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1. Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2)

Author

Tilman Reiff, Hans-Henning Eckstein, Ulrich Mansmann, Olav Jansen, Gustav Fraedrich, Harald Mudra, Dittmar Böckler, Michael Böhm, Hartmut Brückmann, E. Sebastian Debus, Jens Fiehler, Klaus Mathias, E. Bernd Ringelstein, Jürg Schmidli, Robert Stingele, Ralf Zahn, Thomas Zeller, Wolf-Dirk Niesen, Kristian Barlinn, Andreas Binder, Jörg Glahn, Peter Arthur Ringleb, F Beyersdorf, M Grügerny, R-R Macharzina, G Lechner, C Menz, S Schonhardt, M Weinbeck, O Greb, D Otto, T Winker, H Berger, H Poppert, V Pütz, K Haase, U Bodechtel, N Weiss, H Bergert, J Meyne, J Groß, A Botsch, M Kruse, B Gerdes, WD Reinbold, H Wuttig, A Maier-Hasselmann, M Segerer, H-H Fuchs, S Gass, H Schultz, C Groden, M Niedergethman, M Griebe, M Rosenkranz, C Beck, G Thomalla, H Zeumer, M Jauß, W Kneist, M Kneist, T Staudacher, A Bernhard, D Jost, N Prey, J Knippschild, O Kastrup, M Köhrmann, B Frank, V Bongers, J Hoffmann, H-W Kniemeyer, M Knauth, K Wasser, T Stojanovic, H Emmert, J Tacke, B Schwalbe, E-M Nam, U van Lengerich, S Lowens, K Gröschel, T Uphaus, S Gröschel, S Boor, B Dorweiler, E Schmid, H Henkes, T Hupp, O Singer, G Hamann, M Wagner-Heck, S Kerth-Krick, M Kilic, P Huppert, K Niederkorn, J Fruhwirth, G Klein, U Pulkowski, K Jöster, J-H Wacks, E Kloppmann, B Vatankhah, S Hopf-Jensen, H Stolze, S Müller-Hülsbeck, KP Walluscheck, H-M Schmitt, A Grüger, J Seemann, B Tilahun, M Dichgans, F Wollenweber, A Dörr, A Zollver, G Gäbel, G Hedtmann, R Kollmar, D Claus, C Petermann, S Kirsch, B Bosnjak, J Heiß, H Mühling, S Wunderlich, PN Sabisch, G Gahn, M Storck, S Arnold, U Fischer, J Gralla, M von Mering, R Dißmann, D Kirsch, C Schmidauer, P Waldenberger, M Furtner, H Kazarians, P Breuer, C Arning, J Rieper, G Schmidt, M Arnold, G Schroth, J Weise, J Zanow, T Mayer, R Töpper, W Gross-Fengels, H Daum, R Dittrich, M Ritter, B Kasprzak, G Torsello, C Pohlmann, R Brüning, H Amiri, I Ludwig, E Blessing, M Möhlenbruch, A Crispin, M Hofman, and T Müller

Subjects
Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Carotid endarterectomy, Carotid Intima-Media Thickness, Risk Assessment, Predictive Value of Tests, Risk Factors, Internal medicine, Occlusion, medicine, Humans, Carotid Stenosis, Plaque morphology, In patient, Prospective Studies, cardiovascular diseases, Asymptomatic carotid artery stenosis, Stroke, Aged, Endarterectomy, Carotid, business.industry, Endovascular Procedures, Rehabilitation, Middle Aged, medicine.disease, Plaque, Atherosclerotic, Europe, Clinical trial, Stenosis, Treatment Outcome, Asymptomatic Diseases, Cardiology, Female, Stents, Surgery, Neurology (clinical), Cardiology and Cardiovascular Medicine, business
Abstract

Background Asymptomatic carotid artery stenosis (ACS) has a low risk of stroke. To achieve an advantage over noninterventional best medical treatment (BMT), carotid endarterectomy (CEA) or carotid artery stenting (CAS) must be performed with the lowest possible risk of stroke. Therefore, an analysis of risk-elevating factors is essential. Grade of ipsilateral and contralateral stenosis as well as plaque morphology are known risk factors in ACS. Methods The randomized, controlled, multicenter SPACE-2 trial had to be stopped prematurely after recruiting 513 patients. 203 patients were randomized to CEA, 197 to CAS, and 113 to BMT. Within one year, risk factors such as grade of stenosis and plaque morphology were analyzed. Results Grade of contralateral stenosis (GCS) was higher in patients with any stroke (50%ECST vs. 20%ECST; p=0.012). Echolucent plaque morphology was associated with any stroke on the day of intervention (OR 5.23; p=0.041). In the periprocedural period, any stroke was correlated with GCS in the CEA group (70%ECST vs. 20%ECST; p=0.026) and with echolucent plaque morphology in the CAS group (6% vs. 1%; p=0.048). In multivariate analysis, occlusion of the contralateral carotid artery (CCO) was associated with risk of any stroke (OR 7.00; p=0.006), without heterogeneity between CEA and CAS. Conclusion In patients with asymptomatic carotid artery stenosis, GCS, CCO, as well as echolucent plaque morphology were associated with a higher risk of cerebrovascular events. The risk of stroke in the periprocedural period was increased by GCS in CEA and by echolucent plaque in CAS. Due to small sample size, results must be interpreted carefully.

