36 results on '"Yeo-Joo Kim"'
Search Results
2. Comparison of the Efficacy and Safety of Insulin Detemir Administered Once Daily According to Two Titration Algorithms (3-0-3 and 2-4-6-8) in Patients with Type 2 Diabetes Mellitus
- Author
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Keun Yong Park, Yeo Joo Kim, Jun Hwa Hong, Jongmin Lee, Hea Min Yu, Kang Seo Park, Bon Jeong Ku, and Tae Kun Oh
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Adult ,Blood Glucose ,Male ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Drug Administration Schedule ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin Detemir ,Diabetes mellitus ,medicine ,Clinical endpoint ,Insulin ,Humans ,Hypoglycemic Agents ,In patient ,Insulin detemir ,Aged ,Glycated Hemoglobin ,lcsh:RC648-665 ,Dose-Response Relationship, Drug ,business.industry ,Type 2 Diabetes Mellitus ,nutritional and metabolic diseases ,Diabetes mellitus, type 2 ,Middle Aged ,medicine.disease ,Prognosis ,Metformin ,030220 oncology & carcinogenesis ,Hyperglycemia ,Clinical Study ,Original Article ,Female ,Once daily ,business ,Algorithm ,Algorithms ,Biomarkers ,medicine.drug ,Follow-Up Studies - Abstract
Background This study was conducted to compare glycaemic control with insulin detemir administered according to two titration algorithms (3-0-3 and 2-4-6-8) after 20 weeks of treatment in subjects with type 2 diabetes mellitus inadequately controlled on metformin. Methods This was a 20-week, randomised, multicentre, open-labelled, treat-to-target trial. Forty-six patients were randomised in a 1:1 manner to either the 3-0-3 (G3, n=23) or 2-4-6-8 (G2, n=23) algorithm. The primary endpoint was change of haemoglobin A1c (HbA1c), and the secondary safety endpoint included hypoglycaemic events. Results After 20 weeks, HbA1c decreased similarly in the G3 and G2 groups, with a mean change of -0.9% from baseline. The mean change in fasting plasma glucose was numerically similar in both groups. The hypoglycaemia event rate per 100-patient-years of exposure (r) in the G2 group (r=1,427) was higher than that in the G3 group (r=807). Conclusion Both treatment groups had numerically similar HbA1c reductions. A trend towards fewer hypoglycaemia episodes after dose stabilisation was seen with the simpler G3. Clinically, this may be an important observation, as a simpler titration algorithm may support self-management and maintenance of insulin therapy.
- Published
- 2020
3. Adefovir-induced Fanconi syndrome associated with osteomalacia
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Woo Il Kim, Seung Kuy Cha, Kyu Sang Park, Sang Mi Lee, Ji Hee Kim, Samel Park, Eun Young Lee, Dai Hyun Cho, Yeo Joo Kim, Ji Hye Lee, and Hong Soo Kim
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Adult ,Fibroblast growth factor 23 ,Glycosuria ,medicine.medical_specialty ,Hypophosphatemia ,Organophosphonates ,030209 endocrinology & metabolism ,Adefovir ,urologic and male genital diseases ,Gastroenterology ,Bone and Bones ,Kidney Tubules, Proximal ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,lcsh:RC799-869 ,Molecular Biology ,Osteomalacia ,Proteinuria ,Hepatology ,Reabsorption ,business.industry ,Adenine ,Fanconi syndrome ,Proximal tubules ,Hepatitis B ,medicine.disease ,Mitochondria ,Fibroblast Growth Factors ,Fibroblast Growth Factor-23 ,Endocrinology ,Female ,lcsh:Diseases of the digestive system. Gastroenterology ,medicine.symptom ,business ,medicine.drug - Abstract
Fanconi syndrome is a dysfunction of the proximal renal tubules that results in impaired reabsorption and increased urinary loss of phosphate and other solutes. The pathophysiology of drug-induced Fanconi syndrome is unclear. Here we report the case of a 36-year-old woman who presented with pain in multiple bones and proteinuria. She had a 7-year history of taking adefovir at 10 mg/day for chronic hepatitis B. Three years previously she had received surgery for a nontraumatic right femur neck fracture, after which she continued to complain of pain in multiple bones, and proteinuria, glycosuria, and phosphaturia were noted. The findings of a light-microscope examination of a renal biopsy sample were normal, but mitochondrial damage of the proximal tubules was evident in electron microscopy. Western blot analysis revealed that the level of serum fibroblast growth factor 23 (FGF23) was lower than in normal controls. After 2 months of treatment, hypophosphatemia and proximal tubular dysfunction were reversed, and serum FGF23 had normalized. This case suggests that direct mitochondrial damage in proximal tubules can cause drug-induced Fanconi syndrome associated with osteomalacia.
- Published
- 2018
4. Globular adiponectin acts as a melanogenic signal in human epidermal melanocytes
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Yeo Joo Kim, Mingyeong Kang, Sae Woong Oh, Seonhee Lee, E. Jung, Yong Seek Park, Juhee Cho, and Jueun Lee
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0301 basic medicine ,MAPK/ERK pathway ,endocrine system ,Skin Pigmentation ,Dermatology ,Melanocyte ,CREB ,Cell Line ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Protein Domains ,Downregulation and upregulation ,medicine ,Humans ,Cyclic adenosine monophosphate ,Protein kinase A ,Enzyme Assays ,Melanins ,Microphthalmia-Associated Transcription Factor ,integumentary system ,biology ,Monophenol Monooxygenase ,nutritional and metabolic diseases ,Microphthalmia-associated transcription factor ,Up-Regulation ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,Adipose Tissue ,Epidermal Cells ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,Melanocytes ,Phosphorylation ,Adiponectin ,Epidermis ,Signal Transduction - Abstract
Background Adiponectin is an adipocyte-derived cytokine that circulates as a full-length protein and a fragment containing the globular domain of adiponectin (gAd). A recent study has reported the antimelanogenic effects of full-length adiponectin. Objectives To examine the involvement of gAd in melanogenesis and its mechanisms of action. Methods The effects of gAd on melanogenesis and its mechanisms of action were investigated in human epidermal melanocytes and reconstructed epidermis, including melanin content, cellular tyrosinase activity, cyclic adenosine monophosphate (cAMP) production and protein kinase A (PKA) activity, expression and phosphorylation of signalling molecules. Results Exogenous gAd increased melanin content, and the mRNA levels of microphthalmia-associated transcription factor (MITF) and its downstream genes TRP1, but not TRP2, were increased by gAd. However, cAMP production and PKA activity were not affected by gAd. Moreover, attempts to elucidate the underlying mechanism behind the gAd-mediated effect revealed that gAd could regulate melanogenesis by upregulating MITF through phosphorylation of the cAMP response element-binding protein (CREB). In addition, upregulation of MITF was mediated by activation of adenosine monophosphate-activated protein kinase (AMPK)-p38 mitogen-activated protein kinase (MAPK) signalling. Taken together, these findings indicate that promotion of melanogenesis by gAd occurs through increased expression of MITF, which is mediated by activation of the AMPK-p38 MAPK-CREB pathway. Conclusions These findings suggest that gAd contributes to epidermal homeostasis via its effect on melanocyte biology, and products of adipose tissue could affect epidermal biology.
