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Objectives: This study investigated the determinants of undiagnosed hypertension among Indonesian adults.Methods: This study involved an analysis of secondary data from the 2014 Indonesia Family Life Survey (IFLS) on 5914 Indonesian adults (≥40 years). The determinant variables examined in this cross-sectional study were education level, monthly per capita expenditures (PCE), whether the participant experienced headaches in the morning, and other general health variables. The outcome variable was undiagnosed hypertension, which was defined as participants with hypertension who had not received a hypertension diagnosis from a health professional and had never been prescribed medication for treating hypertension. The data were analyzed using logistic regression.Results: A total of 3322 participants (56.2%) were found to have undiagnosed hypertension. The odds ratios (ORs) and 95% confidence intervals (CIs) of undiagnosed hypertension were significantly higher among those who completed primary school or lower (OR, 1.60; 95% CI, 1.29 to 1.98), had low monthly PCE (OR, 1.28; 95% CI, 1.13 to 1.43), did not report experiencing headaches in the morning (OR, 1.97; 95% CI, 1.76 to 2.21), and reported a general health status of healthy (OR, 2.05; 95% CI, 1.82 to 2.30) than those who had a higher education level, had high monthly PCE, experienced headaches in the morning, and were unhealthy.Conclusions: Education level, monthly PCE, the experience of headaches in the morning, and general health status were associated with undiagnosed hypertension. The monitoring system for detecting undiagnosed hypertension cases must be strengthened. Health promotion is also necessary to reduce the prevalence of undiagnosed hypertension.

Rationality of Diclofenac Use in Osteoarthritis Outpatient Case at RSUP MH Palembang in January-March 2018. Osteoarthritis (OA) is the most common disease in joints that affects people in their middle until late years. In Indonesia the prevalence of OA is relatively high and disturbs their daily activity. Diclofenac is one of the drug of choice in treating OA. To avoid multiple side effects from Diclofenac use, the usage must be in accordance to rationality indicators which are correct dose, correct frequency, and correct length of use. This study is aimed to know the rationality of Diclofenac use in Osteoarthritis outpatient cases at RSUP Mohammad Hoesin Palembang. This study is a descriptive observational with a cross-sectional approach to know the rationality of Diclofenac use in outpatient cases of osteoarthritis at RSUP Mohammad Hoesin Palembang. Samples were medical records of OA patients in outpatient setting from January to March 2018 which fulfilled the inclusion and exclusion criteria. Sampling technique used was total sampling. The amount of samples fulfilling the inclusion criteria were 201 patients, with the most were aged 46- 65 years (60.2%), female (55.7%), and has a history of comorbidity which includes low back pain (22.8%). The result of this study shows pattern of Diclofenac use with dosage of 2 x 25mg (73.6%), length of use about

Litsea elliptica is traditionally believed to prevent and treat stomach ulcers, cancer, fever and headaches. This study investigates the phytochemical composition, antioxidant and cytotoxic effects of L. elliptica leaf extracts. The phytochemical content was determined via GCMS analysis and total phenolic content (TPC) and total flavonoid content (TFC) were analysed using the Folin-Ciocalteu and aluminium-chloride assays. Antioxidant activities were determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging and ferric-ion reducing antioxidant power (FRAP) assays, whereas cytotoxicity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and calcein/ethidium viability assays. The mechanism of cytotoxicity was investigated using Annexin V/propidium iodide. Modifications in the mitochondria were investigated using MitoTracker Red CMXRos. Ten and twenty-six compounds were characterized in the young-leaf and mixed-leaves extracts, respectively. The young-leaf methanolic extract demonstrated the highest antioxidant capacity of at least four-folds greater than the mixed-leaves and ethanolic extracts. The methanolic extract also had higher TPC and TFC values compared to the ethanolic extract. Although the mixed L. elliptica leaves had lower antioxidant capacities compared to the young leaves, the mixed leaves extract has demonstrated greater cytotoxicity against the A549 cancer cell line. Further investigation revealed that the L. elliptica leaves-induced cytotoxicity on A549 cells was possibly via the non-inflammatory mitochondria-mediated apoptotic pathway. Overall, our results showed the potential of the L. elliptica leaves possessing cytotoxic activities against carcinoma cells where the compounds present can be further investigated for its therapeutic application.

