1. Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds
- Author
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Mike Angstadt, Mary M. Heitzeg, Luke W. Hyde, Tristan Greathouse, Brian M. Hicks, Saige Rutherford, D. Angus Clark, Sarah J. Brislin, Aman Taxali, Daniel Kessler, Alexander Weigard, and Chandra Sripada
- Subjects
Adolescent ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Article ,Long-term memory ,Cellular and Molecular Neuroscience ,Cognitive development ,medicine ,Humans ,ADHD ,Biological Psychiatry ,Default mode network ,Brain Mapping ,Psychopathology ,Mental Disorders ,Brain ,Cognition ,Hyperconnectivity ,Human brain ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,medicine.anatomical_structure ,Multiple comparisons problem ,Psychology ,Neuroscience ,Neurotypical ,RC321-571 - Abstract
Convergent research identifies a general factor (“P factor”) that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns associated with the P factor are limited, especially in early adolescence when most mental disorders are first emerging. We studied 11,875 9- and 10-year olds from the Adolescent Brain and Cognitive Development (ABCD) study, of whom 6593 had high-quality resting-state scans. Network contingency analysis was used to identify altered interconnections associated with the P factor among 16 large-scale networks. These connectivity changes were then further characterized with quadrant analysis that quantified the directionality of P factor effects in relation to neurotypical patterns of positive versus negative connectivity across connections. The results showed that the P factor was associated with altered connectivity across 28 network cells (i.e., sets of connections linking pairs of networks); pPERMUTATION values pPERMUTATION
- Published
- 2021