Back to Search
Start Over
Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2004
-
Abstract
- Focal adhesion kinase (FAK) is a tyrosine kinase that is found in cellular structures called focal adhesions. FAK appears to be a key element in signal transduction pathways involved in cell adhesion and locomotion. FAK is overexpressed in various tumors, including tumors derived from regions of the head and neck, colon, breast, prostate, and liver. In this study, we investigated immunohistochemically whether FAK expression was increased in thyroid cancers. FAK staining was not seen in any of the 20 normal thyroid tissues or the 6 nodular hyperplasia specimens. In contrast, FAK staining was observed in all of 17 papillary carcinomas, 9 follicular carcinomas, 8 medullary carcinomas, and 2 anaplastic carcinomas. Nine of 17 follicular adenomas showed FAK immunoreactivity. FAK was not expressed in normal tissue and nodular hyperplasia, but was expressed in some of the follicular adenoma, and all of the follicular, papillary, medullary and anaplastic thyroid carcinoma. This result indicates that the up-regulation of FAK may play a role in the development of thyroid carcinogenesis.
- Subjects :
- Adenoma
Adult
Male
Pathology
medicine.medical_specialty
endocrine system
Biology
medicine.disease_cause
Focal adhesion
Protein-Tyrosine Kinase
medicine
Carcinoma
Biomarkers, Tumor
Humans
Thyroid Neoplasms
Thyroid Nodule
Thyroid cancer
Aged
Focal Adhesions
Thyroid
General Medicine
Hyperplasia
Middle Aged
Protein-Tyrosine Kinases
medicine.disease
Immunohistochemistry
Carcinoma, Papillary
Focal Adhesion Kinase
medicine.anatomical_structure
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Cancer research
Female
Original Article
biological phenomena, cell phenomena, and immunity
Carcinogenesis
Subjects
Details
- ISSN :
- 10118934
- Volume :
- 19
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Korean medical science
- Accession number :
- edsair.doi.dedup.....19b0a601126583d1ef698da6cbb2518c