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High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Culex mosquitoes particularly Culex quinquefasciatus are important arboviral and filariasis vectors, however despite this important epidemiological role, there is still a paucity of data on their bionomics. The present study was undertaken to assess the insecticide resistance status of Cx. quinquefasciatus populations from four districts of Yaoundé (Cameroon). All Culex quinquefasciatus populations except one displayed high resistance to bendiocarb and malathion with mortalities ranging from 0 to 89% while high resistance intensity against both permethrin and deltamethrin was recorded. Molecular analyses revealed high frequencies of the ACE-1 G119S mutation (ranging from 0 to 33%) and kdr L1014F allele (ranging from 55 to 74%) in all Cx. quinquefasciatus populations. Significant overexpression was detected for cytochrome P450s genes CYP6AA7 and CYP6Z10, as well as for Esterase A and Esterase B genes. The total cuticular hydrocarbon content, a proxy of cuticular resistance, was significantly increased (compared to the S-lab strain) in one population. The study confirms strong insecticide resistance mediated by different mechanisms in Cx. quinquefasciatus populations from the city of Yaoundé. The expansion of insecticide resistance in Culex populations could affect the effectiveness of current vector control measures and stress the need for the implementation of integrated vector control strategies in urban settings.
- Subjects :
- 0301 basic medicine
Veterinary medicine
Insecticides
Mosquito Control
Insecticide Resistance
chemistry.chemical_compound
0302 clinical medicine
Pyrethrins
Cameroon
education.field_of_study
Multidisciplinary
biology
Geography
Culex
qx_510
Malathion
Insect Proteins
Medicine
Female
medicine.drug
Population dynamics
Science
030231 tropical medicine
Population
Bendiocarb
Mosquito Vectors
wc_765
Article
Filariasis
03 medical and health sciences
qx_600
Nitriles
parasitic diseases
medicine
Animals
education
Alleles
Permethrin
Gene Expression Profiling
fungi
wa_240
biology.organism_classification
medicine.disease
Culex quinquefasciatus
Hydrocarbons
030104 developmental biology
Deltamethrin
qx_530
chemistry
Mutation
Entomology
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....d039a8f6252bf35c4db402c726117aeb