Published
2021
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2. Aneurysmen der thorakalen und thorakoabdominalen Aorta

Author

U. Settmacher and J. Zanow

Subjects
Gynecology, medicine.medical_specialty, Transplant surgery, business.industry, Cardiothoracic surgery, medicine, Surgery, business, Abdominal surgery
Abstract

Thorakale und thorakoabdominale Aortenaneurysmen werden bei steigender Inzidenz zunehmend operativ behandelt. Die Indikation zur Rekonstruktion besteht wegen der Rupturgefahr ab einem Durchmesser von 6 cm, bei Risikogruppen ab 5,5 cm. Die anspruchsvolle offene chirurgische Therapie ist bis heute mit einer relevanten Mortalitat und Morbiditat verbunden. Die sich als Alternative rasch entwickelnde endovaskulare Therapie, als komplett endovaskulare Operation oder in Kombination mit Debranching-Prozeduren durchgefuhrt, scheint ein im Vergleich dazu geringeres operatives Risiko aufzuweisen. Insbesondere fur Altere und Risikopatienten sowie fur die von der Morphologie optimal behandelbaren Befunde hat die endovaskulare Behandlung dieser Aneurysmen einen festen Stellenwert eingenommen. Dennoch erscheint aktuell ein kompletter Paradiagmenwechsel von der offenen zur endovaskularen Rekonstruktion fur alle Patienten, insbesondere bei komplexen Befunden, noch nicht begrundet.

Published
2014
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3. Choices of stent and cerebral protection in the ongoing ACST-2 trial: a descriptive study