Oral ulcers are pathological conditions that are characterized by loss of epithelial tissue, causing inflammation. During inflammation, the inflammatory mediator is TNF will increase. Therefore, drugs are needed to suppress TNF-levels to suppress inflammation. One of the herbal ingredients that can suppress inflammation is garlic. In vivo laboratory experimental research with pre-post systems. The samples used were 36 male Wistar white rats divided into 6 groups (6 individuals / groups), namely the group without drug treatment (as pre-treatment data), negative control group namely HPMC gel base, positive control given benzydamin, group treatment I was given a garlic water extract gel 20%, treatment group II was given a garlic water extract gel 40%, treatment group III were given a garlic water extract gel 80%. The drug is given topically 2 times a day for 4 days. Making oral ulcers is done by placing filter paper that has been soaked in a 50% acetic acid solution in the labial area of the mandibular gingival tissue. Measurement of oral ulcers was performed on the 1st day after the manufacture of oral ulcers and the 5th day. On the 5th day all the mice were sacrificed to be taken gingival tissue and TNF-levels were measured. using ELISA. Data analysis using SPSS version 24 and One Way Anova test with 5% specification followed by Post Hoc Test using LSD test and Games Howell. Analysis using One Way Anova showed that there were significant differences in TNF-levels and the diameter of the oral ulcer (p

Objective The attitude of medical personnel towards suicide may influence the outcome of suicidal-patients management. This study aimed to determine the attitudes of medical undergraduates towards suicide and its association with their help-seeking behavior. Methods A cross-sectional study involving 290 medical undergraduates was conducted in a Malaysian university. The questionnaires on the attitude towards suicide and general help-seeking behavior were used as research instruments. Results The mean age of the participants was 22.4 years. Participants who did psychiatry posting indicated a greater tendency to agree on suicide as a way of communication (p = 0.008) than those who did not. Participants previously diagnosed with a psychiatric illness indicated a greater ability to understand and accept suicide (p < 0.001) as well as a greater tendency to agree on the normality of suicide (p = 0.019) than those without a previous diagnosis. Those who attended a suicide prevention program also indicated a greater tendency to agree that loneliness and avoidance could be triggers to suicide (p = 0.037) than those who did not. No correlation was found between the “attitude towards suicide” and “general help-seeking behavior” variable. Conclusion Education programs in suicide prevention and management need to be incorporated early into the undergraduate medical curriculum to cultivate a more positive attitude towards suicide and help-seeking behavior.

BACKGROUND: Pelvic organ prolapse (pop) is a chronic disorder, often asymptomatic. There are several factors involved in the aetio-pathogenesis of POP. Perimenopausal women bear most of the burden of pop. Vaginal delivery is an established risk factor and clinical presentation may take years when women are symptomatic in menopausal age. METHOD: A cross-sectional study was done for one year in a rural teaching hospital, where 150 pop women were included. Variables associated with both asymptomatic & symptomatic pop were analyzed. The mean, proportion, & simple logistic regression were used to analyze the data and p value

Objectives: We present the survey data on molecular testing and its implications among lung cancer specialists in the South Asian Association for Regional Cooperation (SAARC) region. Material and Methods: An online survey Google form was developed that could be completed in Results: We had 354 responders from 8 SAARC countries, 58.9% (209/354) being medical oncologists, and 30.1% (107/354) radiation oncologists. Nearly 50% of responders were seeing patients in the second wave of coronavirus disease 2019 and 89% had seen reduction in their lung cancer patients during first wave. Biomarker testing in advanced lung cancer using next-generation sequencing as the preferred method was more among medical oncologists (76%) as compared to all the other specialists (24%); (Pearson Chi-square = 0.006). The practice of waiting for the molecular testing report before starting first line treatment was 55.4% in corporate/private hospitals as compared to 27% in the government/charity hospital sectors (Pearson Chi-square = 0.015). A total of 89.6% responders believed that targeted therapy has resulted in improved overall survival in advanced lung cancer. Conclusion: Educational activities need to be strengthened so that lung cancer specialists follow comprehensive NGS testing in appropriate settings, as shown by medical oncologists

Protective and risk factors are important in reducing vulnerability towards drug abuse among adolescents. This study, therefore, aims to explore gender differences in such vulnerability in high-risk areas identified by the National Anti-Drugs Agency Malaysia. The study employs a survey design, with questionnaires distributed to 213 adolescents who fulfilled the inclusion criteria. The researchers developed the questionnaire and comprised five parts: the demographic profile, interpersonal conflict, negative emotions, social support, and mental health. The data were analyzed using descriptive and inferential statistics. The results show no significant gender differences in interpersonal conflict, negative emotions, and mental health. However, there was a significant difference in social support based on gender, with females showing a higher mean than males. These findings imply the importance of identifying the relevant factors to prevent early involvement in drug abuse.

