13 results on '"Xiangning Cui"'
Search Results
2. Abnormalities of hippocampus and frontal lobes in heart failure patients and animal models with cognitive impairment or depression: A systematic review.
- Author
-
Ziwen Lu, Yu Teng, Lei Wang, Yangyang Jiang, Tong Li, Shiqi Chen, Baofu Wang, Yang Li, Jingjing Yang, Xiaoxiao Wu, Weiting Cheng, Xiangning Cui, and Mingjing Zhao
- Subjects
Medicine ,Science - Abstract
AimsThis systematic review aimed to study the hippocampal and frontal changes of heart failure (HF) patients and HF animal models with cognitive impairment or depression.MethodsA systematic review of the literature was conducted independently by reviewers using PubMed, Web of Science, Embase, and the Cochrane Library databases.Results and conclusions30 studies were included, involving 17 pieces of clinical research on HF patients and 13 studies of HF animal models. In HF patients, the hippocampal injuries were shown in the reduction of volume, CBF, glucose metabolism, and gray matter, which were mainly observed in the right hippocampus. The frontal damages were only in reduced gray matter and have no difference between the right and left sides. The included HF animal model studies were generalized and demonstrated the changes in inflammation and apoptosis, synaptic reduction, and neurotransmitter disorders in the hippocampus and frontal lobes. The results of HF animal model studies complemented the clinical observations by providing potential mechanistic explanations of the changes in the hippocampus and frontal lobes.
- Published
- 2022
- Full Text
- View/download PDF
3. Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes
- Author
-
Laiyun Xin, Zihuan Shen, Zhilin Jiang, Jialiang Gao, Chang Shang, Xuqin Fang, Yuling Wang, Mi Xiang, Hongchen Lin, Yingdong Lu, Yi Qu, and Xiangning Cui
- Subjects
Cinnamomum zeylanicum ,Endothelium ,Anti-Inflammatory Agents ,Adipose tissue ,Blood lipids ,Inflammation ,Coronary Artery Disease ,Pharmacology ,Carbohydrate metabolism ,medicine.disease_cause ,Functional Food ,Diabetes mellitus ,medicine ,Humans ,Platelet activation ,Plant Extracts ,business.industry ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,medicine.symptom ,business ,Oxidative stress ,Phytotherapy ,Food Science - Abstract
Cardiovascular diseases (CVDs) and diabetes are the leading causes of death worldwide, which underlines the urgent necessity to develop new pharmacotherapies. Cinnamon has been an eminent component of spice and traditional Chinese medicine for thousands of years. Numerous lines of findings have elucidated that cinnamon has beneficial effects against CVDs in various ways, including endothelium protection, regulation of immune response, lowering blood lipids, antioxidative properties, anti-inflammatory properties, suppression of vascular smooth muscle cell (VSMC) growth and mobilization, repression of platelet activity and thrombosis and inhibition of angiogenesis. Furthermore, emerging evidence has established that cinnamon improves diabetes, a crucial risk factor for CVDs, by enhancing insulin sensitivity and insulin secretion; regulating the enzyme activity involved in glucose; regulating glucose metabolism in the liver, adipose tissue and muscle; ameliorating oxidative stress and inflammation to protect islet cells; and improving diabetes complications. In this review, we summarized the mechanisms by which cinnamon regulates CVDs and diabetes in order to provide a theoretical basis for the further clinical application of cinnamon.
