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Inflammation in Glaucoma: From the back to the front of the eye, and beyond
- Source :
- Progress in Retinal and Eye Research, Progress in Retinal and Eye Research, Elsevier, 2021, 83, ⟨10.1016/j.preteyeres.2020.100916⟩, Progress in Retinal and Eye Research, 2021, 83, pp.100916. ⟨10.1016/j.preteyeres.2020.100916⟩, Baudouin, C, Kolko, M, Melik-Parsadaniantz, S & Messmer, E M 2021, ' Inflammation in Glaucoma : From the back to the front of the eye, and beyond ', Progress in Retinal and Eye Research, vol. 83, 100916 . https://doi.org/10.1016/j.preteyeres.2020.100916
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; The pathophysiology of glaucoma is complex, multifactorial and not completely understood. Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic nerve damage. In addition, age-related oxidative stress in the retina concurrently with chronic mechanical and vascular stress is crucial for the initiation of retinal neurodegeneration. Oxidative stress is closely related to cell senescence, mitochondrial dysfunction, excitotoxicity, and neuroinflammation, which are involved in glaucoma progression. Accumulating evidence from animal glaucoma models and from human ocular samples suggests a dysfunction of the para-inflammation in the retinal ganglion cell layer and the optic nerve head. Moreover, quite similar mechanisms in the anterior chamber could explain the trabecular meshwork dysfunction and the elevated IOP in primary open-angle glaucoma. On the other hand, ocular surface disease due to topical interventions is the most prominent and visible consequence of inflammation in glaucoma, with a negative impact on filtering surgery failure, topical treatment efficacy, and possibly on inflammation in the anterior segment. Consequently, glaucoma appears as an outstanding eye disease where inflammatory changes may be present to various extents and consequences along the eye structure, from the ocular surface to the posterior segment, and the visual pathway. Here we reviewed the inflammatory processes in all ocular structures in glaucoma from the back to the front of the eye and beyond. Our approach was to explain how para-inflammation is necessary to maintain homoeostasis, and to describe abnormal inflammatory findings observed in glaucomatous patients or in animal glaucoma models, supporting the hypothesis of a dysregulation of the inflammatory balance toward a pro-inflammatory phenotype. Possible anti-inflammatory therapeutic approaches in glaucoma are also discussed.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
genetic structures
Eye disease
Ocular surface
[SDV]Life Sciences [q-bio]
Glaucoma
Benzalkonium chloride
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Neuroinflammation
Ophthalmology
medicine
Animals
Humans
Trabecular meshwork
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Intraocular Pressure
Inflammation
Retina
business.industry
Optic-nerve head degeneration
Retinal
medicine.disease
Sensory Systems
eye diseases
3. Good health
Posterior segment of eyeball
Treatment
030104 developmental biology
medicine.anatomical_structure
chemistry
Retinal ganglion cell
[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Oxidative stress
Neuroinflammatory Diseases
030221 ophthalmology & optometry
Optic nerve
IOP-Lowering drugs
Para-inflammation
sense organs
business
Primary open-angle glaucoma
Preservatives
Glaucoma, Open-Angle
Subjects
Details
- Language :
- English
- ISSN :
- 13509462
- Database :
- OpenAIRE
- Journal :
- Progress in Retinal and Eye Research, Progress in Retinal and Eye Research, Elsevier, 2021, 83, ⟨10.1016/j.preteyeres.2020.100916⟩, Progress in Retinal and Eye Research, 2021, 83, pp.100916. ⟨10.1016/j.preteyeres.2020.100916⟩, Baudouin, C, Kolko, M, Melik-Parsadaniantz, S & Messmer, E M 2021, ' Inflammation in Glaucoma : From the back to the front of the eye, and beyond ', Progress in Retinal and Eye Research, vol. 83, 100916 . https://doi.org/10.1016/j.preteyeres.2020.100916
- Accession number :
- edsair.doi.dedup.....ffa2fdbbcfff2abe76d2f62ee7706b6c