- Published
- 2018
5. Preoperative serum thyroglobulin and changes in serum thyroglobulin during TSH suppression independently predict follicular thyroid carcinoma in thyroid nodules with a cytological diagnosis of follicular lesion
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Yeo Joo Kim, Dong Won Byun, Hyeong Kyu Park, Sang Jin Kim, Hye Jeong Kim, Kyoil Suh, Ji-Oh Mok, Chul Hee Kim, and Myung Hi Yoo
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Adult ,Male ,Thyroid nodules ,endocrine system ,Pathology ,medicine.medical_specialty ,endocrine system diseases ,Adenoma ,medicine.medical_treatment ,Levothyroxine ,Thyrotropin ,030209 endocrinology & metabolism ,Malignancy ,Thyroglobulin ,Thyroid carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Adenocarcinoma, Follicular ,Follicular phase ,Biomarkers, Tumor ,medicine ,Humans ,Thyroid Neoplasms ,Thyroid Nodule ,Aged ,Retrospective Studies ,business.industry ,Thyroid ,General Medicine ,Middle Aged ,medicine.disease ,Thyroxine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Preoperative Period ,Female ,business ,medicine.drug - Abstract
Fine-needle aspiration biopsy (FNAB) cannot distinguish a follicular thyroid carcinoma (FTC) from a follicular adenoma in follicular lesions. We designed this study to determine whether the preoperative thyroglobulin (Tg) and change in serum Tg during thyroid-stimulating hormone (TSH) suppression can predict FTC in thyroid nodules with a cytological diagnosis of follicular lesion.Among 854 patients who underwent thyroid surgery, the 198 patients who presented with thyroid nodules with a cytological diagnosis of follicular lesion were analyzed. Predictive factors for malignancy were evaluated using multivariate logistic regression models. Subgroup analyses of patients with TSH suppression therapy by levothyroxine were also conducted.Thirty-two patients (16%) had FTC, and 166 patients had confirmed benign nodules. The median preoperative serum Tg levels were significantly higher in patients with FTC compared to those with benign pathology (449 vs. 34 ng/mL, p0.001). The serum Tg (odds ratios (OR) 10.311, p0.001) and tumor volume (OR 4.500, p = 0.035) were found to be independent predictors for FTC in all patients with a cytological diagnosis of follicular lesion. Forty-eight patients received TSH suppression therapy. When we performed subgroup analyses on the patients with TSH suppression therapy, decrease less than 15% in serum Tg during TSH suppression was found to be an independent predictor of FTC (OR 13.918, p = 0.018).Preoperative serum Tg and changes in serum Tg during TSH suppression independently predict FTC in thyroid nodules with a cytological diagnosis of follicular lesion.
- Published
- 2016
6. The Usefulness of the Glycosylated Hemoglobin Level for the Diagnosis of Gestational Diabetes Mellitus in the Korean Population
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Joo Ok Na, Yeo Joo Kim, Ah Jeong Ryu, Hyuk Jin Moon, Sang Jin Kim, Sang Il Mo, and Jeong Ran Byun
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medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Diabetes mellitus ,Internal medicine ,Hemoglobin A, glycosylated ,Diagnosis ,Medicine ,Oral glucose tolerance ,lcsh:RC648-665 ,business.industry ,Korean population ,Obstetrics ,Diabetes, gestational ,nutritional and metabolic diseases ,medicine.disease ,female genital diseases and pregnancy complications ,Obesity and Metabolic Syndrome ,carbohydrates (lipids) ,Gestational diabetes ,Blood draw ,Endocrinology ,Original Article ,Hemoglobin ,business - Abstract
Background An oral glucose tolerance test (OGTT) is the current method used for screening and diagnosis of gestational diabetes mellitus (GDM). OGTT is a relatively complicated procedure and is expensive. Thus, new strategies that do not require fasting or more than a single blood draw may improve the diagnosis of GDM and increase the rate of GDM testing. We investigated the utility of monitoring glycosylated hemoglobin (HbA1c) levels for the diagnosis of GDM. Methods The data from 992 pregnant women with estimated gestational ages ranging from 24 to 28 weeks were retrospectively reviewed. There were 367 women with plasma glucose levels ≥140 mg/dL 1 hour after a 50-g OGTT. GDM was diagnosed according to the Carpenter-Coustan criteria for a 3-hour 100 g OGTT. A HbA1c assessment was performed at the same time. Results We enrolled 343 women in this study, and there were 109 women with GDM. The area under the curve the receiver operating characteristic curve for HbA1c detection of GDM was 0.852 (95% confidence interval, 0.808 to 0.897). A HbA1c cutoff value ≥5.35% had maximal points on the Youden index (0.581). The sensitivity was 87.2% and the specificity was 70.9% for diagnosing GDM. A threshold value ≥5.35% indicated that 163 patients had GDM and that 68 (41.7%) were false positive. The positive predictive value was 58.3% at this threshold value. Conclusion Despite substantial progress in methodology, HbA1c values cannot replace OGTT for the diagnosis of GDM.
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- 2015
7. Retroperitoneal Bronchogenic Cyst Presenting Paraadrenal Tumor Incidentally Detected by 18F-FDG PET/CT
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Sang Mi Lee, Youn Soo Jeon, Yeo Joo Kim, Hyun Deuk Cho, Jiyoun Choi, Ye Ri Yoon, and Jeong Won Lee
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medicine.medical_specialty ,business.industry ,Bronchogenic cyst ,Soft tissue ,Case Report ,medicine.disease ,Asymptomatic ,Precontrast ,Hounsfield scale ,medicine ,Radiology, Nuclear Medicine and imaging ,Fdg pet ct ,Radiology ,Differential diagnosis ,medicine.symptom ,business ,Thyroid cancer - Abstract
A follow-up (18)F-fluorodeoxyglucose ((18)F-FDG) PET/CT scan of a 57-year-old asymptomatic male who had undergone total thyroidectomy for thyroid cancer revealed a 5.0 × 4.0-cm, well-defined, ovoid-shaped mass around the left adrenal gland without definite FDG uptake. On the adrenal CT scan, the left paraadrenal tumor showed high attenuation on the precontrast scan without enhancement. The average Hounsfield unit (HU) was 58.1 on the precontrast scan and 58.4 on the postcontrast scan. The patient underwent laparoscopic adrenalectomy for resection of the left paraadrenal tumor. The final histopathologic examination revealed a bronchogenic cyst. Although retroperitoneal bronchogenic cysts are rare, they should be considered in the differential diagnosis of retroperitoneal cystic tumors. The preoperative diagnosis is difficult, but a contrast-enhanced CT scan or (18)F-FDG PET/CT scan may be useful for differentiating hyperattenuated cysts from other soft tissue masses.