Background It is well known that diabetes mellitus (DM) affects health-related quality of life (HRQOL) in both younger (aged 18–64 years) and older adults (aged ≥ 65 years). However, to date, no study has compared HRQOL and its predictors between younger and older adults with DM in Indonesia. Such a comparison is important because the results can guide nurses and clinicians to establish evidence-based educational programs that are specific and suitable for patients. Therefore, the aim of this study was to investigate the difference in HRQOL and its predictors in younger and older adults with DM in Indonesia. Methods A cross-sectional study was conducted on 641 patients with type 2 diabetes mellitus (T2DM) who were recruited via simple random sampling from 16 primary health centers in Banyumas Regency, Indonesia. A self-administered questionnaire containing the Summary of Diabetes Self-Care Activities, the DDS17 Bahasa Indonesia, the Beck Depression Inventory II, the Self-Efficacy for Diabetes Scale, the Family APGAR, and the 36-item Short-Form Health Survey was used to measure diabetes self-management (DSM), diabetes distress (DD), depression, self-efficacy, family support, and HRQOL, respectively. Independent t-tests were used to compare the physical component summary (PCS) and mental component summary (MCS) scores between younger and older adults with T2DM. Hierarchical multiple regression analyses were used to examine the factors associated with HRQOL in both groups. Results PCS scores were significantly different between the two groups. Older adults reported lower PCS scores than younger adults. No differences between the two groups were observed in the MCS scores. The hierarchical multiple regression analysis showed that level of education, employment status, number of diabetes-related complications, DSM, DD, depression, and self-efficacy were significant predictors of HRQOL in younger adults, while income, depression, DD, and self-efficacy were significant predictors of HRQOL in older adults. DD was the strongest predictor of HRQOL in younger adults, and depression was the strongest predictor in older adults. Conclusion Older adult patients had lower PCS scores than younger adult patients. This study is the first to show that the predictors of HRQOL differ between younger and older adults with T2DM. It provides insights for nurses and clinicians in Indonesia to establish evidence-based, age-specific educational programs.

Organophosphate pesticides are one of the causes of contamination in animal feed. The cholinesterase enzyme test is used to diagnose toxic exposure due to organophosphate pesticides. Quantitative research with survey design using cross sectional design using 35 samples of cows. The study was conducted in March - September 2020. Concentration measurement on cholinesterase enzyme concentrations of blood plasma used the biosystem A15 DGKC-Colorimetric Kinetic method. This study aims to evaluate the concentration of the enzyme cholinesterase as a marker of organophosphate poisoning in cattle. Blood samples were collected from the ventrolateral neck veins of male and female cattle aged 1-7 years and collected from local cattle in the Ogan Ilir area. The results showed that the cows raised in breeders were exposed to organophosphate pesticides as indicated by a decrease in the concentration and levels of the cholinesterase enzyme in the plasma of female cows. Cholinestrase enzyme levels in female cows were 0.20 ± 0.067 U / ml and bulls were 0.27 ± 0.183 U / ml. The highest concentration of cholinesterase enzyme levels occurred in cows aged 2 years, namely 0.25 ± 0.34 U / ml and the lowest was in cows aged 7 years, namely 0.12 ± 0.04 U / ml.

In the world, the incidence of nosocomial infections in hospitals had increased. There had been an increase in the incidence of infections caused by Enterobacteriaceae, one of them is Klebsiella pneumonia, which resistant to carbapenem in the worldwide. The consequences of increased rates of resistance to many drugs pose a high need for the discovery of new types of antibiotic drugs. Rhodomyrtus tomentosa (aiton) hassk has an antibacterial effect that has long been used by Indonesians as a traditional drug. This study aims to find out the effectiveness of karamunting leaf fraction as an antimicrobial in carbapenemase resistant K.pneumonia bacteria and to find out the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the active compound of karamunting leaves as antimicrobial in Carbapenemase resistant Klebsiella pneumonia (CRKP) bacterial isolates. This research was an experimental laboratory research in vitro that exploratory analytical. The results of the study obtained the value of MIC ethyl acetate fraction started at a concentration of 125 μg/ml and n-hexan fraction at a concentration of 4000 μg/ml. MBC value was 125 μg/ml for ethyl acetat fraction and n-hexan fraction of karamunting leaves was 8000 μg/ml. From the bacterial activity test obtained at a concentration 32000 μg/ml of n-hexan fraction, the average diameter of the inhibitory zone 7.80 ± 1.30 mm and ethyl acetate fraction at a concentration of 4000 μg/ml can inhibit the growth of CRKP bacteria with an average of inhibition zone diameter was 9.40 ± 1.67 mm. From the results of the analysis using the Independent T Test and mann whitney test obtained a probability value between all groups with positive control was

Introduction: Relapse occurs when there is a strong desire for repeating drug-seeking behaviour due to high-risk situations such as social environment, interpersonal conflict, and negative emotions. Objective: This article aims to analyse the relationship between drug craving and high-risk situations for relapse among inmates with substance abuse issues serving in Malaysian prisons. Material and Methods: This study was conducted using a quantitative approach. A total number of 407 inmates with substance abuse issues were randomly selected as respondents of the study. The data were analysed using descriptive and inferential analysis via SPSS software. Results: The result indicates that there is a positive and significant moderate relationship between drug craving and high-risk situations for relapse (r=0.452, p˂0.01). Therefore, it can be concluded that drug craving is associated with high-risk situations for relapse among inmates with substance abuse issues. Conclusion: The findings of this study is expected to provide implications to the stakeholders such as counsellors and drug rehabilitation officers to improvise the existing rehabilitation modules and programs to address relapse issues among inmates in Malaysia.