Author

D.D. de Waard, A. Halliday, G.J. de Borst, R. Bulbulia, A. Huibers, R. Casana, L.H. Bonati, V. Tolva, G. Fraedrich, B. Rantner, E. Gizewski, I. Gruber, J. Hendriks, P. Cras, P. Lauwers, P. van Scheil, F. Vermassen, I. Van Herzeele, M. Geenens, D. Hemelsoet, P. Lerut, B. Lambrecht, G. Saad, A. Peeters, M. Bosiers, E. da Silva, N. de Luccia, J.C. Sitrangulo, A.E.V. Estenssoro, C. Presti, I. Casella, J.A.T. Monteiro, W. Campos, P. Puech-Leao, V. Petrov, C. Bachvarov, M. Hill, A. Mitha, J. Wong, C.-W. Liu, L. Bao, C. Yu, I. Cvjetko, V. Vidjak, J. Fiedler, S. Ostry, L. Sterba, P. Kostal, R. Staffa, R. Vlachovsky, M. Privara, Z. Kriz, B. Vojtisek, P. Krupa, M. Reif, V. Benes, P. Buchvald, L. Endrych, V. Prochazka, M. Kuliha, D. Otahal, T. Hrbac, D. Netuka, M. Mohapl, F. Kramier, M. Eldessoki, H. Heshmat, F. Abd-Allah, V. Palmiste, S. Margus, T. Toomsoo, J.-P. Becquemin, P. Bergeron, T. Abdulamit, J.-M. Cardon, S. Debus, G. Thomalla, J. Fiehler, C. Gerloss, U. Grzyska, M. Storck, E. LaMacchia, H.H. Eckstein, H. Söllner, H. Berger, M. Kallmayer, H. Popert, A. Zimmermann, A. Guenther, C. Klingner, T. Mayer, J. Schubert, J. Zanow, D. Scheinert, U. Banning-Eichenseer, Y. Bausback, D. Branzan, S. Braünilch, J. Lenzer, A. Schidt, H. Staab, M. Ulirch, J. Barlinn, K. Haase, A. Abramyuk, U. Bodechtel, J. Gerber, C. Reeps, T. Pfeiffer, G. Torello, A. Cöster, A. Giannoukas, K. Spanos, M. Matsagkas, S. Koutias, S. Vasdekis, J. Kakisis, K. Moulakakis, A. Lazaris, C. Liapas, E. Brountzos, M. Lazarides, N. Ioannou, A. Polydorou, B. Fulop, E. Fako, E. Voros, M. Bodosi, T. Nemeth, P. Barzo, S. Pazdernyik, L. Entz, Z. Szeberin, E. Dosa, B. Nemes, Z. Jaranyi, S. Pazdernyia, P. Madhaban, A. Hoffman, E. Nikolsky, R. Beyar, R. Silingardi, A. Lauricella, G. Coppi, E. Nicoloci, N. Tusini, F. Strozzi, E. Vecchiati, M. Ferri, E. Ferrero, D. Psacharopulo, A. Gaggiano, A. Viazzo, L. Farchioni, G. Parlani, V. Caso, P. De Rangoy, F. Verzini, P. Castelli, M.L. DeLodovici, G. Carrafiello, A.M. Ierardi, G. Piffaretti, G. Nano, M.T. Occhiuto, G. Malacrida, D. Tealdi, S. Steghter, A. Stella, R. Pini, G. Faggioli, S. Sacca, M.D. Negri, M. Palombo, M.C. Perfumo, G.F. Fadda, H. Kasemi, C. Cernetti, D. Tonello, A. Visonà, N. Mangialardi, S. Ronchey, M.C. Altavista, S. Michelagnoli, E. Chisci, F. Speziale, L. Capoccia, P. Veroux, A. Giaquinta, F. Patti, R. Pulli, P. Boggia, D. Angiletta, G. Amatucci, F. Spinetti, F. Mascoli, E. Tsolaki, E. Civilini, B. Reimers, C. Setacci, G. Pogany, A. Odero, F. Accrocca, G. Bajardi, I. Takashi, E. Masayuki, E. Hidenori, B. Aidashova, N. Kospanov, S. Bakke, M. Skjelland, A. Czlonkowska, A. Kobayashi, R. Proczka, A. Dowzenko, W. Czepel, J. Polanski, P. Bialek, G. Ozkinis, M. Snoch-Ziólkiewicz, M. Gabriel, M. Stanisic, W. Iwanowski, P. Andziak, F.B. Gonçalves, V. Starodubtsev, P. Ignatenko, A. Karpenko, D. Radak, N. Aleksic, D. Sagic, L. Davidovic, I. Koncar, I. Tomic, M. Colic, D. Bartkoy, F. Rusnak, M. Gaspirini, P. Praczek, Z. Milosevic, V. Flis, A. Bergauer, N. Kobilica, K. Miksic, J. Matela, E. Blanco, M. Guerra, V. Riambau, P. Gillgren, C. Skioldebrand, N. Nymen, B. Berg, M. Delle, J. Formgren, T.B. Kally, P. Qvarfordt, G. Plate, H. Pärson, H. Lindgren, K. Bjorses, A. Gottsäter, M. Warvsten, T. Kristmundsson, C. Forssell, M. Malina, J. Holst, T. Kuhme, B. Sonesson, B. Lindblad, T. Kolbel, S. Acosta, L. Bonati, C. Traenka, M. Mueller, T. Lattman, M. Wasner, E. Mujagic, A. Von Hessling, A. Isaak, P. Stierli, T. Eugster, L. Mariani, C. Stippich, T. Wolff, T. Kahles, R. Toorop, F. Moll, R. Lo, A. Meershoek, A.K. Jahrome, A.W.F. Vos, W. Schuiling, R. Keunen, M. Reijnen, S. Macsweeney, N. McConachie, A. Southam, G. Stansby, T. Lees, D. Lambert, M. Clarke, M. Wyatt, S. Kappadath, L. Wales, R. Jackson, A. Raudonaitis, S. MacDonald, P. Dunlop, A. Brown, S. Vetrivel, M. Bajoriene, R. Gopi, C. McCollum, L. Wolowczyk, J. Ghosh, D. Seriki, R. Ashleigh, J. Butterfield, M. Welch, J.V. Smyth, D. Briley, U. Schulz, J. Perkins, L. Hands, W. Kuker, C. Darby, A. Handa, L. Sekaran, K. Poskitt, J. Morrison, P. Guyler, I. Grunwald, J. Brown, M. Jakeways, S. Tysoe, D. Hargroves, G. Gunathilagan, R. Insall, J. Senaratne, J. Beard, T. Cleveland, S. Nawaz, R. Lonsdale, D. Turner, P. Gaines, R. Nair, I. Chetter, G. Robinson, B. Akomolafe, J. Hatfield, K. Saastamoinen, J. Crinnion, A.A. Egun, J. Thomas, S. Drinkwater, S. D'Souza, G. Thomson, B. Gregory, S. Babu, S. Ashley, T. Joseph, R. Gibbs, G. Tebit, A. Mehrzad, P. Enevoldson, D. Mendalow, A. Parry, G. Tervitt, A. Clifton, M. Nazzel, R. Peto, H. Pan, J. Potter, R. Bullbulia, B. Mihaylova, M. Flather, A. Mansfield, D. Simpson, D. Thomas, W. Gray, B. Farrell, C. Davies, K. Rahimi, M. Gough, P. Cao, P. Rothwell, A. Belli, M. Mafham, W. Herrington, P. Sandercock, R. Gray, C. Shearman, A. Molyneux, A. Gray, A. Clarke, M. Sneade, L. Tully, W. Brudlo, M. Lay, A. Munday, C. Berry, S. Tochlin, J. Cox, R. Kurien, and J. Chester

Subjects
Plaque echolucency, Time Factors, medicine.medical_treatment, Practice Patterns, 030204 cardiovascular system & hematology, Severity of Illness Index, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Risk Factors, Occlusion, Carotid artery stenosis, Carotid Stenosis, Practice Patterns, Physicians', Stroke, Endarterectomy, Plaque, Atherosclerotic, Endarterectomy, Carotid, Endovascular Procedures, Plaque, Atherosclerotic, Treatment Outcome, Cerebrovascular Circulation, Stents, Radiology, medicine.symptom, Cardiology and Cardiovascular Medicine, Carotid artery stenting, medicine.medical_specialty, Clinical Decision-Making, education, Cerebral protection devices, Stent design, Surgery, Prosthesis Design, Asymptomatic, Embolic Protection Devices, 03 medical and health sciences, Severity of illness, medicine, Humans, Carotid, Chi-Square Distribution, Physicians', business.industry, Patient Selection, Stent, METANÁLISE, medicine.disease, Asymptomatic Diseases, Cerebrovascular Disorders, Stenosis, business, 030217 neurology & neurosurgery
Abstract