- Published
- 2014
8. Airway Compression Caused by Bilateral Thyroid Hematoma after Fine-Needle Aspiration
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Hee Soon Park, Nam-Jun Cho, Mi Hae Seo, Sang Jin Kim, Dong-Jae Han, Yeo Joo Kim, and Ju Young Lee
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medicine.medical_specialty ,Fine-needle aspiration ,Hematoma ,medicine.anatomical_structure ,medicine.diagnostic_test ,business.industry ,Airway compression ,Thyroid ,medicine ,Radiology ,business ,medicine.disease ,Fine needle biopsy - Published
- 2013
9. Endoscopic submucosal dissection with sentinel node navigation surgery for early gastric cancer
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Yeo Joo Kim, Chang Gyun Chun, Gene Hyun Bok, Joo Young Cho, Seong Ran Jeon, So-Young Jin, Hyun Gun Kim, and Tae Hoon Lee
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medicine.medical_specialty ,Frozen section procedure ,business.industry ,medicine.medical_treatment ,Gastroenterology ,Endoscopic submucosal dissection ,Sentinel node ,medicine.disease ,Surgery ,Metastasis ,Early Gastric Cancer ,Dissection ,chemistry.chemical_compound ,chemistry ,Medicine ,Gastrectomy ,business ,Indocyanine green - Abstract
We combined endoscopic submucosal dissection (ESD) and sentinel node navigation surgery with the purpose of achieving complete resection of early gastric cancer while preserving the organ and assessing pathological nodal status. A total of 13 patients with cT1( ≤ 3 cm)N0 early gastric cancer underwent combined ESD and sentinel node navigation surgery (ESN) at a single tertiary referral center. Sentinel node navigation surgery using indocyanine green was performed during ESD and all suspected sentinel nodes were removed laparoscopically and examined intraoperatively. ESN was converted to gastrectomy with D2 dissection if there was evidence of metastasis on frozen section. ESN was completed in 12 patients and in 1 patient was converted to gastrectomy after sentinel node navigation surgery. En bloc tumor resection was achieved in all cases. Two patients underwent additional gastrectomy because they had tumor-positive vertical margins. In all cases ESN was conducted without intraoperative or postoperative adverse events. ESN is a feasible minimally invasive procedure that allows en bloc tumor resection to be achieved while assessing the pathological status of the lymph nodes.
- Published
- 2012
10. MRI Features of Skeletal Muscle Lymphoma
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Won-Hee Jee, Jeong-Mi Park, Yeo Joo Kim, Sang Hoon Lee, Chang Woo Chun, Hye Jung Park, and Sung-Hwan Park
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Adult ,Gadolinium DTPA ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Lymphoma ,Contrast Media ,Muscle mass ,Metastasis ,Diagnosis, Differential ,Normal muscle ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Child ,Muscle, Skeletal ,Aged ,Retrospective Studies ,Aged, 80 and over ,Muscle Neoplasms ,MUSCLE ENLARGEMENT ,business.industry ,Cancer ,Skeletal muscle ,Intermediate signal intensity ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Child, Preschool ,Female ,business - Abstract
The purpose of this study was to assess the MRI findings of skeletal muscle lymphoma.MR images of pathologically proven lymphoma of skeletal muscle in 20 patients were retrospectively reviewed for the presence or absence of individual imaging findings. Nine patients had primary muscle lymphoma, and 11 patients had muscle metastasis from systemic lymphoma.The initial manifestation of skeletal muscle lymphoma was a muscle mass in 15 patients (75%) and abnormal muscle signal intensity in five patients (25%). Muscle enlargement was found in all cases. Long segmental involvement with orientation of the tumor along muscle fascicles was found in 15 patients (75%). Seventeen patients (85%) had traversing vessels within involved muscles. All of the tumors had equal to slightly increased signal intensity compared with normal muscle on T1-weighted images and intermediate signal intensity compared with fat on T2-weighted images. Among the 19 patients who underwent contrast-enhanced imaging, skeletal muscle lymphoma exhibited diffuse homogeneous enhancement in 13 patients (68%), predominantly peripheral thick bandlike enhancement in four patients (21%), and marginal septal enhancement in two patients (11%). Thick irregular enhancement of both deep and superficial fascia was found in 16 patients (84%), and one patient (5%) had deep enhancement only. Subcutaneous stranding was found in 16 patients (80%) and skin thickening in four patients (20%).Skeletal muscle lymphoma has distinctive MRI features that help differentiate it from other soft-tissue tumors and tumorlike lesions.
- Published
- 2010
11. A Case of Isolated Thyroid Stimilating Hormone Deficiency
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Yeo Joo Kim, Hyun Wook Cho, and Sang Jin Kim
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endocrine system ,medicine.medical_specialty ,endocrine system diseases ,medicine.diagnostic_test ,business.industry ,Thyroid ,Magnetic resonance imaging ,Stimulation ,Prolactin ,medicine.anatomical_structure ,Endocrinology ,Thyroid-stimulating hormone ,Serum free ,Internal medicine ,Pituitary hormones ,medicine ,business ,hormones, hormone substitutes, and hormone antagonists ,Hormone - Abstract
Isolated thyroid stimulating hormone (TSH) deficiency is very rare. Only a few patients are reported in the world. A 50-year-old woman was admitted to Soonchunhyang University Cheonan Hospital because of a distal radius fracture. She was diagnosed with hypothyroidism incidentally. Serum free T4 and TSH were low. After administration of exogenous TSH releasing hormone, no TSH response was noted. The response of prolactin and other pituitary hormones were appropriate after stimulation. Pituitary magnetic resonance image did not reveal any abnormalities. The diagnosis of isolated TSH deficiency was established for this patient.
- Published
- 2012
12. Successful Pregnancy and Childbirth in a Patient with Diabetic Kidney Disease Receiving Hemodialysis
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Yun Sook Kim, Yeo-Joo Kim, Young Il Kim, Jeoung Hoon Kim, Eun Young Lee, and Hee Jae Jung
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Pregnancy ,Pediatrics ,medicine.medical_specialty ,Anemia ,business.industry ,medicine.medical_treatment ,Disease ,medicine.disease ,Low birth weight ,Diabetes mellitus ,medicine ,Childbirth ,Hemodialysis ,medicine.symptom ,business ,Kidney disease - Abstract
Pregnancy outcomes for women uncontrolled diabetes mellitus are poor. Women with chronic kidney disease and end-stage renal disease, if pregnant, will develop pregnancy-related complications. In the case of severe renal failure and diabetes mellitus, the incidence of prematurity, low birth weight, and neonatal death increases. Despite these risks, there have been few reported cases of successful pregnancy outcomes for these women. Adherence to a schedule of strict glucose monitoring, blood pressure and volume control, correction of anemia, and intensive hemodialysis may play important roles in the management of these women. Successful pregnancy and childbirth in a patient with diabetic kidney disease receiving hemodialysis have not been previously reported in Korea, to our knowledge. Herein, we report a case of a successful pregnancy outcome in a patient with diabetic end-stage renal disease undergoing hemodialysis.