Candida krusei (C. krusei) is associated with oral candidiasis, particularly in immunecompromised patients. The objective of the study was to determine the effect of phenotypic switching to the susceptibility of C. krusei towards amphotericin B, nystatin and aqueous extract of Piper betle (P. betle). To induce phenotypic switching, C. krusei was inoculated in yeast extract peptone dextrose (YEPD) broth supplemented with 5 mg mL-1 phloxine B andincubated for five hours at 25 °C. Later, 100 µL of the suspension was inoculated on YEPD agar supplemented with 5 mg mL-1 phloxine B and incubated for five days at 25 °C. Disc diffusion and minimum inhibitory concentration (MIC) assays were conducted to determine the susceptibility of C. krusei. The results showed that all C. krusei switched generations were susceptible towards amphotericin B and nystatin with the 3rd and 4th generations significantly more susceptible than the un-switched, respectively (P

Striga hermonthica infestation causes significant losses of maize yield in the Nigerian savannas and several technologies have been developed and promoted to control Striga in maize. However, since no single technology has been found to be effective against Striga, integrated management is needed to achieve satisfactory and sustainable Striga control. Both on-station and on-farm trials were undertaken from 2013 to 2015 in Bauchi and Kano States of Nigeria to evaluate the performance of integrated Striga control technologies. In the on-station trials, a soybean–maize rotation did not suppress Striga in maize in either location. However, nitrogen application suppressed and reduced Striga infection, except in Bauchi in 2014. The soybean–maize rotation accompanied by N application reduced Striga damage in both locations. On farmers’ fields, rotating soybean with maize significantly reduced Striga infection. At the same time, the use of maize varieties with a combined tolerance to drought and resistance to Striga parasitism also increased maize grain yield on farmers’ fields, probably due to three factors: a reduction in Striga infection, reduced effects of a mid-season moisture deficit, and increased uptake of nutrients from the soil. We concluded that the use of Striga-resistant maize varieties in combination with the application of N fertilizer and rotation with soybean could increase the productivity of maize in Striga-infested fields in the Nigerian savannas.

Depression in tuberculosis (TB) increases the risks of adverse health outcomes. However, little is known about depression in tuberculosis patients in Malaysia. The aim of this study was to determine the prevalence and associated factors of depression in tuberculosis patients in primary care clinics. A cross-sectional study was adapted for this study. A total of 235 TB patients were recruited in six primary care clinics in the district of Kuching, Sarawak in Malaysia using convenience sampling method. A self-administered questionnaire, Patient Health Questionnaire-9 (PHQ-9), was used to screen for depression, and social support was accessed using Multidimensional Scale of Perceived Social Support, MSPSS. This study showed that the prevalence of depression among TB patients was 7.7%. Socio-demographic factors, tuberculosis-related clinical data and social support are not significantly associated with participant’s depressive states. Findings also showed that there is no different in terms of social support received by depressive and non-depressive tuberculosis patients. Conclusively, depression in TB patients is considered low; however, screening for depression in TB patients should not be neglected because it can lead to better treatment outcomes.

Background: Public health cadres can play an important role in improving disaster response and recovery. However, a multidimensional instrument is needed to assess the levels of disaster knowledge for community health cadres. This instrument is important to develop a complete and effective educational program for disaster preparation for health cadres. Therefore, this study aimed to test validity and reliability of the disaster preparedness knowledge instrument for health cadres in areas prone to volcanic disasters.Methods: A cross-sectional study was conducted by involving 300 respondents. The instrument was developed by conducting literature review followed by completing a qualitative study. We reduced the original instrument from 50 items to a final instrument comprising 41 items, classified into 6 categories: 1) early warning [16 items]; 2) disaster triage [4 items]; 3) basic life support [7 items]; 4) first aid [7 items]; 5) search and rescue [5 items]; and 6) logistic, communications and team organization [2 items]. Instrument validation was assessed by using Pearson Product moment and the reliability was estimated by using internal consistency reliability.Results: 300 respondents were involved in this study with all respondents were women aged between 40-49 years old. All of them were either health cadre or high school students. In instrumental testing, all 41 items of the instrument were confirmed through content validity (Pearson Product Moment). Using internal consistency reliability, the study found reasonable inter-item reliability for all items (Cronbach’s α: 0.785-0.807).Conclusion: Higher score on disaster triage aspect suggest that health cadres have pivotal role in emergency care during disaster. The finding revealed that disaster triage technique and skills for health cadres or lay man is very important.