- Published
- 2021
4. Efficacy and safety of Whole-lung lavage for pulmonary alveolar proteinosis: A protocol for systematic review and meta-analysis
- Author
-
Guangxi Li, Yuanyuan Duan, Kun Xia, Mengran Xiong, Xiangning Cui, and Shi-Xu Liu
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Meta-analysis ,Medicine ,Whole lung lavage ,business ,Pulmonary alveolar proteinosis ,medicine.disease - Published
- 2021
5. Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments
- Author
-
Yuling Wang, Yi Qu, Hongchen Lin, Xuqin Fang, Mi Xiang, Yingdong Lu, Zhilin Jiang, Xiangning Cui, Zihuan Shen, Chang Shang, Mingjing Zhao, Jialiang Gao, and Laiyun Xin
- Subjects
0301 basic medicine ,Aging ,medicine.medical_specialty ,Myocardial Ischemia ,Inflammation ,Oxidative phosphorylation ,Disease ,Review Article ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Pathological ,QH573-671 ,business.industry ,Autophagy ,Cell Biology ,General Medicine ,medicine.disease ,Oxidative Stress ,030104 developmental biology ,Apoptosis ,Reperfusion ,Cardiology ,medicine.symptom ,Cytology ,business ,Reperfusion injury ,Oxidative stress - Abstract
Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is currently the standard intervention. However, the reperfusion may lead to further myocardial damage, known as myocardial ischemia/reperfusion injury (MI/RI). Oxidative stress is one of the most important pathological mechanisms in reperfusion injury, which causes apoptosis, autophagy, inflammation, and some other damage in cardiomyocytes through multiple pathways, thus causing irreversible cardiomyocyte damage and cardiac dysfunction. This article reviews the pathological mechanisms of oxidative stress involved in reperfusion injury and the interventions for different pathways and targets, so as to form systematic treatments for oxidative stress-induced myocardial reperfusion injury and make up for the lack of monotherapy.
- Published
- 2021
6. Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review
- Author
-
Chang Shang, Hongchen Lin, Yi Qu, Yuling Wang, Yingdong Lu, Laiyun Xin, Jialiang Gao, and Xiangning Cui
- Subjects
0301 basic medicine ,Inflammation ,Traditional Chinese medicine ,Disease ,Review ,medicine.disease_cause ,Bioinformatics ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Pharmacology (medical) ,Myocardial infarction ,baicalin ,oxygen reactive species ,immunomodulatory ,Pharmacology ,biology ,business.industry ,lcsh:RM1-950 ,apoptosis ,medicine.disease ,biology.organism_classification ,cardiovascular diseases ,030104 developmental biology ,lcsh:Therapeutics. Pharmacology ,chemistry ,inflammation ,030220 oncology & carcinogenesis ,Heart failure ,Scutellaria baicalensis ,medicine.symptom ,business ,Baicalin ,Oxidative stress - Abstract
Cardiovascular disease is the leading cause of high morbidity and mortality worldwide,wnich emphasizes the urgent necessity to develop new pharmacotherapies.In eastern countries, traditional Chinese medicine Scutellaria baicalensis has been widely used clinically for thousands of years. Baicalin is one of the main active ingredients extracted from Chinese medicine Scutellaria baicalensis. Emerging evidences have established that baicalin improves chronic in flammation, immune imbalance, disturbance of lipid metabolism, apoptosis and oxidative stress and thereby offers beneficial roles against the initiation and progression of cardiovascular diseases such as atherosclerosis, hypertension, myocardial infarction and reperfusion, heart failure. In this review, we summarize the relevant mechanisms by which baicalin regulates cardiovascular disease in hope of revealing more possibilities of baicalin in caidiovascular disease prevention and/or therapy.