- Published
- 2012
13. Immunohistochemical Expression of COX-2 in Thyroid Nodules
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Yeo Joo Kim, Kyo Il Suh, Ji Sung Yoon, Ji O Mok, Sang Jin Kim, Myung Hi Yoo, Hyeong Kyu Park, Dongwon Byun, Jae-Hak Lee, and Chul Hee Kim
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Thyroid nodules ,Pathology ,medicine.medical_specialty ,endocrine system ,endocrine system diseases ,medicine.disease_cause ,Malignancy ,Thyroiditis ,medicine ,Biomarkers, Tumor ,Humans ,Anaplastic carcinoma ,Thyroid Nodule ,business.industry ,Thyroid ,Membrane Proteins ,Hyperplasia ,COX-2 ,medicine.disease ,Immunohistochemistry ,Isoenzymes ,medicine.anatomical_structure ,Cyclooxygenase 2 ,Prostaglandin-Endoperoxide Synthases ,Original Article ,Carcinogenesis ,business - Abstract
Background: Recent evidence indicates that elevated COX-2 expression is associated with the carcinogenesis of numerous neoplasms. In this study, we investigated COX-2 expression in various thyroid specimens in order to elucidate its physiological role in pathologic conditions, and to evaluate the efficiency of COX-2 protein expression as a molecular marker of malignancy in the thyroid gland. Methods: COX-2 expression was studied immunohistochemically in 19 papillary carcinomas, 8 follicular carcinomas, 14 follicular adenomas, 2 Hurthle cell carcinomas, 4 Hurthle cell adenomas, 8 nodular hyperplasias, 3 Graves' diseases, 3 Hashimoto's thyroiditis, 2 medullary carcinomas, 1 anaplastic carcinoma, and 20 normal thyroid tissues. Results: COX-2 staining was not seen in any of the normal thyroid, Graves' disease, or nodular hyperplasia specimens. In contrast, COX-2 staining was observed in all of papillary carcinomas, Hashimoto's thyroiditis, Hurthle cell carcinomas, and Hurthle cell adenomas tissues. Moreover, 7 of 8 follicular carcinomas and 11 of 14 follicular adenomas showed COX-2 staining. Conclusion: These results indicate that COX-2 is not useful as a marker of malignancy. Since COX-2 expression was evident in follicular adenomas and in papillary and follicular carcinomas. Thus, the enzyme may be involved in the early process of thyroid tumorigenesis.
- Published
- 2003
14. Aldosterone-Producing Adrenocortical Carcinoma without Hypertension
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Sung Woo Seo, Sang Byung Bae, Sang Jin Kim, Yeo Joo Kim, and Min Soo Song
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Adult ,Pathology ,medicine.medical_specialty ,Biopsy ,Case Report ,chemistry.chemical_compound ,Hyperaldosteronism ,medicine ,Carcinoma ,Adrenocortical Carcinoma ,Adrenocortical carcinoma ,Humans ,Aldosterone ,business.industry ,Adrenalectomy ,medicine.disease ,Adrenal Cortex Neoplasms ,Treatment Outcome ,chemistry ,Hypertension ,Female ,business ,Tomography, X-Ray Computed - Abstract
Although adrenocortical tumors are common, adrenocortical carcinomas are rare. Moreover, aldosterone-producing adrenocortical carcinomas without hypertension are exceedingly rare, with only two previously reported cases.
- Published
- 2012
15. Efficacy of two different self-expanding nitinol stents for atherosclerotic femoropopliteal arterial disease (SENS-FP trial): study protocol for a randomized controlled trial
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Jung Min Bong, Jon Suh, Seung J. Lee, Yeo Joo Kim, Sung Ho Her, Woong Gil Choi, Jae Bin Seo, Sang-Ho Park, Sang Min Kim, Yong Hoon Kim, Yun Hyeong Cho, Woo-Young Chung, Joo Han Kim, Eung Ju Kim, Won Yu Kang, Dong Joo Oh, Mahn Won Park, Hwan Jun Choi, Ki Chang Kim, Cheol Ung Choi, Won Ho Kim, Seung-Hyuk Choi, Min Woong Kim, Sens-Fp Investigators, Jang Hyun Cho, Jang Ho Bae, Seung-Woon Rha, Jae Wan Soh, and Ju Yeol Baek
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Bare-metal stent ,medicine.medical_specialty ,Ticlopidine ,Time Factors ,medicine.medical_treatment ,Tetrazoles ,Medicine (miscellaneous) ,Prosthesis Design ,law.invention ,Study Protocol ,Peripheral Arterial Disease ,Clinical Protocols ,Randomized controlled trial ,law ,Angioplasty ,Internal medicine ,Alloys ,medicine ,Humans ,Popliteal Artery ,Pharmacology (medical) ,Prospective Studies ,cardiovascular diseases ,Vascular Patency ,Aspirin ,business.industry ,Stent ,equipment and supplies ,Clopidogrel ,Cilostazol ,Prosthesis Failure ,Surgery ,Femoral Artery ,Treatment Outcome ,Research Design ,Cardiology ,Platelet aggregation inhibitor ,Drug Therapy, Combination ,Stents ,business ,Angioplasty, Balloon ,Platelet Aggregation Inhibitors ,medicine.drug - Abstract
Background There have been few randomized control trials comparing the incidence of stent fracture and primary patency among different self-expanding nitinol stents to date. The SMART™ CONTROL stent (Cordis Corp, Miami Lakes, Florida, United States) has a peak-to-valley bridge and inline interconnection, whereas the COMPLETE™-SE stent (Medtronic Vascular, Santa Rosa, California, United States) crowns have been configured to minimize crown-to-crown interaction, increasing the stent's flexibility without compromising radial strength. Further, the 2011 ESC (European society of cardiology) guidelines recommend that dual antiplatelet therapy with aspirin and a thienopyridine such as clopidogrel should be administered for at least one month after infrainguinal bare metal stent implantation. Cilostazol has been reported to reduce intimal hyperplasia and subsequent repeat revascularization. To date, there has been no randomized study comparing the safety and efficacy of two different antiplatelet regimens, clopidogrel and cilostazol, following successful femoropopliteal stenting. Methods/Design The primary purpose of our study is to examine the incidence of stent fracture and primary patency between two different major representative self-expanding nitinol stents (SMART™ CONTROL versus COMPLETE™-SE) in stenotic or occlusive femoropopliteal arterial lesion. The secondary purpose is to examine whether there is any difference in efficacy and safety between aspirin plus clopidogrel versus aspirin plus cilostazol for one month following stent implantation in femoropopliteal lesions. This is a prospective, randomized, multicenter trial to assess the efficacy of the COMPLETE™-SE versus SMART™ CONTROL stent for provisional stenting after balloon angioplasty in femoropopliteal arterial lesions. The study design is a 2x2 randomization design and a total of 346 patients will be enrolled. The primary endpoint of this study is the rate of binary restenosis in the treated segment at 12 months after intervention as determined by catheter angiography or duplex ultrasound. Discussion This trial will provide powerful insight into whether the design of the COMPLETE™-SE stent is more fracture-resistant or effective in preventing restenosis compared with the SMART™ CONTROL stent. Also, it will determine the efficacy and safety of aspirin plus clopidogrel versus aspirin plus cilostazol in patients undergoing stent implantation in femoropopliteal lesions. Trial registration Registered on 2 April 2012 with the National Institutes of Health Clinical Trials Registry (ClinicalTrials.gov identifier# NCT01570803).