Backgrounds: Snake bites are a medical emergency that can cause permanent disability and even death (Wintoko and Prameswari 2020). The main principle recommended for the first treatment of a snakebite is to immobilize the area with a pressure bandage (pressure immobilization bandages) then immediately referred to the hospital for further treatment.Objective: To know the effectiveness of pressure immobilization bandages (PIB) first aid against snake bite.Methods: Article searches were conducted electronically using Google Scholar, PubMed, Science direct, National Library and Pro quest databases. Articles used from 2016 to 2021. The keywords in this article search were “pressure immobilization bandages” and “snake bite. So that 5 research articles were reviewed. Inclusion criteria included articles published in 2016-2021, articles in Indonesian and English, involving snake bite patients and being given the Pressure immobilization bandage technique intervention. Meanwhile, the exclusion criteria include articles that cannot be accessed, based on meta-analysis, and journals that discuss snake bites but are not in accordance with the topic to be reviewed.Results: Pressure immobilization bandages (PIB) can be used in first aid because they can inhibit the spread of snake venom and are 20 times faster in the healing process if done in first aid.Conclusion: Pressure immobilization bandages (PIB) are effective in first aid for snake bites.Keywords: Pressure immobilization bandages; snake bite

Background: Patients with emergency conditions will get the first health service in the Emergency Room (IGD). The emergency room nurse has an important role in assessing and determining the severity of the patient. The nurse determines the priority of action and the need for treatment in Intensive Care Unit (ICU) using triage. One of the triage that can be done is triage scoring to facilitate nurses in determining high-risk and low-risk patients. Purpose: To find out the triage scoring used during the pandemic. Methods: Literature search is conducted using the PICO framework. This systematic review is limited to articles published from 2019-2021 with articles in English. The database used is Google Scholar. PubMed, Science Direct, and ProQuest which using the keywords score, triage, pandemic and emergency care. Results: Based on the three articles reviewed, an overview of the use of triage scores during a pandemic is obtained using the SODA score, modified PRIEST and double triage and telemedicine protocols. Giving the triage score can make it easier for health workers to identify high-risk patients and prevent unexpected events. Conclusion: Triage scoring can be applied at Covid-19 referral hospitals which helps nurses determine priorities and prevents special mortality in Indonesia, which is experiencing the second wave Keywords: Score, Triage, Pandemic

Background Relapsed acute myeloid leukemia (AML) is associated with the acquisition of additional somatic mutations which are thought to drive phenotypic adaptability, clonal selection and evolution of leukemic clones during treatment. We performed high throughput exome sequencing of matched presentation and relapsed samples from 6 cytogenetically normal AML (CN-AML) patients treated with standard remission induction chemotherapy in order to contribute with the investigation of the mutational landscape of CN-AML and clonal evolution during AML treatment. Result A total of 24 and 32 somatic variants were identified in presentation and relapse samples respectively with an average of 4.0 variants per patient at presentation and 5.3 variants per patient at relapse, with SNVs being more frequent than indels at both disease stages. All patients have somatic variants in at least one gene that is frequently mutated in AML at both disease presentation and relapse, with most of these variants are classic AML and recurrent hotspot mutations including NPM1 p.W288fs, FLT3-ITD, NRAS p.G12D and IDH2 p.R140Q. In addition, we found two distinct clonal evolution patterns of relapse: (1) a leukemic clone at disease presentation acquires additional mutations and evolves into the relapse clone after the chemotherapy; (2) a leukemic clone at disease presentation persists at relapse without the addition of novel somatic mutations. Conclusions The findings of this study suggest that the relapse-initiating clones may pre-exist prior to therapy, which harbor or acquire mutations that confer selective advantage during chemotherapy, resulting in clonal expansion and eventually leading to relapse.