- Published
- 2020
7. The molecular mechanisms of ferroptosis and its role in cardiovascular disease
- Author
-
Laiyun Xin, Yang Zhang, Yuling Wang, Xiangning Cui, Yan Wang, Mi Xiang, Yingdong Lu, and Chang Shang
- Subjects
Lipid Peroxides ,Programmed cell death ,Iron ,Lipid peroxidation ,Ischemia ,Cardiomyopathy ,RM1-950 ,Disease ,GPX4 ,chemistry.chemical_compound ,Metabolic Diseases ,medicine ,Animals ,Ferroptosis ,Humans ,Pharmacology ,Cell Death ,Metabolic disorder ,General Medicine ,medicine.disease ,chemistry ,Cardiovascular Diseases ,Cancer research ,Therapeutics. Pharmacology ,Oxidation-Reduction ,Intracellular - Abstract
Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of lipid peroxides (LOOH) and redox disequilibrium. Ferroptosis shows unique characteristics in biology, chemistry, and gene levels, compared to other cell death forms. The metabolic disorder of intracellular LOOH catalyzed by iron causes the inactivity of GPX4, disrupts the redox balance, and triggers cell death. Metabolism of amino acid, iron, and lipid, including associated pathways, is considered as a specific hallmark of ferroptosis. Epidemiological studies and animal experiments have shown that ferroptosis plays an important character in the pathophysiology of cardiovascular disease such as atherosclerosis, myocardial infarction (MI), ischemia/reperfusion (I/R), heart failure (HF), cardiac hypertrophy, cardiomyopathy, and abdominal aortic aneurysm (AAA). This review systematically summarized the latest research progress on the mechanisms of ferroptosis. Then we report the contribution of ferroptosis in cardiovascular diseases. Finally, we discuss and analyze the therapeutic approaches targeting for ferroptosis associated with cardiovascular diseases.
- Published
- 2022
8. Guanxinshutong Alleviates Atherosclerosis by Suppressing Oxidative Stress and Proinflammation in ApoE−/− Mice
- Author
-
Yingdong Lu, Dandan Zhang, Zhilin Jiang, Yuchan Sun, Yi Qu, Hongchen Lin, Xiangning Cui, Chang Shang, and Mingjing Zhao
- Subjects
Antioxidant ,Article Subject ,medicine.medical_treatment ,Inflammation ,Oxidative phosphorylation ,030204 cardiovascular system & hematology ,Pharmacology ,medicine.disease_cause ,Proinflammatory cytokine ,03 medical and health sciences ,chemistry.chemical_compound ,Other systems of medicine ,0302 clinical medicine ,medicine ,Oil Red O ,030304 developmental biology ,0303 health sciences ,medicine.diagnostic_test ,business.industry ,Glutathione ,Complementary and alternative medicine ,chemistry ,medicine.symptom ,business ,Lipid profile ,Oxidative stress ,RZ201-999 - Abstract
Atherosclerosis (AS) is a chronic progressive disease related to dyslipidemia, inflammation, and oxidative stress. Guanxinshutong capsule (GXST), a traditional Chinese medicine, has been widely used in treating coronary atherosclerotic heart disease, while its mechanism actions on AS are still not to be well addressed. Our present study is aimed to examine the effect of GXST on AS and elucidate the multitarget mechanisms of GXST on AS. Network pharmacology analysis was employed to screen the multitarget mechanisms of GXST on AS. ApoE−/− mice were used to validate these effects. Circulating lipid profile and oxidative stress-related factors were measured by the Elisa kit. Furthermore, the aortic trunk and aortic root were excised for oil red O staining, histopathological and immunohistochemical analysis. We first discovered that GXST was clued to exert synergistically antiatherosclerosis properties including lipid-lowering, anti-inflammation, and antioxidation through the computational prediction based on a network pharmacology simulation. Next, the validation experiments in atherosclerosis mice provided evidence that GXST significantly reduced atherosclerotic lesions, increased collagen deposition, and attenuated LV remodeling to some extent. Mechanistically, GXST modulated lipid profile, downregulated the level of inflammatory cytokines and NF-κBp65. GXST also reduced the activity of oxidative parameter MDA and upregulated the activities of antioxidant enzymes (SOD and GSH) compared with the AS model group. In conclusion, GXST intervention might attenuate atherosclerosis by mechanisms involving reducing lipid deposition, modulating oxidative stress and inflammatory responses, but a larger controlled trial is necessary for confirmation.