- Published
- 2014
16. Thyroid Associated Ophthalomopathy in a Patient with Hashimoto's Thyroiditis
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Yeo-Joo Kim, Suk-Hoe Kweon, Ho-Jun Lee, and Ah-Jeong Ryu
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medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Internal medicine ,Thyroid ,medicine ,medicine.disease ,business ,Gastroenterology ,Thyroiditis - Published
- 2016
17. DNA methylation of RUNX3 in papillary thyroid cancer
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Hee Ja Ko, Kyo Suh, Chan-Hee Jung, Yeo Joo Kim, Chul Hee Kim, Sung Gu Kang, Sang Jin Kim, Bo-Yeon Kim, Dong Won Byun, Hyeong Kyu Park, Myung Hi Yoo, Sung Wan Chun, and Ji Oh Mok
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endocrine system ,endocrine system diseases ,RUNX3 ,Gene Expression ,Decitabine ,Methylation ,Papillary thyroid cancer ,Cell Line, Tumor ,Gene expression ,medicine ,Carcinoma ,Biomarkers, Tumor ,Humans ,Thyroid Neoplasms ,Transcription factor ,business.industry ,Thyroid ,DNA Methylation ,medicine.disease ,digestive system diseases ,Carcinoma, Papillary ,medicine.anatomical_structure ,Core Binding Factor Alpha 3 Subunit ,Editorial ,Thyroid Cancer, Papillary ,DNA methylation ,Cancer research ,Azacitidine ,Original Article ,PAX8 ,business - Abstract
Background/Aims The relationship between Runt-related transcription factor 3 (RUNX3) gene inactivation and various solid tumors has been reported; however, little information is available about RUNX3 in thyroid cancers. Methods We evaluated the DNA methylation of RUNX3 in 13 papillary thyroid cancer tissues and four thyroid cancer cell lines. Additionally, using reverse transcriptase-polymerase chain reaction, we analyzed RUNX3 gene expression in several thyroid cancer cell lines after treating with the demethylating agent 5-aza-2'-deoxycytidine (DAC). Results RUNX3 was hypermethylated in many thyroid cancer cell lines and in 10 of the 12 papillary thyroid cancer tissues. Treatment with DAC increased the expression of RUNX3 in some thyroid cancer cell lines. Conclusions We suggest that RUNX3 is associated with thyroid carcinogenesis, and RUNX3 methylation is a potentially useful diagnostic marker for papillary thyroid cancer.
- Published
- 2011
18. The Effect of Vildagliptin on Visfatin in Korean Patients with Type 2 Diabetes: A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Prospective Study
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Kang Seo Park, Dong Mee Lim, Hyun-Jin Kim, Hyuk Jin Moon, Eun Young Lee, Gyu Tae Yoon, Yeo Joo Kim, Jae Kook Yang, Ah Jeong Ryu, Young Hwan Jang, Sang Jin Kim, Dong Hyun In, Jong Min Lee, In Suk Lee, Bon Jeong Ku, Keun Yong Park, and Jae Min Lee
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medicine.medical_specialty ,endocrine system diseases ,business.industry ,nutritional and metabolic diseases ,Adipokine ,Type 2 diabetes ,medicine.disease ,Placebo ,Gastroenterology ,Metformin ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Diabetes mellitus ,Internal medicine ,medicine ,Vildagliptin ,Glycated hemoglobin ,Prospective cohort study ,business ,medicine.drug - Abstract
Background: The effects of dipeptidyl peptidase-4 inhibitors on adipokines remain obscure. The aim of this study was to evaluate the effect of the addition of vildagliptin on visfatin, an adipokine that represents inflammatory biomarkers of adipose tissue, in patients with type 2 diabetes inadequately controlled with prior metformin monotherapy. Methods: In this 16-week, double-blind, randomized, parallel-group, placebo-controlled study, 71 patients were randomly assigned to vildagliptin 50 mg twice a day (n = 35) or placebo (n = 36) added to ongoing metformin therapy. Fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), plasma lipids
- Published
- 2015
19. The High Proportion of Painless Thyroiditis as a Cause of Thyrotoxicosis in Korea
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Sang Jin Kim, Yeo Joo Kim, Sang Il Mo, and A Jeong Ryu
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medicine.medical_specialty ,Pediatrics ,Endocrinology ,business.industry ,Graves' disease ,Internal medicine ,Thyroid scan ,medicine ,medicine.disease ,business ,Thyroiditis - Published
- 2015
20. Survey of Depression in the Elderly Patients with Diabetes Mellitus
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Sang-Ho Park, Seon Cheol Park, Young Jun Kwon, Jae Sung Choi, Yeo Joo Kim, Bum Sung Choi, Ho Sung Lee, Sung Hae Chang, Sewoong Kim, Hoo Rim Song, Se Hoon Shim, and Hwa Young Lee
- Subjects
medicine.medical_specialty ,business.industry ,Mental hospital ,University hospital ,medicine.disease ,Mental health ,humanities ,Pulmonology ,Internal medicine ,Diabetes mellitus ,Family medicine ,Medicine ,business ,Depression (differential diagnoses) - Abstract
1 Department of Psychiatry, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea Department of Psychiatry, Mindlle Hospital, Paju, Korea Department of Psychiatry, Yong-In Mental Hospital, Yongin, Korea Institute of Mental Health, Hanyang University, Seoul, Korea 5 Departments of Psychiatry, Rheumatology, Pulmonology, Endocrinology, Cardiology, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan, Korea
- Published
- 2015
21. Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study
- Author
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Yeo Joo Kim, Ji Sung Yoon, Sang Jin Kim, So Young Jin, Myung Hi Yoo, Chul Hee Kim, Yong-Jin Lee, Dong Won Byun, Hyeong Kyu Park, Jin Woo Park, Ji O Mok, and Kyo Il Suh
- Subjects
Adenoma ,Adult ,Male ,Pathology ,medicine.medical_specialty ,endocrine system ,Biology ,medicine.disease_cause ,Focal adhesion ,Protein-Tyrosine Kinase ,medicine ,Carcinoma ,Biomarkers, Tumor ,Humans ,Thyroid Neoplasms ,Thyroid Nodule ,Thyroid cancer ,Aged ,Focal Adhesions ,Thyroid ,General Medicine ,Hyperplasia ,Middle Aged ,Protein-Tyrosine Kinases ,medicine.disease ,Immunohistochemistry ,Carcinoma, Papillary ,Focal Adhesion Kinase ,medicine.anatomical_structure ,Focal Adhesion Kinase 1 ,Focal Adhesion Protein-Tyrosine Kinases ,Cancer research ,Female ,Original Article ,biological phenomena, cell phenomena, and immunity ,Carcinogenesis - Abstract
Focal adhesion kinase (FAK) is a tyrosine kinase that is found in cellular structures called focal adhesions. FAK appears to be a key element in signal transduction pathways involved in cell adhesion and locomotion. FAK is overexpressed in various tumors, including tumors derived from regions of the head and neck, colon, breast, prostate, and liver. In this study, we investigated immunohistochemically whether FAK expression was increased in thyroid cancers. FAK staining was not seen in any of the 20 normal thyroid tissues or the 6 nodular hyperplasia specimens. In contrast, FAK staining was observed in all of 17 papillary carcinomas, 9 follicular carcinomas, 8 medullary carcinomas, and 2 anaplastic carcinomas. Nine of 17 follicular adenomas showed FAK immunoreactivity. FAK was not expressed in normal tissue and nodular hyperplasia, but was expressed in some of the follicular adenoma, and all of the follicular, papillary, medullary and anaplastic thyroid carcinoma. This result indicates that the up-regulation of FAK may play a role in the development of thyroid carcinogenesis.