DETERMINANTS OF DIABETES SELF-CARE ON PATIENTS WITH TYPE 2 DIABETES MELLITUS IN BANYUMAS REGENCYEva Rahayu, Ridlwan Kamaluddin, Eti Dwi HapsariLecturer of Nursing Department, Jenderal Soedirman University“ummufawwaz.rahayu@gmail.com” ABSTRAKPenderita diabetes tipe 2 perlu menerapkan perawatan mandiri diabetes dalam rangka meminimalisir berbagai komplikasi dan penurunan kualitas hidup. Beberapa faktor diduga memiliki pengaruh terhadap penerapan perawatan mandiri diabetes oleh penderita diabetestipe 2 di Kabupaten Banyumas. Tujuan penelitian ini adalah untuk mengetahui faktor determinan yang berhubungan dengan penerapan perawatan mandiri diabetes tipe 2 di Wilayah Kabupaten Banyumas. Penelitian ini menggunakan desain cross sectional. Populasi adalah seluruh penderita diabetes melitus tipe 2 se-Kabupaten Banyumas. Metode penarikan sample dengan teknik cluster sampling dengan besar sampel 532 orang yang tersebar di 22 puskesmas se-Kabupaten Banyumas. Analisis data menggunakan uji korelasi Spearman dan Regresi Linier Ganda. Hasil penelitian menunjukkan nilai p pada masing–masing variabel yang dihubungkan dengan perawatan mandiri diabetes antara lain adalah jenis kelamin (p=0,043),usia (p=0,18), lama menderita diabetes (p= 0,11) pengetahuan (p=0,000), motivasi (=0,01), serta dukungan keluarga (p= 0,000). Sebesar 10,4 % variasi perawatan mandiri diabetes dapat dijelaskan oleh variabel pengetahuan dengan koefisien β = 0,32. Kesimpulan penelitian adalah ada hubungan antara jenis kelamin, pengetahuan, motivasi dan dukungan keluarga dengan perawatan mandiri diabetes. Variabel pengetahuan menjadi faktor yang paling dominan berhubungan dengan perawatan mandiri diabetes.Kata kunci : determinan, diabetes melitus, perawatan mandiri diabetes   ABSTRACT Patients with type 2 diabetes need to apply self-care in order to minimize various complications and decreasing quality of life. Several factors are assumed to have an effect on the application of diabetes self-care by patients with type 2 diabetes in Banyumas Regency. The purpose of this research was to determine the determinants related to the application of diabetes self care by patients withtype 2 diabetesin Banyumas Regency. This research used cross sectional design. Population was all patients with type 2 diabetes mellitus in Banyumas Regency. Sampling method was performed by cluster sampling technique with sample size of 532 patients spreading in 22 community health centers (Puskesmas) in Banyumas Regency. Data analysis used Spearman correlation test and Multiple Linear Regression. The result indicated that p value in each variable affecting diabetes self-care was gender (p=0,043), age (p=0.18), duration of diabetes (p= 0.11) , knowledge (p=0.000), motivation (=0.01), and family support (p= 0.000). 10.4 % variation in diabetes self-care can be explained by knowledge variable with the coefficient β = 0.32. It can be concluded that there was a relationship among gender, knowledge, motivation and family support on diabetes self-care. Knowledge variable was the most dominant factor related to diabetes self-care. Keywords : determinants, diabetes mellitus, diabetes self-care

This study was conducted to examine the relationship between smartphone addiction, sleep quality, and academic performance. The study presented quantitative research on 323 students in a public university in Sabah to explore the relationship between smartphone addiction, sleep quality, and academic performance. A simple random sampling was used in the study. The Smartphone Addiction Scale Short Version (SAS-SV) and the Pittsburgh Sleep Quality Index (PSQI) were used in this study. SPSS was used as a tool of analysis for descriptive and inferential analysis. Pearson correlation was involved to test the hypothesis of the study. The result indicated that the greater the smartphone addiction, the lower the academic performance of university students. The finding also proved that students with poor sleep quality might exhibit low academic performance. Smartphone addiction was found to be associated with sleep quality where overusing smartphones was related to poor sleep quality in university students. On this basis, the problem of smartphone addiction and sleep quality should be tackled in order to improve the academic performance of university students and their overall health.

In addition to social and environmental factors, individual personality traits have intricately linked with maladaptive behaviour. Thus, the purpose of this article was to review the link between individual personality traits and criminality. A systematic review was conducted to obtain information regarding the link between individual personality traits with criminal behaviour in the Sage, Web of Science, APA PsycNet, Wiley Online Library, and PubMed databases. The results indicate that individual personality traits that contribute towards criminality are (i) psychopathy; (ii) low self-control; and (iii) difficult temperament. As an overall impact, the review is expected to provide in-depth understanding of the link between individual personality traits and criminality; hence, greater consideration will be given to the dimension of personality as a notable risk factor of criminal behaviour.

Adolescents involved in bullying can be at risk of developing behavioural problems, physical health problems and suicidal ideation. In view of this, a quantitative research design using a cross-sectional study was conducted to determine the prevalence of bullying and associated individual, peer, family and school factors. The study involved 4469 Malaysian public-school students who made up the response rate of 89.4%. The students were selected using a randomized multilevel sampling method. The study found that 79.1% of student respondents were involved in bullying as perpetrators (14.4%), victims (16.3%), or bully–victims (48.4%). In a multivariate analysis, the individual domain showed a significant association between students’ bullying involvement and age (OR = 1.38, 95% CI 1.12–1.70), gender (OR = 1.73, 95% CI 1.47–0.91), ethnicity (OR = 0.66, 95% CI 0.47–0.91), duration of time spent on social media during the weekends (OR = 1.43, 95% CI 1.09–1.87) and psychological distress level (OR = 2.55, 95% CI 1.94–3.34). In the peer domain, the significantly associated factors were the number of peers (OR = 0.69, 95% CI 0.56–0.86) and frequency of quarrels or fights with peers (OR = 2.12, 95% CI 1.24–3.26). Among the items in the school domain, the significantly associated factors were students being mischievous in classrooms (OR = 1.52, 95% CI 1.06–2.06), student’s affection towards their teachers (OR = 1.53, 95% CI 1.06–2.20), frequency of appraisal from teachers (OR = 1.49, 95% CI 1.16–1.94), frequency of friends being helpful in classrooms (OR = 1.92, 95% CI 1.09–3.38) and frequency of deliberately skipping class (OR = 2.91, 95% CI 2.90–1.72). As a conclusion, the study revealed high levels and widespread bullying involvement among students in Malaysia. As such, timely bullying preventions and interventions are essential, especially in terms of enhancing their mental health capacity, which substantially influences the reduction in the prevalence rates of bullying involvement among students in Malaysia.