Objectives Several plaque and lesion characteristics have been associated with an increased risk for procedural stroke during or shortly after carotid artery stenting (CAS). While technical advancements in stent design and cerebral protection devices (CPD) may help reduce the procedural stroke risk, and anatomy remains important, tailoring stenting procedures according to plaque and lesion characteristics might be a useful strategy in reducing stroke associated with CAS. In this descriptive report of the ongoing Asymptomatic Carotid Surgery Trial-2 (ACST-2), it was assessed whether choice for stent and use or type of CPD was influenced by plaque and lesion characteristics. Materials and methods Trial patients who underwent CAS between 2008 and 2015 were included in this study. Chi-square statistics were used to study the effects of plaque echolucency, ipsilateral preocclusive disease (90–99%), and contralateral high-grade stenosis (>50%) or occlusion of the carotid artery on interventionalists' choice for stent and CPD. Differences in treatment preference between specialties were also analysed. Results In this study, 831 patients from 88 ACST-2 centres were included. Almost all procedures were performed by either interventional radiologists (50%) or vascular surgeons (45%). Plaque echolucency, ipsilateral preocclusive disease (90–99%), and significant contralateral stenosis (>50%) or occlusion did not affect the choice of stent or either the use of cerebral protection and type of CPD employed (i.e., filter/flow reversal). Vascular surgeons used a CPD significantly more often than interventional radiologists (98.6% vs. 76.3%; p < .001), but this choice did not appear to be dependent on patient characteristics. Conclusions In ACST-2, plaque characteristics and severity of stenosis did not primarily determine interventionalists' choice of stent or use or type of CPD, suggesting that other factors, such as vascular anatomy or personal and centre preference, may be more important. Stent and CPD use was highly heterogeneous among participating European centres.

Published
2017

4. Which factors affect the long-term survival of patients with hepatocellular carcinoma UICC stage IV?

Author

J. Zanow, C. Malessa, Annelore Altendorf-Hofmann, S. Schüle, Utz Settmacher, and A. Bauschke

Subjects
Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Carcinoma, Hepatocellular, Adolescent, Gastroenterology, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, medicine, Hepatectomy, Humans, Stage (cooking), Lymph node, Survival analysis, Aged, Neoplasm Staging, Aged, 80 and over, business.industry, Proportional hazards model, Liver Neoplasms, Multimodal therapy, General Medicine, Middle Aged, medicine.disease, Prognosis, Survival Analysis, BCLC Stage, Dissection, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, 030211 gastroenterology & hepatology, Female, business
Abstract

In the 7th edition of the TNM classification, not only HCC with distant metastases but also those with regional lymph node metastases are classified as stage IV. From our prospectively recorded tumor registry, 138 patients (17 %) with HCC were in stage IV. Among those were 68 and 70, respectively, in stage IVA (regional lymph node metastases) and IVB (distant metastases). The tumors were less frequently treated with resection or local ablative treatment (chemoembolization, RFA, SIRT, percutaneous radiation) than patients in stage I–III. Ten HCCs were resected. Five of the resected patients were in stage IVA and five in stage IVB. After tumor resection, patients lived longer than those who underwent local or systemic treatment only (p = 0.003 or p = 0.001, respectively). In the univariate survival analysis, the stage IV patients’ long-term survival was decreased statistically significantly through elevated bilirubin, low albumin, Okuda stage III and BCLC stage D. Patients’ age and sex, pre-treatment AFP level, Child stage and the presence of venous invasion did not influence survival. In the multivariate analysis (Cox regression), tumor resection and BCLC stage were independent prognostic factors. Patients with HCC in TNM stage IV have a very poor prognosis. Only few patients are eligible for resection because of the extent of tumor growth, comorbidities and general condition. These, however, benefit markedly from tumor resection with lymph node dissection and possibly resection of distant metastases.

Published
2016

5. Prothetische Gefäßzugänge für die Hämodialyse

Author

U. Settmacher and J. Zanow

Subjects
Gynecology, medicine.medical_specialty, Transplant surgery, Cardiothoracic surgery, business.industry, medicine, Surgery, business, Abdominal surgery
Abstract

Arteriovenose Dialysezugange unter Verwendung von Gefasprothesen haben eine niedrigere Offenheitsrate und hohere Komplikationsrate als solche mit korpereigenen Gefasen und stellen deshalb insbesondere bei ungeeigneten oder verbrauchten oberflachlichen Armvenen eine sekundare oder tertiare Option des Gefaszuganges dar. Bei guter Planung unter Beachtung der patientenspezifischen Besonderheiten, sorgfaltigem operativem Vorgehen und adaquater Behandlung auftretender Komplikationen konnen bei einer Vielfalt moglicher Konfigurationen von Protheseninterponaten zwischen Arterie und einer meist tiefen Vene uber Jahre funktionsfahige Gefaszugange geschaffen werden. So haben diese prothetischen Gefaszugange weiterhin ihre Berechtigung, werden bei zunehmender Komorbiditat der Patienten eher an Bedeutung zunehmen und sind einem getunnelten Vorhofkatheter fur die dauerhafte Hamodialyse unbedingt vorzuziehen. Der vorliegende Beitrag stellt die Indikationen, operativen Moglichkeiten und Besonderheiten prothetischer Dialysezugange dar.

