1. Nocturnal stridor in multiple system atrophy: Video-polysomnography and clinical features
- Author
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Juyeon Kim, Mi-Jung Kim, Sooyeoun You, Sang-Ahm Lee, Kiju Kim, Young Jin Kim, Hyo Jae Kim, Sun Ju Chung, and Ho-Sung Ryu
- Subjects
Male ,0301 basic medicine ,Time Factors ,Polysomnography ,Stridor ,Video Recording ,Sudden death ,03 medical and health sciences ,Sleep Apnea Syndromes ,0302 clinical medicine ,Atrophy ,Activities of Daily Living ,otorhinolaryngologic diseases ,medicine ,Humans ,Aged ,Respiratory Sounds ,Retrospective Studies ,Cerebellar ataxia ,business.industry ,Apnea ,Middle Aged ,Multiple System Atrophy ,medicine.disease ,respiratory tract diseases ,030104 developmental biology ,Blood pressure ,Neurology ,Respiratory failure ,Anesthesia ,Breathing ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Introduction Nocturnal stridor, a life-threatening condition linked to respiratory failure and sudden death during sleep, is a serious issue in patients with multiple system atrophy (MSA). However, little is known about polysomnographic findings and clinical features of MSA patients with nocturnal stridor. Hence, we investigated video-polysomnography (VPSG) findings and clinical features associated with nocturnal stridor in patients with MSA. Methods We retrospectively analyzed the clinical data of patients with MSA (n = 49) who underwent overnight VPSG for the evaluation of sleep-disordered breathing. The presence of nocturnal stridor was confirmed based on overnight VPSG findings. Clinical data, including VPSG findings and clinical features, were compared between MSA patients with and without nocturnal stridor. Results Nocturnal stridor was present in 31 (63.3%) patients with MSA. Patients with stridor showed significantly higher apnea-hypopnea, respiratory disturbance, and oxygen desaturation indices than those without stridor (P = 0.024, P = 0.049, and P = 0.006, respectively). Patients with stridor had more severe axial motor features, more impaired activities of daily living, and longer disease duration than those without stridor (P = 0.012, P = 0.036, and P = 0.003, respectively). However, there were no significant between-group differences in sex, age at disease onset, MSA subtype, parkinsonian features, cerebellar ataxia, residual urine volume, or systolic and diastolic blood pressure change. Conclusions MSA with nocturnal stridor is related to higher apnea indices in conjunction with higher O2 desaturation index, more severe axial motor features, more impaired activities of daily living, and longer disease duration.
- Published
- 2021