Erectile Dysfunction (ED) cases are quite high in both women and men and increase with age. Areca fruit, ginseng and purwoceng are plants that have been traditionally used to increase male vitality. This in vivo experimental research study with pre and post-test control group design located in the laboratory of animal house and the biomolecular laboratory Faculty of Medicine Sriwijaya University. The subjects of this study were albino rats (Rattus norvegicus), Wistar strains, divided into 6 groups are negative control, Sildenafil, Areca Fruit Extract (AFE) 50 mg/kgBW, AFE 100 mg/kgBW, Combination of Areca Fruit, Ginseng and Purwoceng (AGP) 50 mg/kgBW and AGP 100 mg/kgBW. Female rat was injected by giving 500 mg/100 g of subcutaneous progesterone and 10 μg/100 g of BB benzoate 48 hours before mating so that female mice enter the esterus phase. In this study it was found that Combination of Areca fruit, Ginseng and Purwoceng (AGP) group 50mg/kgBW significantly improved testosterone levels compared to sildenafil, while single areca fruit (AFE) dose 50mg/kgBW increased FSH and LH levels as well as sildenafil statistically. Keywords: areca fruit, erectile dysfunction, FSH, ginseng, LH, purwoceng, testosteron.

Mental health disorders are major causes of disability to those affected, their families and the wider society. Absence of mental illness, or ambitiously, the presence of psychological well-being is key to the optimal functioning of individuals, for them to lead fuller lives and essential for them to contribute actively to society. Some studies have explored the links between psychological well-being and emotional intelligence. However, no such study has focussed on rural, and more often than not, poor students. Our study looked at the effects of emotional intelligence on the psychological well-being of rural poor students in Sabah, Malaysia. It was a cross-sectional study of 430 students. We found that 73% and 90% of the rural students rated their emotional intelligence and psychological well-being as moderate respectively. Regression analysis showed that emotional intelligence could predict one’s psychological well-being. We suggest further research into the differences between school students and school dropouts, and between urban and rural poor students.

The carboxymethyl cellulose and polyvinyl alcohol (CMC/PVA) based hybrid polymer (HPe) system with different ratio of composition have been prepared via solution casting. The features of interaction between CMC and PVA were investigated using X-ray diffraction (XRD), and infrared (IR) spectroscopy to disclose the reduction of crystallinity of the HPe system. Morphological properties observed by Scanning electron microscopy (SEM) confirmed the homogeneity of the HPe system. Differential scanning calorimetry (DSC) result explains the miscibility of the HPe system which was confirmed by means of variations in the glass transition temperature (Tg). Two degradation mechanisms were revealed by thermogravimetric analysis (TGA) in the HPe system attributed to the decarboxylation in CMC and degradation of bond scission in PVA backbone. The blend of 80:20 compositions of CMC/PVA HPe system was found to be the optimum ratio with an increase in conductivity of CMC/PVA by one magnitude order from 10−7 to 10−6 S/cm with the lowest in crystallinity.

In recent years, gangsterism and gang related activities among Indians are perplexing and alarming. Although this issue is considered as an old phenomenon, researches related to underlying factors for gangsterism are still lacking. With this in mind, this study aimed to explore psychological and criminogenic factors behind gangsterism among Indians in Malaysia. This study utilized a non-experimental research design. This study is a qualitative research (semi-structured, face-to-face individual interview guide) that makes use of the inductive approach based on a combination of subjectivism and interpretivist philosophies. Six ex-gangsters and four police personnel were interviewed; and their experiences of gangsterism were used to gain a reality-based understanding regarding the factors underlying gangsterism. The thematic analyses generated three psychological factors (negative emotional responses, low self-control, and high impulsivity) and three criminogenic factors (substance abuse, having antisocial peers, and dysfunctional families). One new theme emerged: monetary gain, with three sub-themes (ease of obtaining money, amount and immediacy, and benefits derived from illegal monetary gains). The outcome of this explorative research provides insight to the growing body of knowledge on gangsterism in Malaysia and is useful for community leaders and law enforcement agencies to strategize appropriate intervention, prevention, and suppression efforts to combat gangsterism.