- Published
- 2004
22. Actinomyces-like organisms in cervical smears: the association with intrauterine device and pelvic inflammatory diseases
- Author
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Jee Hyun Kim, Yeo Joo Kim, Jina Youm, and Byung Chul Jee
- Subjects
Pathology ,medicine.medical_specialty ,biology ,business.industry ,Obstetrics ,Incidence (epidemiology) ,Actinomyces-like organism ,Obstetrics and Gynecology ,Intrauterine device ,biology.organism_classification ,Cervical smears ,Obstetrics and gynaecology ,Intrauterine devices ,Pelvic inflammatory disease ,medicine ,Original Article ,General Gynecology ,Vaginal smears ,business ,Actinomyces - Abstract
Objective To investigate the incidence of actinomyces-like organisms in routine cervical smears of Korean women and to evaluate its association with the development of pelvic inflammatory disease (PID) in these women. Methods The results of cervical smears between 2011 and 2012 at a single university hospital were searched. If positive for actinomyces-like organisms, the medical record of the patient was searched and development of PID was followed. If the data were not available in the medical record, the patient was contacted by telephone. Results The incidence of actinomyces-like organisms in cervical smears was 0.26% (52/20,390). Forty-two women (80.8%) were intrauterine device (IUD) users: the copper-IUD in 25 women and the levonorgestrel-releasing intrauterine system in 13 women (type unknown in 4 women). The majority (71.4%, 30/42) of the IUD users maintained the IUD. Prophylactic antibiotics were prescribed to 12 women. Two continuous IUD users were later diagnosed with PID, but these cases were not pelvic actinomycosis. Conclusion It would be a reasonable option to choose the expectant management for asymptomatic women who incidentally showed actinomyces-like organisms in their cervical smear.
- Published
- 2014
23. Survey of Depression in the Elderly Patients with Chronic Obstructive Pulmonary Disease
- Author
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Hee-Yeun Jeong, Ho Sung Lee, Hwa Young Lee, Jae Sung Choi, Young-Jun Kwon, Seung-Hwan Sung, Se-Hoon Shim, Sang-Ho Park, and Yeo-Joo Kim
- Subjects
COPD ,medicine.medical_specialty ,business.industry ,Hamilton Rating Scale for Depression ,Pulmonary disease ,medicine.disease ,behavioral disciplines and activities ,Obstructive lung disease ,Psychiatric history ,mental disorders ,Physical therapy ,Medicine ,business ,Physical illness ,Depression (differential diagnoses) ,Korean version - Abstract
MethodsZZThe eighty-seven patients with COPD were enrolled. The subjects are over 60 years old. The medical and psychiatric history, Hamilton Rating Scale for Depression (HDRS), Patient Health Questionnaire-9 (PHQ-9), Patient Health Questionnaire-2 (PHQ-2), Geriatric Depression Scale-Short form Korean (GDS-SF-K), Mini-Mental Status Exam Korean version (MMSE-KC) were investigated. Global Initiative for Chronic Obstructive Lung Disease (GOLD), which predict the severity of COPD, also investigated.
- Published
- 2013
24. Clinical Characteristics of Thyrotoxicosis Presented by Coronary Spasm
- Author
-
Kiwon Kim, Sung Wan Chun, Yeo Joo Kim, Sang Jin Kim, and Se Whan Lee
- Subjects
medicine.medical_specialty ,business.industry ,Coronary vasospasm ,Internal medicine ,Cardiology ,medicine ,medicine.disease ,business - Published
- 2013
25. Endoscopic comparison of alendronate alone and the enteric-coated alendronate with calcitriol combination in postmenopausal Korean females
- Author
-
Chang Beom Ryu, Yeo Joo Kim, Chul Hee Kim, Sang Jin Kim, Ji Oh Mok, Kyo Suh, Myung Hi Yoo, Dong Won Byun, Hyeong Kyu Park, and Chan-Hee Jung
- Subjects
medicine.medical_specialty ,Time Factors ,Calcitriol ,Treatment outcome ,Osteoporosis ,Administration, Oral ,Gastroenterology ,Esophagus ,Sex Factors ,Predictive Value of Tests ,Sex factors ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Endoscopy, Digestive System ,Enteric coated ,Aged ,Alendronate ,Bone Density Conservation Agents ,medicine.diagnostic_test ,business.industry ,Esophagogastroduodenoscopy ,Age Factors ,Vitamins ,Middle Aged ,medicine.disease ,Postmenopause ,Drug Combinations ,Treatment Outcome ,Endocrinology ,Gastric Mucosa ,Female ,Original Article ,Tablets, Enteric-Coated ,Safety ,business ,medicine.drug - Abstract
Background/Aims This study was performed to compare the mucosal findings after esophagogastroduodenoscopy in two groups before and after the use of alendronate only and following administration of the enteric-coated alendronate (5 mg) and calcitriol (0.5 µg) combined drug (Maxmarvil, Yuyu Co.). Methods The study population consisted of 33 postmenopausal healthy female volunteers, aged 50 to 70 years (mean age, 58 ± 5) without gastrointestinal symptoms and with normal baseline endoscopic findings. Esophagogastroduodenoscopy was performed at baseline and was repeated 2 weeks later after daily intake of Maxmarvil (n = 17 subjects) or alendronate only (n = 16 subjects). Mucosal injury scores were reported by an endoscopist after 2 weeks of treatment with each medication schedule. Results Esophageal mucosal injuries developed in two of 16 subjects in the alendronate only group and 0 of 17 in the Maxmarvil group. Gastric mucosal injuries developed in eight subjects in the alendronate group and four subjects in the Maxmarvil group; this difference was statistically significant. Conclusions The mucosal damage scores for the alendronate group (total score 24) were significantly higher than those for the Maxmarvil group (total score 9) in the esophagus and stomach. Therefore, this study suggested that enteric-coated Maxmarvil is less harmful to gastrointestinal mucosa than alendronate, and may improve the tolerability of osteoporosis medication in clinical practice.
