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Your search keyword '"Adele Gregory"' showing total 3 results
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3 results on '"Adele Gregory"'

1. Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND)

Author

Cassandra Brookes, Shaun Barber, Mark Liddle, Neil Nixon, Peter Bates, Richard Morriss, Marilyn James, Ana Suazo Di Paola, Paul M Briley, Louise Thomson, Lucy Webster, Mohamed Abdelghani, Dorothee P Auer, Andrew Blamire, Sarina Iwabuchi, Catherine Kaylor-Hughes, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Alex O'Neill-Kerr, Stefan Pszczolkowski Parraguez, Yvette Walters, Lorraine Bastick, Rosie Carr, Alison Cartlidge, Harry Clark, William Cottam, Robert De Vai, Linda Davison, John Gledhill, Adele Gregory, Christopher Griffiths, Andrew Hamilton, Delilah Harding, Kelly Heath, Rachel Hobson, Gbeminiyi Ireoluwa, Najat Khalifa, Kate Johnstone, Charlotte Kirkland, Jessica Lynch, Jehill Parikh, Isabel Reid, Noemi Reiner, Sandra Simpson, Beverley Smith, Tina Sore, Joseph Stone, Carly Taylorson, Rebecca Toney, Claire Turner, Sarah Wilkinson, Andy Willis, and Tom Willis

Subjects
Medicine
Abstract

Introduction The BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression.Methods and analysis The study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachusetts General Hospital Staging Score) and moderate to severe (scoring >16 on the 17-item Hamilton Depression Rating Scale (HDRS-17)), will be recruited from primary and secondary care settings at four treatment centres in the UK. The primary outcome is depression response at 16 weeks (50% or greater reduction in HDRS-17 score from baseline). Secondary outcomes include assessments of self-rated depression, anxiety, psychosocial functioning, cognition and quality of life at 8, 16 and 26 weeks postrandomisation. Cost-effectiveness, patient acceptability, safety, mechanism of action and predictors of response will also be examined.Ethics and dissemination Ethical approval was granted by East Midlands Leicester Central Research Ethics Committee (ref: 18/EM/0232) on 30 August 2018. The results of the study will be published in relevant peer-reviewed journals, and then through professional and public conferences and media. Further publications will explore patient experience, moderators and mediators of outcome and mechanism of action.Trial registration number ISRCTN19674644

Published
2020
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2. Duration and Voice Quality of Early Infant Vocalizations

Author

Adele Gregory, Marija Tabain, and Michael P. Robb

Subjects
Male, Linguistics and Language, medicine.medical_specialty, Time Factors, Voice Quality, media_common.quotation_subject, Audiology, Language and Linguistics, 030507 speech-language pathology & audiology, 03 medical and health sciences, Speech and Hearing, 0302 clinical medicine, medicine, Humans, Quality (business), 030223 otorhinolaryngology, media_common, Infant, Newborn, Infant, Infant newborn, Nonlinear Dynamics, Duration (music), Infant Behavior, Female, 0305 other medical science, Psychology
Abstract

Purpose Infant vocal durations have been studied from a variety of perspectives, including medical, social, and linguistic. The resultant developmental profile across the first 6 months of life, however, is still far from clear. The purpose of this study was to evaluate the durational properties of infant vocalizations from the unique perspective of voice quality. By considering an infant's modal and nonmodal voice qualities, the developmental range of vocalizations produced by infants during the early months of life was captured. Method Four Australian English–speaking infants were recorded for approximately 1 hr per week during the first 6 months of life. A total of 6,309 vocalizations were perceptually identified and labeled according to voice quality. The duration of each vocalization was subsequently measured. Results A nonlinear curve was evident for the duration of all vocalizations combined. Duration increased significantly between Months 3 and 5. Modal voice was the only voice quality that displayed a linear increase in duration across the study. All other voice qualities displayed polynomial trends. Conclusions Based on the current results, the inconsistent pattern of vocal duration development found previously can be reconciled when voice quality properties of vocalizations are taken into account. A nonlinear curve is evident when a broad corpus of infant vocalizations is used, whereas a narrow corpus containing predominantly modal vocalizations displays a linear trend. The results demonstrate the necessity of including nonmodal voice qualities in infant duration experiments so as to not overstate the linear nature of duration increases.

Published
2017

3. Duration of early vocalisations

Author

Adele Gregory, Marija Tabain, and Michael P. Robb

Subjects
Modal voice, medicine.medical_specialty, Duration (music), Computer science, medicine, Contrast (statistics), Audiology
Abstract

The duration of three infants' vocalisations were examined during a six-month longitudinal study. In contrast to most other infant research, this study included in its analysis all vocalisations including those deemed vegetative or those having nonmodal voice quality. All three infants produced vocalisations which decreased in duration in the initial months. However between the 3rd and 5th month a significant increase (p

Published
2013
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