- Published
- 2020
9. Qiliqiangxin Attenuates Cardiac Remodeling via Inhibition of TGF-β1/Smad3 and NF-κB Signaling Pathways in a Rat Model of Myocardial Infarction
- Author
-
Qi Zheng, Anbang Han, Yizhou Zhao, Xiangning Cui, Mingjing Zhao, Yingdong Lu, and Jian Zhang
- Subjects
Male ,0301 basic medicine ,TGF-β1/Smad3 ,Physiology ,Rat model ,Myocardial Infarction ,Traditional Chinese medicine ,030204 cardiovascular system & hematology ,Collagen Type I ,NF-κB ,lcsh:Physiology ,Rats, Sprague-Dawley ,Transforming Growth Factor beta1 ,lcsh:Biochemistry ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,NF-KappaB Inhibitor alpha ,medicine ,Animals ,lcsh:QD415-436 ,Smad3 Protein ,Myocardial infarction ,Myocardial infarction rat ,Cardiac remodeling ,Ventricular Remodeling ,Qiliqiangxin ,lcsh:QP1-981 ,Interleukin-6 ,business.industry ,Myocardium ,Tgf β1 smad3 ,NF-kappa B ,Heart ,medicine.disease ,Actins ,Rats ,Nf κb signaling ,Disease Models, Animal ,030104 developmental biology ,chemistry ,Echocardiography ,Heart failure ,Acute Disease ,Cancer research ,business ,Drugs, Chinese Herbal ,Signal Transduction - Abstract
Background/Aims: Qiliqiangxin (QL), a traditional Chinese medicine, has been demonstrated to be effective and safe for the treatment of chronic heart failure. Left ventricular (LV) remodeling causes depressed cardiac performance and is an independent determinant of morbidity and mortality after myocardial infarction (MI). Our previous studies have shown that QL exhibits cardiac protective effects against heart failure after MI. The objective of this study was to explore the effects of QL on myocardial fibrosis in rats with MI and to investigate the underlying mechanism of these effects. Methods: A rat model of acute myocardial infarction was induced by ligating the left anterior descending coronary artery. The rats were treated with QL (1.0 g/kg/day) for 4 weeks after surgery. Echocardiography and histology examination were performed to evaluate heart function and fibrosis, respectively. Protein levels of transforming growth factor-β1 (TGF-β1), phosphorylated Smad3 (p-Smad3), phosphorylated Smad7 (p-Smad7), collagen I (Col- I), alpha smooth muscle actin (a-SMA), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), nuclear factor κB (NF-κB), and phosphorylated inhibitor of kappa B alpha (p-IκBα) were measured by western blot analysis. Results: QL treatment ameliorated adverse cardiac remodeling 8 weeks after AMI, including better preservation of cardiac function, decreased inflammation, and reduced fibrosis. In addition, QL treatment reduced Col-I, a-SMA, TGF-β1, and p-Smad3 expression levels but increased p-Smad7 levels in postmyocardial infarct rat hearts. QL administration also reduced the elevated levels of cardiac inflammation mediators, such as TNF-α and IL-6, as well as NF-κB and p-IκBα expression. Conclusions: QL therapy exerted protective effects against cardiac remodeling potentially by inhibiting TGF-β1/Smad3 and NF-κB signaling pathways, thereby preserving cardiac function, as well as reducing myocardial inflammation and fibrosis.