Published
2012
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6. Contents Vol. 84, 2010

Author

F. Marchese, J. Zanow, Yoshihisa Kawai, L. Macchione, Vanessa Sandim, J. Masood, Jocelyn M. Rieder, H. Wunderlich, Marc Fourmarier, Kohsuke Sasaki, Rany Shamloul, Tomoyuki Murakami, Nicolas Barry Delongchamps, Yoshiaki Yamamoto, Stephan A. Krueger, O.W. Hakenberg, Christian Schwentner, S. Fuessel, Kristina Hotakainen, I. Ioannou, Takahiko Hara, Jörg Hennenlotter, N. Kroeger, A. Di Benedetto, F. Fraggetta, Kazuhiro Nagao, Gilda Alves, Christian Saussine, Karen Stern, Klaus G. Fink, C. Magno, Charles Ballereau, Claudius Fuellhase, Pascual Chuan-Nuez, Johan Lundin, T. Briggs, José M. Martínez-Jabaloyas, Ursula Kuehs, M. Madonia, Bertrand Lukacs, Donald C. McMillan, Taku Misumi, G. Grasso, Sherif R. Aboseif, John Brusky, Hideyasu Matsuyama, Rashad Mammadov, Harald Trummer, Alexander Winter, Erkan Kismali, Salih Sanlioglu, Aurélien Descazeaud, Viet Tran, Harri Visapää, Omer Kutlu, Adnan Şimşir, I. Petersen, N. Buchholz, Roman Szlauer, Friedhelm Wawroschek, Olivier Haillot, G. Candiano, Badereddin Mohamad Al-Ali, G. Shaw, Francois Desgrandchamps, Denise A. Pereira, Shigeru Sakano, Hideaki Ito, Ahter Dilsad Sanlioglu, Jens Uphoff, Martti Ala-Opas, I. Pirozhok, Luis Arenas, T. Castelli, M.P. Wirth, Arnulf Stenzl, Kazuhiko Nakano, J. Gelister, T. Steiner, Gurhan Gunaydin, F. Aragona, G. Romano, Alexandre de la Taille, Antonio A. Ornellas, Heinz-Peter Schlemmer, Daniela Colleselli, Kazumi Suzuki, Levent A. Guner, Tahir Qayyum, A. Meye, Richard Zigeuner, Satoshi Eguchi, Marian Devonec, Ismail Turker Koksal, David Schilling, Ljiljana Paras, G. Morgia, A. Galia, Rafael Villamón-Fort, Ulrich H. Vogel, P. Pepe, Katsusuke Naito, Cag Cal, M. Gajda, Manuel Gil-Salom, Karl Pummer, Rolf-Peter Henke, A. Papatsoris, U. Settmacher, A. Galì, G. Mucciardi, Tatsuo Morita, Grégoire Robert, Olivier Dumonceau, J. Fichtner, G. Bonvissuto, Ulf-Håkan Stenman, Matthias P. Lichy, Seiji Yano, P A McArdle, and Rahmene Azzouzi

Subjects
Traditional medicine, business.industry, Urology, Medicine, business
Published
2010
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7. Downsizing a Tumor Thrombus of Advanced Renal Cell Carcinoma with Neoadjuvant Systemic Therapy and Resulting Histopathological Effects

Author

T. Steiner, U. Settmacher, J. Zanow, M. Gajda, N. Kroeger, Heiko Wunderlich, and I. Petersen

Subjects
Oncology, medicine.medical_specialty, Indoles, Urology, medicine.medical_treatment, Antineoplastic Agents, Vena Cava, Inferior, urologic and male genital diseases, Nephrectomy, Systemic therapy, Tumor thrombus, Renal cell carcinoma, Internal medicine, Sunitinib, medicine, Carcinoma, Humans, Neoplasm Invasiveness, Pyrroles, Carcinoma, Renal Cell, Neoadjuvant therapy, Thrombectomy, Venous Thrombosis, Chemotherapy, business.industry, Middle Aged, Neoplastic Cells, Circulating, medicine.disease, Kidney Neoplasms, Neoadjuvant Therapy, Treatment Outcome, Chemotherapy, Adjuvant, Radiology, Tomography, X-Ray Computed, business, medicine.drug
Abstract

Background: We report a treatment option in surgical therapy of locally advanced renal cell carcinoma (RCC). Method: A 63-year-old patient with locally advanced RCC including an atrial thrombus underwent 2 cycles of neoadjuvant therapy (Sutent® 50 mg daily for 4 weeks followed by 2 weeks off) and then tumor surgery. Primary surgical therapy had to be delayed because of suspected bronchial carcinoma and additional diagnostics. After neoadjuvant therapy to downsize the tumor thrombus and exclusion of any additional malignant tumors, operation was done via abdominal access; no sternotomy was necessary. Results: Histopathological examinations of the primary tumor after tyrosine kinase inhibitor therapy were evaluated and compared to tumor biopsy material taken before therapy. Conclusion: Neoadjuvant therapy with Sutent® may represent a favorable treatment option in cases of locally advanced clear-cell RCC with extended tumor thrombus.