- Published
- 2013
26. Insulin Autoimmune Syndrome with Diabetic Ketoacidosis
- Author
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Sung Wan Chun, Ki Won Kim, Young Il Kim, Sang Jin Kim, Su Jin Lee, Yeong Geol Jo, and Yeo Joo Kim
- Subjects
medicine.medical_specialty ,Endocrinology ,Diabetic ketoacidosis ,business.industry ,Internal medicine ,Diabetes mellitus ,Insulin autoimmune syndrome ,medicine ,Hypoglycemia ,medicine.disease ,business ,Insulin Autoantibody - Published
- 2012
27. Papillary Thyroid Carcinoma Manifesting as an Autonomously Functioning Thyroid Nodule
- Author
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Hee Ja Ko, Chang-Jin Kim, Yeo Joo Kim, Gyeong Jae Na, Sung Wan Jeon, Hyeun Duk Jo, Ji Hyun Kim, Sang Jin Kim, and Ki Won Kim
- Subjects
Thyroid nodules ,endocrine system ,Pathology ,medicine.medical_specialty ,endocrine system diseases ,medicine.diagnostic_test ,business.industry ,Endocrinology, Diabetes and Metabolism ,Thyroid ,Nodule (medicine) ,Hot Nodule ,medicine.disease ,Papillary thyroid cancer ,Thyroid carcinoma ,Endocrinology ,medicine.anatomical_structure ,Fine-needle aspiration ,medicine ,medicine.symptom ,Thyroid function ,business - Abstract
Tc thyroid scintigraphy showed a 2 × 2 cm-sized hyperactive hot nodule at the left lobe. Despite radioactive iodine treat- ment with a dose of 10 mCi 131 I, thyroid function did not improve. Fine needle aspiration revealed papillary thyroid cancer. The pa - tient underwent total thyroidectomy. Although clinical features and thyroid scans suggest a benign nodule, the possibility of malig- nancy should not be ruled out. Malignant thyroid hot nodules are rare; however, its possibility should be taken into account. There - fore, we suggest that ruling out malignancy by existing diagnostic guidelines can misdiagnose even a typical case with benign fea- tures. As thyroid nodule detection is getting sensitive and accurate, we present this case to discuss whether additional diagnostic approaches would be necessary for thyroid nodules. (Endocrinol Metab 27:59-62, 2012)
- Published
- 2012
28. A Case of Painless Thyroiditis Followed by Graves' Disease
- Author
-
Hee Ja Ko, Se Yoon Park, Sang Jin Kim, Ki Won Kim, Gyeong Jae Na, Sung Wan Jeon, Yeo Joo Kim, and Ji Hyun Kim
- Subjects
endocrine system ,medicine.medical_specialty ,Weakness ,endocrine system diseases ,business.industry ,Endocrinology, Diabetes and Metabolism ,Graves' disease ,Thyroid ,medicine.disease ,eye diseases ,Radioactive iodine uptake ,Thyroiditis ,body regions ,Endocrinology ,medicine.anatomical_structure ,Rare case ,Scintigraphic imaging ,medicine ,Radiology ,medicine.symptom ,business - Abstract
A 30-year-old man was admitted to our hospital because of fatigue, palpitation and severe weakness of both legs. The admission laboratory findings revealed thyrotoxicosis, and I thyroid scintigraphic imaging revealed a low radioactive iodine uptake. He was treated for painless thyroiditis for about 4 months. However, thyrotoxic state had continued and radioactive iodine uptake was markedly increased in the follow up scan. Painless thyroiditis often relapses, but rarely develops into Graves’ disease. This is a rare case in which painless thyroiditis was followed by Graves’ disease. (Endocrinol Metab 27:147-150, 2012)
- Published
- 2012
29. A Case of Idiopathic Granulomatous Hypophysitis
- Author
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Hyun Deuk Cho, Min Soo Song, Hack Gun Bae, Yeo Joo Kim, Du Shin Jeong, Sang Jin Kim, and Chul Ho Chung
- Subjects
Adult ,Pathology ,medicine.medical_specialty ,Pituitary gland ,Biopsy ,Pituitary Diseases ,Pituitary Function Tests ,Optic chiasm ,Case Report ,Hypopituitarism ,Giant Cells ,Severity of Illness Index ,Predictive Value of Tests ,medicine ,Humans ,Abnormal Finding ,Bitemporal hemianopsia ,Inflammation ,Granuloma ,medicine.diagnostic_test ,business.industry ,Granulomatous hypophysitis ,Headache ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Hyperprolactinemia ,Treatment Outcome ,medicine.anatomical_structure ,Giant cell ,Optic Chiasm ,Pituitary Gland ,Hemianopsia ,Female ,business - Abstract
Granulomatous hypophysitis is a rare pituitary condition that commonly presents with enlargement of the pituitary gland. A 31-year-old woman was admitted to the hospital with a severe headache and bitemporal hemianopsia. Magnetic resonance imaging (MRI) showed an 18 × 10-mm sellar mass with suprasellar extension and compression of the optic chiasm. Interestingly, brain MRI had shown no abnormal finding 4 months previously. On hormonal examination, hypopituitarism with mild hyperprolactinemia was noted. The biopsy revealed granulomatous changes with multinucleated giant cells. We herein report this rare case and discuss the relevant literature.
- Published
- 2012
30. A Case of Killian-Jamieson Diverticulum Mimicking a Thyroid Nodule
- Author
-
Yeo Joo Kim and Sang Jin Kim
- Subjects
Killian–Jamieson diverticulum ,medicine.anatomical_structure ,business.industry ,Normal esophagus ,Thyroid ,medicine ,Nodule (medicine) ,Anatomy ,Creative commons ,medicine.symptom ,medicine.disease ,business ,Thyroid lobe - Abstract
Copyright c 2012, the Korean Thyroid Association. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fig. 1. (A) The axial US scan shows normal esophagus. (B, C) The axial (B) and longitudinal (C) US scan of the left thyroid lobe shows 10.6×8.6×13.4 mm sized low echogenic lesion with some echogenic foci. 갑상선결절로 오인된 Killian-Jamieson 게실 1예
- Published
- 2012
31. Resistance to Thyroid Hormone with Missense Mutation (V349M) in the Thyroid Hormone Receptor Beta Gene
- Author
-
Yong Wha Lee, Kyung Uk Lee, Ji Yon Kim, Yeo Joo Kim, Eun Suk Choi, Jong-Chan Lee, and Sang Jin Kim
- Subjects
Adult ,Thyroid Hormone Resistance Syndrome ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,DNA Mutational Analysis ,Mutation, Missense ,Case Report ,Thyroid Function Tests ,Gene mutation ,Thyroid function tests ,Thyroid hormone receptor beta ,Exon ,Internal medicine ,Humans ,Medicine ,Missense mutation ,Thyroid hormone receptor ,medicine.diagnostic_test ,business.industry ,Thyroid ,Thyroid Hormone Receptors beta ,Endocrinology ,medicine.anatomical_structure ,Mutation ,Female ,Missense ,business ,Hormone - Abstract
Resistance to thyroid hormone (RTH) is a syndrome characterized by reduced sensitivity to the thyroid hormone. It is generally caused by mutations in the thyroid hormone receptor beta (TR beta) gene. On the basis of its clinical features, two different forms of this syndrome have been described: generalized resistance and pituitary resistance. A total of 122 TR beta gene mutations have been identified thus far. A 38-year-old woman presented with intermittent palpitation. Thyroid function tests revealed elevated levels of free T4 and TSH. TSH a-subunit levels were 0.41 mlU/mL, and magnetic resonance images of the sellar region evidenced no abnormal findings. The TSH response to TRH stimulation was found to be normal. The sequence analysis of the TR beta gene verified a missense mutation in exon 11, and the observed amino acid alteration was a substitution of a valine for a methionine at codon 349. We report the first case of a woman with RTH, which was found to be caused by a missense mutation (V349M) in the TR beta gene.