- Published
- 2018
10. Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic Heart Failure via TGF-β1/Smad3 Pathway
- Author
-
Mingjing Zhao, Xiangning Cui, Bai Du, Huiting Fan, Yonglie Zhao, Yizhou Zhao, Yaoyao He, Jian Cao, Zi Wang Liu, and Xin Zhao
- Subjects
Pathology ,medicine.medical_specialty ,Lung ,business.industry ,Lung injury ,medicine.disease ,Pulmonary edema ,Vascular remodelling in the embryo ,medicine.anatomical_structure ,Complementary and alternative medicine ,Heart failure ,medicine ,Immunohistochemistry ,Tumor necrosis factor alpha ,Myocardial infarction ,business - Abstract
Qili qiangxin (QL) capsule is a traditional Chinese medicine that is widely used for the treatment of patients with chronic heart failure (CHF) of all etiologies, although the exact mechanisms of action remain unclear. CHF leads to pulmonary vascular remodelling and thickening of the alveolar-capillary barrier that may be important mechanisms in the poor clinical outcome in patients with end-stage heart failure. We examined whether QL could improve lung injury in ischemic CHF by reducing lung remodeling. Rats with myocardial infarct received QL (1.0 g/kg/day) for 4 weeks. Echocardiographic and morphometric measurements were obtained followed by echocardiography, histological staining, and immunohistochemical analysis of lung sections. CHF caused significant lung structural remodeling evidenced by collagen deposition and thickening of the alveolar septa after myocardial infarct that were greatly improved by QL. Lung weight increased after infarct with no evidence of pulmonary edema and was normalized by QL. QL also reduced lung transforming growth factor-β1 (TGF-β1), p-Smad3, tumor necrosis factor-α(TNF-α), and Toll-like receptor-4 (TLR4) expression. Thus, QL reduces lung remodeling associated with CHF, mainly by suppressing the TGF-β1/Smad3 signaling pathway. The mechanism may also involve inhibition of TLR4 intracellular signaling.
- Published
- 2015
11. Quantitative iTRAQ LC-MS/MS Proteomics Reveals Transcription Factor Crosstalk and Regulatory Networks in Hypopharyngeal Squamous Cell Carcinoma
- Author
-
Meiling Huang, She Li, Donghai Huang, Yong Liu, Changyun Yu, Ming Wei, Xin Zhang, Haolei Tan, Yongquan Tian, Gengming Cai, Gangcai Zhu, and Xiangning Cui
- Subjects
medicine.diagnostic_test ,Biology ,Proteomics ,Bioinformatics ,medicine.disease_cause ,medicine.disease ,Metastasis ,Crosstalk (biology) ,iTRAQ ,Oncology ,Cell-matrix adhesion ,Western blot ,Proteomics analysis ,Hypopharyngeal squamous cell carcinoma ,Cancer research ,medicine ,Transcriptional regulation ,Transcription factor network ,Carcinogenesis ,Transcription factor ,Research Paper - Abstract
To date, no effective therapeutic treatments have been developed for hypopharyngeal squamous cell carcinoma (HPSCC), a disease that has a five-year survival rate of approximately 31% because of its late diagnosis and aggressive nature. Despite recent improvements in diagnostic methods, there are no effective measures to prevent or detect HPSCC in an early stage. The goal of the current study was to identify molecular biomarkers and networks that can facilitate the speedy identification of HPSCC patients who could benefit from individualized treatment. Isobaric tags for relative and absolute quantification (iTRAQ) labeling was employed with two-dimensional liquid chromatography-tandem mass spectrometry to identify quantitatively the differentially expressed proteins among three types of HPSCC disease stages. The iTRAQ results were evaluated by literature searches and western blot analysis. For example, FUBP1, one of 412 proteins with significantly altered expression profiles, was confirmed to have elevated expression in fresh HPSCC tissues. Integrin-mediated cell matrix adhesion and actin filament-inducing cytoskeleton remodeling were the cellular events that were the most relevant to HPSCC tumorigenesis and the metastatic process. The construction of transcriptional regulation networks led to the identification of key transcriptional regulators of tumor development and lymph node metastasis of HPSCC, including Sp1, c-Myc and p53. Additionally, our study indicated that the interactions among Sp1, c-Myc and p53 may play vital roles in the carcinogenesis and metastasis of HPSCC.
