1. Association of Dry Eye with Laryngopharyngeal Reflux in Clinical Practice
- Author
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Pasquale Aragona, J.M. Benitez Castillo, V. Damiani, Sergio Bonini, Elisabeth M. Messmer, Christophe Baudouin, Maurizio Rolando, G. Ciprandi, Murat Irkec, and Marc Labetoulle
- Subjects
Male ,medicine.medical_specialty ,Population ,Disease ,Cellular and Molecular Neuroscience ,Laryngopharyngeal reflux ,Internal medicine ,Laryngopharyngeal Reflux ,Prevalence ,Humans ,Medicine ,Ocular Surface Disease Index ,education ,Pathological ,Retrospective Studies ,education.field_of_study ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Sensory Systems ,Clinical Practice ,Ophthalmology ,Tears ,Dry Eye Syndromes ,Female ,business ,Ocular surface - Abstract
BACKGROUND Dry eye disease (DED) is a common disorder, accounting for up to 35% of the general population. Therefore, we hypothesized that laryngopharyngeal reflux (LPR), inducing refluxate rising into airways, may involve the ocular surface and may either induce or worsen DED. AIM To investigate the prevalence and relevance of suspected LPR in DED patients and subjects with refractive problems (RP) without DED, they were defined as non-dry eye group (NEG) in clinical practice. METHODS This retrospective study included consecutive patients evaluated because of dry eye-like symptoms at eight tertiary ophthalmological clinics. Parameters included reflux symptom index (RSI), ocular surface disease index (OSDI), symptom assessment in dry eye (SANDE) for frequency and severity, Schirmer test, tear break-up time (BUT), and Oxford grading. RESULTS The study included 245 subjects (72.5% females; mean age 56.3 years), 152 DED patients, and 93 sex- and age-matched NEG subjects. Pathological RSI (score>13) was detected in 80 subjects (32.6%); 68 (85%) with DED and 12 (15%) CG (OR = 8; p
- Published
- 2021