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Your search keyword '"Wong, Chi-Hin"' showing total 2 results
Start Over Author "Wong, Chi-Hin" Topic liver cancer
2 results on '"Wong, Chi-Hin"'

1. Nanoparticle–DNA–polymer composites for hepatocellular carcinoma cell labeling, sensing, and magnetic resonance imaging.

Author

Leung, Ken Cham-Fai, Lee, Siu-Fung, Wong, Chi-Hin, Chak, Chun-Pong, Lai, Josie M.Y., Zhu, Xiao-Ming, Wang, Yi-Xiang J., Sham, Kathy W.Y., and Cheng, Christopher H.K.

Subjects
*LIVER cancer, *POLYMERIC composites, *CANCER cells, *NANOMEDICINE, *MAGNETIC resonance imaging of cancer, *ENDOCYTOSIS, *FOURIER transform infrared spectroscopy
Abstract

Highlights: [•] HepG2 transfection efficacies are studied with MRI, fluorescence and luminescence. [•] Sensing in receptor-mediated endocytosis depends on functional groups of composites. [•] Magnetofection enhances uptake efficacy with at most two orders of magnitude. [•] Cell viabilities of HepG2 and MDCK vary from 70 to 90% with different composites. [Copyright &y& Elsevier]

Published
2013
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2. Increased Efficacies in Magnetofection and Gene Delivery to Hepatocellular Carcinoma Cells with Ternary Organic-Inorganic Hybrid Nanocomposites.

Author

Leung, Ken Cham ‐ Fai, Chak, Chun ‐ Pong, Lee, Siu ‐ Fung, Lai, Josie M. Y., Zhu, Xiao ‐ Ming, Wang, Yi ‐ Xiang J., Sham, Kathy W. Y., Wong, Chi ‐ Hin, and Cheng, Christopher H. K.

Subjects
*DEFEROXAMINE, *LIVER cancer, *SUPERPARAMAGNETIC materials, *FERRIC oxide, *MAGNETIC resonance imaging, *GENE transfection
Abstract

A magnetic personality: Magnetofection and gene delivery have been investigated in HepG2 cells using ternary organic–inorganic hybrid nanocomposites that contain deferoxamine ‐ coated iron oxide nanoparticles (NPs), circular plasmid DNA, and branched polyethylenimine (PEI). It was found that the cellular uptake efficacies depend on the ratio of components in PEI/DNA/NP, as assessed by Prussian staining, magnetic resonance imaging, and luciferase expression in the presence and absence of a magnet during transfection. [ABSTRACT FROM AUTHOR]

Published
2013
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