1. Bisphenol A acts as developmental agonist in Culex quinquefasciatus Say
- Author
-
Ayana Gayathri and Evans Da
- Subjects
Agonist ,endocrine system ,Bisphenol A ,Ecdysone ,medicine.drug_class ,Health, Toxicology and Mutagenesis ,Mosquito Vectors ,Biology ,Pharmacology ,chemistry.chemical_compound ,Phenols ,medicine ,Animals ,Environmental Chemistry ,Benzhydryl Compounds ,urogenital system ,fungi ,Water ,General Medicine ,biology.organism_classification ,Pollution ,Culex quinquefasciatus ,Culex ,Ecdysterone ,chemistry ,Phospholipases ,Larva ,Plastics - Abstract
Plastic – derived Bisphenol A (BPA) contaminated sewages in Trivandrum, Kerala, India are mosquito breeding sites. After summer rain, BPA in the stagnant water samples ranged between 0.86 and 1.14ppm. 1.0 ppm BPA is considered as environmentally relevant concentration. Present study revealed that BPA is a developmental agonist of Culex quinquefasciatus. Embryonic and larval development are shortened by BPA but pupal development is unaffected. Under the atmospheric temperature of 26 to 310C lifecycle was completed within 312 hours but during summer it was completed within 278 hours, meanwhile atmospheric temperature ranged between 30 and 370C. Reduction in the duration of development due to BPA was 50 to 70 hours during summer and 60 to 80 hours in other seasons. Larval – pupal stadium of the mosquito has three surges of 20-hydroxy ecdysone(20-HE), at 24,32 and 48th hour of the 4th instar. BPA resulted dose-dependent advancement of 20-HE peaks, Phospholipase A2 induction and expression of Ecdysone receptor EcRA and Ecdysone inducible gene E75A, which culminated in early pupation. Adults emerging from 1.0 ppm BPA treatment did not show significant difference in sanguivory and fecundity compared to control but pupae developed in 2 and 4 ppm BPA were significantly small.
- Published
- 2022