- Published
- 2008
32. A Case of Primary Hypothyroidism with Anti-Triiodothyronine Autoantibody
- Author
-
Kyo Il Suh, Ji Hoon Ahn, Yeo Joo Kim, Chul Hee Kim, Ji Oh Mok, Dong Won Byun, Mi Hee Kang, Hyeong Kyu Park, Jae Ho Park, Jong Chul Won, Sang Jin Kim, Kyung Wook Lee, and Myung Hi Yoo
- Subjects
endocrine system ,medicine.medical_specialty ,Triiodothyronine ,endocrine system diseases ,business.industry ,Thyroid ,Primary hypothyroidism ,Autoantibody ,Radioimmunoassay ,Disease ,medicine.anatomical_structure ,Endocrinology ,Internal medicine ,Polyethylene glycol precipitation ,medicine ,business ,Hormone - Abstract
Antithyroid hormone autoantibodies can be present in the sera of patients with thyroid and non-thyroid disorders. Antithyroid hormone autoantibodies in a patient's serum interfere with radioimmunoassay of thyroid hormones. Clinically, this interference can result in discordance between the serum thyroid hormone levels and the clinical features of the patient, which can lead to misdiagnosis or inappropriate treatment. We experienced a woman who had primary hypothyroidism with unexpectedly high concentrations of serum total triiodothyronine (T3) and free T3, and she had been treated for Graves' disease in the past. Through the use of a polyethylene glycol precipitation method, we detected the anti-triiodothyronine autoantibodies in her serum. We report on this case along with a review of the related literature. (J Kor Endocrinol Soc 21:428~432, 2006)
- Published
- 2006
33. A Case of Multifocal Pyomyositis in Diabetes Mellitus
- Author
-
Joo Hyun Kim, Chul Hee Kim, Bo Yong Jung, Kyo Il Suh, Jun Young Lee, Ji Hun Ahn, Soon Ho Hwang, Ji O Mok, Sang Jin Kim, Dong Won Byun, Myung Hi Yoo, Hyeong Kyu Park, Eun Seo Park, Jong Kyu Han, Jae Ho Park, Kyung Wook Lee, and Yeo Joo Kim
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Pyomyositis ,business.industry ,medicine.medical_treatment ,Type 2 Diabetes Mellitus ,Disease ,Malignancy ,medicine.disease ,Surgery ,Internal medicine ,Diabetes mellitus ,Incision and drainage ,medicine ,Blood culture ,business ,Abscess - Abstract
Abstract Pyomyositis is an acute bacterial infection of skeletal muscle, usually caused by Staphylococcus aureus. It is common in the tropics but rare in temperate climates. In temperature climate there are predisposing factors, such as dia betes, HIV infection, malignancy. The incidence of reported bacterial pyomyositis is increasing in recently, especially among immunocompromised persons such as HIV infection or diabetes mellitus. We experience multifocal pyomyositis in 49-year-old man with type 2 diabetes mellitus presented with drowsy mental state. Muscular USG and MRI finding shows multifocal abscess in thigh. Blood culture revealed Staphyloccus aureus. And patient received a intravenous broad-spectrum antibiotics, incision and drainage. He was successfully managed with drainage and antibiotics then discharge. Since diabetes or infection with HIV predisposes patients to bacterial infection, pyomyositis will occur more frequently. Increased awareness if the disease will improve management (J Kor Diabetes Assoc 30:140~144, 2006).
- Published
- 2006
34. A Case of Panhypopituitarism with Rhabdomyolysis
- Author
-
Yeo Joo Kim, Ji-Young Park, Ji O Mok, Dong Won Byun, Hyeong Kyu Park, Eun Jung Lee, Chul Hee Kim, Ji Sung Yoon, Jae Woo Kim, Sungwook Hong, Sang Jin Kim, Myung Hi Yoo, and Kyo Il Suh
- Subjects
medicine.medical_specialty ,Pediatrics ,biology ,Diabetic ketoacidosis ,business.industry ,Metabolic disorder ,Electrolyte disturbance ,medicine.disease ,Muscle injury ,Endocrinology ,Hyperosmolar nonketotic coma ,Internal medicine ,medicine ,biology.protein ,Creatine kinase ,business ,Rhabdomyolysis ,Acute rhabdomyolysis - Abstract
Rhabdomyolysis is the consequence of extensive muscle injury with the release of muscle cell constituents into plasma. It can arise from trauma and also from a variety of nontraumatic causes. Trauma, drugs, toxins and infection are the major causes of rhabdomyolysis, but it is rarely associated with metabolic disorders such as severe electrolyte disturbance, diabetic ketoacidosis, hyperosmolar nonketotic coma, hypothyroidism and thyrotoxicosis. There have been several reported cases of metabolic rhabdomyolysis, but panhypopituitarism as a cause has never been identified. We experienced a case of acute rhabdomyolysis associated with panhypopituitarism. Thus, So we report this case with the review of related literature. Metabolic disorder is a rare cause of rhabdomyolysis, but it should always be considered in a patient having and unexplained increased of the creatine kinase concentration (J Kor Soc Endocrinol 20:174~178, 2005).
- Published
- 2005
35. A Case of Kallmann's Syndrome with Unilateral Renal Aplasia and Diabetes Mellitus
- Author
-
Yun Ki Hong, Kyo Il Suh, Ji O Mok, Chul Hee Kim, En Jung Lee, Won Kyung Bae, Ji Sung Yoon, Sungwook Hong, Dong Won Byun, Yeo Joo Kim, Hyeong Kyu Park, Myung Hi Yoo, and Sang Jin Kim
- Subjects
Unilateral renal agenesis ,medicine.medical_specialty ,Pediatrics ,Blindness ,business.industry ,Anosmia ,medicine.disease ,Renal Aplasia ,Endocrinology ,Hyposmia ,Hypogonadotropic hypogonadism ,Internal medicine ,Diabetes mellitus ,medicine ,medicine.symptom ,business ,Kallmann's syndrome - Abstract
Kallmann's syndrome is defined as the combination of hypogonadotropic hypogonadism and anosmia/hyposmia. The syndrome is a result of defect in the embryonic migratory pathway of gonadotropin-releasing hormone, which synthesizes neurons and olfactory axons. The hypogonadotropic hypogonadism results due to absence of or incomplete pubertal development and may be associated with anosmia, hyposmia, midline defect (color blindness, cleft-lip, cleft-palate, unilateral renal agenesis, sensorineural deafness), cryptorchidism and skeletal anomaly. Till date in Korea, few cases of Kallmann's syndrome have been reported but there are no available reports on cases of Kallmann's syndrome with unilateral renal aplasia and diabetes mellitus. We handled a case of Kallmann's syndrome associated with unilateral renal agenesis and diabetes mellitus. In the current work, we present a peculiar case as afore mentioned with the review of related literature (J Kor Soc Endocrinol 20:96~102, 2005).
- Published
- 2005
36. A Case of Hungry Bone Syndrome after Parathyroidectomy in Patient with Tertiary Hyperparathyroidism and Hemodialysis Patient
- Author
-
Sang Jin Kim, Tae Yoon Kim, Dan Song, Min Hyuk Lee, Se Yong Hong, Seung Ha Yang, Hyung Hwan Kim, Jong Kyu Han, Yeo Joo Kim, Eun Young Lee, Myoung Won Son, Moo Sik Cho, and Sung Yong Kim
- Subjects
Parathyroidectomy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,medicine ,Chronic renal failure ,In patient ,Hemodialysis ,Tertiary hyperparathyroidism ,medicine.disease ,business ,Surgery - Published
- 2005
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