line (MCF10) were analyzed by immunofluorescence and quantitative polymerase chain reaction, respectively. RESULTS The frequency of cytoplasmic-only, pancellular (combined nuclear and cytoplasm) and no staining of maspin were 31%, 14.0% and 55%, respectively. The cytoplasmic-only subgroup showed significantly higher histological grade (p=0.004), negative progesterone receptor status (p=0.003) and shorter disease-free survival compared to the pancellular subgroup (p=0.043). High HDAC1 expression was observed in 60% of cases and was significantly correlated with cytoplasmic-only staining compared to pancellular (p
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- 2017
11. First experience of robotic extended thymectomy in Japan for myasthenia gravis with thymoma
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Yasuaki Kubouchi, Ken Miwa, Shinji Fujioka, Yuji Taniguchi, Yuzo Takagi, Tomohiro Haruki, Yohei Yurugi, and Hiroshige Nakamura
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Pulmonary and Respiratory Medicine ,Insufflation ,medicine.medical_specialty ,Supine position ,Thymoma ,medicine.medical_treatment ,Patient Positioning ,Aortopulmonary window ,Japan ,Myasthenia Gravis ,medicine ,Humans ,Neoplasms, Glandular and Epithelial ,Aged ,Thoracic Surgery, Video-Assisted ,business.industry ,Robotics ,Thymus Neoplasms ,General Medicine ,Thymectomy ,medicine.disease ,Magnetic Resonance Imaging ,Myasthenia gravis ,Cardiac surgery ,Surgery ,Treatment Outcome ,Surgery, Computer-Assisted ,Cardiothoracic surgery ,Female ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business - Abstract
We performed robot (da Vinci)-assisted thoracoscopic extended thymectomy (rThx) for myasthenia gravis with thymoma. The patient was a 66-year-old woman who complained of palpebral heaviness. Robotic operation was performed in the supine position by placing four ports in the right chest wall under 10 mmHg CO(2) insufflation using three arms and one assist port. Compared with conventional video-assisted thoracic surgery (VATS), the bilateral upper horns, fat around the diaphragm, and aortopulmonary window could be resected more easily. The tumor measured 41 mm maximum diameter and was diagnosed as type AB noninvasive thymoma. The operating time was 298 min, console operating time was 203 min, and the amount of bleeding was small. The postoperative course was uneventful with no complications. This is a report of the first Japanese case of rThx for myasthenia gravis. rThx is a promising technique, and further improvement in the procedure is expected.
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- 2012
12. P1.08-002 The Prognostic Significance of Pleural Lavage Cytology before and after Lung Resection
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Takashi Ono, Yohei Yurugi, Yoshiteru Kidokoro, Hiroshige Nakamura, Ken Miwa, Yuji Taniguchi, Makoto Wakahara, Kunio Araki, and Yasuaki Kubouchi
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Oncology ,business.industry ,Cytology ,General surgery ,Medicine ,Lung resection ,business ,Risk assessment - Published
- 2017
13. Thymic metastasis of breast cancer 22 years after surgery: A case report
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Ken Miwa, Yohei Yurugi, Hiroshige Nakamura, Shinji Fujioka, Yuji Taniguchi, Yuzo Takagi, and Kiyosuke Ishiguro
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medicine.medical_specialty ,Thymoma ,Lung ,Aromatase inhibitor ,business.industry ,medicine.drug_class ,Cancer ,Estrogen receptor ,General Medicine ,medicine.disease ,Surgery ,Metastasis ,medicine.anatomical_structure ,Breast cancer ,medicine ,Pericardium ,business - Abstract
We report a rare case of thymic metastasis of breast cancer. A 68-year-old woman, who had undergone surgery for cancer in her right breast and had been free of recurrence for 22 years, was noted to have an abnormal shadow on a chest X-ray at a regular medical checkup. Further workup, including chest CT, revealed a 22 × 18-mm mass in the anterior mediastinum. Fluorine-18-fluorodeoxyglucose-PET showed increased fluorine-18-fluorodeoxyglucose uptake that was highly suggestive of thymoma. Thoracoscopic thymothymectomy was performed. The tumor had invaded the pericardium, which was also resected. A small nodule was found in the right lung, and it was also resected. The intraoperative frozen-section diagnosis was breast cancer metastasis to the thymus and lung. The pathological diagnosis was luminal A solid tubular carcinoma (strongly estrogen receptor and progesterone receptor positive, HER2 negative) with an MIB-1 index of less than 5%. After surgery, the patient was treated with an aromatase inhibitor. As of August 2013, she has been free of recurrence for more than 36 months. It is extremely rare for breast cancer to metastasize to the thymus more than 20 years after surgery.
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- 2013
14. P1.05-058 Prognostic Factors of Post-Recurrence Survival in Resected Stage I Non-Small Cell Lung Cancer
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Yasuaki Kubouchi, Yoshiteru Kidokoro, Makoto Wakahara, Ken Miwa, Yohei Yurugi, Hiroshige Nakamura, Yuji Taniguchi, Takashi Oono, and Kunio Araki
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Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,Stage I Non-Small Cell Lung Cancer ,business.industry ,Internal medicine ,medicine ,business - Published
- 2017
15. P1.08-052 Comparison Study of Perioperative Outcomes in Robotic, Video-Assisted Thoracic Surgery, and Thoracotomy Approaches for Lung Cancer
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Yohei Yurugi, Hiroshige Nakamura, Ken Miwa, Yoshiteru Kidokoro, Makoto Wakahara, T. Haruki, Yasuaki Kubouchi, Kunio Araki, Yuji Taniguchi, and Takashi Ono
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,General surgery ,medicine.medical_treatment ,Perioperative ,Minimal invasive surgery ,medicine.disease ,Surgery ,Oncology ,Video assisted thoracic surgery ,medicine ,Comparison study ,Thoracotomy ,Lung cancer ,business - Published
- 2017
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