Due to inadequate regulatory mechanisms, the accuracy of the self-monitoring blood glucose (SMBG) devices is not ensured leading to potentially serious clinical consequences in Bangladesh. The present study was undertaken to evaluate the technical accuracy of ten most commonly used SMBG devices marketed in Dhaka City of Bangladesh. Top ten SMBG devices sold in Dhaka City were studied on a group of 100 type 2 diabetes mellitus subjects. Blood glucose values estimated (at fasting and 2 h after breakfast) by SMBG devices, using a blinding technique, were compared with the corresponding laboratory values by enzymatic method using the Dimension RXLMax automated chemistry analyzer. Hematocrit was measured using the Sysmex XT 2000 hematology autoanalyzer. The mean absolute relative error (MARE, %) was used as an indicator of accuracy and precision together. A highly significant correlation was observed between the device and laboratory values. However, none of the devices showed an acceptable accuracy at 5–10% deviation from the corresponding laboratory values either at fasting or postprandial states. On pooling together data from two prandial states, even at 15% deviation limits, 70% of the devices failed to show accurate results. On calculation of MARE, 60% devices were found to be beyond 15% error limit at 95% accuracy level. Corresponding analysis with 90% accuracy level showed 30% beyond the limit. Blood glucose results from around 30% of the top ten SMBG devices sold in Dhaka City do not have even minimum level of technical accuracy, and many others are not optimum in their accuracy levels.

Background Haloperidol is categorized as the first class antipsychotic drug. Long-term use of haloperidol may convey to increased Reactive Oxygen Species (ROS) that will yield oxidative damage which further leads to cell death. Several studies had identified the effects of cinnamon extract on cell death. This study aimed to determine the efficacy of cinnamon extract (Cinnamomum burmanii) on the protection of neuronal cell death in haloperidol-induced male Wistar white rats. Methods This study was experimental with pre and post-test design. Thirty male Wistar rats were divided into 5 groups, induced with haloperidol and followed by treatment. Caspase-3 and dopamine were assayed by ELISA sandwich method using ELISA kit. Mean difference of caspase expression and dopamine levels before and after induction were shown (p0,05) and there were also no mean differences of positive group dopamine level with group of cinnamon extract of 100 and 200mg/kgBW (p>0.05). Conclussion Cinnamomum burmanii extract at dose of 100 and 200mg/kgBW were effective in the protection against neuronal cell death in haloperidol induced male Wistar white rats.

Child sexual abuse is a public health issue that has been associated with a variety of negative health outcomes. Child sexual abusers constitute a heterogeneous population of individuals. This review lays out an overview of the current understanding of typologies and psychological profiles of child sexual abusers. Typologies of child sexual abusers in general and online child sexual abusers are reviewed to summarise the existing knowledge. Psychological traits including personality traits, cognitive distortion, empathy, and impulsivity are examined to provide a wider perspective of the psycho-criminogenic factors of child sexual abuse. Although past research on child sexual abusers has provided insights into the organisation and classification of different types of child sexual abusers, the classification of these typologies has drawn widespread criticisms. In this review, we discuss the challenges and limitations pertaining to the existing typologies and studies related to the psychological profile of child sexual abusers.

Introduction/Objective Myoepithelial carcinoma is identified by nearly exclusive myoepithelial differentiation and evidence of malignancy. It may arise de novo or in preexisting benign tumors including pleomorphic adenoma and benign myoepithelioma. It occurs most commonly in the parotid gland followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Nasopharyngeal origin has been rarely reported. Methods/Case Report An afebrile 19-year-old female presented to the emergency department with persistent facial pressure, otalgia (right side greater than left side), rhinorrhea, and several episodes of epistaxis. One month before, she has been treated with Amoxicillin for three days with no relief, where Augmentin started for her for five days. About four days prior presentation, she was placed on Prednisone and Cefdinir. Over the next several days, she began having throat pain with difficulty swallowing. Routine blood work revealed a leukocytosis of 14.2 with normal differentiation. CT of the neck showed a large soft tissue mass centered at the right nasopharynx. Flexible nasal endoscopy performed bilaterally to reveal the nasopharynx is entirely obstructed with a lobulated mass filling the nasopharynx. On the right side, it extends into the posterior nasal passage filling the sphenoethmoid recess and the posterior floor of the nasal passage. Outpatient biopsy from nasopharynx mass is also performed. Results (if a Case Study enter NA) Mass biopsy reveals a mucinous and chondromyxoid background with mixed epithelial and myoepithelial differentiation. The is squamous metaplasia of myoepithelial cells and prominent mitotic activity and apoptotic activity. Immunohistochemistry was positive for CK5/6, calponin, BCL2, SMA, BerEp4, Sox10, and a proliferative index up to 40%. Based on this information Myoepithelial Carcinoma ex-pleomorphic adenoma of the nasopharynx is the diagnosis. Conclusion Carcinoma ex pleomorphic adenoma is usually a high-grade malignancy. It occurs most commonly in the parotid gland, followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Our case is one of the few cases of myoepithelial carcinoma arising in nasopharyngeal pleomorphic adenoma.