Published
2010
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8. Erratum to 'Choices of Stent and Cerebral Protection in the Ongoing ACST-2 Trial: A Descriptive Study' [Eur J Vasc Endovasc Surg 53 (2017) 617–625]

Author

D.D. de Waard, A. Halliday, G.J. de Borst, R. Bulbulia, A. Huibers, R. Casana, L.H. Bonati, V. Tolva, G. Fraedrich, B. Rantner, E. Gizewski, I. Gruber, J. Hendriks, P. Cras, P. Lauwers, P. van Scheil, F. Vermassen, I. Van Herzeele, M. Geenens, D. Hemelsoet, P. Lerut, B. Lambrecht, G. Saad, A. Peeters, M. Bosiers, E. da Silva, N. de Luccia, J.C. Sitrangulo, A.E.V. Estenssoro, C. Presti, I. Casella, J.A.T. Monteiro, W. Campos, P. Puech-Leao, V. Petrov, C. Bachvarov, M. Hill, A. Mitha, J. Wong, C.-W. Liu, L. Bao, C. Yu, I. Cvjetko, V. Vidjak, J. Fiedler, S. Ostry, L. Sterba, P. Kostal, R. Staffa, R. Vlachovsky, M. Privara, Z. Kriz, B. Vojtisek, P. Krupa, M. Reif, V. Benes, P. Buchvald, L. Endrych, V. Prochazka, M. Kuliha, D. Otahal, T. Hrbac, D. Netuka, M. Mohapl, F. Kramier, M. Eldessoki, H. Heshmat, F. Abd-Allah, V. Palmiste, S. Margus, T. Toomsoo, J.-P. Becquemin, P. Bergeron, T. Abdulamit, J.-M. Cardon, S. Debus, G. Thomalla, J. Fiehler, C. Gerloss, U. Grzyska, M. Storck, E. LaMacchia, H.H. Eckstein, H. Söllner, H. Berger, M. Kallmayer, H. Popert, A. Zimmermann, A. Guenther, C. Klingner, T. Mayer, J. Schubert, J. Zanow, D. Scheinert, U. Banning-Eichenseer, Y. Bausback, D. Branzan, S. Braünilch, J. Lenzer, A. Schidt, H. Staab, M. Ulirch, J. Barlinn, K. Haase, A. Abramyuk, U. Bodechtel, J. Gerber, C. Reeps, T. Pfeiffer, G. Torello, A. Cöster, A. Giannoukas, K. Spanos, M. Matsagkas, S. Koutias, S. Vasdekis, J. Kakisis, K. Moulakakis, A. Lazaris, C. Liapas, E. Brountzos, M. Lazarides, N. Ioannou, A. Polydorou, B. Fulop, E. Fako, E. Voros, M. Bodosi, T. Nemeth, P. Barzo, S. Pazdernyik, L. Entz, Z. Szeberin, E. Dosa, B. Nemes, Z. Jaranyi, S. Pazdernyia, P. Madhaban, A. Hoffman, E. Nikolsky, R. Beyar, R. Silingardi, A. Lauricella, G. Coppi, E. Nicoloci, N. Tusini, F. Strozzi, E. Vecchiati, M. Ferri, E. Ferrero, D. Psacharopulo, A. Gaggiano, A. Viazzo, L. Farchioni, G. Parlani, V. Caso, P. De Rangoy, F. Verzini, P. Castelli, M.L. DeLodovici, G. Carrafiello, A.M. Ierardi, G. Piffaretti, G. Nano, M.T. Occhiuto, G. Malacrida, D. Tealdi, S. Steghter, A. Stella, R. Pini, G. Faggioli, S. Sacca, M.D. Negri, M. Palombo, M.C. Perfumo, G.F. Fadda, H. Kasemi, C. Cernetti, D. Tonello, A. Visonà, N. Mangialardi, S. Ronchey, M.C. Altavista, S. Michelagnoli, E. Chisci, F. Speziale, L. Capoccia, P. Veroux, A. Giaquinta, F. Patti, R. Pulli, P. Boggia, D. Angiletta, G. Amatucci, F. Spinetti, F. Mascoli, E. Tsolaki, E. Civilini, B. Reimers, C. Setacci, G. Pogany, A. Odero, F. Accrocca, G. Bajardi, I. Takashi, E. Masayuki, E. Hidenori, B. Aidashova, N. Kospanov, S. Bakke, M. Skjelland, A. Czlonkowska, A. Kobayashi, R. Proczka, A. Dowzenko, W. Czepel, J. Polanski, P. Bialek, G. Ozkinis, M. Snoch-Ziólkiewicz, M. Gabriel, M. Stanisic, W. Iwanowski, P. Andziak, F.B. Gonçalves, V. Starodubtsev, P. Ignatenko, A. Karpenko, D. Radak, N. Aleksic, D. Sagic, L. Davidovic, I. Koncar, I. Tomic, M. Colic, D. Bartkoy, F. Rusnak, M. Gaspirini, P. Praczek, Z. Milosevic, V. Flis, A. Bergauer, N. Kobilica, K. Miksic, J. Matela, E. Blanco, M. Guerra, V. Riambau, P. Gillgren, C. Skioldebrand, N. Nymen, B. Berg, M. Delle, J. Formgren, T.B. Kally, P. Qvarfordt, G. Plate, H. Pärson, H. Lindgren, K. Bjorses, A. Gottsäter, M. Warvsten, T. Kristmundsson, C. Forssell, M. Malina, J. Holst, T. Kuhme, B. Sonesson, B. Lindblad, T. Kolbel, S. Acosta, L. Bonati, C. Traenka, M. Mueller, T. Lattman, M. Wasner, E. Mujagic, A. Von Hessling, A. Isaak, P. Stierli, T. Eugster, L. Mariani, C. Stippich, T. Wolff, T. Kahles, R. Toorop, F. Moll, R. Lo, A. Meershoek, A.K. Jahrome, A.W.F. Vos, W. Schuiling, R. Keunen, M. Reijnen, S. Macsweeney, N. McConachie, A. Southam, G. Stansby, T. Lees, D. Lambert, M. Clarke, M. Wyatt, S. Kappadath, L. Wales, R. Jackson, A. Raudonaitis, S. MacDonald, P. Dunlop, A. Brown, S. Vetrivel, M. Bajoriene, R. Gopi, C. McCollum, L. Wolowczyk, J. Ghosh, D. Seriki, R. Ashleigh, J. Butterfield, M. Welch, J.V. Smyth, D. Briley, U. Schulz, J. Perkins, L. Hands, W. Kuker, C. Darby, A. Handa, L. Sekaran, K. Poskitt, J. Morrison, P. Guyler, I. Grunwald, J. Brown, M. Jakeways, S. Tysoe, D. Hargroves, G. Gunathilagan, R. Insall, J. Senaratne, J. Beard, T. Cleveland, S. Nawaz, R. Lonsdale, D. Turner, P. Gaines, R. Nair, I. Chetter, G. Robinson, B. Akomolafe, J. Hatfield, K. Saastamoinen, J. Crinnion, A.A. Egun, J. Thomas, S. Drinkwater, S. D'Souza, G. Thomson, B. Gregory, S. Babu, S. Ashley, T. Joseph, R. Gibbs, G. Tebit, A. Mehrzad, P. Enevoldson, D. Mendalow, A. Parry, G. Tervitt, A. Clifton, M. Nazzel, R. Peto, H. Pan, J. Potter, R. Bullbulia, B. Mihaylova, M. Flather, A. Mansfield, D. Simpson, D. Thomas, W. Gray, B. Farrell, C. Davies, K. Rahimi, M. Gough, P. Cao, P. Rothwell, A. Belli, M. Mafham, W. Herrington, P. Sandercock, R. Gray, C. Shearman, A. Molyneux, A. Gray, A. Clarke, M. Sneade, L. Tully, W. Brudlo, M. Lay, A. Munday, C. Berry, S. Tochlin, J. Cox, R. Kurien, and J. Chester

