Back to Search
Start Over
Prognostic Significance of Solid and Micropapillary Components in Invasive Lung Adenocarcinomas Measuring ≤3 cm
- Source :
- Anticancer Research. 36:4923-4930
- Publication Year :
- 2016
- Publisher :
- Anticancer Research USA Inc., 2016.
-
Abstract
- Background/aim We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. Patients and methods A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and the European Respiratory Society classification. The presence of solid (S+) or micropapillary component (MP+) was defined when the component constituted ≥1% of the entire tumor. The impact of these components on disease-free (DFS) and disease-specific (DSS) survival was analyzed. Results Thirty (26.1%) cases with S+ and 27 (23.5%) with MP+ were identified, and multivariate analysis indicated that S+ status significantly reduced the duration of DFS and DSS. In 86 patients of acinar- and papillary-predominant subgroups, S+ and/or MP+ had the most significant effect on DFS and DSS by multivariate analysis. Conclusion S+ and/or MP+ status predict worse prognosis in patients with acinar- and papillary-predominant lung adenocarcinoma.
- Subjects :
- Adult
Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
Pathology
Lung Neoplasms
Multivariate analysis
Adenocarcinoma of Lung
Kaplan-Meier Estimate
Adenocarcinoma
Gastroenterology
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Neoplasm Invasiveness
In patient
Lung cancer
Aged
Neoplasm Staging
Lung
business.industry
General Medicine
Middle Aged
Prognosis
medicine.disease
Adenocarcinoma, Papillary
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Female
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 02507005
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....31262cec344b4969ccdeab3ca10b17b5