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Effects of Qili Qiangxin Capsule on AQP2, V2R, and AT1R in Rats with Chronic Heart Failure
- Source :
- Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015)
- Publication Year :
- 2015
- Publisher :
- Hindawi Publishing Corporation, 2015.
-
Abstract
- Qili qiangxin capsule (QL), a traditional Chinese herbal compound, has been proved to be effective and safe for the treatment of chronic heart failure (CHF). Upregulation of aquaporin-2 (AQP2) accounts for the water retention in CHF. The aim of the present study was to evaluate the effects of QL on the expression of AQP2 in rats with CHF induced by acute myocardial infarction and to investigate the underlying mechanisms. The urine output of all rats was quantified and collected every day at the first week and the 4th week after administration of QL or Valsartan. The expression of AQP2, vasopressin type 2 receptor (V2R), and angiotensin II type 1 receptor (AT1R) were examined after treatment for 4 weeks. Urinary output increased significantly after administration of QL. Importantly, the protein expression of AQP2 and AQP2 phosphorylated at serine 256 (pS256-AQP2) was downregulated after administration of QL and Valsartan to CHF rats. Furthermore, QL reduced plasma arginine vasopressin (AVP) and angiotensin II (AngII) level and downregulated V2R and AT1R protein expression. Thus, QL exerts its diuretic effect and improves cardiac function in CHF rats by reversing the increases in both AQP2 and pS256-AQP2 expression. The possible mechanisms may involve inhibition of V2R and AT1R.
- Subjects :
- Cardiac function curve
Vasopressin
Article Subject
business.industry
urogenital system
medicine.medical_treatment
lcsh:Other systems of medicine
Pharmacology
lcsh:RZ201-999
medicine.disease
urologic and male genital diseases
Angiotensin II
Complementary and alternative medicine
Valsartan
Aquaporin 2
Heart failure
medicine
Myocardial infarction
Diuretic
business
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17414288 and 1741427X
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- Evidence-based Complementary and Alternative Medicine : eCAM
- Accession number :
- edsair.doi.dedup.....57a9a2f2c3c97c47fb12461a866584a2