Subjects
medicine.medical_specialty, Surgery, Cardiology and Cardiovascular Medicine, business.industry, Published Erratum, medicine.medical_treatment, Physical therapy, medicine, MEDLINE, Stent, Descriptive research, business
Published
2017
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9. Subject Index Vol. 84, 2010

Author

G. Bonvissuto, Rahmene Azzouzi, G. Mucciardi, Tatsuo Morita, Adnan Şimşir, Friedhelm Wawroschek, Olivier Haillot, F. Marchese, Kohsuke Sasaki, Claudius Fuellhase, Pascual Chuan-Nuez, Francois Desgrandchamps, Denise A. Pereira, Olivier Dumonceau, Ursula Kuehs, Omer Kutlu, Tomoyuki Murakami, Seiji Yano, P A McArdle, Shigeru Sakano, Kristina Hotakainen, I. Ioannou, Takahiko Hara, Kazuhiro Nagao, Gilda Alves, J. Fichtner, G. Grasso, Roman Szlauer, I. Pirozhok, Luis Arenas, Marc Fourmarier, Aurélien Descazeaud, A. Papatsoris, Viet Tran, G. Shaw, Stephan A. Krueger, Martti Ala-Opas, S. Fuessel, Donald C. McMillan, Christian Schwentner, Satoshi Eguchi, F. Aragona, Antonio A. Ornellas, N. Buchholz, Klaus G. Fink, Kazumi Suzuki, J. Zanow, Ismail Turker Koksal, J. Gelister, Yoshihisa Kawai, I. Petersen, T. Castelli, Levent A. Guner, Kazuhiko Nakano, T. Steiner, Vanessa Sandim, Richard Zigeuner, Taku Misumi, L. Macchione, Marian Devonec, Johan Lundin, Gurhan Gunaydin, P. Pepe, Tahir Qayyum, A. Meye, John Brusky, Katsusuke Naito, Rany Shamloul, N. Kroeger, Rashad Mammadov, Alexandre de la Taille, A. Di Benedetto, Nicolas Barry Delongchamps, Heinz-Peter Schlemmer, Yoshiaki Yamamoto, Alexander Winter, Cag Cal, Salih Sanlioglu, M. Gajda, José M. Martínez-Jabaloyas, Daniela Colleselli, Rafael Villamón-Fort, Ulrich H. Vogel, Ahter Dilsad Sanlioglu, Jens Uphoff, Christian Saussine, M. Madonia, Charles Ballereau, Bertrand Lukacs, David Schilling, Ljiljana Paras, G. Morgia, G. Candiano, Jörg Hennenlotter, A. Galia, Arnulf Stenzl, Hideyasu Matsuyama, Erkan Kismali, F. Fraggetta, Jocelyn M. Rieder, M.P. Wirth, H. Wunderlich, Harri Visapää, O.W. Hakenberg, Karen Stern, T. Briggs, U. Settmacher, A. Galì, Grégoire Robert, G. Romano, Ulf-Håkan Stenman, Matthias P. Lichy, J. Masood, Karl Pummer, Rolf-Peter Henke, Manuel Gil-Salom, C. Magno, Sherif R. Aboseif, Harald Trummer, Badereddin Mohamad Al-Ali, and Hideaki Ito