- Published
- 2014
12. Effects of Qili Qiangxin Capsule on AQP2, V2R, and AT1R in Rats with Chronic Heart Failure
- Author
-
Yizhou Zhao, Jian Zhang, Xin Zhao, Anbang Han, Yaoyao He, Jian Cao, Xiangning Cui, Mingjing Zhao, Yuxiu Sun, and Yubo Li
- Subjects
Cardiac function curve ,Vasopressin ,Article Subject ,business.industry ,urogenital system ,medicine.medical_treatment ,lcsh:Other systems of medicine ,Pharmacology ,lcsh:RZ201-999 ,medicine.disease ,urologic and male genital diseases ,Angiotensin II ,Complementary and alternative medicine ,Valsartan ,Aquaporin 2 ,Heart failure ,medicine ,Myocardial infarction ,Diuretic ,business ,medicine.drug ,Research Article - Abstract
Qili qiangxin capsule (QL), a traditional Chinese herbal compound, has been proved to be effective and safe for the treatment of chronic heart failure (CHF). Upregulation of aquaporin-2 (AQP2) accounts for the water retention in CHF. The aim of the present study was to evaluate the effects of QL on the expression of AQP2 in rats with CHF induced by acute myocardial infarction and to investigate the underlying mechanisms. The urine output of all rats was quantified and collected every day at the first week and the 4th week after administration of QL or Valsartan. The expression of AQP2, vasopressin type 2 receptor (V2R), and angiotensin II type 1 receptor (AT1R) were examined after treatment for 4 weeks. Urinary output increased significantly after administration of QL. Importantly, the protein expression of AQP2 and AQP2 phosphorylated at serine 256 (pS256-AQP2) was downregulated after administration of QL and Valsartan to CHF rats. Furthermore, QL reduced plasma arginine vasopressin (AVP) and angiotensin II (AngII) level and downregulated V2R and AT1R protein expression. Thus, QL exerts its diuretic effect and improves cardiac function in CHF rats by reversing the increases in both AQP2 and pS256-AQP2 expression. The possible mechanisms may involve inhibition of V2R and AT1R.
- Published
- 2015
13. Management of SAH with traditional Chinese medicine in China
- Author
-
Xingquan Zhao, Yongjun Wang, Chunxue Wang, Xiangning Cui, Shujing Mao, and Yuehua Pu
- Subjects
medicine.medical_specialty ,Pueraria ,Subarachnoid hemorrhage ,Traditional Chinese medicine ,Salvia miltiorrhiza ,law.invention ,Aneurysm ,Randomized controlled trial ,law ,Internal medicine ,Epidemiology ,medicine ,Animals ,Humans ,cardiovascular diseases ,Medicine, Chinese Traditional ,biology ,Ginkgo biloba ,business.industry ,General Medicine ,Subarachnoid Hemorrhage ,medicine.disease ,biology.organism_classification ,nervous system diseases ,Surgery ,Neurology ,Neurology (clinical) ,business ,Drugs, Chinese Herbal - Abstract
China lacks large scale authorized epidemiological study results in allusion to subarachnoid hemorrhage (SAH) within recent 15 years since MONICA (multinational monitoring of trends and determinants in cardiovascular disease) study revealed SAH situation in China in 2000. The main cause of SAH in China is aneurysm which takes up 30-50%, while over 90% aneurysm locates at Willis circle. Early surgery for SAH after aneurysm rupture is the dominant procedure to deal with SAH in China. Moreover, calcium antagonists rank the absolute leading position for cerebral vascular spasm (CVS) among medication-based treatment options. However, traditional Chinese medicine such as Salvia miltiorrhiza, Acanthopanax senticosus, Ginkgo biloba, Pueraria lobata, Liguisticum chuanxiong, cow bezoar, Diospyros kaki and Gynostemma pentaphyllum have been proven beneficial in CVS prevention and treatment, while Salvia miltiorrhiza and TCM soup have unique effects on bleeding absorption. In addition, aescine and some TCM soup might relieve strong headache after SAH. In general, TCM integrated with western medicine have shown unique advantages in the current treatment of SAH in China. However, it is a pity that China still lacks larger scale randomized controlled trials and research on SAH treatment focusing on TCM and the related mechanism of TCM on SAH still need to be investigated further.
- Published
- 2006
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.