Subjects
Gerontology, Index (economics), business.industry, Urology, Medicine, Subject (documents), business
Published
2010
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10. Chirurgische Therapie des Pancreas- und periampullären Carcinoms bei älteren Patienten

Author

J. Zanow and T. Benhidjeb

Subjects
medicine.medical_specialty, Anastomotic leakage, business.industry, medicine.medical_treatment, Operative mortality, medicine, Geriatric surgery, Patient group, Complication, Pancreaticoduodenectomy, business, Surgery
Abstract

A review of morbidity and mortality was performed for 84 patients over 70 years of age who underwent pancreaticoduodenectomy at our institution. Anastomotic leakage was the only significant complication. Operative mortality, although greater in this patient group, is acceptable

Published
1996
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11. Retraction of Authorship

Author

A. Papatsoris, Taku Misumi, Tomoyuki Murakami, Tahir Qayyum, A. Meye, Viet Tran, Rahmene Azzouzi, Kazuhiro Nagao, Gilda Alves, Arnulf Stenzl, Kohsuke Sasaki, F. Marchese, Cag Cal, M. Gajda, Rashad Mammadov, Kristina Hotakainen, I. Ioannou, Takahiko Hara, Jörg Hennenlotter, Donald C. McMillan, Heinz-Peter Schlemmer, David Schilling, Ljiljana Paras, G. Morgia, Marian Devonec, Christian Saussine, Shigeru Sakano, Omer Kutlu, Ulf-Håkan Stenman, Hideyasu Matsuyama, Daniela Colleselli, Adnan Şimşir, Olivier Dumonceau, I. Pirozhok, Luis Arenas, José M. Martínez-Jabaloyas, Satoshi Eguchi, Matthias P. Lichy, Erkan Kismali, Friedhelm Wawroschek, Badereddin Mohamad Al-Ali, J. Masood, J. Fichtner, Roman Szlauer, M. Madonia, Claudius Fuellhase, Olivier Haillot, F. Aragona, M.P. Wirth, Charles Ballereau, Antonio A. Ornellas, Karl Pummer, Bertrand Lukacs, Pascual Chuan-Nuez, Manuel Gil-Salom, Alexander Winter, A. Galia, Francois Desgrandchamps, Denise A. Pereira, G. Mucciardi, Kazumi Suzuki, Tatsuo Morita, Levent A. Guner, Ismail Turker Koksal, Kazuhiko Nakano, Martti Ala-Opas, Marc Fourmarier, Ursula Kuehs, I. Petersen, T. Steiner, Salih Sanlioglu, Rolf-Peter Henke, G. Bonvissuto, J. Gelister, Richard Zigeuner, T. Castelli, Hideaki Ito, F. Fraggetta, U. Settmacher, A. Galì, G. Shaw, Christian Schwentner, Stephan A. Krueger, Alexandre de la Taille, Gurhan Gunaydin, G. Candiano, S. Fuessel, Ahter Dilsad Sanlioglu, Jens Uphoff, Vanessa Sandim, Grégoire Robert, P. Pepe, Katsusuke Naito, Sherif R. Aboseif, Harri Visapää, G. Grasso, Harald Trummer, Seiji Yano, P A McArdle, Nicolas Barry Delongchamps, Rafael Villamón-Fort, Yoshiaki Yamamoto, Ulrich H. Vogel, John Brusky, Aurélien Descazeaud, C. Magno, Klaus G. Fink, N. Buchholz, J. Zanow, Johan Lundin, L. Macchione, G. Romano, T. Briggs, Jocelyn M. Rieder, H. Wunderlich, O.W. Hakenberg, Karen Stern, Yoshihisa Kawai, Rany Shamloul, N. Kroeger, and A. Di Benedetto

Subjects
business.industry, Urology, Medicine, Engineering ethics, business
Published
2010
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